Development of Duloxetine Hydrochloride Tablets for Delayed and Complete Release Using Eudragit L 100 by M. Yasmin Begum, Ali Alqahtani, Mohammed Ghazwani, Noura Abdullah Alhamood, Umme Hani, Avanthi Jajala, Mohamed Rahamathulla

“…In conclusion, the optimized formulation could resist the drug release in acidic environment of gastrointestinal region and release the drug at a time once the tablet reaches the intestine.…”
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Evidence That ADAM17 Mediates the Protective Action of CGRP against Angiotensin II-Induced Inflammation in Vascular Smooth Muscle Cells by Si-yu Zeng, Li Yang, Chen-liang Hong, Hui-qin Lu, Qiu-jiang Yan, Yan Chen, Xu-ping Qin

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Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian by Bai-xia Zhang, Jian Li, Hao Gu, Qiang Li, Qi Zhang, Tian-jiao Zhang, Yun Wang, Cheng-ke Cai

“…The results suggested that the PPI network of SHL exhibited a scale-free property and modular architecture. The drug target network of SHL was structured with 21 functional modules. …”
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Antifungal Activity of Chitosan Nanoparticles and Correlation with Their Physical Properties by Ling Yien Ing, Noraziah Mohamad Zin, Atif Sarwar, Haliza Katas

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Formulation and development of Serratiopeptidase enteric coated tablets and analytical method validation by UV Spectroscopy by Vijay Kumar Panthi, Saurav Kumar Jha, Raghvendra Chaubey, Rudra Pangeni

“…Serratiopeptidase (SRP) is a proteolytic enzyme that emerged as one of the most potent anti-inflammatory and analgesic drugs. The purpose of the present study was to formulate and evaluate enteric-coated tablets for SRP and investigate their stability using a simple and validated analytical method by ultraviolet (UV) spectroscopy. …”
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Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine by Antonella Napolitano, Peter R. Murgatroyd, Nick Finer, Elizabeth K. Hussey, Robert Dobbins, Steve O'Rahilly, Derek J. R. Nunez

“…We have explored whole-body indirect calorimetry to detect the metabolic effects of thermogenic drugs through administration of ephedrine hydrochloride and have assessed ephedrine's merits as a comparator compound in the evaluation of novel thermogenic agents. …”
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Progress in the role of nanoparticles in the diagnosis and treatment of bone and joint tuberculosis by Yitong Ding, Baiyun Li, Yangfei Yi, Can Liu, Jie Wen, Jie Wen, Xiaohong Jian, Yufei Li

“…Bone and joint tuberculosis (BJTB), caused by Mycobacterium tuberculosis (MTB), is a prevalent form of extrapulmonary tuberculosis that poses significant challenges to global public health due to difficulties in early diagnosis, prolonged treatment cycles, and drug resistance. Recent advancements in nanotechnology have introduced novel solutions for the early detection and precise treatment of BJTB, leveraging unique physicochemical properties such as high specific surface area, targeted delivery capabilities, sustained drug release, and excellent biocompatibility. …”
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Identification of an Autophagy-Related Signature Based on Whole Bone Marrow Sequencing for the Prognosis and Immune Microenvironment Characterization of Multiple Myeloma by Licheng Li, Ting Chen, Jishi Wang, Mengxing Li, Qinshan Li

“…Myeloma (MM) is a malignant plasma cell disorder, which is incurable owing to its drug resistance. Autophagy performs an integral function in homeostasis, survival, and drug resistance in multiple myeloma (MM). …”
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Assessing Knowledge, Attitudes, and Practices of Medication Disposal: A Study on Rural Communities in Sarojini Nagar, Lucknow by Saurabh Kashyap, Akshata MA, Anubhav Agrawal, Abhishek Singh, Aman Verma, Ish Gupta

“…Introduction: The increasing global consumption of medications has led to a significant rise in the improper disposal of unused and expired drugs, posing risks to both human health and the environment. …”
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Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii),Ni (ii) and Co (ii) complexes by Haftom Welderufael, Dagne Addisu Kure, Endalkachew Asefa Moges, Lelisa File, Salah Hamza Sherif

