Targeting AI-2 quorum sensing: harnessing natural products against Streptococcus suis biofilm infection by Shuji Gao, Shuo Yuan, Yingying Quan, Wenjie Jin, Yamin Shen, Rishun Li, Baobao Liu, Yuxin Wang, Li Yi, Shaohui Wang, Xiaogai Hou, Yang Wang

“…This study established a small natural product library by integrating commercial drug molecules with Chinese herbal medicine molecules. …”
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Improved Antibacterial Activity of Water-Soluble Nanoformulated Kaempferol and Combretastatin Polyphenolic Compounds by Y. Santhosh Kumar, Langeswaran Kulanthaivel, G. S. Hikku, R. Saravanan, Thangavelu Lakshmi, C. Kirubhanand, Murugesan Karthikeyan, P. Vijayalakshmi, Gowtham Kumar Subbaraj

“…The drug release kinetics of the nanoformulated drugs were carried out using the dialysis membrane method and were compared with their pristine forms. …”
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Risk factors of multidrug resistant tuberculosis among patients with tuberculosis at selected multidrug resistance treatment initiative centres in southern Ethiopia: a case-control... by Fantahun Admassu, Ermias Abera, Addisalem Gizachew, Tagesse Sedoro, Taye Gari

“…In order to reduce the burden of drug resistance, strategies of controlling MDR-TB in the study area should emphasise on enhancing public health education and reducing treatment interruptions of patients with TB and drug-resistant TB.…”
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Determination of Levetiracetam in Human Plasma by Dispersive Liquid-Liquid Microextraction Followed by Gas Chromatography-Mass Spectrometry by Greyce Kelly Steinhorst Alcantara, Leandro Augusto Calixto, Luiz Alberto Beraldo de Moraes, Regina Helena Costa Queiroz, Anderson Rodrigo Moraes de Oliveira, Cristiane Masetto de Gaitani

“…Levetiracetam (LEV) is an antiepileptic drug that is clinically effective in generalized and partial epilepsy syndromes. …”
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One Earth-One Health (OE-OH): Antibacterial Effects of Plant Flavonoids in Combination with Clinical Antibiotics with Various Mechanisms by Ganjun Yuan, Fengxian Lian, Yu Yan, Yu Wang, Li Zhang, Jianping Zhu, Aiman Fatima, Yuxing Qian

“…<b>Conclusions</b>: The findings align with the drug selection principle of synergistic combinations and suggest that plant flavonoids could extensively enhance antibiotic efficacy. …”
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Transmission of HIV and HCV within Former Soviet Union Countries by Lazzat Aibekova, Aizada Bexeitova, Arailym Aldabergenova, Gonzalo Hortelano, Zhangwen Ge, Feng Yi, Yiming Shao, Jack DeHovitz, Sten H. Vermund, Syed Ali

“…Following the collapse of the Union of Soviet Socialist Republic (USSR) in 1991, trans-border mobility increased within the former Soviet Union (FSU) countries. In addition, drug-trafficking and injection drug use began to rise, leading to the propagation and transmission of blood-borne infections within and across the FSU countries. …”
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A symbiotic mosquito‐gut bacterium for flavivirus control by Jinglin Wang, Yibin Zhu, Jun Leng, Yulin Yuan, Yingyi Cao, Gong Cheng, Xueshan Xia

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A prebiotic intervention improves mood in everyday life in healthy women but not in men: Exploratory results from a larger double-blind placebo controlled cross-over study by Koen Hogenelst, Tanja Krone, Boukje Eveleens Maarse, Ines Warnke, Jessica Snabel, Tim J. van den Broek, Frank Schuren, Matthijs Moerland, Femke P.M. Hoevenaars

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Clinical Symptoms and Types of Samples Are Critical Factors for the Molecular Diagnosis of Symptomatic COVID-19 Patients: A Systematic Literature Review by Milad Zandi, Abbas Farahani, Armin Zakeri, Sara Akhavan Rezayat, Ramin Mohammadi, Umashankar Das, Jonathan R. Dimmock, Shervin Afzali, Mohammadvala Ashtar Nakhaei, Alireza Doroudi, Yousef Erfani, Saber Soltani

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Mesotherapy: From Historical Notes to Scientific Evidence and Future Prospects by Massimo Mammucari, Enrica Maggiori, Domenico Russo, Chiara Giorgio, Gianpaolo Ronconi, Paola E Ferrara, Flora Canzona, Luciano Antonaci, Bartolomeo Violo, Renato Vellucci, Domenico Rocco Mediati, Alberto Migliore, Umberto Massafra, Barbara Bifarini, Fabio Gori, Massimo di Carlo, Stefano Brauneis, Teresa Paolucci, Piergiovanni Rocchi, Anna Cuguttu, Raffaele Di Marzo, Alessandro Bomprezzi, Stefania Santini, Manuela Giardini, Anna Rosa Catizzone, Fiammetta Troili, Dario Dorato, Alessandra Gallo, Costanza Guglielmo, Silvia Natoli

“…Intradermal therapy, known as mesotherapy, is a technique used to inject a drug into the surface layer of the skin. In particular, it involves the use of a short needle to deposit the drug in the dermis. …”
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Effect of trilaciclib administered before chemotherapy in patients with extensive-stage small-cell lung cancer: A pooled analysis of four randomized studies by Ying Liu, Lin Wu, Dingzhi Huang, Qiming Wang, Chen Yang, Li Zhou, Shuguang Sun, Xiaomei Jiang, Ying Cheng

