Clinical Significance and Characterization of AZT-Resistant Strains of HIV-1 by Mark A Wainberg, Ronald Rooke, Michel Tremblay, XuGuang Li, Michael A Parniak, Qing Gao, Xiao-Jian Yao, Chris Tsoukas, JSG Montaner, M Fanning, J Ruedy

“…A number of laboratories have now independently confirmed that zidovudine (AZT)-resistant strains of human immunodeficiency virus type 1 (HIV-1) may be isolated from patients undergoing prolonged therapy with this drug. In certain instances, such drug-resistant viral isolates have been obtained from patients with clinical acquired immune deficiency syndrome (AIDS), while in others, isolation of drug-resistant strains has been achieved in the case of HIV seropositive, asymptomatic subjects. …”
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Amphetamine use as a predictor of cardiovascular and cerebrovascular mortality and morbidity: a longitudinal cohort study of criminal justice clients by Ada Åhman, Jonas Berge, Anders Håkansson

“…However, few long-term studies examine amphetamine users' risk of cardiovascular and cerebrovascular pathology, in comparison to users of other drugs. In addition, in a criminal justice system, illicit drug use and psychiatric comorbidity is common, whereas structured treatment and follow-up is uncommon, and stimulant use is common in this setting. …”
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Diversity-oriented synthesis of stereodefined tetrasubstituted alkenes via a modular alkyne gem-addition strategy by Xuan Di, Sitian Zhou, Yali Qin, Wenjun Li, Yue Zhang, Jie Zhang, Xu Shen, Jie Han, Jin Xie, Hongming Jin

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Alternative buffer systems in biopharmaceutical formulations and their effect on protein stability by Lebar Blaž, Zidar Mitja, Mravljak Janez, Šink Roman, Žula Aleš, Pajk Stane

“…The formulation of biopharmaceutical drugs is designed to eliminate chemical instabilities, increase conformational and colloidal stability of proteins, and optimize interfacial stability. …”
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Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque by Tingfu Du, Shuaiyao Lu, Qinfang Jiang, Yun Li, Kaili Ma

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To Measure or Not to Measure: Direct Oral Anticoagulant Laboratory Assay Monitoring in Clinical Practice by Tania Ahuja, Veronica Raco, Sharonlin Bhardwaj, David Green

“…The need for therapeutic drug monitoring of direct oral anticoagulants (DOACs) remains an area of clinical equipoise. …”
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Development of a UPLC-MS/MS Method for the Quantification of VS-5584 and Its Application in Pharmacokinetic Studies in Rats by Chunling Zhou, Xiaoxin Li, Aiping He, Tianzhu Liu, Jinmiao Tian, Meihua Jiang, Lina Fang

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Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents by null Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani

“…The lipid-based drug delivery system (LBDDS) is a well-established technique that is anticipated to bring about comprehensive transformations in the pharmaceutical field, impacting the management and administration of drugs, as well as treatment and diagnosis. …”
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Green Synthesis of Gold and Iron Nanoparticles for Targeted Delivery: An In Vitro and In Vivo Study by Beenish Khanzada, Nosheen Akthar, Muhammad Zeeshan Bhatti, Hammad Ismail, Mohammed Alqarni, Bushra Mirza, Gomaa Mostafa-Hedeab, Gaber El-Saber Batiha

“…Furthermore, FeNPs from Ficus microcarpa demonstrated high drug loading efficiency (65%) as compared to an anti-inflammatory drug (diclofenac potassium, DFP). …”
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Encapsulation of Vecuronium and Rocuronium by Sugammadex Investigated by Surface-Enhanced Raman Spectroscopy by Adriana Kenđel, Ivo Piantanida, Snežana Miljanić

“…The observed changes in SERS signals are applicable in biorelevant conditions and support further studies of <b>SDX</b>/drug complexes in vivo.…”
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In Vivo and In Vitro Studies Assessing the Antiviral Efficacy of Double Combinations Against Coxsackievirus B Infection by Adelina Stoyanova, Simeon Galabov, Vadim Makarov, Angel S. Galabov

“…Coxsackievirus B (CVB) infections, ranging from mild to severe diseases, lack specific antiviral treatments, underscoring the need for novel therapeutic strategies. Drug therapy is an important tool for controlling enterovirus infections, but clinically effective drugs do not currently exist, mainly due to the development of drug resistance. …”
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Development and Evaluation of Nanoemulsifying Preconcentrate of Curcumin for Colon Delivery by Jyoti Wadhwa, Abhay Asthana, Gyati Shilakari, Arun Kumar Chopra, Ranjit Singh

