The modification of conventional liposomes for targeted antimicrobial delivery to treat infectious diseases by Nnamdi Ikemefuna Okafor, Omobolanle Ayoyinka Omoteso, Yahya E. Choonara

“…Abstract Some of the most crucial turning points in the treatment strategies for some major infectious diseases including AIDS, malaria, and TB, have been reached with the introduction of antimicrobials and vaccines. Drug resistance and poor effectiveness are key limitations that need to be overcome. …”
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Effect of Atypical Antipsychotic Usage at Therapeutic Doses on Daytime Sleepiness by Birol Topcu, Meltem Alan, Tuğba Nurcan Yüksel

“…The aim of this study is to determine the effect of using atypical antipsychotic drug usage at therapeutic doses on daytime sleepiness. …”
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Low-Intensity Light-Responsive Anticancer Activity of Platinum(II) Complex Nanocolloids on 2D and 3D In Vitro Cancer Cell Model by Viviana Vergaro, Francesca Baldassarre, Federica De Castro, Danilo Migoni, Maria Michela Dell’Anna, Piero Mastrorilli, Francesco Paolo Fanizzi, Giuseppe Ciccarella

“…This study aimed to evaluate the therapeutic efficacy of low-intensity visible light responsive nanocolloids of a Pt-based drug using a 2D and three-dimensional (3D) in vitro cancer cell model. …”
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Antibiotic Susceptibility Pattern and Biofilm Formation in Clinical Isolates of Enterococcus spp. by Sridevi Shridhar, Biranthabail Dhanashree

“…Enterococcus is a commensal in the intestine and is now emerging as a drug-resistant pathogen. It produces different virulence factors. …”
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Optimal Control in Two Strain Pneumonia Transmission Dynamics by Mary C. Swai, Nyimvua Shaban, Theresia Marijani

“…A mathematical model for the transmission dynamics of pneumonia disease in the presence of drug resistance is formulated. Intervention strategies, namely, vaccination, public health education, and treatment are implemented. …”
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Brivaracetam to Treat Partial Onset Seizures in Adults by Dustin Latimer, David Le, Evan Falgoust, Patrick Ingraffia, Alaa Abd-Elsayed, Elyse M. Cornett, Rupin Singh, JooHee Choi, Giustino Varrassi, Adam M. Kaye, Alan D. Kaye, Latha Ganti

“…Brivaracetam is a novel antiepileptic agent that was approved for use by the FDA in 2016 and is showing promising results as monotherapy and adjunctive therapy in individuals with drug-refractory focal seizures while minimizing adverse drug reactions.…”
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Preparation, characterization, and in vivo pharmacokinetics of thermosensitive in situ nasal gel of donepezil hydrochloride by Gu Fugen, Fan Huimin, Cong Zhixin, Li Shuang, Wang Yi, Wu Chunzhi

“…The in vitro erosion and in vitro release tests exhibited obvious drug sustained release behavior. Meantime, main pharmacokinetic parameters such as tmax, cmax and AUC in plasma as well as in brain were significantly different between the nasal gel formulation and intragastric drug solution in rats (p < 0.01). …”
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Crystal structure of (E)-7-fluoro-2-((6-methoxypyridin-3-yl)methylene)-3,4-dihydronaphthalen-1(2H)-one, C17H14FNO2 by Su Xiang-Yi, Zhang Xiao-Fan, Meng Qing-Guo, Li Hong-Juan

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Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i> by Hovakim Grabski, Siranuysh Grabska, Ruben Abagyan

“…The development of new therapeutic strategies based on inhibiting essential viral enzymes or viral–host protein interactions is problematic due to the fast mutation rate and rapid emergence of drug resistance. This study focuses on the NS2B-NS3 protease as a promising target for antiviral drug development. …”
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Aducanumab, a Novel Anti-Amyloid Monoclonal Antibody, for the Treatment of Alzheimer’s Disease: A Comprehensive Review by Hannah W Haddad, Garett W. Malone, Nicholas J. Comardelle, Arielle E. Degueure, Adam M. Kaye, Alan D. Kaye

