Catheter ablation versus antiarrhythmic drugs with risk factor modification for treatment of atrial fibrillation: a protocol of a randomised controlled trial (PRAGUE-25 trial) by Stepan Havranek, Jiri Jarkovsky, Otakar Jiravský, Pavel Osmancik, Veronika Bulková, Jan Chovančík, Tomáš Roubíček, Dalibor Heřman, Zuzana Čarná, Vladimír Tuka, Martin Matoulek, Martin Fiala, Sylvie Stregl-Hruskova, Adam Latiňák, Jiřina Kotryová

“…Catheter ablation (CA) has been documented to be superior to treatment by antiarrhythmic drugs (AADs) in terms of sinus rhythm maintenance. …”
Get full text

Exploring ketogenic diet resistance in glucose transporter type 1 deficiency syndrome: A comprehensive review and critical appraisal by Raffaele Falsaperla, Vincenzo Sortino, Gerhard Josef Kluger, Thomas Herberhold, Andrea Rüegger, Pasquale Striano, Martino Ruggieri, Joerg Klepper, Georgia Ramantani

“…So, we conducted a comprehensive literature review on PubMed, focusing on studies documenting pediatric GLUT1DS patients with drug‐resistant epilepsy unresponsive to KDT. …”
Get full text

How far back do we need to look to capture diagnoses in electronic health records? A retrospective observational study of hospital electronic health record data by Tom Marshall, Elizabeth Sapey, Miles D Witham, Steve Harris, Rachel Cooper, Chris Plummer, Felicity Evison, James Wason, Heather J Cordell, Suzy Gallier, Fiona E Matthews, Ewan Pearson, Avan A Sayer, Mervyn Singer, Joanne Field, Mohammed Osman, Sian Robinson, Victoria Bartle, Thomas Scharf, Jadene Lewis, Rominique Doal, Peta le Roux, Ray Holding, Paolo Missier

“…This requires accurate and complete ascertainment of a broad range of diagnoses, something not always recorded on an admission document at a single point in time. This study aimed to ascertain how far back in time electronic hospital records need to be interrogated to capture long-term condition diagnoses.Design Retrospective observational study of routinely collected hospital electronic health record data.Setting Queen Elizabeth Hospital Birmingham (UK)-linked data held by the PIONEER acute care data hub.Participants Patients whose first recorded admission for chronic obstructive pulmonary disease (COPD) exacerbation (n=560) or acute stroke (n=2142) was between January and December 2018 and who had a minimum of 10 years of data prior to the index date.Outcome measures We identified the most common International Classification of Diseases version 10-coded diagnoses received by patients with COPD and acute stroke separately. …”
Get full text

Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients by M. Matta, A. Pavy-Le Traon, S. Perez-Lloret, C. Laporte, I. Berdugo, N. Nasr, H. Hanaire, J. M. Senard

“…The prevalence of cardiovascular autonomic neuropathy (CAN) in diabetes mellitus is well documented. However, the rate and predictors of both the development and progression of CAN have been less studied. …”
Get full text

Unlocking the genetic potential of Ethiopian fenugreek (Trigonella foenum-graecum L.) genotypes for future breeding by Zebib Berhe, Tesfaye Awas, Asmare Dejen, Metadel Adane, Baye Akele, Musa Adal, Faris Hailu

“…Generally, the study indicate that indigenous knowledge held by fenugreek farmers has to be documented and preserved in appropriate formats including in databases and the fenugreek can be improved through selection easily with considering the traits that show high variation with genetic advance for future breeding.…”
Get full text

Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells by Christian Sávio-Silva, Stephany Beyerstedt, Poliana E. Soinski-Sousa, Expedito B. Casaro, Maria Theresa A. Balby-Rocha, Antônio Simplício-Filho, Jamille Alves-Silva, Érika B. Rangel

“…Phase I clinical trials have evaluated the safety profile of MSC-based therapy in humans, and phase II clinical trials (proof of concept in trial participants) still need to answer important questions for treating DKD, yet metabolic control has already been documented. Therefore, randomized and controlled trials considering the source, optimal cell number, and route of delivery in DM patients are further required to advance MSC-based therapy. …”
Get full text

