Evaluation of a strategy for tumor-initiating stem cell eradication in primary human glioblastoma cultures as a model by E. V. Dolgova, A. S. Proskurina, E. A. Potter, T. V. Tyrinova, O. S. Taranov, Ya. R. Efremov, K. E. Orishchenko, S. V. Mishinov, V. V. Stupak, A. A. Ostanin, E. R. Chernykh, S. S. Bogachev

“…The effectiveness of a new therapeutic approach aimed at destroying the cancer cell community was evaluated on the primary cell lines of human glioblastoma culture by employing a new strategy of tumor-initiating stem cell synchronization and a domestic strategy of their eradication "3+1". The key elements of the strategy were the following indicator results: (1) evaluation of the presence of tumor-initiating stem cells in a population of cells from analyzed cultures by their ability to internalize double-stranded labeled DNA (TAMRA+ cells); (2) determination of the reference time points of the repair cycle of DNA interstrand cross-links induced by cross-linking cytostatic mitomycin C; (3) evaluation of cell cycle synchronization; (4) determination of the time (day after therapy initiation) when TAMRA+ cells were synchronously present in phase G1/S of the cell cycle, sensitive to the therapy; and (5) establishment of the TAMRA+ (tumor-initiating stem cells) eradication schedule. …”
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Phylogeography and biological characterization of H12N2 virus isolated from whooper swan in Central China by Pengfei Ren, Zhen Gao, Xing Li, Jiao Tang, Pei Li, Zhonglin Huang, Jinchi Guo, Pengfei Cui, Lin Jin, Junping Li, Libin Liang

“…Animal experiments in domestic ducks and chickens demonstrated that the virus replicates at low levels in the respiratory tract of poultry and exhibits moderate horizontal transmission in ducks. …”
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Incidence and temporal trends of out-of-hospital cardiac arrest in Shenzhen, China (2011–2018) by Hong Zhu, Junpeng Liu, Tianqi Yang, Yan Zhang, Yanjun Xu, Yunfeng Xu, Hao Wu, Li Li, Yufeng Luo, Cai Wen, Tao Yu

“…Conclusions: OHCA incidence in Shenzhen is lower than both domestic and international levels but increasing. Low bystander intervention rated and prolonged response times contribute to poor outcome, underscoring the need for system improvements.…”
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The Association Between Occupational Smoke Exposures and the Prevalence of Eye and Respiratory Health Conditions Among Commercial Fish Smokers in Abuesi, Ghana: A Cross-Sectional S... by Charity Owusu, Albert Ofori, Frank Adusei-Mensah, Carl Halladay Abraham, Samuel Kyei, Reginald Quansah, David Kofi Essumang

“…While substantial research has addressed indoor air pollution from domestic cooking, the specific risks faced by fish smokers have received insufficient attention. …”
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The importance of genotyping within the climate-smart plant breeding value chain – integrative tools for genetic enhancement programs by Ana Luísa Garcia-Oliveira, Rodomiro Ortiz, Fatma Sarsu, Søren K. Rasmussen, Paterne Agre, Asrat Asfaw, Moctar Kante, Subhash Chander

“…Meanwhile, the digital world is rapidly advancing with the digital economy estimated at about 20% of the global gross domestic product, suggesting that digital technologies are increasingly accessible even in areas affected by food insecurity. …”
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Production of subtilisin proteases in bacteria and yeast by A. S. Rozanov, S. V. Shekhovtsov, N. V. Bogacheva, E. G. Pershina, A. V. Ryapolova, D. S. Bytyak, S. E. Peltek

“…This situation can explain the high level of interest in these enzymes and points to the high importance of designing domestic technologies for their manufacture. The review covers subtilisin classif ication, the history of their discovery, and subsequent research on the optimization of their properties. …”
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Land-use and land-cover changes and emerging non-tuberculous and tuberculous infectious diseases in humans and animals: a mixed-methods review of research findings from global and... by Jean-François Guégan, Carlos A Vargas Campos, Christine Chevillon, Ahmadou Sylla, Magdalene Dogbe, Kayla M Fast, Jennifer Pechal, Alex Rakestraw, Matthew E Scott, Michael W Sandel, Heather Jordan, M Eric Benbow

“…Here, using both a bibliometric and scoping review method, we summarize the reliability and availability of published relevant studies on LULC effects on mycobacteria, an important group of infectious bacteria that affect humans and both wild and domestic animals. We make connections of LULC with environmental changes (e.g. soils) that likely lead to an increased risk of mycobacteria spillover to human and other animal populations. …”
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Parental preference for influenza vaccine for children in China: a discrete choice experiment by Gang Chen, Ping Liu, Xiaochen Ma, Hai Fang, Zhiyuan Hou, Hongguo Rong, Xiaozhen Lai, Shunping Li, Tiantian Gong

“…Contrary to our initial expectation, respondents have a stronger preference for the domestic than the imported vaccine. Some preference heterogeneity among parents was also found and in particular, parents who were older, or highly educated placed a higher weight on a higher protection rate.Conclusion Vaccination safety and vaccine effectiveness are the two most important characteristics that influenced parents’ decision to vaccinate against influenza for their children in China. …”
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Forecasting Weather using Deep Learning from the Meteorological Stations Data : A Study of Different Meteorological Stations in Kaski District, Nepal by Supath Dhital, Kapil Lamsal, Sulav Shrestha, Umesh Bhurtyal

