Exploring SME owners’ motivation to learn and acquire new skills for the adoption of e-commerce by Naledi D.D. Gallant, Anthea P. Amadi-Echendu, Elriza Esterhuyzen

“…Contribution: By providing nuanced insights into the intricate processes that drive SME owners to embrace new skills and e-commerce technologies in Soweto, the findings add to the body of information already in existence. …”
Get full text

FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models by Timothy Weeden, Tyler Picariello, Brendan Quinn, Sean Spring, Pei-Yi Shen, Qifeng Qiu, Benjamin F. Vieira, Lydia Schlaefke, Ryan J. Russo, Ya-An Chang, Jin Cui, Monica Yao, Aiyun Wen, Nelson Hsia, Tama Evron, Katy Ovington, Pei-Ni Tsai, Nicholas Yoder, Bo Lan, Reshmii Venkatesan, John Hall, Cody A. Desjardins, Mo Qatanani, Scott Hilderbrand, John Najim, Zhenzhi Tang, Matthew K. Tanner, Romesh Subramanian, Charles A. Thornton, Oxana Ibraghimov-Beskrovnaya, Stefano Zanotti

“…Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by expanded CUG triplets in the DMPK RNA, which sequester splicing proteins in the nucleus, lead to spliceopathy, and drive disease progression. Methods Multiple surrogate conjugates were generated to characterize the FORCE platform. …”
Get full text

Viral Transcript and Tumor Immune Microenvironment-Based Transcriptomic Profiling of HPV-Associated Head and Neck Squamous Cell Carcinoma Identifies Subtypes Associated with Progno... by Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden

“…Our results suggest that HPV-transcript expression patterns may drive the modulation of the TME, and thereby impact prognosis.…”
Get full text

Improvement of crop production in controlled environment agriculture through breeding by Krishna Bhattarai, Andrew B. Ogden, Sudeep Pandey, Germán V. Sandoya, Ainong Shi, Amol N. Nankar, Murukarthick Jayakodi, Heqiang Huo, Tao Jiang, Pasquale Tripodi, Chris Dardick

“…The availability of published genomes and trait-linked molecular markers should enable rapid progress in the breeding of CEA-specific food crops that will help drive the growth of this industry.…”
Get full text

Impacts of Chemical Initial Conditions in the WRF-CMAQ Model on the Ozone Forecasts in Eastern China by Tangyan Hou, Shaocai Yu, Yaping Jiang, Xue Chen, Yibo Zhang, Mengying Li, Zhen Li, Zhe Song, Pengfei Li, Jianmin Chen, Xiaoye Zhang

“…The influences of different chemical initial conditions on the O3 forecasts are presented by using two sets of meteorological data (NCEP Final Operational Global Analysis [FNL] and Global Forecast System [GFS]) as initial conditions (IC) and boundary conditions (BC) to drive the WRF/CMAQ model. It was found that the O3 concentrations forecasted by FNL-GFS, in which the chemical IC derived from the CMAQ simulation results by using the FNL data as IC and BC, were closer to observations in all cities than GFS-GFS, in which the chemical IC derived from the CMAQ simulation results by using the GFS data as IC and BC. …”
Get full text

Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience by Niall Leahy, Cillian O’Brien, Sara Essa Alsubai, Eileen Coen, Darragh Murphy, Faisal Sharif

“…Fluid retention manifesting in dyspnoea and oedema are important clinical features of decompensated heart failure and drive hospital admissions. Intracardiac and pulmonary artery pressure (PAP) monitoring can help predict heart failure decompensation, as changes in these haemodynamics occur before clinical congestion manifests. …”
Get full text

Unveiling the prognostic value of ARID3A in breast cancer through bioinformatic analysis by Wen-Run Cai, Xu-Gang Sun, Yue Yu, Xin Wang, Xu-Chen Cao, Xiao-Feng Liu

“…Conclusion: These findings indicate that ARID3A may serve as a prognostic biomarker and therapeutic target in breast cancer, providing insights into its involvement in oncogenic pathways and interactions, particularly with TP53, that may drive cancer development and progression.…”
Get full text

Is International Travel an Emerging Issue on Transmission of Beijing Lineage Mycobacterium tuberculosis? by Pavithra S. Madamarandawala, Srinath Satyanarayana, Collins Timire, Aashifa Yaqoob, Dushantha Madegedara, Dhammika N. Magana-Arachchi

“…The prevalence of BL strains in Kandy, Sri Lanka, was high compared to previously reported figures in Sri Lanka, and the percentage drives closer to the countries in South East Asia. …”
Get full text

Combined biochemical profiling and DNA sequencing in the expanded newborn screening for inherited metabolic diseases: the experience in an Italian reference center by Simona Fecarotta, Lorenzo Vaccaro, Alessandra Verde, Marianna Alagia, Alessandro Rossi, Chiara Colantuono, Maria Teresa Cacciapuoti, Patrizia Annunziata, Sara Riccardo, Antonio Grimaldi, Tonya Fusco, Rosa De Santis, Fernando Barretta, Lucia Albano, Daniela Crisci, Fabiana Vallone, Antonietta Tarallo, Marcella Cesana, Nicola Brunetti-Pierri, Giulia Frisso, Margherita Ruoppolo, Davide Cacchiarelli, Giancarlo Parenti

“…This allows overtaking the actual limitations of NBS on DBS, enhancing our capacity to identify variants that can drive a genetic disease. Through this approach, we could reach 100% of cases solved, with 37.9% of cases (41/108) for which the combination of the biochemical and NGS analysis was indispensable for a correct diagnosis. …”
Get full text

