Treatment Patterns for Patients on Overactive Bladder Therapy: A Retrospective Statistical Analysis Using Canadian Claims Data by Adrian Wagg, Demitri Diles, Todd Berner

“…**Background:** Overactive bladder (OAB) is a chronic condition which may be associated with a significant negative impact on quality of life. Antimuscarinic drugs are currently the mainstay of medical therapy, but persistence and adherence are generally poor. …”
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Cholestatic Hepatocellular Injury with Azathioprine: A Case Report and Review of the Mechanisms of Hepatotoxicity by Joseph Romagnuolo, DC Sadowski, E Lalor, L Jewell, ABR Thomson

“…Azathioprine is a drug commonly used for the treatment of inflammatory bowel disease, organ transplantation and various autoimmune diseases. …”
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Characterizing safety, toxicity, and breast cancer risk reduction using a long-term fulvestrant eluting implant by Scott Thomas, Elysia Roche, Pujan Desai, Nela Pawlowska, Diana Bauer, David Gingrich, Emily Hsu, Amelia N. Deitchman, Fran Aweeka, Pamela N. Munster

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Quality Analysis of Long dan Xie gan Pill by a Combination of Fingerprint and Multicomponent Quantification with Chemometrics Analysis by Jing Liu, Hui Liu, Zhong Dai, Shuangcheng Ma

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Comparative Quality Evaluation of Selected Brands of Cefuroxime Axetil Tablets Marketed in the Greater Accra Region of Ghana by Christina Osei-Asare, Esther Eshun Oppong, Frederick William Akuffo Owusu, John Antwi Apenteng, Yvonne Ochesinda Alatu, Robert Sarpong

“…All the brands had ƒ2 values > 50 indicating similarity of their drug release profiles with the innovator. Hence, all the sampled cefuroxime axetil brands can be considered as pharmaceutical equivalents to the innovator drug. …”
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A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens by Gina Bouchard, Weiruo Zhang, Ilayda Ilerten, Irene Li, Asmita Bhattacharya, Yuanyuan Li, Winston Trope, Joseph B. Shrager, Calvin Kuo, Michael G. Ozawa, Amato J. Giaccia, Lu Tian, Sylvia K. Plevritis

“…Our data show that assembloids recapitulate human LUAD tumor-stroma spatial organization, justifying their use as a tool for investigating the spatial biology of human disease. Intriguingly, drug-perturbation studies identify drug-induced spatial rearrangements that also appear in treatment-naïve human tumor samples, suggesting potential directions for characterizing spatial (re)-organization related to drug resistance. …”
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Urinary Metabolomics on the Biochemical Profiles in Diet-Induced Hyperlipidemia Rat Using Ultraperformance Liquid Chromatography Coupled with Quadrupole Time-of-Flight SYNAPT High-... by Hua Miao, Hua Chen, Xu Zhang, Lu Yin, Dan-Qian Chen, Xian-Long Cheng, Xu Bai, Feng Wei

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Comparative Direct Compression Property of a Novel Pregelatinized Starch in Paracetamol Tablets by Tamrat Balcha Balla, Nisha Mary Joseph, Anteneh Belete

“…PGTBIS could accommodate higher drug cargo than Starch 1500® with acceptable tablet properties. …”
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Antimalarial Activity of Piperine by Artitaya Thiengsusuk, Phunuch Muhamad, Wanna Chaijaroenkul, Kesara Na-Bangchang

“…Piperine could be a promising candidate for further development as an antimalarial drug based on its antimalarial potency and low risk of resistance development.…”
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Anticancer effects of PEP06 (TB01) in combination with Trifluridine/Tipiracil (TAS-102) in a xenograft model of human colorectal cancer by Ruohong Lin, Jiaxing Cheng, Jinlong Zhao, Liang Zhou, Jian Li, Xinchun Yang

“…Objective To evaluate the therapeutic efficacy of the combination of the anti-angiogenic drug PEP06 (TB01) and the cytotoxic drug Trifluridine/Tipiracil (TAS-102) in human CRC HCT-116 xenograft mouse model. …”
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Synthesis and Experimental Validation of New Designed Heterocyclic Compounds with Antiproliferative Activity versus Breast Cancer Cell Lines MCF-7 and MDA-MB-231 by Vincenza Barresi, Carmela Bonaccorso, Domenico A. Cristaldi, Maria N. Modica, Nicolò Musso, Valeria Pittalà, Loredana Salerno, Cosimo G. Fortuna