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Responsible research in health disparities using the Adolescent Brain Cognitive DevelopmentSM (ABCD) study by MR Gonzalez, C Cardenas-Iniguez, DE Linares, S Wonnum, K Bagot, EJ White, A Cuan, S DiMatteo, YD Akiel, P Lindsley, JC Harris, E Perez-Amparan, TD Powell, Comité Organizador Latino de City Heights (COLCH), G Dowling, D Alkire, WK Thompson, TM Murray

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Holistic health and social care outreach for people experiencing homelessness with recent non-fatal overdose in Glasgow, Scotland: the Pharmacist and third sector Homeless charity... by Vibhu Paudyal, Nicola Greenlaw, Frances S Mair, Kate Stock, Andrew McPherson, Andrea E Williamson, Richard Lowrie, Donogh Maguire, Steven Ross, James Roy Robertson, Alison Boyle, Clare Duncan, Rebecca Blair, Cian Lombard, Fiona Hughes, Jane Moir, Ailsa Scott, Frank Reilly, Laura Sills, Jennifer Hislop, Stephen Wishart, David Brannan, Rebekah Ramage

“…Objectives To examine randomised controlled trial (RCT) progression criteria including emergency department (ED) attendance and non-fatal overdose, from a holistic, integrated health and social care outreach intervention (PHOENIx), for people experiencing homelessness with recent non-fatal street drug overdose.Design Pilot RCT. 1:1 randomisation to PHOENIx plus usual care (UC) or UC.Setting Glasgow, Scotland.Participants 128 adults experiencing homelessness with at least one non-fatal street drug overdose in the preceding 6 months.Interventions Pharmacists from the National Health Service and third sector homelessness workers offered weekly outreach. …”
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Mucocutaneous Adverse Events in Patients With Cancer Treated with the Highly Selective RET Kinase Inhibitor Selpercatinib (LOXO-292) by Rachel E. Reingold, MD, Rose Parisi, MD, MBA, Guilherme Harada, MD, Andrea P. Moy, MD, George Dranitsaris, PhD, Jasmine H. Francis, MD, Julia Canestraro, OD, FAAO, Julia A. Lester, MPH, Lauren A. Kaplanis, RN, Dazhi Liu, PharmD, BCOP, Mario E. Lacouture, MD, Alexander Drilon, MD

“…There were 18 (14%) MAE-related therapy interruptions, including the following: three (2%) rechallenged with dose maintained, 10 (7%) with a 50% dose reduction, 5 (4%) with a 25% dose reduction, and no drug discontinuations. A treatment algorithm was created for the most common MAEs: xerostomia managed with saliva and lubricants; mucositis with steroid rinses; rashes with topical steroids with or without topical ammonium lactate; periorbital edema with cold or caffeine compresses; and xerosis and pruritus with emollients. …”
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Physicochemical properties and cytochromes P-450 kinetics of the trifluoroacetamido derivative of phenacetin by Hannah L. Cure, Thomas A. Shell

“…A trifluoroacetamido derivative (TFA-phenacetin) of phenacetin, an analgesic antipyretic drug, was synthesized to compare its lipophilicity to the parent molecule by determining octanol–water partition coefficients. …”
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N-of-1 medicine by Peter Wang, Qiao Ying Leong, Ni Yin Lau, Wei Ying Ng, Siong Peng Kwek, Lester Tan, Shang-Wei Song, Kui You, Li Ming Chong, Isaiah Zhuang, Yoong Hun Ong, Nigel Foo, Xavier Tadeo, Kirthika Senthil Kumar, Smrithi Vijayakumar, Yoann Sapanel, Marlena Natalia Raczkowska, Alexandria Remus, Agata Blasiak, Dean Ho

“…Examples include genome/molecular alteration-guided drug selection, single-patient gene therapy design and synergy-based drug combination development, and these approaches can yield substantially diverse recommendations. …”
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Semi-Empirical Predictions on the Structure and Properties of ent-Kaurenoic Acid and Derivatives by Jose Isagani B. Janairo, Gerardo C. Janairo, Derrick Ethelbhert C. YU

“…Results revealed that the molecule possess favourable attributes which renders it possible to be considered as a drug lead only that its very hydrophobic nature can result to poor bioavailabilty, low absorption and poor systemic circulation. …”
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Short Communication: In Vitro Efficacy Testing of Praziquantel, Ivermectin, and Oxfendazole against Taenia Solium Cysts by S. Cederberg, C. S. Sikasunge, Å. Andersson, M. V. Johansen

“…Oxfendazole is recommended as the drug of choice for treating porcine cysticercosis. …”
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DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences by Gaëlle Lenglet, Marie-Hélène David-Cordonnier

“…DNA targeting drugs represent a large proportion of the actual anticancer drug pharmacopeia, both in terms of drug brands and prescription volumes. …”
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Ezetimibe and Improving Cardiovascular Outcomes: Current Evidence and Perspectives by Akshyaya Pradhan, Monika Bhandari, Rishi Sethi

“…It also reduces biomarkers and induces plaque regression like statins. The drug has now established itself as an add-on therapy to statin when monotherapy fails to achieve LDL goals and when it is not tolerated. …”
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