Genetic Analysis of Sodium Channel Genes in Pediatric Epilepsy Patients of Pakistan by Aqsa Ashfaq, Tayyaba Saleem, Nadeem Sheikh, Hafsa Maqbool

“…Although antiepileptic drugs work for the majority of epileptic patients, these drugs do not work for some of the patients, subjecting them to drug-resistant epilepsy (DRE). …”
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Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method by Karolewicz Bożena, Nartowski Karol, Pluta Janusz, Górniak Agata

“…The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at different drug-to-polymer ratios. The obtained physical mixtures and solid dispersions were examined in terms of drug content and possible physical and chemical interactions between the drug and polymer using FTIR spectral studies, differential scanning calorimetry and powder X-ray diffraction analysis. …”
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N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis by Haisheng Zhang, Cheng Yi, Jianing Li, Yunqing Lu, Haoran Wang, Lijun Tao, Jiawang Zhou, Yonghuang Tan, Jiexin Li, Zhuojia Chen, Gholamreza Asadikaram, Jie Cao, Jianxin Peng, Wanglin Li, Junming He, Hongsheng Wang

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Fatty Liver and Insulin Resistance in the Liver-Specific Knockout Mice of Mitogen Inducible Gene-6 by Byung Kil Park, Eun-Ah Lee, Hee-Youn Kim, Jun Choul Lee, Koon Soon Kim, Won Hoon Jeong, Ki Young Kim, Bon Jeong Ku, Sang Dal Rhee

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Medication adherence among hospitalized hypertension patients in Shenyang city by Wenqi NING, Ding LI, Liping YANG, Yuxian ZHANG, Hongzhu LIU, Rui HU, Mingzhu CHEN, Tong MENG, Min JIA, Ran ZHANG, Chang LU, Jian GONG

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5-Aminopyrazole Dimerization: Cu-Promoted Switchable Synthesis of Pyrazole-Fused Pyridazines and Pyrazines via Direct Coupling of C-H/N-H, C-H/C-H, and N-H/N-H Bonds by Yi-Xin Chai, Jun-Jie Ren, Yi-Ming Li, Yi-Cheng Bai, Qing-Qing Zhang, Yi-Zhen Zhao, Xue Yang, Xiao-Han Zhang, Xin-Shuang Zhang, An-Xin Wu, Yan-Ping Zhu, Yuan-Yuan Sun

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Corrigendum to “The Bridge between Screening and Assessment: Establishment and Application of Online Screening Platform for Food Risk Substances” by Kang Hu, Shaoming Jin, Hong Ding, Jin Cao

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Structural tailoring of etoricoxib: A spectrochemical, medicinal and pharmacological study by Bakul Akter, Silvia Aishee, Abdullah Hridoy, Md. Mehedi Hasan Pulok, Mohammad Ariful Islam, Antu Biswas, Aurna Patwary, Majedul Hoque, MD. Sazidul Islam, Md. Nipatul Hasan Nirob, Faisal Islam Chowdhury, Monir Uzzaman

“…Furthermore, molecular dynamics (MD) simulations accomplished by exploiting the YASARA dynamics software program with the AMBER14 energy field throughout 100 ns revealed that the ETC9 and ETC19 derivatives exhibited enhanced stability and flexibility profiles compared to the parent drug, ETC. ADMET and PASS predictions confirmed the drug-like properties of most derivatives, particularly ETC19 and ETC9, which also showed improved absorption, better blood-brain barrier penetration, and reduced toxicity. …”
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Heterologous vaccination with subunit protein vaccine induces a superior neutralizing capacity against BA.4/5‐included SARS‐CoV‐2 variants than homologous vaccination of mRNA vacci... by Dandan Peng, Tingmei Zhao, Weiqi Hong, Minyang Fu, Cai He, Li Chen, Wenyan Ren, Hong Lei, Jingyun Yang, Aqu Alu, Yanghong Ni, Jian Liu, Jiong Li, Wei Wang, Guobo Shen, Zhiwei Zhao, Li Yang, Jinliang Yang, Zhenling Wang, Yoshimasa Tanaka, Guangwen Lu, Xiangrong Song, Xiawei Wei

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Palmitic Acid Accelerates Endothelial Cell Injury and Cardiovascular Dysfunction via Palmitoylation of PKM2 by Yu He, Senlin Li, Lujing Jiang, Kejue Wu, Shanshan Chen, Linjie Su, Cui Liu, Peiqing Liu, Wenwei Luo, Shilong Zhong, Zhuoming Li

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Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance-based relative binding activity a... by Shuai Wang, Yanqiu Wang, Zhenzhen Li, Ye Hong, Zhaohui Wang, Jiteng Fan, Qiong Wang, Yuanjie Ge, Xiaofeng Zhao, Guangcun Cheng, Changyan Chen, Yadan Wu, Yayuan Fu

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GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models by Yu Huang, Jinyong Wang, Xiling Wei, Hui Zhang, Wei Shang, Xiangling Zhang, Lanjiao Zhai, Xi Chen, Huiming Li, Suofu Qin

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Nano Delivery System for Atherosclerosis by Zhuoyi Rong, Xuan He, Tianjian Fan, Haitao Zhang

“…Nanoparticles, such as liposomes and polymeric nanoparticles, have been developed for drug delivery in atherosclerosis treatment. This review will focus on how nanoparticles effectively improve drug safety and efficacy, as well as the continuous development and optimization of nanoparticles of the same material and further explore current challenges and future opportunities in this field.…”
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Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63 by Kathryn E. King, Linan Ha, Tura Camilli, Wendy C. Weinberg

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An Improved Method for Extracting Rat Cerebrospinal Fluid with Repeatable Large-Scale Collection by Limei Wang, Wei Yang, Yanhong Ran, Hui Song, Xinxin Yan, Jianmin Guo

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Transdermal delivery of PeptiCRAd cancer vaccine using microneedle patches by Carmine D'Amico, Manlio Fusciello, Firas Hamdan, Federica D'Alessio, Paolo Bottega, Milda Saklauskaite, Salvatore Russo, Justin Cerioni, Khalil Elbadri, Marianna Kemell, Jouni Hirvonen, Vincenzo Cerullo, Hélder A. Santos

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Plasma Membrane Transporters in Modern Liver Pharmacology by Jose J. G. Marin

“…The liver plays a crucial role in the detoxification of drugs used in the treatment of many diseases. The liver itself is the target for drugs aimed to modify its function or to treat infections and tumours affecting this organ. …”
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Determination of the Contents of Antioxidants and Their Degradation Products in Sodium Chloride Injection for Blood Transfusion by Bo Tao, Gang Wang, Zongning Yin, Xiaocong Pu, Yan Jiang, Luohong Zhang, Jie Cheng, Yong Li, Jiayu Zhang

“…Therefore, the antioxidants and their degradation products migrating into the drug solution would not cause drug safety risks.…”
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Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus by Dongdong Lin, Cong Tang, Junbin Wang, Yun Yang, Hao Yang, Yanan Zhou, Wenhai Yu, Bai Li, Qing Huang, Haixuan Wang, Ran An, Xiaoming Liang, Yuhuan Yan, Longhai Yuan, Xuena Du, Yuxia Yuan, Yanwen Li, Shuaiyao Lu

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SLC29A1 and SLC29A2 are human nicotinamide cell membrane transporters by Mingyang Chen, Luexiang Yuan, Binxin Chen, Hui Chang, Jun Luo, Hengbin Zhang, Zhongjian Chen, Jiao Kong, Yaodong Yi, Mengru Bai, Minlei Dong, Hui Zhou, Huidi Jiang

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