Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin by Ziwei Yang, Ziwei Yang, Tixin Han, Ruibin Yang, Ruibin Yang, Yinuo Zhang, Yinuo Zhang, Yifei Qin, Yifei Qin, Yifei Qin, Jialu Hou, Jialu Hou, Fei Huo, Fei Huo, Zhuan Feng, Zhuan Feng, Yaxin Ding, Yaxin Ding, Jiali Yang, Jiali Yang, Gang Zhou, Gang Zhou, Shijie Wang, Shijie Wang, Xiaohang Xie, Xiaohang Xie, Peng Lin, Peng Lin, Zhi-Nan Chen, Zhi-Nan Chen, Jiao Wu, Jiao Wu

“…It not only inhibits tumor growth but also enhances immunotherapy responses and overcomes drug resistance in cancer therapy. The inhibition of the cystine-glutamate antiporter, system Xc–, induces ferroptosis. …”
Get full text

ORAL CONTROLLED RELEASE MATRIX FORMULATION DESIGN AND THEIRRATE CONTROLLING FACTORS by Maria Ashfaq et al

“… The trend of formulation development of controlled release (CR) matrix drug delivery system has been increased to many folds during the last few years. …”
Get full text

Insights into Novel Arylazopyrazolo[1,5‑a]pyrimidines as Promising MurA Inhibitors and Antibiofilm Candidates: Design, Synthesis, Antimicrobial Evaluation, and Molecular Docking by Omkulthom Al kamaly, Amel S. Younes, Mona H. Ibrahim, Marwa F. Harras, Aisha A. Alsfouk, Rehab Sabour

Get full text

Nanotechnology-Based Surface Plasmon Resonance Affinity Biosensors for In Vitro Diagnostics by Riccarda Antiochia, Paolo Bollella, Gabriele Favero, Franco Mazzei

Get full text

Ataxia and Seizures despite Phenytoin: A Case Report Highlighting the Importance of TDM and Genetic Influences by Rachel Manoj, Arpita Meher, Jefry Winner G.

“…Adverse drug reactions to commonly prescribed medications such as phenytoin, used for seizures, often go undetected due to various factors. …”
Get full text

Chitosan-Based Nanogel Enhances Chemotherapeutic Efficacy of 10-Hydroxycamptothecin against Human Breast Cancer Cells by Hui Guo, Faping Li, Heping Qiu, Qi Zheng, Chao Yang, Chao Tang, Yuchuan Hou

“…The characteristics of CS/HCPT were evaluated by assessing particle size, drug loading content, and drug loading efficiency. …”
Get full text

Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and... by Monton Chaowalit, Chuanchom Panupong, Popanit Puwadon, Settharaksa Sukanya, Pathompak Pathamaporn

Get full text

Development and Evaluation of Herbal Formulations for Hair Growth by Lipi Purwal, Surya Prakash B. N. Gupta, S. Milind Pande

“…Similarly higher concentrations of drug in the formulation were found to have higher hair growth activities. …”
Get full text

Think Stop before Going 'Off-Label' by Gerald Y Minuk

“…What then can we expect when a drug is used for a medical condition in which no such review process has been undertaken ('offlabel' use of the drug)?…”
Get full text

Efficacy of carbonyl cyanide-3-chlorophenylhydrazone in combination with antibiotics against Mycobacterium abscessus by Jifang Zheng, Qiang Liu, Haoran Wang, Fengmin Huo, Junnan Jia, Hairong Huang, Suting Chen

“…These insights not only advance our understanding of antimicrobial synergy but also hold promise for the development of more effective treatment regimens against drug-resistant M. abscessus infections.…”
Get full text

Ruthenium(II) Lipid‐Mimics Drive Lipid Phase Separation to Arouse Autophagy‐Ferroptosis Cascade for Photoimmunotherapy by Yue Zheng, Wen‐Jin Wang, Jing‐Xin Chen, Kun Peng, Xiao‐Xiao Chen, Qing‐Hua Shen, Bing‐Bing Liang, Zong‐Wan Mao, Cai‐Ping Tan

