Lopinavir and Ritonavir have High Affinity Toward the SARS-CoV-2 S-protein Receptor-binding Domain Sequenced in Brazil by Aline Diogo Marinho, Helyson Lucas Bezerra Braz, João Alison de Moraes Silveira, Danilo Galvão Rocha, Roberta Jeane Bezerra Jorge, Geanne Matos de Andrade

“…Results: Among the seven drugs tested, only lopinavir and ritonavir demonstrated significant binding affinities to the RBD. …”
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Enhancement of Doxorubicin Efficacy by Bacopaside II in Triple-Negative Breast Cancer Cells by Sima Kianpour Rad, Kenny K. L. Yeo, Runhao Li, Fangmeinuo Wu, Saifei Liu, Saeed Nourmohammadi, William M. Murphy, Yoko Tomita, Timothy J. Price, Wendy V. Ingman, Amanda R. Townsend, Eric Smith

“…A 3D culture model simulated drug-resistant TNBC, and combination effects were evaluated with live-cell imaging. …”
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CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis by Ying Zhang, Ruiwei Yao, Mingyi Li, Chongkai Fang, Kunliang Feng, Xiuru Chen, Jinan Wang, Rui Luo, Hanqian Shi, Xinqiu Chen, Xilin Zhao, Hanlin Huang, Shuwei Liu, Bing Yin, Chong Zhong

“…Abstract The high mortality rate from hepatocellular carcinoma (HCC) is due primarily to challenges in early diagnosis and the development of drug resistance in advanced stages. Many first-line chemotherapeutic drugs induce ferroptosis, a form of programmed cell death dependent on ferrous iron-mediated oxidative stress, suggesting that drug resistance and ensuing tumor progression may in part stem from reduced ferroptosis. …”
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Spectrophotometric Determination of Ezetimibe by P. Baby Sudha Lakshmi, D. Ramchandran, C. Rambabu

“…Two simple, sensitive, selective and accurate spectro-photometric methods (Method A and Method B) for the determination of eztimibe in bulk drug and pharmaceutical formulations (tablets) have been described. …”
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Nonsurgical Management of Nifedipine Induced Gingival Overgrowth by George Sam, Staly Chakkalakkal Sebastian

“…Drug-induced gingival overgrowth is frequently associated with three particular drugs: phenytoin, cyclosporin, and nifedipine. …”
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Synthesis, Computational Studies and Preliminary Pharmacological Evaluation of New Arylpiperazines by Sushil Kumar, A. K. Wahi, Ranjit Singh

“…The physicochemical similarity of the target compounds with respect to standard drugs clozapine, ketanserine and risperidone was assessed by calculating from a set of physiochemical properties using software programs. …”
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UV Spectrophotometric Method for Determination of Cinitapride in Pure and its Solid Dosage Form by B. Thangabalan, A. Elphine Prabahar, R. Kalaichelvi, P. Vijayaraj Kumar

“…A new, rapid, precise, accurate and sensitive analytical method was developed for the UV spectrophotometric assay of cinitapride (CTP). The drug obeyed the Beer's law and showed good correlation. …”
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Treatments for Severe Cutaneous Adverse Reactions by Yung-Tsu Cho, Chia-Yu Chu

“…It consists of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE). …”
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Efficacy of the herbal preparation STW 5 in multi-target therapy of functional dyspepsia by A. A. Sheptulin, V. O. Kaybysheva

“…To discuss mechanisms of action and results of clinical application of plant-derived drug STW 5 (Iberogast®) for treatment of functional dyspepsia (FD).Key points. …”
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Bilateral Multifocal Central Serous-Like Chorioretinopathy due to MEK Inhibition for Metastatic Cutaneous Melanoma by Scott D. Schoenberger, Stephen J. Kim

“…There was a complete resolution of findings after drug stoppage. After resuming a lower dose of the MEK inhibitor, the findings recurred again but resolved after drug stoppage. …”
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CIHR Canadian HIV Trials Network Co-Infection and Concurrent Diseases Core: Updated Canadian Guidelines for the Treatment of Hepatitis C Infection in HIV-hepatitis C Coinfected Adu... by Mark Hull, Stephen Shafran, Alice Tseng, Pierre Giguère, Marina B Klein, Curtis Cooper

“…Management of HIV-HCV coinfection is more complex due to the accelerated progression of liver disease, the timing and nature of antiretroviral and HCV therapy, mental health and addictions management, socioeconomic obstacles and drug-drug interactions between new HCV direct-acting antiviral therapies and antiretroviral regimens.…”
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Tofersen and other antisense oligonucleotides in ALS by Albert Ludolph, Maximilian Wiesenfarth

“…The results of treatment with the ASO tofersen in SOD1-ALS show that the drug has a convincing beneficial effect on ALS caused by SOD1 mutations, that preclinical studies in rodents predicted the therapeutic effect in the human disease, and that clinical efficacy is associated with a specific sequence of effects of the drug on mechanistic and degenerative biomarkers and, subsequently, functional outcomes such as weight stabilization and ALSFRS-R. …”
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Confidence Region Approach for Assessing Bioequivalence and Biosimilarity Accounting for Heterogeneity of Variability by Jianghao Li, Shein-Chung Chow

“…For approval of generic drugs, the FDA requires that evidence of bioequivalence in average bioequivalence in terms of drug absorption be provided through the conduct of a bioequivalence study. …”
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Progress of Clinical Research on Trop2 in Solid Tumors by Ying ZHANG, Yueping LIU

“…Various targeted therapeutics against Trop2, such as anti-Trop2 antibodies and antibody-drug conjugate drugs targeting Trop2, have been developed, and some therapeutics have been approved or are in clinical trials for cancer treatment. …”
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A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab Cardiotoxicity by Sylvana Hidalgo, Carol A. Albright, Gretchen L. Wells

“…Furthermore, the patient did not respond to withdrawal of the drug or medical therapy for heart failure.…”
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Hashish Body Packing: A Case Report by Manuel Jesus Soriano-Perez, Jose Luis Serrano-Carrillo, Inmaculada Marin-Montin, Alfonso Cruz-Caballero

“…A 42-year-old African male was brought by the police to the emergency department under suspicion of drug smuggling by body-packing. Plain abdominal radiograph showed multiple foreign bodies within the gastrointestinal tract. …”
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MATRIX: a platform for cultivation profiling and bioactive discovery in natural product research by Zeinab G. Khalil, Thulasi Sritharan, Angela A. Salim, Robert J. Capon

“…The MATRIX approach offers a resource-efficient platform for microbial biodiscovery, contributing significantly to natural product research and drug development.…”
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Blasting neuroblastoma using optimal control of chemotherapy by Craig Collins, K. Renee Fister, Bethany Key, Mary Williams

“…A mathematical model is used to investigate the effectiveness of thechemotherapy drug Topotecan against neuroblastoma. Optimal control theoryis applied to minimize the tumor volume and the amount of drug utilized.The model incorporates a state constraint that requires the level ofcirculating neutrophils (white blood cells that form an integral part of the immune system) to remain above an acceptable value. …”
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Hallucination in a Seizure Patient Using Levetiracetam: A Case Report by D. R. Shakya, A. Dutta, R. Gautam

“…Levetiracetam, a relatively new antiepileptic drug (AED), is used mainly as adjuvant and less as monotherapy of seizure. …”
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Crystal structure of 1-isopropyl-3-(prop-1-en-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, C11H15N5 by Wang Yanjiao, Tang Xiaoqin, Liu Bin

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