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  1. 481

    Surgical management of single-level thoracolumbar vertebral body segmentation and formation failure causing progressive thoracolumbar myelopathy in three adult large-breed dogs by Francisca Couto, Joana Tabanez, Jeremy Rose, Colin Driver

    Published 2025-01-01
    “…ObjectiveThis study aimed to evaluate the medium-term outcome following spinal cord decompression and instrumented fixation of single-level congenital thoracolumbar vertebral malformations, characterized by combined failures of segmentation and formation, causing thoracolumbar myelopathy in three large-breed dogs.Study designThis was a retrospective clinical study.AnimalsThe animals involved in the study were three large-breed dogs.MethodsElectronic patient records were retrospectively reviewed for adult large-breed dogs (>1 year) (>25 kg) with thoracolumbar myelopathy and a radiologic diagnosis of spinal cord compression associated with thoracolumbar vertebral malformation. …”
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    Analysis of genetic polymorphisms in the intron 9–10/exon 10 region of the BRCA1 gene in a population sample of dogs with mammary cancer from Uruguay by Alicia Decuadro, Micaela Sosa, Federico García, Nariné Balemian, María del Carmen Montenegro, Silvia Llambí

    Published 2025-01-01
    “… This study involved clinical and genetic analysis of 15 female dogs with mammary tumors. Fourteen healthy female dogs were used as controls, and blood samples were collected from them for genetic analysis. …”
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    Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from Chronic Trypanosoma cruzi-Infected Dogs by Guilherme de Paula Costa, Laís Roquete Lopes, Maria Cláudia da Silva, Aline Luciano Horta, Washington Martins Pontes, Cristiane M. Milanezi, Paulo Marcos da Mata Guedes, Wanderson Geraldo de Lima, Richard Schulz, João Santana da Silva, Andre Talvani

    Published 2016-01-01
    “…This study investigated the long-term treatment with subantimicrobial doses of doxycycline (Dox) in association, or not, with benznidazole (Bz) on the expression of CK and CKR in cardiac tissue. Thirty mongrel dogs were infected, or not, with the Berenice-78 strain of T. cruzi and grouped according their treatments: (i) two months after infection, Dox (50 mg/kg) 2x/day for 12 months; (ii) nine months after infection, Bz (3,5 mg/kg) 2x/day for 60 days; (iii) Dox + Bz; and (iv) vehicle. …”
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  13. 493

    Simultaneous Determination of Six Components in Beagle Dog Plasma by UPLC-MS/MS and Its Application to a Comparative Pharmacokinetic Study of Three Different Yuanhu Zhitong Preparations by Yang Wang, Zhaorui Yin, Kai Zhang, Qingfen Meng, Jianli Guan, Guanwei Fan

    Published 2022-01-01
    “…This study has developed a sensitive, simple, and reliable ultrahigh performance liquid chromatography tandem mass spectrometry method for the simultaneous determination of corydaline, tetrahydropalmatine, tetrahydroberberine, tetrahydrocoptisine, byakangelicin, and byakangelicol in beagle dog plasma after oral administration of Yuanhu Zhitong (YHZT) oral liquid, dispersible tablet, and dropping pills. …”
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    Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs by Yoonhee Kim, Wonhee Lee, Byunggak Kim, Bonghwan Jang, Kyung‐Rok Yu, Hong Sook Kim, Minok Ryu, Yein Oh, Kyoungwon Seo, Chul Park, Ulsoo Choi, Dongha Bhang, Hwayoung Youn

    Published 2025-01-01
    “…Methods TK1 autoantibody, ECPKA autoantibody, and CRP were measured using LFIA methods in serum samples of dog to design a new neoplastic index (NI) for early detection of malignant tumors in dogs. …”
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  17. 497

    Insights into host-pathogen interaction based on the comparison of genomes of Leptospira interrogans isolated from dogs, humans, and a rodent in the same epidemiological context: A one health approach by Lucas Nogueira Paz, Laise de Moraes, Luciane Amorim Santos, Camila Hamond, Melissa Hanzen Pinna

    Published 2025-01-01
    “…Four strains of L. interrogans serogroup Icterohaemorrhagiae from naturally infected and clinically symptomatic dogs (C20, C29, C51, and C82) were processed for whole genome sequencing (WGS). …”
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