“…This project aims to forecast the next 2-hour Precipitation and Air Temperature for Pokhara Domestic Airport meteorological station and the next day's Precipitation, Maximum and Minimum Air Temperature forecast for Lumle, Begnas, and Lamachaur meteorological station, total of four meteorological stations of the Kaski District, Nepal using Long Short-Term Memory (LSTM): a Recurrent Neural Network (RNN) and deploy the outputs through the web portal. …”
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Informatics Consideration on the Hierarchical System of Rare Diseases Clinical Care in China by GONG Mengchun, GUO Yanying, ZHENG Xihong, FAN Junkang, LIU Peng, NIU Ling, YANG Yining, ZOU Xiaoguang

“…Currently, the implementation of the domestic hierarchical diagnosis and treatment system for rare diseases still confronts numerous challenges, such as ambiguous referral standards and processes of primary medical institutions, and ineffective information interaction among institutions at all levels. …”
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Managing Friends and Foes: Sanctioning Mutualists in Mixed‐Infection Nodules Trades off With Defense Against Antagonists by Camille E. Wendlandt, Saumik Basu, Angeliqua P. Montoya, Paige Roberts, Justin D. Stewart, Allison B. Coffin, David W. Crowder, E. Toby Kiers, Stephanie S. Porter

“…We studied interactions among wild and domesticated pea plants, pea aphids, an aphid‐vectored virus (Pea Enation Mosaic Virus, PEMV), and mutualistic rhizobial bacteria that fix nitrogen in root nodules. …”
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Integrating whole-genome re-sequencing and transcriptome data to reveal the molecular mechanism of TBX5 gene regulating feathered feet in Guangxi native chickens by Zhuliang Yang, Yongcui Liu, Jintang Luo, Cong Xiao, Hong Yuan, Wenya Du, Xiurong Yang

“…Feathered foot is a trait observed in domestic and wild chickens, resulting from the partial or complete transformation of scales on the tarsus, shanks, and toes into feathers. …”
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Streptococcus halichoeri: Comparative Genomics of an Emerging Pathogen by Kirsi Aaltonen, Ravi Kant, Marjut Eklund, Mirja Raunio-Saarnisto, Lars Paulin, Olli Vapalahti, Thomas Grönthal, Merja Rantala, Tarja Sironen

“…Beginning in 2010, two concurrent epidemics were identified in Finland, in fur animals and domestic dogs, respectively. The fur animals suffered from a new disease fur animal epidemic necrotic pyoderma (FENP) and the dogs presented with ear infections with poor treatment response. …”
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Ensuring the Sustainable and High-Quality Development of Aquaculture Through Biosecurity: A Review and Prospects by Xuan DONG, Jie HUANG

“…Subsequently, the article outlines the key scientific and technological issues involved in the biosecurity framework and introduces the current state of research and development in the fields of science, technology, and policy, both internationally and domestically. Furthermore, this article discusses the role of global and regional organizations in promoting aquaculture biosecurity strategies and the practices of different countries and regions in constructing aquaculture biosecurity regulatory systems. …”
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Performance of HPV16/18 in Triage of Cytological Atypical Squamous Cells of Undetermined Significance by Xiaoqin Cao, Shuzheng Liu, Manman Jia, Hongmin Chen, Dongmei Zhao, Bing Dong, Zhen Guo, Lingyan Ren, Shaokai Zhang, Xibin Sun

“…HPV16/18 and 12 other types were tested with domestic hybridization capture and chemiluminescence signal amplification (DH3). …”
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Place of injuries of elbow joint in the structure of primary permanent disability among Ukrainian population by L.Y.  Naumenko, T.O. Zub, A.O. Mametyev

“…The causes of primary permanent disability were domestic injuries (90.8%), occupational injuries (5.0%), injures during military service and battle injuries (2.1%) and disability since the childhood (2.1%). …”
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The use of radar-optical remote sensing data and geographic information system–analytical hierarchy process–multicriteria decision analysis techniques for revealing groundwater rec... by Wang Yuxia, Han Yanzhong, Guo Yujiao, Wang Jingwei, Wang Nana, Abdelkareem Mohamed

“…Arid/semi-arid regions face water challenges much like the Arabian Peninsula, which is primarily caused by continuing shortages and growing activities of reclaimed land, as well as industrial and domestic activities. Consequently, identifying groundwater prospective zones (GWPZs) has become essential for securing water resources. …”
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Caregivers’ experiences of being asked about adverse childhood experiences and receiving support from an integrated health and social care hub: a qualitative study by Ashraful Kabir, Harriet Hiscock, Hueiming Liu, Lingling Chen, Rebecca Bosward, Natalie White, Sarah Loveday, Wilhelmina Ebbett

“…Using a semistructured interview guide, 29 in-depth interviews were conducted with caregivers of children who were experiencing a range of adversities, including maltreatment and household dysfunction, child neglect, parent mental illness, domestic violence, family conflict, community dysfunction, discrimination, poverty or financial hardship. …”
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Assessment of the effect of heterosis by productive parameters of young-of-the-year carps obtained from crossing Ukrainian and Polish breeds by H. Kurinenko, A. Derenko

“…The results obtained demonstrate the effectiveness of using new foreign carp lines to improve the genetic structure of domestic carp farming. A comprehensive analysis of the productive and biological parameters of the offspring obtained from the crossing of Polish lines and structural units of Ukrainian carp breeds will allow developing strategies for obtaining and growing new highly productive lines and crosses.…”
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Application Progress of Transcranial Direct Current Stimulation in Rehabilitation of Chronic Low Back Pain by SHI Jian, WAN Ruihan, WANG Yafei, GONG Chen, WANG Yuling

“…This article reviews the current domestic and international research progress of tDCS in CLBP rehabilitation in recent years and discusses the factors that affect its curative effect (e.g., stimulation target, frequency, and synergistic treatment scheme) and possibly effective treatment modes. …”
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