Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang by Hyejin Shin, Jihyun Kim, Musun Park, Heeseon Jo, Myunggyo Lee, Seongwon Cha, Haeseung Lee, Sooseong You

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Preparation and in vivo evaluation of a gel-based nasal delivery system for risperidone by Gu Fugen, Ma Weina, Meng Gendalai, Wu Chunzhi, Wang Yi

“…Relative bioavailability of the drug nasal preparation to the oral suspension was up to 1600.0 %. …”
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Severe Rhabdomyolysis Associated with Simvastatin and Role of Ciprofloxacin and Amlodipine Coadministration by Nicolas De Schryver, Xavier Wittebole, Peter Van den Bergh, Vincent Haufroid, Eric Goffin, Philippe Hantson

“…In addition to age, gender, ethnicity, genetic predisposition, and dose, drug-drug interactions play a major role. This is particularly true for drugs that are extensively metabolized by cytochrome P450 (CYP)3A4. …”
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Analysis of Risk Factors Associated with Hepatitis B and C Infection in Correctional Institutions in British Columbia by RG Préfontaine, RK Chaudhary, RG Mathias

“…The relative risk for hbv in intravenous drug users was 4.4 times that in nonusers; for hcv relative risk was 3.4 times. …”
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Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides by Mohamed I. Attia, Mohamed N. Aboul-Enein, Aida A. El-Azzouny, Yousreya A. Maklad, Hazem A. Ghabbour

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Latest Approved Therapies for Metastatic Melanoma: What Comes Next? by Farid Menaa

“…., sequence and timing of agent administration; drug selectivity; compatibility of combined therapies i.e., adoptive T cell or agents, i.e., MEK inhibitor trametinib, PD-1 and PDL-1 blockers). …”
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Microfluidic mixing probe: generating multiple concentration-varying flow dipoles by Dima Samer Ali, Ayoub Glia, Pavithra Sukumar, Muhammedin Deliorman, Mohammad A. Qasaimeh

“…The MMP’s ability to localize drug exposure across cell cultures without cross-contamination opens new avenues for drug testing, personalized medicine, and molecular biology. …”
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Myelotoxic effects of cholaramphenicol and its metabolites by Ahmet Levent Baş

“…The most important unwanted eflect of chloramphenicol is depression of the bone-marrow resulting in pancytopenia- an effect which may occur even with very low doses in some indivudiats.Within the Turkey the drug is approved for use only in non-food producing animals: it is illegal to use the drug in food animals. …”
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Editorial: Integrating machine learning with physics-based modeling of physiological systems by Jae H. Lee, Hao Gao, Michael Döllinger

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Healthy Living: Food Can Affect Your Medicines by Paulina Wittkowsky, Linda B. Bobrof

“…Follow the information in this revised 2-page fact sheet to reduce your risk of common food and drug interactions. Written by Paulina Wittkowsky and Linda B. …”
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New insights into Notch signaling as a crucial pathway of pancreatic cancer stem cell behavior by chrysin-polylactic acid-based nanocomposite by Eman M. Ragab, Doaa M. El Gamal, Fares F. El-najjar, Hager A. Elkomy, Mahmoud A. Ragab, Mariam A. Elantary, Omar M. Basyouni, Sherif M. Moustafa, Shimaa A. EL-Naggar, Abeer S. Elsherbiny

“…Chrysin-loaded polylactic acid (PLA) as polymeric nanoparticles systems have been growing interest in using as platforms for improved drug delivery. This review aims to explore innovative strategies for targeted therapy and optimized drug delivery in pancreatic CSCs by manipulating the Notch pathway and leveraging PLA-based drug delivery systems. …”
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Molecular Epidemiology of Escherichia coli Resistant to Carbapenems, Fluoroquinolones, and Aminoglycosides Isolated from One of the Largest Hospitals in Vietnam in 2014–2019 by Tohru Miyoshi-Akiyama, Do Van Thanh, Truong Thai Phuong, Nguyen Quang Huy, Pham Thi Phuong Thuy, Teruo Kirikae, Pham Hong Nhung, Norio Ohmagari

“…Dominant plasmid type carrying drug resistance gene was IncQ1_1. The percentage of isolates positive for drug resistance genes, such as anti-beta-lactams and aminoglycosides, was relatively high because the isolates screened were resistant to carbapenems, fluoroquinolones, and aminoglycosides. …”
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Investigating the Presence of Falsified and Poor-Quality Fixed-Dose Combination Artemether-Lumefantrine Pharmaceutical Dosage Forms in Kumasi, Ghana by Simon Nyarko, Kwabena Ofori-Kwakye, Raphael Johnson, Noble Kuntworbe, Denis Dekugmen Yar

“…The study results indicate that most of the tested products met the required quality standards, demonstrating satisfactory drug content and other quality specifications. The presence of substandard drugs underscores the necessity for robust pharmacovigilance and surveillance systems to eliminate counterfeit and substandard drugs from the Ghanaian market.…”
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Evaluation of Five Ready-to-Use Bases for the Topical Administration of Propranolol Hydrochloride to Treat Infantile Hemangioma by Chiara Lacassia, Annalisa Cutrignelli, Flavia Maria la Forgia, Sergio Fontana, Antonio Lopalco, Nunzio Denora, Angela Assunta Lopedota

“…The chemical stability of the drug in the five formulations was assessed by using a high-performance liquid chromatography (HPLC) method. …”
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Comparative Evaluation of Cyclooxygenase Inhibition Profiles Across Various NSAID Forms and Doses: Implications for Efficacy and Adverse Effects by Kenshu Shirakawa, Masafumi Takeno, Hidekazu Kuma, Takaaki Terahara, Shigeki Yamaguchi

“…Abstract Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain disorders and exert pharmacological effects by inhibiting cyclooxygenase (COX). …”
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Experimental hypothermia by cold air: a randomized, double-blind, placebo-controlled crossover trial by Ane M. Helland, Sigurd Mydske, Jörg Assmus, Guttorm Brattebø, Øystein Wiggen, Haakon K. Kvidaland, Øyvind Thomassen

“…Results At termination, the active drug vs placebo group differed in temperature by 1.4 °C. …”
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Lutein administration during gestation protects morphine withdrawal-induced on reflexive motor behavior in mice offspring's by Sahand Sariaslani, Shahin Hassanpour, Bita Vazir

“…Fourteen male mice and 56 adult female mice were randomly assigned to seven groups: the control group containing male and female mice that refrained from morphine; group 2 was morphine-abstinent male mice and female mice with no prior drug exposure; group 3 including morphine-abstinent female mice and male mice without drug experience; and group 4 of drug-naïve male and female mice. …”
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The rapid rise of SARS‐CoV‐2 Omicron subvariants with immune evasion properties: XBB.1.5 and BQ.1.1 subvariants by Danyi Ao, Xuemei He, Weiqi Hong, Xiawei Wei

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Tolerability and efficacy of Mycobacterium avium complex pulmonary disease treatment in elderly patients by Kyota Shinfuku, Hiromichi Hara, Keitaro Okuda, Hanae Miyagawa, Naoki Takasaka, Takeo Ishikawa, Jun Araya

“…Treatment efficacy of the two-drug regimen was non-inferior, and no cases of macrolide resistance were observed. …”
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Prednisolone pharmacokinetics in dogs with protein‐losing enteropathy by Sara A. Jablonski, Jessica L. Strohmeyer, John P. Buchweitz, Andreas F. Lehner, Daniel K. Langlois

“…Conclusions and Clinical Importance Overall drug exposures are similar between PLE dogs and healthy controls. …”
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