Clinical validation and optimization of machine learning models for early prediction of sepsis by Xi Liu, Meiyi Li, Xu Liu, Yuting Luo, Dong Yang, Hui Ouyang, Jiaoling He, Jinyu Xia, Fei Xiao, Fei Xiao, Fei Xiao

“…Early prediction of sepsis onset can drive effective interventions and improve patients’ outcome.MethodsData were collected retrospectively from a cohort of 2,329 adult patients with positive bacteria cultures from a tertiary hospital in China between October 1, 2019 and September 30, 2020. …”
Get full text

The Application of an Intelligent <i>Agaricus bisporus</i>-Harvesting Device Based on FES-YOLOv5s by Hao Ma, Yulong Ding, Hongwei Cui, Jiangtao Ji, Xin Jin, Tianhang Ding, Jiaoling Wang

“…To confirm the impact of vibration on the harvesting process, a stepper motor drive test was conducted using both trapezoidal and S-curve acceleration and deceleration motor control algorithms. …”
Get full text

Cancer stem cell populations are resistant to 5-aminolevulinic acid-photodynamic therapy (5-ALA-PDT) by Chantel P. J. Rice, Vipin Shankar Chelakkot, Noah T. Conohan, Kensuke Hirasawa

“…As cancer stem cells (CSCs) are known to drive resistance to other cancer treatments and have high efflux of chemotherapeutic agents via ABC-family transporters, we hypothesize that CSCs underlie 5-ALA-PDT resistance. …”
Get full text

“Gleaning a lot from the history and physical exam,” and “reasonably confident without imaging”: a qualitative study of primary care clinicians' management of patients with low bac... by Lynn Haslam-Larmer, Kathleen E. Norman, Andrea M. Patey, Isabella M. Thomas, Michael E. Green, Jeremy M. Grimshaw, Jill A. Hayden, Jan Hartvigsen, Noah M. Ivers, Hazel Jenkins, Simon D. French

“…Many clinicians across disciplines expressed the following themes: (1) imaging may result in an incidental finding or otherwise cause harm to patients, and drive up health system costs (TDF domain Beliefs about consequences); (2) clinicians were confident in their abilities to diagnose, to explain to patients the rationale for not recommending imaging, and to respond to their needs (domains Beliefs about capabilities; Skills). …”
Get full text

Extrapolating evidence for molecularly targeted therapies from common to rare cancers: a scoping review of methodological guidance by Sarah J Lord, Saskia Cheyne, John Simes, Doah Cho, Chee Khoon Lee

“…Objectives Cancer is increasingly classified according to biomarkers that drive tumour growth and therapies developed to target them. …”
Get full text

Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024 by Xinran He, Tingyi Xie, Li Shi, Xuyi Kuang, Lei Li, Xingyu Shang, Bo Fu

“…In addition, keyword and cluster analysis showed that immune checkpoint inhibitors, cancer-associated fibroblasts, macrophage polarization, intestinal microbiota, colorectal cancer liver metastasis, drug resistance, scRNA-seq, etc. may be the research hotspots and trends in this field.ConclusionsColorectal cancer and tumor microenvironment research is in the developmental stage, and strengthening international cooperation can help to drive this field forward. The main components and signaling in TME, CRC immunotherapy, colorectal cancer liver metastasis, and new research techniques are the hot research directions in this domain. …”
Get full text

Unpacking the Mood States of Children and Youth in Saskatchewan, Canada, in the Context of the COVID-19 Pandemic: Insights from the “See Us, Hear Us 2.0” Study by Nahin Shakurun, Tamara Hinz, Daniel A. Adeyinka, Nazeem Muhajarine

Get full text

Obesity Index That Better Predict Metabolic Syndrome: Body Mass Index, Waist Circumference, Waist Hip Ratio, or Waist Height Ratio by Abdulbari Bener, Mohammad T. Yousafzai, Sarah Darwish, Abdulla O. A. A. Al-Hamaq, Eman A. Nasralla, Mohammad Abdul-Ghani

Get full text

Implemetasi Komputasi Akar Kuadrat Resolusi Tinggi pada Field Programmable Gate Array (FPGA) by Muhammad Irfan, Hendra Setiawan

“…Selain itu, sistem ini membutuhkan 157 Logic Elements dan 120 register dengan kecepatan clock tertinggi yang dicapainya adalah 205 MHz untuk input 32 bit   Abstract Square root computing is required in several control processes, such as for Direct Torque Control (DTC) on motor drive systems that require a very fast calculation process. …”
Get full text

Factors Associated with Malaria Infection among Head Porters in Agbogbloshie Market in the Greater Accra Region of Ghana by Patience Kwofie, John Tetteh, Reindorf Elijah Akakpo, Bismark Sarfo

“…The inability to identify them because they are mobile means that they can continue to drive malaria transmission even if malaria in the general population is controlled. …”
Get full text

Post-Spring Frost Canopy Recovery, Vine Balance, and Fruit Composition in cv. Barbera Grapevines by Filippo Del Zozzo, Ginevra Canavera, Silvia Pagani, Matteo Gatti, Stefano Poni, Tommaso Frioni

“…In the case of spring frost damage, the number of PBS avoiding fatal injuries will drive agronomic results at harvest since SBS contribution to total yield is modest due to low shoot fruitfulness. …”
Get full text