“…Recent drug discovery efforts are highly focused towards identification, design, and synthesis of small molecules as anticancer agents. …”
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Adherence to four healthy lifestyle factors and their influencing factors among residents aged 35 – 75 in South China: a cross-sectional survey by Wenyan HE, Xingyi ZHANG, Chunqi WANG, Xueke BAI, Yang YANG, Wei XU, Lijuan SONG, Yan ZHANG, Hao YANG, Xi LI, Jianlan CUI

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Development and In Vitro Evaluation of Oral Capsules from Antiaris: A Convenient Substitute for Peripheral Neuropathy by Mary-Ann Archer, Doris Kumadoh, Samuel Nii-Bortier Gaizer, Adelaide Mensah, Jonathan Jato, Micheal Odoi Kyene, Susana Oteng Mintah, Genevieve Naana Yeboah, Paul kwesi Sodzi, Ofosua Adi-Dako

“…From the study, all formulated granules had excellent flow properties with Carr’s index from 7.83 to 9.56%, Hausner’s ratio from 1.09 to 1.10, and angle of repose from 25.13 to 27.87°. Drug-excipient compatibility studies demonstrated no interaction between extract and used excipients. …”
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Evaluation of fluorinated phospholipid analogs: A study on ADMET profiles, molecular docking and dynamics simulation in anticancer therapy by Saqib Ishaq, Obaid Habib, Abdul Aziz, Raheel Tahir, Hira Mushtaq, Said Hassan, Sarah Sarwar, Mohammad S. Mubarak, Ajaz Ahmad, Amin Ullah

“…Comparative interpretation emphasized Edelfosine drug enhanced pharmacokinetic properties depicted by lower RMSD values, stable solvent-accessible surface area and reduced structural fluctuations relative to Ilmofosine drug. …”
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Analysis of the efficacy of multidisciplinary integration based on 3D reconstruction technology for the treatment of gout stone by Shizhe Zhou, Zengxiao Zhang, Tian Liu, Yijun Xu, Yuehai Pan, Ying Chen

“…After adjusting for confounders, multifactorial logistic regression showed that the uric acid attainment rate of patients in the MDT surgery group was 4.011 times higher than that of the drug group (OR: 4.011, 95% CI: 1.595, 10.086, P = 0.003); the proportion of patients with an increase in SF-36 in the MDT surgery group was 4.976 times higher than that of the drug group (OR: 4.976, 95% CI: 2.243, 11.040, P < 0.001); the proportion of patients treated with high-dose medication in the MDT surgery group was 1.8% of that of patients in the drug group (OR: 0.018, 95% CI: 0.002, 0.148, P < 0.001); and the proportion of patients in the MDT surgery group who developed frequent gout was 2.8% of that in the drug group (OR: 0.028 95% CI: 0.003, 0.2398, P = 0.001). the proportion of patients in the MDT surgery group who developed abnormal liver function was 0.317 times higher than that in the drug group (OR: 0.317, 95% CI: 0.121, 0.831, P = 0.019). …”
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HPLC-MS/MS-Mediated Analysis of the Pharmacokinetics, Bioavailability, and Tissue Distribution of Schisandrol B in Rats by Dahu Liang, Zijing Wu, Yanhao Liu, Chao Li, Xianghong Li, Bin Yang, Haitang Xie, Hua Sun

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End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle by Xiaoyan Hu, Jingqi Zeng, Lijuan Ma, Xiaomeng Wang, Jing Du, Lu Yao, Zhisheng Wu

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Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance by Linna Xu, Xiaofen Mo, Hui Zhang, Fen Wan, Qixia Luo, Yonghong Xiao

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Risk-Based Prenatal Hepatitis C Testing Practices and Results, Alaska 2013-2016 by Leisha D. Nolen, Courtney Gustin, Sara Seeman, Neil Murphy, Sarah Truitt, Sarah Schillie, Michael G. Bruce, Dana Bruden, James Tiesinga, Brian McMahon

“…Multiple risk behaviors were evaluated, including drug dependency or abuse (drug abuse), tobacco use, alcohol dependency or abuse, and late presentation to prenatal care. …”
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Developing a medication-safety self-assessment tool for rural primary care units - a case from Finnish Lapland by Päivi Sova, Ercan Celikkayalar, Sami Sneck, Anna-Riia Holmström

“…The included 144 statements were divided into 12 thematic sub-groups: (1) Patient information, (2) Drug information, (3) Communication of drug orders and other drug information; (4) Drug labeling, packaging and nomenclature; (5) Drug storage and distribution, (6) Medication device acquisition and use, (7) Environmental factors, workflow and staffing patterns; (8) Staff competency and education, (9) Patient education, (10) Preventive risk management, 11. …”
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