Different Metabolites in the Roots, Seeds, and Leaves of Acanthopanax senticosus and Their Role in Alleviating Oxidative Stress by Jie Su, Qi Wang, Zhifeng Li, Yan Feng, Yan Li, Shinlin Yang, Yulin Feng

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Leaflet: Operative Steps for Interventional Studies in Neuroscience by Maria Meringolo, Sergio Delle Monache, Giuseppina Martella, Antonella Peppe

“…Background/Objectives: Drug development involves multiple stages, spanning from initial discovery to clinical trials. …”
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Synergistic Approach of High-Precision 3D Printing and Low Cell Adhesion for Enhanced Self-Assembled Spheroid Formation by Chunxiang Lu, Aoxiang Jin, Chuang Gao, Hao Qiao, Huazhen Liu, Yi Zhang, Wenbin Sun, Shih-Mo Yang, Yuanyuan Liu

“…Fluorescent viability staining confirmed the biocompatibility and reliability of the chip. Finally, drug response experiments were conducted using the chip. …”
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Observer Performance in the Use of Digital and Optical Microscopy for the Interpretation of Tissue-Based Biomarkers by Marios A. Gavrielides, Catherine Conway, Neil O’Flaherty, Brandon D. Gallas, Stephen M. Hewitt

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PROTACs: Mechanism and Bioavailability enhancement strategies by nanotechnology, RNA viral infections (vaccine strategy) and Prodrug development by Sanaul Mustafa, Md Sabir Hussain Siddiquee

“…This review also includes new progress, clinical applicability, and development trend of PROTAC for the change of disease therapy and drug delivery. …”
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Occipital Nerve Blockade for the Treatment of Occipital Neuralgia-Like Acute Postcraniotomy Headache: A Retrospective Study by Shaoheng Wang, Xueye Han, Chunmei Zhao, Fang Luo

“…Forty-one patients, who developed drug-resistant ON-APCH after elective craniotomy and received ONB with lidocaine for diagnoses, were included in this study, all of whom were treated using dexamethasone and lidocaine. …”
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Patients Hospitalized in General Wards via the Emergency Department: Early Identification of Predisposing Factors for Death or Unexpected Intensive Care Unit Admission—A Historical... by Thierry Boulain, Isabelle Runge, Nathalie Delorme, Angèle Bouju, Antoine Valéry

“…We identified 9 predictors of the target event including the oxygen administration on the ED, unknown current medications, and use of psychoactive drug(s). All predictors put the patients at risk during the first 15 days of hospitalization. …”
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Efficacy and safety of ciprofol versus propofol for induction of general anaesthesia or sedation: A systematic review and meta-analysis of randomised controlled trials by Abdallah Saeed, Mariam Elewidi, Ahmad Nawlo, Amr Elzahaby, Asmaa Khaled, Abdalla Othman, Mohamed Abuelazm, Basel Abdelazeem

“…Background and Aims: Propofol has been used in medical practice as an anaesthetic drug for producing and sustaining general anaesthesia due to its advantages. …”
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Chemical Fingerprint and Metabolic Profile Analysis of Tianshu Tablets by Ultra-High Performance Liquid Chromatography/Quadrupole-Time of Flight Mass Spectrometry by Lin Chen, Renhao Chen, Hui Ouyang, Qi Wang, Zhifeng Li, Yulin Feng, Shilin Yang

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Levetiracetam Induced Behavioral Abnormalities in a Patient with Seizure Disorder: A Diagnostic Challenge by Oluwaseun Ogunsakin, Terence Tumenta, Scarlet Louis-Jean, Ayesha Mahbub, Peterson Rabel, Tolu Olupona, Shaheen Alam

“…Levetiracetam is a second-generation antiepileptic drug that is chemically unrelated to other antiepileptic drugs. …”
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Anti-Biofilm Effect of Ampicillin-Loaded Poly (Lactic-co-glycolic Acid) Nanoparticles Conjugated with Lysostaphin on Methicillin-Resistant Staphylococcus aureus by Elahe Norouzi, Seyed Mostafa Hosseini, Babak Asghari, Reza Mahjoub, Ehsan Nazarzadeh Zare, Mohammad-Ali Shahbazi, Fereshte Kalhori, Mohammad Reza Arabestani

