Prevalence and molecular characterization of Beta-lactamase resistance gene in multidrug resistance bacteria, Proteus spp. by Sabiha S. Salih, Shno J. Mohammed, Imad M Noori, Lana MA Mohammed, Taib A. Hama Soor

“…Existing of drug resistance bacteria in meat is a series of health concern and beta-lactamase is responsible to generate multi drug resistances in bacteria. …”
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Evaluating Normalization Methods for Robust Spectral Performance Assessments of Hyperspectral Imaging Cameras by Siavash Mazdeyasna, Mohammed Shahriar Arefin, Andrew Fales, Silas J. Leavesley, T. Joshua Pfefer, Quanzeng Wang

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Design of a thermal stress microfluidic platform to screen stability of therapeutic proteins in pharmaceutical formulations by O. Bortone, S. Fiorenza, M. Baldassarre, N. Falco, M. Amidi, T. Markkula, P.A. Netti, E. Torino

“…Therapeutic proteins have great potentialities for the care of a wide spectrum of diseases, for which other small synthetic drugs result ineffective. Due to challenges related to their immunogenicity, the journey of biologics into clinics still faces obstacles. …”
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With big data comes big responsibility: Strategies for utilizing aggregated, standardized, de‐identified electronic health record data for research by Veronica R. Olaker, Sarah Fry, Pauline Terebuh, Pamela B. Davis, Daniel J. Tisch, Rong Xu, Margaret G. Miller, Ian Dorney, Matvey B. Palchuk, David C. Kaelber

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The Effects of Synthetic Polymers on the Release Patterns of Bupivacaine Hydrochloride from Sodium Hyaluronate Hydrogels by Dorota Wójcik-Pastuszka, Roksana Iwaszkiewicz, Witold Musiał

“…Background: Using hydrogels for the controlled release of drugs is beneficial for patients, who then receive the proper dose of the medicinal substance. …”
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Investigation of Chip Morphology in Elliptical Vibration Micro-Turning of Silk Fibroin by Zhengjian Wang, Xichun Luo, Jining Sun, Wenkun Xie, Yinchuan Piao, Yonghang Jiang, Xiuyuan Chen

“…Silk fibroin, known for its biocompatibility and biodegradability, holds significant promise for biomedical applications, particularly in drug delivery systems. The precise fabrication of silk fibroin particles, specifically those ranging from tens of nanometres to hundreds of microns, is critical for these uses. …”
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HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007) by Raj Kalkeri, Junzhong Peng, Chunsheng Huang, Zhaohui Cai, Roger G. Ptak, Mark J. Suto

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An Efficient Herbal Approach for Treating Fungal Infection in Cervical Cancer Patients by Developing and Optimizing a Vaginal Suppository by Mohammed Ghazwani, Umme Hani, Riyaz Ali M. Osmani, Mohamed Rahamathulla, M. Yasmin Begum, Shadma Wahab, D. V. Gowda, Akhila Akkihebbal Ravikumar, Honnavalli Yogish kumar, Hissana Ather, Afrasim Moin

“…Combinations of PEG 1500 (10%–40%), PEG 6000 (40%–60%), and Poloxamer 407 (5%–30%) were entered as factors, and the responses evaluated were hardness, deformation time, and % drug release. In addition, the formulation was also evaluated for visual examination, weight variation, pH determination, drug content, hardness test, disintegration time, melting zone, deformation time, in vitro drug release, antifungal activity, and stability tests. …”
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Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: Molecular mechanisms and targeted therapies by Pinglian Yang, Xiaoling Rong, Zhechang Gao, Jiaojiao Wang, Zhiping Liu

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The Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro by Yakubu Jibira, Elizabeth Cudjoe, Frederick M. Tei-Maya, Benjamin Ayensu, Linda E. Amoah

“…Background. Drug resistance in malaria is a global problem, with reports of Plasmodium parasites resistant to the current first-line antimalarial drug, artemisinin, expanding from Southeast Asia to Africa. …”
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The large-scale whole-genome sequencing era expedited medical discovery and clinical translation by Qingxin Yang, Shuhan Duan, Yuguo Huang, Chao Liu, Mengge Wang, Guanglin He

“…Here, a concise overview of the recent revolution in human genomic research is provided, emphasizing how these projects, in the era of large-scale whole-genome sequencing, have advanced genomic science, genomic medicine, and evolutionary genomics, as well as their clinical translational applications in disease prediction, cancer, drug response, and rare disease diagnosis.…”
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Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay by Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian

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Sponsor's Foreword by David Shurtleff, Sergi Ferré

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Synthesis and Antitubercular Evaluation of Diverse Glycosylated Ureas from D-Glucose by Neetu Tripathi, Vinod K. Tiwari

“…Tripathi, Former Chief Scientist at CSIR-Central Drug Research Institute, Lucknow, India, for his extraordinary contribution to “Drug development against Tuberculosis”…”
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Vedolizumab for inflammatory bowel diseasesI by Igor L. Khalif, M. V. Shapina

“…GEMINI-1 study of ulcerative colitis has demonstrated efficacy of the drug in remission induction (clinical response rate of 47,1% of patients, clinical remission of 16,9% and endoscopic remission of 40,9% at the 6th week) and in remission maintenance (percent of patients in clinical remission at 52nd week at drug injection every 4 weeks - 44,8%). …”
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Correction: Rehman et al. Fabrication, In Vitro and In Vivo Assessment of Eucalyptol-Loaded Nanoemulgel as a Novel Paradigm for Wound Healing. <i>Pharmaceutics</i> 2022, <i>14,</i>... by Anis Rehman, Muhammad Iqbal, Barkat A. Khan, Muhammad Khalid Khan, Bader Huwaimel, Sameer Alshehri, Ali H. Alamri, Rami M. Alzhrani, Deena M. Bukhary, Awaji Y. Safhi, Khaled M. Hosny

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A superior preparation method for daidzein-hydroxypropyl-β-cyclodextrin complexes with improved solubility and dissolution: Supercritical fluid process by Pan Hao, Wang Han-Bing, Yu Yi-Bin, Cheng Bing-Chao, Wang Xiao-Yu, Li Ying

“…Particle size, inclusion yield, drug solubility and dissolution of daidzein/HPβCD complexes were evaluated. …”
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In Silico Study of Alkaloids: Neferine and Berbamine Potentially Inhibit the SARS-CoV-2 RNA-Dependent RNA Polymerase by Rishab Marahatha, Asmita Shrestha, Kabita Sharma, Bishnu P. Regmi, Khaga Raj Sharma, Pramod Poudel, Ram Chandra Basnyat, Niranjan Parajuli

“…As the de novo drug development process is expensive and time-consuming, repurposing existing antiviral drugs against SARS-CoV-2 is an alternative and promising approach to mitigate the current situation. …”
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Caloric Restriction Prevents Lead-Induced Oxidative Stress and Inflammation in Rat Liver by Mustafa Mohammadi, Rana Ghaznavi, Rana Keyhanmanesh, Hamid Reza Sadeghipour, Roya Naderi, Hossein Mohammadi

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Manufacture and Characterization of Mucoadhesive Buccal Films Based on Pectin and Gellan Gum Containing Triamcinolone Acetonide by Felipe Pereira Fernandes, Amanda Campos Fortes, Said Gonsalves da Cruz Fonseca, Jörg Breitkreutz, Humberto Gomes Ferraz

“…The treatment of canker sores can be quite compromised by the short period of the drug in the place of action. In this context, there is a need to develop drug dosage forms that allow more contact with the oral mucosa providing prolonged drug release. …”
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