Phylogenetic Aspects of Antibiotic Resistance and Biofilm Formation of P. aeruginosa Isolated from Clinical Samples by Maryam Motevasel, Masoud Haghkhah, Negar Azimzadeh

“…Biofilm production and drug resistance phenomenon play a critical role in P. aeruginosa infections. …”
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Analgesic and Anti-inflammatory Activities of the Stem Bark of Yellow Flamboyant (<i>Peltophorum pterocarpum</i>) by O.K. Ogbeide, C.J. Ogbonnaya, E. Asakitikpi, D.O. Uyi, B.O. Aluge, O. Nosakhare, W.O. Otahagwa, C.A. Ehigie, U. Omoruyi, O.S. Aifuwa, B.O. Gabriel

“…Analgesic activity was investigated by using acetic acid-induced writhing model, using indomethacin as a reference drug. Antiinflammatory activity of n-hexane extract of P. pterocarpum stem bark was investigated by using formalin-induced paw licking model, using aspirin as standard drug. …”
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Therapeutic molecules for multiple human diseases identified from pigeon pea (Cajanus cajan L. Millsp.) through GCâMS and molecular docking by Deepu Mathew, Lidiya John P., Manila T.M., Divyasree P., Sandhya Rajan V.T.K.

“…The molecules identified through docking were further subjected to ADMET analysis and promising drug candidates were identified for each disease. …”
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Severe Diltiazem Poisoning Treated with Hyperinsulinaemia-Euglycaemia and Lipid Emulsion by Nadine Monteiro, Joana Silvestre, João Gonçalves-Pereira, Camila Tapadinhas, Vitor Mendes, Pedro Póvoa

“…Calcium channel blockers (CCBs) drugs are widely used in the treatment of cardiovascular diseases. …”
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Prevalence of Bacterial Vaginosis and Associated Risk Factors among Women Complaining of Genital Tract Infection by Adane Bitew, Yeshiwork Abebaw, Delayehu Bekele, Amete Mihret

“…Cefoxitin and tobramycin were the most active drugs against Gram-positive bacteria. The overall drug resistance level of Gram-negative bacteria was high against tetracycline, ampicillin, and amoxicillin. …”
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Synthesis of Arginase Inhibitors: An Overview by Maria Cristina Molaro, Chiara Battisegola, Marica Erminia Schiano, Mariacristina Failla, Maria Grazia Rimoli, Loretta Lazzarato, Konstantin Chegaev, Federica Sodano

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Substance Abuse and Rural Appalachian Pediatric Trauma in West Virginia by Joshua Rawson, Lindsey Thevenin, Isabella Balko, Federico Seifarth, Hal Meltzer, Vipul Dhumak, Amy Bush, Wesley Kimble, Sijin Wen, Pavithra Ellison

“…The incidence of pediatric trauma as it relates to substance abuse is of concern in the region, where the rate of positive drug screens in pediatric trauma cases is higher than national average. …”
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Polyethylene Glycol 3350 in the Treatment of Chronic Idiopathic Constipation: Post hoc Analysis Using FDA Endpoints by Stacy B. Menees, Anthony J. Lembo, William D. Chey

“…The efficacy and safety of polyethylene glycol 3350 for chronic idiopathic constipation have been demonstrated in randomized controlled trials. A new US Food and Drug Administration-recommended primary efficacy endpoint for evaluating chronic idiopathic constipation prompted our reevaluation of previously reported clinical data with polyethylene glycol 3350. …”
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Early peripheral blood gene expression (Cyp4A11 and Cyp2E1) in cases of brain ischemia in addict cases admitted to Benha university hospital by Nashwa E. Ahmed, Amina M. Nagah, Omima R. Mohamed, Ghada Mohamed Mahmoud, Sania K. Elwia

“…Understanding the molecular mechanisms underlying stroke pathogenesis in drug users can improve diagnosis and treatment. This study explores the roles of CYP4A11, CYP2E1, miR-27b, and miR-214-3p in the pathogenesis of stroke and their potential as diagnostic markers in individuals using tramadol and cannabis. …”
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Evaluating stakeholder coordination and partnerships for NTD elimination in Taraba state, Nigeria: a multi-level analysis by Adeola Onasanya, Oladimeji Oladepo, Gima Humphrey Forje, Eucheria Ekugeni Abua, Uche Veronica Amazigo

