Viloxazine, a Non-stimulant Norepinephrine Reuptake Inhibitor, for the Treatment of Attention Deficit Hyperactivity Disorder: A 3 Year Update by Hannah W Haddad, Paul B. Hankey, Jimin Ko, Zahaan Eswani, Pravjit Bhatti, Amber N. Edinoff, Adam M. Kaye, Alan D. Kaye

“…The extended-release (ER) form was approved by the US Food and Drug Administration (FDA) in April 2021 for the treatment of ADHD in pediatric patients aged 6-17 years. …”
Get full text

Current Potential of Pantoprazole in Treatment and Prevention of Gastrointestinal Diseases by A. A. Sheptulin, S. S. Kardasheva, A. A. Kurbatova

“…It minimally inhibits the CYP2C19 isoenzyme involved in the metabolism of many drugs. Pharmacokinetics of pantoprazole conditions a weaker drug interaction compared to other proton pump inhibitors (PPIs), which enables its use for gastrointestinal bleeding prevention in patients receiving dual antiplatelet therapy. …”
Get full text

Molecular Imaging Probes for Diagnosis and Therapy Evaluation of Breast Cancer by Qingqing Meng, Zheng Li

“…Molecular imaging has the potential to enhance our understanding of breast cancer biology and effects of drug action during both preclinical and clinical phases of drug development. …”
Get full text

Developing anti-TDE vaccine for sensitizing cancer cells to treatment and metastasis control by Stephene S. Meena, Benson K. Kosgei, Geofrey F. Soko, Cheng Tingjun, Ramadhani Chambuso, Julius Mwaiselage, Ray P. S. Han

“…TDEs support cancer progression by suppressing anti-tumor immune responses, promoting metastasis, and conferring drug resistance. Thus, targeting TDEs could improve the efficacy of anti-cancer treatments and control metastasis. …”
Get full text

How Does <i>Saccharomyces cerevisiae</i> DSM 34246 (Canobios-BL) <i>var. boulardii</i> Supplementation Impact the Fecal Parameters of Healthy Adult Dogs? by Nicolò Lonigro, Francesca Perondi, Natascia Bruni, Mauro Bigliati, Annalisa Costale, Elena Pagani, Ilaria Lippi, Alice Melocchi, Lucia Zema, Giorgia Meineri, Elisa Martello

Get full text

Sorafenib-Induced Liver Failure: A Case Report and Review of the Literature by Anneleen Van Hootegem, Chris Verslype, Werner Van Steenbergen

“…We hypothesize that an underlying cytochrome P450 dysfunction with the presence of reactive drug metabolites might lead to this potentially fatal Sorafenib-induced severe liver dysfunction.…”
Get full text

Flakka-Induced Prolonged Psychosis by Craig Crespi

“…In South Florida, there has been a highly addictive new synthetic drug flooding the streets for people looking for a cheap high. …”
Get full text

Mathematical analysis and simulations involving chemotherapy and surgeryon large human tumours under a suitable cell-kill functional response by Diego Samuel Rodrigues, Paulo Fernando de Arruda Mancera

“…Weuse some biological and pharmacological data in a numerical approach,where drug administration occurs in cycles (periodic infusion)and surgery is performed instantaneously. …”
Get full text

Analytical Quality by Design: A Tool for Regulatory Flexibility and Robust Analytics by Ramalingam Peraman, Kalva Bhadraya, Yiragamreddy Padmanabha Reddy

“…Very recently, Food and Drug Administration (FDA) has approved a few new drug applications (NDA) with regulatory flexibility for quality by design (QbD) based analytical approach. …”
Get full text

Exploring the Solubility and Bioavailability of Sodium Salt and Its Free Acid Solid Dispersions of Dolutegravir by Dani Lakshman Yarlagadda, Akshatha M. Nayak, Bheemisetty Brahmam, Krishnamurthy Bhat

“…Both DSSD and DFSD improved the solubility of Dolutegravir (DTG) to 5.7 and 4.54 folds compared to the pure forms. Similarly, drug release from DSSD and DFSD was 2 and 1.5 folds higher than that in the pure form, owing to the rapid dissolution of the drug from the formulations. …”
Get full text