“…Stability study ensures the protection of drug in alkaline media which may further confirm the localised delivery of drug to colonic region. …”
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Impaired Hippocampal Glutamate and Glutamine Metabolism in the db/db Mouse Model of Type 2 Diabetes Mellitus by Jens Velde Andersen, Jakob Dahl Nissen, Sofie Kjellerup Christensen, Kia Hjulmand Markussen, Helle Sønderby Waagepetersen

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Efficacy and Safety of Non-Vitamin K Anticoagulants for Atrial Fibrillation in Relation to Different Renal Function Levels: A Network Meta-Analysis by Hao Jin, Kongbo Zhu, Lina Wang, Yifan Li, Jingjun Meng, Hong Zhi

“…NetMetaXL (version 1.6.1) and winBUGS (version 1.4.3) were used to obtain the cumulative ranking curve (SUCRA) of each drug. Result. In patients with normal renal function, dabigatran150 was ranked as the most effective drug (SUCRA 0.90), followed by dabigatran110 (SUCRA 0.68), apixaban (SUCRA 0.66), and rivaroxaban (SUCRA 0.59). …”
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Functionally important respiratory symptoms and continued cigarette use versus e-cigarette switching: population assessment of tobacco and health study waves 2-6Research in context by James D. Sargent, Kristin Lauten, Kathryn C. Edwards, Susanne E. Tanski, Todd A. MacKenzie, Laura M. Paulin, Mary F. Brunette, Maciej L. Goniewicz, Amanda Malasky, Debra Stark, Fernando B. de Moura, Holly Griffin, Kimberly H. Nguyen, Eric Backlund, Heather L. Kimmel, John H. Kingsbury, Jenny E. Ozga, K Michael Cummings, Andrew Hyland

“…Funding: This manuscript is supported with Federal funds from the National Institute on Drug Abuse (NIDA) at the National Institutes of Health (NIH), and the Center for Tobacco Products (CTP) at the Food and Drug Administration (FDA), Department of Health and Human Services, under contract to Westat (contract nos. …”
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Effects of pyrazosulfuron-ethyl on caudal fin regeneration in zebrafish larvae by Chenkai Ge, Zhijun Ye, Weitao Hu, Jingrong Tang, Huimin Li, Fasheng Liu, Xinjun Liao, Jianjun Chen, Shouhua Zhang, Zigang Cao

“…This study expands our understanding of the potential effects of the pesticide pyrazosulfuron-ethyl on injured fish, highlights the link between the immune system and the regeneration process, and demonstrates the potential application of fin regeneration in risk assessments of environmental toxicology to assess drug toxicity.…”
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Rusførebygging i skulen som diskursivt forma pedagogisk-politisk fenomen. Eit teoretisk-empirisk bidrag til omgrepsutvikling by Øyvind Wiik Halvorsen, Liv Eide, Olin Blaalid Oldeide

“…Second, to try out the framework in an empirical analysis of media texts thematizing drug prevention in schools. The research question for the article is: How is school-based drug prevention discursively shaped in the media public sphere? …”
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Development of Cephradine-Loaded Gelatin/Polyvinyl Alcohol Electrospun Nanofibers for Effective Diabetic Wound Healing: In-Vitro and In-Vivo Assessments by Anam Razzaq, Zaheer Ullah Khan, Aasim Saeed, Kiramat Ali Shah, Naveed Ullah Khan, Bouzid Menaa, Haroon Iqbal, Farid Menaa

“…Electrospinning is one of the most widely used techniques for the fabrication of nanofibers (NFs), induced by a high voltage applied to a drug-loaded polymer solution. Particular attention is given to electrospun NFs for pharmaceutical applications (e.g., original drug delivery systems) and tissue regeneration (e.g., as tissue scaffolds). …”
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The Use of Intravenous Neostigmine in Palliation of Severe Ileus by Pashtoon Murtaza Kasi

“…Neostigmine is a parasympathomimetic drug that acts as a reversible acetylcholinesterase inhibitor. …”
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Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations by Tine Zgavc, An-Gaëlle Ceulemans, Sophie Sarre, Yvette Michotte, Said Hachimi-Idrissi

“…There is an urgent need to develop and/or improve neuroprotective strategies to combat this. Many drugs proven to be neuroprotective in experimental models fail to improve patient outcome in a clinical setting. …”
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