“…The biofilm investigation’s findings, however, indicated that compared to the free drug, the hindering effect of the nanodrug carrier was greater after 72 hours. …”
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Efficiency of Multiparticulate Delivery Systems Loaded with Flufenamic Acid Designed for Burn Wound Healing Applications by Sorina Dinescu, Simona Rebeca Ignat, Andreea Daniela Lazar, Ștefania Marin, Elena Danilă, Maria M. Marin, Denisa Ioana Udeanu, Mihaela Violeta Ghica, Mădălina G. Albu-Kaya, Marieta Costache

“…Therefore, this study is aimed at obtaining and validating a novel multiparticulate system based on a collagen matrix with controlled delivery of flufenamic acid anti-inflammatory drug for burn wound healing applications. In this work, we have characterized the properties and biocompatibility of these multiparticulate drug delivery systems (MDDS) and we have demonstrated their efficiency against burns and soft tissue lesions, particularly when the drug was microencapsulated, and thus with a controlled release. …”
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Impact of bedaquiline resistance probability on treatment decision for rifampicin-resistant TB by T.P.H. Trang, R. Kessels, T. Decroo, A. Van Rie

“…Each percentage point increase in prBDQ R resulted in 8.2% lower odds (OR 0.92, 95% CI 0.90–0.93) of continuing BDQ as a fully effective drug and 5.0% lower odds (OR 0.95, 95% CI 0.94–0.96) of continuing it but not counting it as an effective drug. …”
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Advances in the Development and Application of Human Organoids: Techniques, Applications, and Future Perspectives by Zhangcheng Zhu, Yiwen Cheng, Xia Liu, Wenwen Ding, Jiaming Liu, Zongxin Ling, Lingbin Wu

“…This progress has expanded their application across several domains, including regenerative medicine, where organoids offer potential for tissue replacement and repair; disease modeling, which allows for the study of disease mechanisms and progression in a controlled environment; drug discovery and evaluation, where organoids provide a more accurate platform for testing drug efficacy and safety; and microecological research, where they contribute to understanding the interactions between microbes and host tissues. …”
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Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta‐9‐Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes by Lixuan Qian, Tao Zhang, Jean Dinh, Mary F. Paine, Zhu Zhou

“…Physiologically based pharmacokinetic (PBPK) models for CBD and THC and for drug–drug interaction studies involving CBD or THC as object drugs were developed and verified to improve estimates of these contributions. …”
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Comparison of two plates and screw osteosynthesis configurations in a rat model of critical sized femoral defects to reduce implant related failures by Marc Saab, Anne-Sophie Drucbert, Nicolas Blanchemain, Feng Chai

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Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties by Sa Anongtip, Sawatdee Somchai, Phadoongsombut Narubodee, Buatong Wilaiporn, Nakpeng Titpawan, Sritharadol Rutthapol, Srichana Teerapol

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Chloroplast Genome Sequencing and Comparative Analysis of Six Medicinal Plants of Polygonatum by Jinchen Yao, Zhaohuan Zheng, Tao Xu, Duomei Wang, Jingzhe Pu, Yazhong Zhang, Liangping Zha

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Traditional Chinese Medicine Improves Activities of Daily Living in Parkinson's Disease by Weidong Pan, Shin Kwak, Yun Liu, Yan Sun, Zhenglong Fang, Baofeng Qin, Yoshiharu Yamamoto

“…The results indicate that ZAZ2 improved activities of daily living (ADL) of parkinsonism and, thus, is a potentially suitable drug for long-term use.…”
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Antimicrobial Potential of Streptomyces spp. Isolated from the Rift Valley Regions of Ethiopia by Firew Elias, Sudhamani Muddada, Diriba Muleta, Belachew Tefera

“…The isolates RVE129 and RVE217 showed the maximum zone of inhibition at 27 ± 0.6 mm and 26 ± 0.6 mm, respectively, against S. aureus, and the results were higher than the standard drug streptomycin (25 ± 0.58 mm). The inhibition zone of crude extracts from RVE129 was at the maximum of 22 ± 0.0 mm against P. aeruginosa, almost comparable to the standard drug streptomycin (24 ± 0.58 mm). …”
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