Vector borne disease control interventions in agricultural and irrigation areas in sub-Saharan Africa: A systematic review. by Levi Kalitsilo, Leila Abdullahi, Nyanyiwe Mbeye, Lily Mwandira, Hleziwe Hara, Collins Mitambo, Rose Oronje

“…However, some challenges to these interventions were identified, which include seasonal changes and climate variability, insecticide and drug resistance, and farmers' attitudes toward accepting the interventions. …”
Get full text

QSAR modelling and docking analysis of some thiazole analogues as alfa-glucosidase inhibitors by Muhammad Tukur Ibrahim, Adamu Uzairu, Gideon Adamu Shallangwa, Sani Uba

“…The most active compound was found to be better than standard drug. The outcome of this findings paved way for predicting novel ?…”
Get full text

Advances in Immunotherapy and Targeted Therapy of Malignant Melanoma by Xue Wang, Shanshan Ma, Shuting Zhu, Liucun Zhu, Wenna Guo

“…Traditional treatments such as surgery, chemotherapy, and radiotherapy are unable to achieve the expected results due to MM’s low sensitivity, high drug resistance, and toxic side effects. As treatment advances, immunotherapy and targeted therapy have made significant breakthroughs in the treatment of MM and have demonstrated promising application prospects. …”
Get full text

Dissolving microneedle patch loaded with adipokines-enriched adipose extract relieves atopic dermatitis in mouse via modulating immune disorders, microbiota imbalance, and skin bar... by Jingyan Guan, Kaiqi Chen, Feng Lu, Yunfan He

“…However, problems concerning the control of drug release and inevitable pain caused by injection hinder the application of ACF in clinics. …”
Get full text

Bioactive compounds and probiotics–a ray of hope in COVID-19 management by Indu Bhushan, Mahima Sharma, Malvika Mehta, Shivi Badyal, Varun Sharma, Indu Sharma, Hemender Singh, Srinivas Sistla

Get full text

Repurposing radiosensitising medicines for radiotherapy: an overview by Geoff S Higgins, Jie Man Low, Gonzalo Rodriguez-Berriguete

“…Repurposing established non-cancer drugs for the treatment of cancer offers potential benefits such as speed of clinical translation and financial efficiencies. …”
Get full text

Gene Therapy for Glioblastoma Multiforme by Smit Shah, Joshua Green, Shantelle A. Graff, Qi Li, John D. Heiss

“…Significant limitations to effective GBM treatment include poor drug delivery across the blood–brain barrier, drug resistance, and complex genetic tumor alterations. …”
Get full text

deutetrabenazine for the treatment of chorea associated with Huntington’s disease by Harshit Gupta, Wil Perkins, Cain Stark, Sathya Kikkeri, Juyeon Kakazu, Adam D. Kaye, Alan D. Kaye

“…Although studies so far have displayed mixed results, further research, including head-to-head studies, is necessary to elucidate the true potential of this drug.…”
Get full text

Metformin: A Possible Option in Cancer Chemotherapy by Chidiebere V. Ugwueze, Odunze J. Ogamba, Ekenechukwu E. Young, Belonwu M. Onyenekwe, Basil C. Ezeokpo

“…However, the drug has been used in experimental trials in various aspects of medicine and pharmacology such as in reproductive medicine, cancer chemotherapy, metabolic diseases, and neurodegenerative diseases. …”
Get full text

pitolisant, a novel histamine-3 receptor competitive antagonist, and inverse agonist, in the treatment of excessive daytime sleepiness in adult patients with narcolepsy by Noeen Sarfraz, David Okuampa, Hannah Hansen, Mark Alvarez, Elyse M. Cornett, Juyeon Kakazu, Adam M. Kaye, Alan D. Kaye

“…This review discusses the epidemiology, pathophysiology, risk factors, presentation, treatment of narcolepsy, and the role of a novel drug, Pitolisant, in the treatment of EDS in adults with narcolepsy. …”
Get full text