Highly Aggressive CD4-Positive Mast Cell Leukaemia (Leukaemic Variant) Associated with Isolated Trisomy 19 and Hemophagocytosis by Neoplastic Mast Cells: A Case Report with Challen... by Dina Sameh Soliman, Ahmad Al-Sabbagh, Feryal Ibrahim, Amna Gameil, Mohamed Yassin, Halima El-Omri

“…The expression of T-cell associated markers by abnormal mast cells is well documented; however, CD4 and CD7 expression have not previously been described in association with mast cell leukaemia. …”
Get full text

Effect of rhGH treatment on lipidome and brown fat activity in prepuberal small for gestational age children: a pilot study by Lorena González, Carolina Gonzalez-Riano, Pablo Fernández-García, Rubén Cereijo, Aina Valls, Andrea Soria-Gondek, Nativitat Real, Belén Requena, Joan Bel-Comos, Patricia Corrales, David Jiménez-Pavón, Coral Barbas, Francesc Villarroya, David Sánchez-Infantes, Marta Murillo

“…While its effects on white adipose tissue are well-documented, this pilot study aimed to investigate its impact on the lipidome and the thermogenic and endocrine activities of brown adipose tissue (BAT) in SGA children following rhGH treatment. …”
Get full text

Acceptance and safety of the RSV-preventive treatment of newborns with nirsevimab in the maternity department: a prospective longitudinal cohort study in FranceResearch in context by Charlotte Ocana de Sentuary, Clara Testard, Marion Lagrée, Maxime Leroy, Lisa Gasnier, Alicia Enes-Dias, Constance Leruste, Diariatou Diallo, Michael Génin, Thameur Rakza, François Dubos

“…The occurrence of adverse events (AEs) 2 h after nirsevimab treatment and 7, 14 and 30 days after discharge was documented by the mother. The primary endpoint was the nirsevimab treatment acceptance rate. …”
Get full text

Tigers and Their Prey in Bukit Rimbang Bukit Baling: Abundance Baseline for Effective Wildlife Reserve Management by Febri Anggriawan Widodo, Stephanus Hanny, Eko Hery Satriyo Utomo, Zulfahmi Zulfahmi, Kusdianto Kusdianto, Eka Septayuda, Tugio Tugio, Effendy Panjaitan, Leonardo Subali, Agung Suprianto, Karmila Parakkasi, Nurchalis Fadhli, Wishnu Sukmantoro, Ika Budianti, Sunarto Sunarto

“…We captured 14 tiger individuals including three cubs. We documented the highest density of tigers (individuals/100 km2) in southern sampling block (based on traditional capture recapture (TCR) : 1.52 ± SE 0.55; based on Maximum Likelihood (ML) SCR:0.51 ± SE 0.22) and the lowest in northeastern sampling block (TCR: 0.77 ±SE 0.39; ML SCR: 0.19 ± SE 0.16). …”
Get full text

Perspectives of nurses and patient representatives on the morally competent nurse: An international focus group study by Chris Gastmans, Evelyne Mertens, Alvisa Palese, Brian Keogh, Francesca Apolloni, Johanna Wiisak, Catherine Mc Cabe, Maria Dimitriadou, Alessandro Galazzi, Michael Igoumenidis, Nikos Stefanopoulos, Paraskevi Charitou, Evridiki Papastavrou, Riitta Suhonen, Stefania Chiappinotto

“…Objective: To explore and document the characteristics of the morally competent nurse from the perspectives of nurses and patient representatives practicing in Europe. …”
Get full text

Exploring the role of curcumin in mitigating oxidative stress to alleviate lipid metabolism disorders by Maojun Cheng, Maojun Cheng, Fang Ding, Fang Ding, Liyang Li, Liyang Li, Changmao Dai, Changmao Dai, Xiaolan Sun, Xiaolan Sun, Jia Xu, Jia Xu, Feier Chen, Feier Chen, Mingxiu Li, Xueping Li

“…The activation of the oxidative stress pathway disrupts lipid metabolism and induces cellular stress, significantly contributing to metabolic disorders. A well-documented crosstalk and interconnection between these metabolic disorders exists. …”
Get full text

Intracranial CT findings in traumatic brain injury: A retrospective, cross-sectional study among Igbo population in Nigeria by Angel-Mary Anakwue, Felicitas Ugochinyere Idigo, Uloma Benedicta Nwogu, Sylvester Osita Ogbu, Anthony Nnamani, Kennedy Joseph, Camillus Chukwuemeka Ugwoke

