Recent advances in self-targeting natural product-based nanomedicines by Haifan Liu, Xingyue Jin, Suyi Liu, Xinyue Liu, Xiao Pei, Kunhui Sun, Meifang Li, Ping Wang, Yanxu Chang, Tiejie Wang, Bing Wang, Xie-an Yu

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Self-propelled ferroptosis nanoinducer for enhanced cancer therapy by Wenxin Xu, Hao Tian, Yanzhen Song, Hanfeng Qin, Junbin Gao, Yichi Chen, Weichang Huang, Lin Lin, Haixin Tan, Yicheng Ye, Xiaoting Zhang, Daniela A Wilson, Guang Yang, Fei Peng, Yingfeng Tu

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High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches by Shanshan He, Xiaoyang Li, Yuanyuan He, Ling Guo, Yunzhou Dong, Leilei Wang, Lan Yang, Lin Li, Shiyun Huang, Jiali Fu, Qing Lin, Zhirong Zhang, Ling Zhang

“…Thus, we co-load anti-inflammatory drug triptolide (TP) and anti-fibrotic drug nintedanib (BIBF) on bHDL nanoparticles to treat CKD. …”
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Decoding the m6A epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach by Chuwei Liu, Heng Liang, Arabella H. Wan, Min Xiao, Lei Sun, Yiling Yu, Shijia Yan, Yuan Deng, Ruonian Liu, Juan Fang, Zhi Wang, Weiling He, Guohui Wan

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Visible-Light-Driven Carboxylative 1,2-Difunctionalization of CC Bonds with Tetrabutylammonium Oxalate by Sai Wang, Pei Xu, Zhi-Tao Liu, Yi-Qin Liu, Hao-Qiang Jiang, Tian-Zi Hao, Hui-Xian Jiang, Hui Xu, Xu-Dong Cao, Dong Guo, Xu Zhu

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In situ detection of piRNA‐651 in exosomes and cells for cancer diagnosis by a new gold nanoparticle nucleic acid probe by Qin‐Xin Gao, Qian‐Qian Wu, Zhi‐Ying Dong, Xiao‐Yuan Qin, Lin‐Yan Zhai, Bao‐Ping Xie, Wen‐Jun Duan

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A SARS‐CoV‐2 EG.5 mRNA vaccine induces a broad‐spectrum immune response in mice by Hongyu Wang, Qinhua Peng, Xinxian Dai, Zhifang Ying, Xiaohong Wu, Xinyu Liu, Hongshan Xu, Jia Li, Leitai Shi, Jingjing Liu, Yunpeng Wang, Danhua Zhao, Yanqiu Huang, Lihong Yang, Ren Yang, Guangzhi Yue, Yue Suo, Qiang Ye, Shouchun Cao, Yuhua Li

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Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP‐Deficient Glioma May Be Influenced by Surrounding Normal Cells by Yunjie Wang, Xiaohui Sun, Runchen Ma, Xiaofan Zhang, Shengmin Ji, Zhaofeng Liu, Gangqiang Yang, Hongbo Wang, Peng Zhang, Jianzhao Zhang, Jingwei Tian

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Acute pain pathways: protocol for a prospective cohort study by Christine Lee, Joseph S Ross, Molly Moore Jeffery, Nilay D Shah, David B Page, Nancy Chang, Fernanda Bellolio, Sam Torbati, Jessica D Ritchie, Gregg H Gilbert, Lindsay Emanuel, Mitra Ahadpour, Summer Allen, Richardae Araojo, Laura Ciaccio, Jonathan Fillmore, Patricia Koussis, Heather Lipkind, Celeste Mallama, Tamra Meyer, Megan Moncur, Teryl Nuckols, Michael A Pacanowski, Elektra Papadopoulos, Mat Soukup, Christopher O St. Clair, Stephen Tamang, Douglas W Wallace, Yueqin Zhao, Rebekah Heckmann