“…Currently aducanumab is the only Food and Drug Administration (FDA) approved drug that acts to slow progression of this disease. …”
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Autophagy protein Atg7 is essential for maintaining malaria parasite cellular homeostasis and organelle biogenesis by Akancha Mishra, Suryansh Rajput, Pratik Narain Srivastava, H. Shabeer Ali, Satish Mishra

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Incorporation of Capecitabine Into Extended Chain of N-Acylated Chitosan Carrier by Anita Marlina, Misni Misran, Witta Kartika Restu

“…The drug loading (DL) capacity and EE increased as the amount of drug in the carrier increased. …”
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Anti-furfurative comparison of Kesh Kanti-Herbal Shampoos and synthetic shampoos against Malassezia furfur for dandruff management by Acharya Balkrishna, Nem Kumar Ngpoore, Harshita Jonwal, Savita Lochab, Anurag Varshney

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Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma by Assem Barakat, Fardous F. El-Senduny, Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Yaseen A. M. M. Elshaier, Eman A. Mazyed, Farid A. Badria

“…Additionally, this study involves the development of a commercially viable proniosomal drug delivery system for the compound, facilitating controlled drug release. …”
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Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells by Li-Chun Zhao, Mei Tang, Qian-Hua Zhang, Zhi-Yi Hu, Hong-Wei Gao, Xia-Yun Liao, Gang Wang, Jing Leng

“…A moderate drug loading and pH-dependent drug-release behavior could be observed for 1a. …”
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Inhibition of Growth and Induction of Apoptosis in Fibrosarcoma Cell Lines by Echinophora platyloba DC: In Vitro Analysis by Fatemeh Zare Shahneh, Samira Valiyari, Abbas Azadmehr, Reza Hajiaghaee, Saeid Yaripour, Ali Bandehagh, Behzad Baradaran

“…Our results demonstrated that the extract decreased cell viability, suppressed cell proliferation, and induced cell death in a time- and dose-dependent manner in WEHI-164 cells (IC50 = 196.673 ± 12.4 μg/mL) when compared with a chemotherapeutic anticancer drug, Toxol. Observation proved that apoptosis was the major mechanism of cell death. …”
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Assessment of Inappropriate Dose Adjustment of Antimicrobials and Other Medicines Among Chronic Kidney Disease Patients: A Multicenter Observational Study by Roheena Zafar, Inayat Ur Rehman, Yasar Shah, Khang Wen Goh, Long Chiau Ming

“…Most drugs undergo metabolism and elimination primarily by the kidneys. …”
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Isolation and Bioactivity Analysis of Ethyl Acetate Extract from Acer tegmentosum Using In Vitro Assay and On-Line Screening HPLC-ABTS+ System by Kwang Jin Lee, Na-Young Song, You Chang Oh, Won-Kyung Cho, Jin Yeul Ma

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Highly Sensitive In Vivo Imaging of Bacterial Infections with a Hydrophilicity‐Switching, Self‐Immobilizing, Near‐Infrared Fluorogenic β‐Lactamase Probe Enriched within Bacteria... by Fangfang Chen, Yuyao Li, Yan Peng, Yifan Zhu, Gao He, Zhengwei Zhang, Hexin Xie

“…On the other hand, the expression of the β‐lactam‐hydrolyzing enzyme (β‐lactamase), the major cause of bacterial resistance to β‐lactam antibiotics, provides a distinctive opportunity to visualize bacterial infection, evaluate the efficacy of existing antibiotics, screen for novel antibacterial agents, and optimize drug dosing regimens in live animals. Herein, a hydrophilicity‐switching, self‐immobilizing, near‐Infrared fluorogenic β‐lactamase probe for the highly sensitive imaging of bacterial infection in live mice is reported. …”
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Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 by Charlotte Laurfelt Munch Rasmussen, Signe Frost Frederiksen, Christian Würtz Heegaard, Maj Schneider Thomsen, Eva Hede, Bartosz Laczek, Jakob Körbelin, Daniel Wüstner, Louiza Bohn Thomsen, Markus Schwaninger, Ole N. Jensen, Torben Moos, Annette Burkhart

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