“…Challenges included inconsistent drug distribution, inadequate Community Drug Distributor (CDD) incentives, and limited cross-sector coordination. …”
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Sustainable utilization of bovine adipose tissue derivatives as robust antimicrobial agents against Methicillin-resistant Staphylococcus aureus by Muhammed Abdelhameed Ismael Alcici, Salma Waheed Abdelhaleem, Karima Mogahed Fahim, Neveen Mohamed Saleh, Heba Saeed Farag

“…Hence, assessing new strategies for managing Multi-Drug Resistant (MDR) microorganisms is vital. In this study, the use of mechanically isolated mature adipose cells (MIMACs) and their lysate (Adipolysate) as a new sustainable antimicrobial agent was assessed against Methicillin-resistant Staphylococcus aureus (MRSA). …”
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The Effect of PVP Molecular Weight on Dissolution Behavior and Physicochemical Characterization of Glycyrrhetinic Acid Solid Dispersions by Xiaoyu Sui, Yan Chu, Jie Zhang, Honglian Zhang, Huiyu Wang, Tingting Liu, Cuiyan Han

“…In addition, the dissolution rate and solubility of the SDs with a carrier-drug ratio of 8 : 1 were better than the samples of 4 : 1. …”
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Cellulose- and Saccharide-Based Orally Dispersible Thin Films Transform the Solid States and Dissolution Characteristics of Poorly Soluble Curcumin by Helmy Yusuf, Orchidea Meidy Nurintan Savitri, Nadia Natsya Al-Khalifi, Lavinia Gunawan, Brian Karno Chairul, M. Agus Syamsur Rijal, Dewi Isadiartuti, Retno Sari

“…This study aimed at developing and optimizing the orally dispersible thin film (ODTF) containing a plant-derived drug—curcumin (CUR). CUR belongs to a biopharmaceutical classification system (BCS) class IV compound that requires improving its water solubility and tissue permeability preceding formulation. …”
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Update on the Progress of Musashi-2 in Malignant Tumors by Yiting Niu, Tao Zhou, Yanjun Li

“…A substantial body of evidence has demonstrated that it is closely related to the development, metastasis, migration, and drug resistance of malignant tumors. In recent years, research on the MSI protein has advanced, and many novel viewpoints and drug resistance attempts have been derived; for example, tumor protein p53 mutations and MSI-binding proteins lead to resistance to protein arginine N-methyltransferase 5-targeted therapy in lymphoma patients. …”
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Natural Cyclic Peptides: Synthetic Strategies and Biomedical Applications by Devan Buchanan, Shogo Mori, Ahmed Chadli, Siva S. Panda

“…These advancements can potentially address complex diseases and advance the broader field of biological drug development.…”
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The impact of KRAS mutations on the tumour microenvironment and treatment response in non-small cell lung cancer by Guomin Gu, Chunling Liu, Yan Yang, Yan Zhao, Xiaodan Zhu, Gang Sun

“…KRAS-G12C, KRAS-G12V, and KRAS-G12D mutations may enhance NSCLC drug resistance through immunosuppression.…”
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Effect of Intervention in Subjects with High Risk of Diabetes Mellitus in Pakistan by Muhammad Zafar Iqbal Hydrie, Abdul Basit, A. Samad Shera, Akhtar Hussain

“…Adding drug did not show any improved results. We recommend lifestyle advice and followup should be incorporated in primary health care.…”
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Synthetic data as external control arms in scarce single-arm clinical trials. by Severin Elvatun, Daan Knoors, Simon Brant, Christian Jonasson, Jan F Nygård

“…An external control arm based on health registry data can serve as an alternative comparator in single-arm drug development studies that lack a benchmark for comparison to the experimental treatment. …”
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Evaluation of Brain SPECT with 99mTc-TRODAT-1 in the Differential Diagnosis of Parkinsonism by Giorgio Fabiani, Carlos Henrique Ferreira Camargo, Raul Martins Filho, Gabriel Sampaio Froehner, Hélio Afonso Ghizoni Teive

“…It was handy in differentiating drug-induced Parkinsonism from synucleinopathies. …”
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In Silico Study of Coumarins: Wedelolactone as a Potential Inhibitor of the Spike Protein of the SARS-CoV-2 Variants by Saurav Katuwal, Siddha Raj Upadhyaya, Rishab Marahatha, Asmita Shrestha, Bishnu P. Regmi, Karan Khadayat, Saroj Basnet, Ram Chandra Basnyat, Niranjan Parajuli

“…As an outcome, wedelolactone could be utilized to develop a potent drug candidate against COVID-19 by blocking the viral entry into the host cell.…”
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