Digital therapeutics in Korea: current status, challenges, and future directions – a narrative review by Hee Jun Shin, Ik Tae Cho, Wan Suk Choi, Hong Rae Kim, Min Bong Kang, Won Jong Yang

“…This study utilized a literature review and market analysis approach to examine the latest research, industry reports, and regulatory documents related to DTx. The analysis focused on three primary areas: (1) the current regulatory landscape, (2) technological advancements and challenges, and (3) economic and commercial factors influencing DTx adoption in Korea. …”
Get full text

Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer by Tanya Tripathi, Apoorva Chaudhary, Divya Janjua, Udit Joshi, Nikita Aggarwal, Chetkar Chandra Keshavam, Alok Chandra Bharti

“…The anti-tumor potential of psoralidin has been well-documented. Its capacity to effectively target cancer stem cells (CSCs) in general adds to its therapeutic potential. …”
Get full text

Partial unilateral ovarian torsion in a red-eared slider turtle (Trachemys scripta elegans) by Alessandro Vetere, Martina Gavezzoli, Lucia Victoria Bel, Rosanna Di Lecce, Martina Fumeo, Mattia Bonazzi, Francesco Di Ianni

“…To our knowledge, no previous reports have documented the occurrence of this condition in chelonians. …”
Get full text

Understanding the Spectrum of Mild Clinical Outcomes and Novel Findings in Arterial Tortuosity Syndrome Among Qatari Patients: Implications of SLC2A10 Mutation by Muhammed Riyas K. Rahmath, Haytham Ibrahim, Muhammad Faiyaz-Ul-Haque, Zafar Nawaz, Ahmad Zitoun, Ahmed Hussein, Ahmed Sadek, Ayman El-Menyar, Reema Kamal, Hassan Al-Thani, Gulab Sher

“…Furthermore, rare features previously documented in a limited number of patients, including leg length discrepancy, epilepsy, and migraine headaches, were also observed in our cohort. …”
Get full text

The Central Role and Possible Mechanisms of Bacterial DNAs in Sepsis Development by Zhenxing Cheng, Simon T. Abrams, James Austin, Julien Toh, Susan Siyu Wang, Zhi Wang, Qian Yu, Weiping Yu, Cheng Hock Toh, Guozheng Wang

“…The pathological roles of bacterial DNA have been documented many decades ago. Bacterial DNAs are different from mammalian DNAs; the latter are heavily methylated. …”
Get full text

Digging for Literature on Tailoring Cultural Offers With and for Older People From Ethnic Minority Groups: A Scoping Review by Stephanie Tierney, Jordan Gorenberg, Marta Santillo, Debra Westlake, Geoffrey Wong, Kerryn Husk, Sofia Vougioukalou, Ruthanne Baxter, Shoba Dawson, Nia Roberts, Caroline Potter, Harriet Warburton, Beth McDougall, Johannah Latchem, Kamal R Mahtani

“…Results Screening of 906 references–59 of which were read as full documents–resulted in six sources being included in the review. …”
Get full text

Meningkatkan Minat Belajar Siswa Sekolah Dasar dalam Sains Melalui Integrasi Model SAVI-Mind Mapping by Mokhammad Rizqi Zidane, Putri Arwinda Putri, M. Muhlis, Nadia Putri Mulyani Posangi, Nurma Yuliana

“…Data was collected through questionnaires and documentation from fourth-grade students at MI Miftahul Huda. …”
Get full text

Prevalence and factors associated with burnout syndrome in resident physicians: A cross-sectional study in Italy by Luca DI GIAMPAOLO, Andrea ROSSETTI, Teresa GALANTI, Simone DE SIO, Luca COPPETA, Hector NIETO, Hiroo WADA, Niu QUIAO, Younes RAMI, Hicham KHABBACHE, Driss AIT ALI, Amelia RIZZO, Kavita BATRA, Murat YILDIRIM, Mahmood BAHRAMIZADEH, Francesco CHIRICO

“…Despite its significance, few studies have specifically documented burnout levels among resident physicians. …”
Get full text

Métricas igualitárias na ciência: caminhos para a construção de indicadores de diversidade, equidade, inclusão e acessibilidade by Maria Cristina Piumbato Innocentini Hayashi, Camila Carneiro Dias Rigolin

“…A metodologia adotada incluiu uma abordagem teórico-crítica, apoiada nas teorias da interseccionalidade e do campo científico de Bourdieu, e análise documental, que permitiu uma investigação detalhada de práticas inovadoras. …”
Get full text

Comparative Evaluation of Tear Film and Corneal Surface in Chronic Smokers and Non Smokers: A Cross-sectional Study by Ruchi Dabas, Meena Kumari, Manisha Rathi, Monika Dahiya, Rajni Yadav, Sumit Sachdeva

“…Tobacco smoke is a well-documented ocular irritant that exacerbates Dry Eye Disease (DED) and its associated symptoms. …”
Get full text

