The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K+ channels by Xiong Weichen, Fan Huizhen, Zeng Qingye, Deng Zhenhui, Li Guanhui, Lu Wancheng, Zhang Bei, Lai Shian, Chen Xin, Xu Xueqing

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Epigallocatechin-3-gallate inhibits the collagen accumulation of oral submucous fibrosis induced by arecoline by Ge Gao, Ge Gao, Caipeng Lin, Caipeng Lin, Ruibo Li, Xi Xie, Hai-Bin Luo, Hai-Bin Luo

“…The study also established an OSF model in Sprague-Dawley rats, induced by ARE, with pathological changes characterized using HE and Masson’s staining, further assessing the impact of ARE on ECM-related protein expression in rat oral tissues through RT-qPCR and Western blot methods.ResultsEGCG effectively suppressed the ARE-induced ECM components while concurrently improving the OSF pathological process in vitro and in vivo.ConclusionThe results indicate that the natural product EGCG effectively suppressed the increased ECM components induced by ARE and concurrently improved the OSF pathological process, indicating that EGCG could be potentially a novel anti-fibrotic candidate drug for the treatment of OSF.…”
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Is Rhodamine 123 an Appropriate Fluorescent Probe to Assess P-Glycoprotein Mediated Multidrug Resistance in Vinblastine-Resistant CHO Cells? by Jordi Pétriz, José Enrique O’Connor, Mercè Carmona, Joan García‐López

“…It has been reported that functional assessment of the cationic dye rhodamine 123 (Rho123) efflux reveals accurately the drug‐resistant phenotype. To study cellular drug resistance, we have obtained a CHO‐K1 derived cell line resistant to vinblastine by means of multistep selection. …”
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In Silico Identification of New Anti-SARS-CoV-2 Main Protease (Mpro) Molecules with Pharmacokinetic Properties from Natural Sources Using Molecular Dynamics (MD) Simulations and Hi... by Harrison Onyango, Patrick Odhiambo, David Angwenyi, Patrick Okoth

“…Unfortunately, the traditional drug development methods are time-consuming and expensive. …”
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Crystal structure of (E)-7-fluoro-2-(4-fluorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one, C17H12F2O by Wei Pan-Pan, Meng Qing-Guo, Wang Bao-Gang, Hou Gui-Ge, Song Ya-Bin

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Stem Cells as In Vitro Model of Parkinson's Disease by Patricia L. Martínez-Morales, Isabel Liste

“…In addition, the lack of an adequate in vitro human neuron cell-based model has been an obstacle for the uncover of new drugs for treating PD. The ability to generate induced pluripotent stem cells (iPSCs) from PD patients and a refined capacity to differentiate these iPSCs into DA neurons, the relevant disease cell type, promises a new paradigm in drug development that positions human disease pathophysiology at the core of preclinical drug discovery. …”
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IVIVC from Long Acting Olanzapine Microspheres by Susan D'Souza, Jabar A. Faraj, Stefano Giovagnoli, Patrick P. DeLuca

“…A nearly 1 : 1 correlation (R2>0.96) between in vitro release and in vivo measurements confirmed the excellent relationship between in vitro drug release and the amount of drug absorbed in vivo. …”
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Knockdown of Annexin A1 induces apoptosis, causing G2/M arrest and facilitating phagocytosis activity in human leukemia cell lines by Hasan Masyitah, Kumolosasi Endang, Jantan Ibrahim, Jasamai Malina, Nazarudin Norlaili

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Quantitative Multiparameter Evaluation of Vacuoles in Intraocular Lenses Employing a High-Magnification Digital Microscopy Method by Vincent Spiezio, Bennett N. Walker, Don Calogero, Ilko K. Ilev

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Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopy by Bowen Han, Jing He, Shaohua Huang

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Potentials of Curcumin as an Antidepressant by S.K. Kulkarni, Ashish Dhir, Kiran Kumar Akula

“…Moreover, antidepressants are associated with a plethora of side effects and drug-drug/drug-food interactions. In this context, novel approaches are being tried to find more efficacious and safer drugs for the treatment of major depression. …”
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Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying Phase by Lorena Segale, Lorella Giovannelli, Paolo Mannina, Franco Pattarino

“…In this work alginate and alginate-chitosan beads containing celecoxib solubilized into a self-emulsifying phase were developed in order to obtain a drug delivery system for oral administration, able to delay the drug release in acidic environment and to promote it in the intestinal compartment. …”
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A Case for Doxycycline as an Effective Treatment for Confluent and Reticulated Papillomatosis (CARP) by Aishwarya Sharma, Deborah Moon, Dong Joo Kim

“…Minocycline is considered the drug of choice, but it is not without its host of potential side effects, including drug hypersensitivity, drug-induced lupus/vasculitis/hepatitis, blue-gray skin hyperpigmentation, acute eosinophilic pneumonia, pseudotumor cerebri, and vestibular instability, among others. …”
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The crystal structure of (E)-4-fluoro-N′-(1-(2-hydroxyphenyl)propylidene)benzohydrazide, C16H15FN2O2 by Li Xiaohua, Zhao Xin, Tang Wenqiang

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Extractive Spectrophotometric Methods for the Determination of Etoricoxib in Tablets by Kamal Shah, Alka Gupta, Pradeep Mishra

“…This property of the drug was followed for the development of colorimetric methods for analysis of drug. …”
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Progress in Managing Heart Failure: an in-depth Review of Sacubitril/Valsartan Combination Therapy by Neeraj Hiremath, Jayasheela S. Hiremath, Sanatkumar B. Nyamagoud, Agadi Hiremath Viswanatha Swamy

“…The United States Food and Drug Administration has approved the drug’s use in treating patients with chronic heart failure with reduced ejection fraction (HFrEF). …”
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The crystal structure of bis(pyrazolo[1,5-a]pyrimidine-3-carboxylato-κ2N,O)-copper(ii), C14H8N6O4Cu by Hong Dong-Feng, Chen Ye, Zhu Wen-Li

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Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists. by Sophie L Collier, Sarah N Farrell, Christopher D Goodman, Geoffrey I McFadden

“…These endosymbiotic organelles are crucial to survival and provide well-validated and widely utilised drug targets in parasitic protists such as Plasmodium and Toxoplasma. …”
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The crystal structure of diaqua-bis(pyrazolo[1,5-a]pyrimidine-3-carboxylato-κ2N,O)manganese(II), C14H12N6O6Mn by Hong Dong-Feng, Li Meng-Fei, Chu Tian-Tian

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A Rapid Screening Method for Sibutramine Hydrochloride in Natural Herbal Medicines and Dietary Supplements by Qi Liang, Yue Zhuang, Jun Ma, Jinyan Wang, Rui Feng, Ruisi He, Zhuoya Luo, Honghao Wang, Ruoting Zhan

“…Herbal weight loss drugs are becoming more widely used in the fight against obesity, but ineffective regulation of these products have resulted in harmful additives. …”
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