“…This compound is a good starting point to develop new drug for treating pathogenic diseases. Therefore, synthesis of more analogue were recommended for further discovery of a new drug candidate. …”
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Evaluation of Carboxymethyl Cellulose/Gelatin Hydrogel-Based Dressing Containing Cefdinir for Wound Healing Promotion in Animal Model by Zahra Soleimani, Hadi Baharifar, Najmeh Najmoddin, Kamyar Khoshnevisan

“…The results of the cytotoxicity test showed the absence of cytotoxicity in both drug-containing and drug-free wound dressings, as well as a survival rate of over 75% in cells after 48 h. …”
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Management of intraocular pressure and inflammation using febuxostat film: in vitro - in vivo correlation by Mouli Das, Sk Habibullah, Tanisha Das, Rakesh Swain, Subrata Mallick

“…Key results: Amorphization of the drug was observed from the differential scanning calorimetry and X-ray diffraction results. …”
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Binding Mode Investigation of Polyphenols from Scrophularia Targeting Human Aldose Reductase Using Molecular Docking and Molecular Dynamics Simulations by Abinaya Manivannan, Prabhakaran Soundararajan, Yoo Gyeong Park, Sugunadevi Sakkiah, Byoung Ryong Jeong

“…Aldose reductase (ALR2), a vital enzyme involved in polyol pathway, has befitted as a novel drug target in antidiabetes drug discovery process. …”
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The Gut Microbiota-Related Antihyperglycemic Effect of Metformin by Izabela Szymczak-Pajor, Józef Drzewoski, Małgorzata Kozłowska, Jan Krekora, Agnieszka Śliwińska

“…Metformin is still the first-line drug for treatment of T2DM unless there are contra-indications. …”
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QbD-Driven preparation, characterization, and pharmacokinetic investigation of daidzein-l oaded nano-cargos of hydroxyapatite by Namrata Gautam, Debopriya Dutta, Saurabh Mittal, Perwez Alam, Nasr A. Emad, Mohamed H. Al-Sabri, Suraj Pal Verma, Sushama Talegaonkar

“…A notable entrapment efficiency of 87.23 ± 0.97% and drug release of 91 ± 0.85% from DZHAPNPs was observed over 90 h at pH 7.4. …”
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Carbon Nanomaterials in the Treatment of Infectious Bone Defects and Wound Scars after Wushu Fractures by Shenghui Wei, Lei Zou, Xu Hu, Qiuming Li

“…Studies have shown that when the drug loading of doxycycline increases from 10% to 15%, this is related to the change in properties of the polylactic acid fiber membrane from hydrophobic to hydrophilic caused by the increase in doxycycline drug loading.…”
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Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii),Ni (ii) and Co (ii) complexes by Haftom Welderufael, Dagne Addisu Kure, Endalkachew Asefa Moges, Lelisa File, Salah Hamza Sherif

“…This compound is a good starting point to develop new drug for treating pathogenic diseases. Therefore, synthesis of more analogue were recommended for further discovery of a new drug candidate. …”
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Biological Response Modifiers in Combination with Antivirals against Experimentally-Induced Virus Infections by Robert W Sidwell, John H Huffman, Donald F Smee, John Gilbert, Roland K Robins, Meir Kende, John Huggins

“…Ribavirin was always administered orally twice daily for three days starting 24 h after virus inoculation. Both drug combinations were considered synergistic, increasing the therapeutic index compared to either drug used alone, and significantly reducing the evidence of ribavirin toxicity. …”
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Formulation of Ebastine Fast-Disintegrating Tablet Using Coprocessed Superdisintegrants and Evaluation of Quality Control Parameters by Bhawana Dhakal, Jaybir Kumar Thakur, Reema Kumari Mahato, Ishwori Rawat, D. C. Rabin, Rahul Rana Chhetri, Kedar Prasad Shah, Atul Adhikari, Jitendra Pandey

“…Ebastine is a long-acting, nonsedating, second-generation antihistaminic drug that prevents histamine action, mainly in immediate hypersensitivity. …”
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Patient Management in Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus by A. E. Bagriy, A. D. Zubov, M. V. Khomenko, E. S. Mikhailichenko, E. A. Pylaeva, N. A. Khaustova, E. V. Bryukhovetskaya

“…A current overview of non-pharmacological and drug-based approaches to non-alcoholic fatty liver disease (NAFLD) combined with type 2 diabetes mellitus (T2D).Key points. …”
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