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Novel (Q)SAR models for prediction of reversible and time-dependent inhibition of cytochrome P450 enzymes by Sadegh Faramarzi, Arianna Bassan, Kevin P. Cross, Xinning Yang, Glenn J. Myatt, Donna A. Volpe, Lidiya Stavitskaya

“…The 2020 FDA drug-drug interaction (DDI) guidance includes a consideration for metabolites with structural alerts for potential mechanism-based inhibition (MBI) and describes how this information may be used to determine whether in vitro studies need to be conducted to evaluate the inhibitory potential of a metabolite on CYP enzymes. …”
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Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes by Jens Markus Borghardt, Charlotte Kloft, Ashish Sharma

“…For example, via inhalation, a drug is directly delivered to the target organ, conferring high pulmonary drug concentrations and low systemic drug concentrations. …”
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Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology by Shengming Ou, Xiaoya Nie, Xiangyu Qiu, Xin Jin, Geyan Wu, Rongxin Zhang, Jinrong Zhu

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Screening of Diabetes-Associated Autoantigens and Serum Antibody Profiles Using a Phage Display System by Jun Lin, Zhenyu Wang, Hongtao Wang, Yuping Li, Yao Liu, Yige He, Qian Liu, Zichuan Chen, Yuan Ji

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Pharmacovigilance in veterinary profession by Fatih Doğan

“…<p> <b>Results:</b> 81% of veterinarians had experienced at least one adverse drug reaction. When the drug groups were evaluated, most adverse drug reactions were determined (p<0.05) in vitamin-mineral-amino acid preparates (39%), and this group was followed by antibacterials (26%) and antiparasitics (26%). …”
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The Link between Hypersensitivity Syndrome Reaction Development and Human Herpes Virus-6 Reactivation by Joshua C. Pritchett, Radu M. Nanau, Manuela G. Neuman

“…There are challenges in the clinical diagnosis of drug-induced injury and in obtaining information on the reactivation of human herpes viruses (HHV) during idiosyncratic adverse drug reactions. …”
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Rational application of fructose-1,6-diphosphate: From the perspective of pharmacokinetics by Li Ting-Ting, Xie Jian-Zhong, Wang Ling, Gao Yang-Yang, Jiang Xue-Hua

“…In the current study, the preliminary pharmacokinetics of FDP given orally to humans was investigated, and no typical peak was observed in the serum drug-time curve. Then, the pharmacokinetic studies were performed following multiple doses of FDP in rats, and the Caco-2 monolayer model was used to study the absorption of FDP in vitro. …”
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Authentication of Processed Epimedii folium by EA-IRMS by Fengyan He, Mengyi Li, Yi He, Zhe Dong, Jin Cao, Zhong Dai, Shuangcheng Ma

“…Processing of crude drug is a key character of traditional Chinese medicine (TCM), which could enhance the efficacy and/or reduce the toxicity of crude drugs to fulfill different requirements of TCM clinical practice. …”
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First, Do No Harm: Addressing AI's Challenges With Out‐of‐Distribution Data in Medicine by Chu Weng, Wesley Lin, Sherry Dong, Qi Liu, Hanrui Zhang

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Cancer, Natural Products and Nanodrug Delivery Systems by Yong Sze Ong, Loh Teng-Hern Tan

“…The nanoparticles that act as drug reservoirs also aim to control the drug release, enhance the drug uptake by targeted delivery and protect the drug against enzymatic degradation. …”
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Studies of the Interaction between Isoimperatorin and Human Serum Albumin by Multispectroscopic Method: Identification of Possible Binding Site of the Compound Using Esterase Activ... by Samira Ranjbar, Yalda Shokoohinia, Sirous Ghobadi, Nooshin Bijari, Saeed Gholamzadeh, Nastaran Moradi, Mohammad Reza Ashrafi-Kooshk, Abbas Aghaei, Reza Khodarahmi

“…Isoimperatorin is one of the main components of Prangos ferulacea as a linear furanocoumarin and used as anti-inflammatory, analgesic, antispasmodic, and anticancer drug. Human serum albumin (HSA) is a principal extracellular protein with a high concentration in blood plasma and carrier for many drugs to different molecular targets. …”
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