CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension by Lea Strohm, Henning Ubbens, Dominika Mihalikova, Alexander Czarnowski, Paul Stamm, Michael Molitor, Stefanie Finger, Matthias Oelze, Dorothee Atzler, Philip Wenzel, Philipp Lurz, Thomas Münzel, Christian Weber, Esther Lutgens, Andreas Daiber, Steffen Daub

“…CD40L–CD40–TRAF signaling is involved in the progression of atherosclerosis and drives the development of coronary heart disease (CHD). …”
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Cell culture expansion media choice affects secretory, protective and immuno-modulatory features of adipose mesenchymal stromal cell-derived secretomes for orthopaedic applications by Enrico Ragni, Andrea Papait, Michela Maria Taiana, Paola De Luca, Giulio Grieco, Elsa Vertua, Pietro Romele, Cecilia Colombo, Antonietta Rosa Silini, Ornella Parolini, Laura de Girolamo

“…Although the undeniable advantages for GMP compliant processes, this study results suggest that new media formulations would deserve a deep characterization to drive the choice of the most effective one tailored to each specific application.…”
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Ecological impacts of single-axis photovoltaic solar energy with periodic mowing on microclimate and vegetation by Yudi Li, Yudi Li, Alona Armstrong, Alona Armstrong, Christopher Simmons, Noah Z. Krasner, Noah Z. Krasner, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez, Rebecca R. Hernandez

“…Marked differences in vegetation across micro-patches indicated that GPVs drive changes in plant community composition, structure, and productivity. …”
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Association of Sociodemographic Factors With Overtriage, Undertriage, and Value of Care After Major Surgery by Tyler J. Loftus, MD, Matthew M. Ruppert, MS, Benjamin Shickel, PhD, Tezcan Ozrazgat-Baslanti, PhD, Jeremy A. Balch, MD, Kenneth L. Abbott, MD, Die Hu, MS, Adnan Javed, MD, Firas Madbak, MD, Faheem Guirgis, MD, David Skarupa, MD, Philip A. Efron, MD, Patrick J. Tighe, MD, William R. Hogan, MD, Parisa Rashidi, PhD, Gilbert R. Upchurch, Jr, MD, Azra Bihorac, MD

“…Unique sociodemographic phenotypes within both overtriage and undertriage cohorts had similar outcomes and value of care, suggesting that triage decisions, rather than patient characteristics, drive outcomes and value of care. Conclusions:. Postoperative triage decisions should ensure equality across sociodemographic groups by anchoring triage decisions to objective patient acuity assessments, circumventing cognitive shortcuts and mitigating bias.…”
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Synthetic inhibition of SREBP2 and the mevalonate pathway blocks rhabdomyosarcoma tumor growth in vitro and in vivo and promotes chemosensitization by Silvia Codenotti, Michela Asperti, Maura Poli, Luisa Lorenzi, Alberto Pietrantoni, Matteo Cassandri, Francesco Marampon, Alessandro Fanzani

“…Finally, we found that forced Akt1 activation in RD cells was sufficient to drive SREBP2, HMGCR and SQLE protein expression, promoting increased susceptibility to MVP inhibitors. …”
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En Balance: The Contribution of Physical Activity to the Efficacy of Spanish Diabetes Education of Hispanic Americans with Type 2 Diabetes by Dequina A. Nicholas, Lorena M. Salto, Kristen Lavelle, Joy Wilson, W. Lawrence Beeson, Anthony Firek, William H. R. Langridge, Zaida Cordero-MacIntyre, Marino De Leon

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Reduced retinal microvascular density in women with coronary microvascular dysfunction: A pilot study by Sakshi Shiromani, Ahmed AlBadri, Aaron Lindeke-Myers, Arielle Schwartz, Nishant Vatsa, Esha Dave, Fauzia Rashid, Nieraj Jain, Puja K. Mehta

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Scaling Arctic landscape and permafrost features improves active layer depth modeling by Wouter Hantson, Daryl Yang, Shawn P Serbin, Joshua B Fisher, Daniel J Hayes

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Exoplanet Occurrence Rate with Age for FGK Stars in Kepler by Maryum Sayeed, Ruth Angus, Travis A. Berger, Yuxi(Lucy) Lu, Jessie L. Christiansen, Daniel Foreman-Mackey, Melissa K. Ness

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Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension by Heather L. Clark, Daniel Lachant, Allison N. Light, Deborah Haight, Samia Lopia, Nigel Mackman, R. James White

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The Effects of Body Acupuncture on Obesity: Anthropometric Parameters, Lipid Profile, and Inflammatory and Immunologic Markers by Hamid Abdi, Baixiao Zhao, Mahsa Darbandi, Majid Ghayour-Mobarhan, Shima Tavallaie, Amir Ali Rahsepar, Seyyed Mohammad Reza Parizadeh, Mohammad Safariyan, Mohsen Nemati, Maryam Mohammadi, Parisa Abbasi-Parizad, Sara Darbandi, Saeed Akhlaghi, Gordon A. A. Ferns