Get full text

Chinese Medicine Huzhen Tongfeng Formula Effectively Attenuates Gouty Arthritis by Inhibiting Arachidonic Acid Metabolism and Inflammatory Mediators by Jianping Deng, Zicong Wu, Chen Chen, Zhenling Zhao, Yifei Li, Zhengquan Su, Yiguang Lin, Yifei Wang, Zhiping Wang

“…HZTF is currently in the late stage of approval process as a new anti-GA drug application. However, the underlying mechanism of HZTF as an antigout medication is unclear. …”
Get full text

Revisiting the Metabolism of Donepezil in Rats Using Non-Targeted Metabolomics and Molecular Networking by Eun-Ji Park, Eui-Hyeon Kim, Ki-Young Kim, Ji-Hyeon Jeon, Im-Sook Song, So-Young Park, Kwang-Hyeon Liu

“…This study indicates that a MN approach combined with a metabolomics approach is a reliable tool to identify unknown metabolites of drugs and drug candidates.…”
Get full text

Ranakinestatin-PPF from the Skin Secretion of the Fukien Gold-Striped Pond Frog, Pelophylax plancyi fukienensis: A Prototype of a Novel Class of Bradykinin B2 Receptor Antagonist P... by Jie Ma, Yu Luo, Lilin Ge, Lei Wang, Mei Zhou, Yingqi Zhang, Jinao Duan, Tianbao Chen, Chris Shaw

Get full text

Interfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applications by Feng Zhao, Feng Liu, Chenglong Gao, Guoqing Wang, Yinfeng Zhang, Fei Yu, Jiawei Tian, Kai Tan, Runhao Zhang, Kang Liang, Zhexun Lian, Junjie Guo, Biao Kong, Junbo Ge, Hui Xin

“…Abstract Drug-eluting stents are a commonly used treatment for coronary artery disease. …”
Get full text

Smartphone Delivery of Mobile HIV Risk Reduction Education by Karran A. Phillips, David H. Epstein, Mustapha Mezghanni, Massoud Vahabzadeh, David Reamer, Daniel Agage, Kenzie L. Preston

Get full text

3D-Printed Tablets of Nifurtimox: In Vitro and In Vivo Anti-<i>Trypanosoma cruzi</i> Studies by Giselle R. Bedogni, Ana Luiza Lima, Idejan P. Gross, Tatiana Prata Menezes, Andre Talvani, Marcilio Cunha-Filho, Claudio J. Salomon

“…Benznidazole and nifurtimox are the only approved drugs for treating this condition, but their low aqueous solubility may lead to erratic bioavailability. …”
Get full text

Diagnostic Fragment-Ion-Based for Rapid Identification of Chlorogenic Acids Derivatives in Inula cappa Using UHPLC-Q-Exactive Orbitrap Mass Spectrometry by Jie Peng, Jing Xie, Silin Shi, Lilan Luo, Kailin Li, Pei Xiong, Wei Cai

Get full text

Modelling the immunopathogenesis of HIV-1 infection and the effect of multidrug therapy: The role of fusion inhibitors in HAART by Gesham Magombedze, Winston Garira, Eddie Mwenje

“…There is currently tremendous effort being directed at developingpotent, highly active antiretroviral therapies that can effectively control HIV-1 infection without the need for continuous, lifelong use of these drugs. Inthe ongoing search for powerful antiretroviral agents that can affect sustainedcontrol for HIV infection, mathematical models can help in assessing both thecorrelates of protective immunity and the clinical role of a given drug regimen aswell as in understanding the efficacy of drug therapies administered at differentstages of the disease. …”
Get full text

Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats by Isaac A. Adedara, Amos O. Abolaji, Blessing E. Odion, Isioma J. Okwudi, Abiola A. Omoloja, Ebenezer O. Farombi

Get full text