“…The objective of this study was to document the pattern of CT findings in TBI cases reported from Igbo people, in Nigeria. …”
Get full text

Evaluation of oral cholera vaccine (Euvichol-Plus) effectiveness against Vibrio cholerae in Bangladesh: an interim analysis by Amanda Tiffany, Ashraful Islam Khan, Firdausi Qadri, John D Clemens, Faisal Ahmmed, Farhana Khanam, Tahmina Shirin, Fahima Chowdhury, Md. Taufiqul Islam, Md Nazmul Islam, Md Nazmul Hasan Rajib, Md Ismail Hossen, Md. Taufiqur Rahman Bhuiyan, Shahinur Haque, Prasanta Kumar Biswas, Amirul Islam Bhuiyan, Zahid Hasan Khan, Mohammad Ashraful Amin, Aninda Rahman, S M Shahriar Rizvi, Lucy Breakwell

“…Vaccination status was documented without knowledge of culture results. Conditional logistic regression models estimated the OR for the vaccination-cholera association, and the VE of the two-dose regimen was calculated as [(1−OR) × 100].Results The analysis included 226 cases and 552 matched controls. …”
Get full text

Identifying corridors for Asiatic black bear (Ursus thibetanus) in a part of Eastern Himalayas, India by Malyasri Bhattacharya, Debanjan Sarkar, Sneha Pandey, Indranil Mondal, Sambandam Sathyakumar, R. Suresh Kumar, Gautam Talukdar

“…Studies carried out in Khangchendzonga National Park have documented the presence of these bears, highlighting their crucial conservation importance in the region. …”
Get full text

Lidar estimates of birch pollen number, mass, and CCN-related concentrations by M. Filioglou, P. Tiitta, P. Tiitta, X. Shang, A. Leskinen, P. Ahola, S. Pätsi, A. Saarto, V. Vakkari, V. Vakkari, U. Isopahkala, M. Komppula

“…In turn, this demonstrates the potential of ground-based lidars such as a ceilometer network with the polarization capacity to document large-scale birch pollen outbursts in detail and thus to provide valuable information for climate, cloud, and air quality modeling efforts, elucidating the role of pollen within the atmospheric system.…”
Get full text

Characterisation of coastal reef fish assemblages across an estuarine-urbanisation gradient using underwater visual census and environmental DNA metabarcoding by Yu-De Pei, Joseph Heard, Wenqian Xu, Shara K.K. Leung, Charmaine C.M. Yung, Alex S.J. Wyatt

“…In many places, baseline data on fish communities are inadequate for understanding and managing the ecological impacts of this urbanisation. Here, we document spatiotemporal patterns in fish diversity (at genus level) across an estuarine gradient around Hong Kong, a highly urbanised coastal megacity bordering the estuary of the Pearl River, the second largest river in the People's Republic of China. …”
Get full text

How prepared is Nigeria digital payment for health workers? A landscape analysis by Folashayo Peter Adeniji, David Ayobami Adewole, Segun Bello, Elizabeth Ekirapa, Juliet Aweko, Vincent Michael Kiberu, Charles Opio, Peter Waiswa, Olufunmilayo Ibitola Fawole

“…Results Digital payment systems for health personnel described in the reviewed documents included the direct disbursement mechanisms, direct bank transfers and mobile money. …”
Get full text

Tracing Aquatic Macrophyte Development in Nansi Lake, Northern China's Largest Freshwater Lake: Plant Macrofossils From 1855 to Present by Qinghui Zhang, Yufei Wu, Liwei Yang, Zekun Li, Zonglei Li, Yuying Yang, Shiyue Chen, Enfeng Liu

“…Multiple factor analysis was employed to investigate the correlation between these shifts and changes in paleolimnological indicators (invertebrates, geochemistry, and grain size), as well as documented records related to hydrology, climate changes, and human activities. …”
Get full text

Non-pharmacological interventions for primary hypertension: a systematic review and network meta-analysis protocol by Tao Xu, Fan-rong Liang, Qifu Li, Taipin Guo, Ziwen Chen, Yun-Jie Shu, Xueli Zhou

“…Two investigators will independently extract information from eligible articles and document reasons for exclusions. The primary outcomes will encompass changes in systolic and diastolic BP. …”
Get full text