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Low body mass index as a predictor of sputum culture conversion and treatment outcomes among patients receiving treatment for multidrug-resistant tuberculosis in Lesotho by Lawrence Oyewusi, Chengbo Zeng, KJ Seung, Stephanie Mpinda, Mikanda Kunda, Carole D Mitnick, Makelele Kanu, Meseret Tamirat, Joalane Makaka, Mabatloung Mofolo, Refiloe Maime, Llang Maama, Ninza Senyo, Bamidele Oguntoyinbo, Lwayi Mayombo, Molly F Franke

“…Addressing the myriad factors that drive low BMI in this setting could hasten culture conversion and improve end-of-treatment outcomes. …”
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Clean and healthy environmental behavior in terms of malnutrition and sanitation by . Nuraeni, N.I. Hawa, D. Utari, E. Parahyanti

“…The family can be part of the subjective norms that drive aspects of attitudes and perceptions of behavioral control related to environment-based chronic malnutritionchronic malnutrition prevention practices. …”
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Intraprosthetic Dislocation Following Dual Mobility Total Hip Arthroplasty: A Retrieval Analysis Study by Salar Sobhi, BSc, MD, Alan Kop, MSc, PhD, Moreica Pabbruwe, PhD, Christopher W. Jones, BCom, BEng(Hons), MBBS(Hons), PhD, FRACS, FAOrthA, Michael A. Finsterwald, MD, FMH, FRACS, FAOrthA

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Immune profiling of human vestibular schwannoma secretions identifies TNF-α and TWEAK as cytokines with synergistic potential to impair hearing by Sasa Vasilijic, Richard Seist, Zhenzhen Yin, Lei Xu, Konstantina M. Stankovic

“…Conclusion This study provides compelling evidence that VS-secreted TNF-α and TWEAK act synergistically to drive tumor-induced SNHL. Targeting the TNF-α/TWEAK axis presents a promising new avenue for preventing VS-induced SNHL.…”
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Effect of COVID-19 Lockdown on Alcohol Consumption Among the Youths in Kampala, Uganda. A Cross-Sectional Study by Namiiro AM, Audo R, Nannungi CD, Pitua I, Kiberu D, Talemwa P, Mujuni E, Lwesabula A, Ageimo P, Khaukha AZ, Kuol MJ, Egaru L, Koire M, Ssewante N

“…Amelia Margaret Namiiro,1 Ritah Audo,1 Charity Doreen Nannungi,1 Ivaan Pitua,1 Denis Kiberu,1 Peter Talemwa,1 Emanuel Mujuni,1 Alex Lwesabula,1 Paul Ageimo,1 Arnold Zephania Khaukha,1 Moses Jok Kuol,1 Lazarous Egaru,1 Malik Koire,1,2 Nelson Ssewante3 1School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; 2Baylor College of Medicine Children’s Foundation, Kampala, Uganda; 3Child Health and Development Centre, College of Health Sciences, Makerere University, Kampala, UgandaCorrespondence: Amelia Margaret Namiiro, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda, Email amiemaggie99@gmail.comBackground: The COVID-19 pandemic led to increased loneliness, emotional stress, and idleness due to job losses and school closures which can drive substance use among vulnerable populations like youths. …”
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Enhancing Food Security via selecting Superior Camelina (Camelina sativa L.) parents: a positive approach incorporating pheno-morphological traits, fatty acids composition, and Toc... by Amin Ebrahimi, Hamzeh Minaei Chenar, Sajad Rashidi-Monfared, Danial Kahrizi

“…Conclusions The study’s findings hold great potential for improving food security by enabling the selection of superior camelina parent plants based on specific traits. This approach can drive the development of high-yielding varieties with enhanced nutritional value and better-quality camelina oil.…”
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SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma ce... by Tianci Han, Xiaoqi Guo, Junwei Xie, Wei Tong, Liang Zhang

“…Furthermore, ETV1 upregulation in tumor tissues was found to drive M2 macrophage infiltration both in vitro (transwell assays) and in vivo (xenograft tumor models). …”
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CO2 capture performance and foaming mechanism of modified amine-based absorbents: A study based on molecular dynamics by Yucong Ge, Zeyu Wang, Li Yang, Xunxuan Heng, Zhenzhen Zhang, Yi Wang, Fang Liu, Xiao Yang, Bo Liu, Kunlei Liu

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“It's hard to talk to a computer, I get it”: An exploratory analysis of clinician connection-building communication practices in rural telepalliative care encounters by Elise C. Tarbi, Natalie Ambrose, Eric C. Anderson, Rebecca N. Hutchinson, Paul K.J. Han, Maija Reblin, Robert Gramling

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