Assessment and incorporation of in vitro correlates to pharmacokinetic outcomes in antibody developability workflows by Tushar Jain, Bianka Prinz, Alexander Marker, Alexander Michel, Katrin Reichel, Valerie Czepczor, Sylvie Klieber, Wei Sun, Sagar Kathuria, Sevim Oezguer Bruederle, Christian Lange, Lena Wahl, Charles Starr, Alessandro Masiero, Lindsay Avery

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Investigation of in situ gelling alginate formulations as a sustained release vehicle for co-precipitates of dextromethrophan and Eudragit S 100 by Maghraby Gamal Mohamed El, Elzayat Ehab Mostafa, Alanazi Fars Kaed

“…Alginate solution (2 %, m/m) was used as a vehicle for the tested formulations. Solid matrix of the drug and Eudragit S 100 was prepared by dissolving the drug and polymer in acetone. …”
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The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases by Lei Zhang, Qun Wang, Wen Liu, Fangyan Liu, Ailing Ji, Yanzhang Li

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A Facile Route to Fabricate CS/GO Composite Film for the Application of Therapeutic Contact Lenses by Pin Chen, Xin Wang, Jingyang Kong, Xiaohong Hu

“…Traditional contact lenses bring convenience for ophthalmic drug delivery. However, either as contact lenses or as drug carriers, traditional materials have still some drawbacks in the field. …”
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Acceptance Factors and Psychological Investigation of Clinical Trials in Cancer Patients by Jiangjie Sun, Jingyi Fang, Chenchen Zhang, Nannan Jia, Weiming Zhao, Jinjian Gao, Yingying Huang, Jiqing Hao, Liping Zhang

“…To understand the degree of oncology patients’ awareness of drug clinical trials and oncology patients’ willingness to participate in drug clinical trials and the factors influencing them. …”
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Isolation of Pleurotus florida derived acetylcholinesterase inhibitor for the treatment of cognitive dysfunction in mice by Kudrat Randhawa, Varinder Singh, Sanimardeep Kaur, Ravinder Kaur, Suresh Kumar, Richa Shri

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Anesthetic-Induced Oxidative Stress and Potential Protection by Cheng Wang, Xuan Zhang, Fang Liu, Merle G. Paule, William Slikker, Jr.

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A class of constrained optimal control problems arising in an immunotherapy cancer remission process by Yineng Ouyang, Zhaotao Liang, Zhihui Ma, Lei Wang, Zhaohua Gong, Jun Xie, Kuikui Gao

“…By considering both the single drug dose and the total drug input during the treatment period, we propose a new optimal control problem by maximizing the immune cell levels and minimizing the tumor cell count, as well as the negative effects of the total drug quantity over time. …”
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Quality Evaluation of Pulsatilla chinensis Total Saponin Extracts via Quantitative Analysis of Multicomponents by Single Marker Method Combined with Systematic Quantified Fingerpri... by Long Chen, Suzhen Liu, Shuhan Feng, Liangliang Zhou, Zhenhua Chen

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Representations of OxyContin in North American Newspapers and Medical Journals by Emma Whelan, Mark Asbridge, Susan Haydt

“…Following the approval of OxyContin (Purdue Pharma, Canada) for medical use, the media began to report the use of OxyContin as a street drug, representing the phenomenon as a social problem. …”
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Pharma TARP: A Troubled Asset Relief Program for Novel, Abandoned Projects in the Pharmaceutical Industry by Tamas Bartfai, Graham Vaughan Lees

“…Society has a real need for the drugs that are no longer going to be developed for, among others, drug-resistant epilepsy, neuropathic and cancer pain, type-2 diabetes, obesity, and schizophrenia. …”
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Successful Desensitization of a Patient with Rituximab Hypersensitivity by Pinar Ataca, Erden Atilla, Resat Kendir, Sevim Bavbek, Muhit Ozcan

“…The delay of treatment or loss of a highly efficient drug can be prevented by rapid drug desensitization method in patients who are allergic to rituximab. …”
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Pharmacodynamics of interspecies interactions in polymicrobial infections by C. Herzberg, J. G. C. van Hasselt

“…Our analyses suggest that both interspecies interactions, modifying either drug sensitivity or bacterial growth rate, and drug-specific pharmacological properties drive the bacterial pharmacodynamic response. …”
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Quality Control of Natural Product Medicine and Nutrient Supplements 2014 by Ying-Yong Zhao, Shuang-Qing Zhang, Feng Wei, Yu-Ming Fan, Feng Sun, Shuhua Bai

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Simple, Rapid and Sensitive UV-Visible Spectrophotometric Method for Determination of Antidepressant Amitriptyline in Pharmaceutical Dosage Forms by Pankaj Soni, Deepak Sinha, Rajmani Patel

“…The paper describes a new and simple approach for spectrophotometric determination of tricyclic antidepressant drug amitriptyline. Enhancement of the colour intensity of the Fe(III)-SCN− complex on addition of the drug amitriptyline forms the basis of the proposed method. …”
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'Pseudo' Treatment Failure of Pulmonary Tuberculosis in Association with a Tuberculoma by Richard Long, Sylvia Chomyc, Evelina Der, Daniel S Sitar

“…Failure of tuberculosis patients to respond to treatment is usually explained by one or more of five mechanisms: improper drug prescription; patient nonadherence to prescribed therapy; primary or acquired drug resistance; drug malabsorption; and rarely, exogenous reinfection with a drug-resistant isolate. …”
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Thrombotic Microangiopathy Secondary to Intravenous Abuse of Opana® ER by Kamia Thakur, Vaibhav Agrawal, Ashley Kass, Lauren M. Dimarino, R. Patrick Dorion, Joseph Vadakara

“…Opana ER (oxymorphone) is an opioid drug available throughout the United States, and intravenous abuse of the crushed oral formulation has been associated with drug-induced thrombotic microangiopathy. …”
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Computational frameworks transform antagonism to synergy in optimizing combination therapies by Jinghong Chen, Anqi Lin, Aimin Jiang, Chang Qi, Zaoqu Liu, Quan Cheng, Shuofeng Yuan, Peng Luo

“…Abstract While drug combinations are increasingly important in disease treatment, predicting their therapeutic interactions remains challenging. …”
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Trimethoprim-Sulfamethoxazole-Induced Aseptic Meningitis: A Rare Presentation of Commonly Used Antibiotic by Salem Agabawi

“…Drug-induced aseptic meningitis is a rare medical condition with trimethoprim-sulfamethoxazole being one of the most common antimicrobial agents associated with it. …”
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Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19 by Aliede E. in ‘t Veld, Manon A. A. Jansen, Luuk C. A. Ciere, Matthijs Moerland

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