Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammat... by Wen Zhang, Junke Song, Wan Li, Dewen Kong, Yu Liang, Xiaoyue Zhao, Guanhua Du

“…It is a promising strategy to develop antistroke drugs targeting inflammation. This study is aimed at investigating the therapeutic effect and anti-inflammatory mechanism of salvianolic acid D (SalD) against cerebral ischemia/reperfusion (I/R) injury. …”
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Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

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Enhancing the Therapeutic Effect and Bioavailability of Irradiated Silver Nanoparticle-Capped Chitosan-Coated Rosuvastatin Calcium Nanovesicles for the Treatment of Liver Cancer by Tamer Mohamed Mahmoud, Mohamed Mahmoud Abdelfatah, Mahmoud Mohamed Omar, Omiya Ali Hasan, Saad M. Wali, Mohamed S. El-Mofty, Mohamed G. Ewees, Amel E. Salem, Tarek I. Abd-El-Galil, Dina Mohamed Mahmoud

“…The FTIR spectra showed that the fingerprint region is not superimposed with that of the drug; DSC thermal analysis depicted a negligible peak shift; and XRPD diffractograms revealed the disappearance of the typical drug peaks. …”
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Smart Pharmaceutical Monitoring System With Personalized Medication Schedules and Self-Management Programs for Patients With Diabetes: Development and Evaluation Study by Jian Xiao, Mengyao Li, Ruwen Cai, Hangxing Huang, Huimin Yu, Ling Huang, Jingyang Li, Ting Yu, Jiani Zhang, Shuqiao Cheng

“…ResultsWe constructed a cloud-based drug information management system loaded with 475 diabetes treatment–related medications; 684 medication constraints; and 12,351 drug-drug interactions and theoretical supports. …”
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Combined mutations in nonstructural protein 14, envelope, and membrane proteins mitigate the neuropathogenicity of SARS-CoV-2 Omicron BA.1 in K18-hACE2 mice by Kotou Sangare, Shufeng Liu, Prabhuanand Selvaraj, Charles B. Stauft, Matthew F. Starost, Tony T. Wang

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A Threshold Technique Study to Understand Patient Preference for Smooth Versus Textured Breast Implants by Dallas Wood, PhD, Peyton N. Williams, MPH, Jessica E. Thompson, PhD, Susana Peinado, PhD, Avery A. Tilley, MS, David Gebben, PhD, Jacqueline M. Major, PhD, Jessica P. Weinberg, MPP, Sung W. Yoon, MD, Michelle E. Tarver, MD, PhD

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Ketamine effects on resting state functional brain connectivity in major depressive disorder patients: a hypothesis-driven analysis based on a network model of depression by Kasper Recourt, Joop Van Gerven, Joop Van Gerven, Nadieh Drenth, Jeroen van der Grond, Kantaro Nishigori, Nic J. Van Der Wee, Gabriël E. Jacobs, Gabriël E. Jacobs

“…Analyzing functional connectivity based on a neurocircuitry model of a specific CNS disease and drug action may be an effective approach that could result in a more targeted analysis in future pharmaco-fMRI studies in CNS drug development.…”
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Antioxidant Properties of Berberis aetnensis C. Presl (Berberidaceae) Roots Extract and Protective Effects on Astroglial Cell Cultures by Agata Campisi, Rosaria Acquaviva, Roberta Bonfanti, Giuseppina Raciti, Andrea Amodeo, Silvana Mastrojeni, Salvatore Ragusa, Liliana Iauk

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Structural basis of CXCR4 assembly and regulation by Aijun Liu, Yezhou Liu, Richard D. Ye

“…Summary: CXC chemokine receptor 4 (CXCR4) is a well-established drug target and a key representative of the chemokine receptor family. …”
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Proteomic insights into dual-species biofilm formation of E. coli and E. faecalis on urinary catheters by Kidon Sung, Miseon Park, Ohgew Kweon, Angel Paredes, Alena Savenka, Saeed A Khan

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Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis by Yan Lin, Yu Dong, Yanfeng Gao, Ranran Shi, Yubing Li, Xiuman Zhou, Wenwen Liu, Guodong Li, Yuanming Qi, Yahong Wu

“…With the increasing number of drug-resistant Mycobacterium tuberculosis (MTB) strains and prevalence of coinfection of MTB with human immunodeficiency virus, many challenges remain in the prevention and treatment of tuberculosis. …”
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Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry by Michael J. Greig, Sherry Niessen, Scott L. Weinrich, Jun Li Feng, Manli Shi, Ted O. Johnson

“…Rapid mutations of proteins that are targeted in cancer therapy often lead to drug resistance. Often, the mutation directly affects a drug’s binding site, effectively blocking binding of the drug, but these mutations can have other effects such as changing the protein turnover half-life. …”
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The algebraic extended atom-type graph-based model for precise ligand–receptor binding affinity prediction by Farjana Tasnim Mukta, Md Masud Rana, Avery Meyer, Sally Ellingson, Duc D. Nguyen

“…Abstract Accurate prediction of ligand-receptor binding affinity is crucial in structure-based drug design, significantly impacting the development of effective drugs. …”
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Microbiological Quality of Salads Served along with Street Foods of Hyderabad, India by Alekhya Sabbithi, R. Naveen Kumar, L. Kashinath, V. Bhaskar, V. Sudershan Rao

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Effect of <i>Satureja montana</i> Essential Oil on Model Lipid Membranes by Simona Sennato, Silvia Trabalzini, Maria Gioia Fabiano, Domenico Truzzolillo, Edouard Chauveau, Cecilia Bombelli, Federica Rinaldi, Maria Carafa

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Microbiological Hazard Identification and Exposure Assessment of Poultry Products Sold in Various Localities of Hyderabad, India by Rao V. Sudershan, R. Naveen Kumar, L. Kashinath, V. Bhaskar, K. Polasa

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Target Proteins in Human Autoimmunity: Cytochromes P450 and Udp-Glycoronosyltransferases by Petra Obermayer-Straub, Christian Peer Strassburg, Michael Peter Manns

“…In a small minority of patients, certain drugs are known to induce immune-mediated, idiosyncratic drug reactions, also known as ’drug-induced hepatitis’. …”
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N-trans-Feruloyloctopamine Wakes Up BBC3, DDIT3, CDKN1A, and NOXA Signals to Accelerate HCC Cell Apoptosis by Bin Ma, Jing Li, Wen-Ke Yang, Mei-Gui Zhang, Xiao-Dong Xie, Zhong-Tian Bai

“…N-trans-Feruloyloctopamine (FO), a natural compound, was reported in our previous study to inhibit a tumor cell malignant phenotype by AKT- and EMT-related signals and might be used as a promising drug for HCC treatment. However, the specific targets and detailed mechanisms still need to be clarified. …”
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Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c Mice by Mohammed S. Jilani, Dexter Tagwireyi, Louis L. Gadaga, Charles C. Maponga, Cosmas Mutsimhu

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A comprehensive review of remimazolam for sedation by Nazir Noor, Rhorer Legendre, Alexandra Cloutet, Ahish Chitneni, Giustino Varrassi, Alan D. Kaye

“…Much of its properties may be credited to being a soft drug, meaning it is a metabolically active drug that is rapidly inactivated in the body. …”
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