MeHg Developing Exposure Causes DNA Double-Strand Breaks and Elicits Cell Cycle Arrest in Spinal Cord Cells by Fabiana F. Ferreira, Dib Ammar, Gilian F. Bourckhardt, Karoline Kobus-Bianchini, Yara M. R. Müller, Evelise M. Nazari

“…The neurotoxicity caused by methylmercury (MeHg) is well documented; however, the developmental neurotoxicity in spinal cord is still not fully understood. …”
Get full text

Patient and Physician Satisfaction with Analgesic Treatment: Findings from the Analgesic Treatment for Cancer Pain in Southeast Asia (ACE) Study by Dang Huy Quoc Thinh, Wimonrat Sriraj, Marzida Mansor, Kian Hian Tan, Cosphiadi Irawan, Johan Kurnianda, Yen Phi Nguyen, Annielyn Ong-Cornel, Yacine Hadjiat, Hanlim Moon, Francis O. Javier

“…Pain intensity, pain control satisfaction, and adequacy of analgesics for pain control were documented using questionnaires. Results. Most patients (84.4%) had stage III or IV cancer. …”
Get full text

Examining the Formalin Fixation Method for Maintaining High RNA Quality in Surgical Lung Specimens by Takashi Teishikata, Manabu Itoh, Yusuke Okamoto, Naofumi Miyahara, Chiho Nakashima, Koichiro Takahashi, Masafumi Hiratsuka, Keita Kai, Keiji Kamohara

“…A certain percentage of test failures in RNA assays owing to poor surgical specimen quality have been documented, and fixation failure is a possible cause. …”
Get full text

Garantia da saúde mental e bem-estar de servidores públicos em Moçambique no âmbito dos Objetivos de Desenvolvimento Sustentável: avanços, limites e perspectivas by Gildo Aliante, Fabio Scorsolini-Comin, Mussa Abacar, Coutinho Maurício José, Alice Costa Macedo

“…Métodos Pesquisa qualitativa, desenvolvida por meio de análise documental e bibliográfica. Resultados A partir de 2016, houve a incorporação de elementos de trabalho decente na legislação laboral vigente, a saber: ingresso no Estado por via de nomeação provisória, condições adequadas de higiene e segurança no trabalho, equidade salarial e justiça laboral. …”
Get full text

Enhancement of BDNF Concentration and Restoration of the Hypothalamic-Pituitary-Adrenal Axis Accompany Reduced Depressive-Like Behaviour in Stressed Ovariectomised Rats Treated wit... by Badriya Al-Rahbi, Rahimah Zakaria, Zahiruddin Othman, Asma’ Hassan, Asma Hayati Ahmad

“…A possible interaction between glucocorticoids and estrogen-induced increases in brain-derived-neurotrophic factor (BDNF) expression in enhancing depressive-like behaviour has been documented. Here we evaluated the effects of Tualang honey, a phytoestrogen, and 17β-estradiol (E2) on the depressive-like behaviour, stress hormones, and BDNF concentration in stressed ovariectomised (OVX) rats. …”
Get full text

Motivation of nursing undergraduate program entrants: A scoping review protocol. by Leonila Santos de Almeida Sasso, Ana Caroline Dos Santos Costa, Ana Maria Rita Pedroso Vilela Torres de Carvalho Engel, Emília Batista Mourão Tiol, Fabrício Renato Teixeira Valença, Natalia Almeida de Arnaldo Silva Rodrigues Castro, João Daniel de Souza Menezes, Cíntia Canato Martins, Carlos Dario da Silva Costa, Maria Aurélia da Silveira Assoni, William Donegá Martinez, Patrícia da Silva Fucuta, Vânia Maria Sabadoto Brienze, Alba Regina de Abreu Lima, Júlio César André

“…Data extraction will involve two independent researchers reviewing each article. Documents such as original articles; theoretical studies; experience reports; clinical study articles; case studies; normative, integrative, and systematic reviews; meta-analyses; meta-syntheses; monographs; theses; and dissertations in English, Portuguese, and Spanish from 2017 to 2023 were included. …”
Get full text

Promoting Computational Access to Digital Collections in the Nordic and Baltic Countries: An Icelandic Use Case by Gustavo Candela, Olga Holownia, Max Odsbjerg, Mirjam Cuper, Nele Gabriëls, Katrine Hofmann, Edward J. Gray, Sally Chambers, Mahendra Mahey

“…We identified common features and best practices and we provide a detailed analysis that can be useful for organisations interested in publishing reproducible code combined with documentation such as Jupyter Notebooks. We also outline open issues that require further work.…”
Get full text

Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study by Gian Luca Erre, Matteo Piga, Anna Laura Fedele, Silvia Mura, Alessandra Piras, Maria Luisa Cadoni, Ignazio Cangemi, Martina Dessi, Gabriele Di Sante, Barbara Tolusso, Elisa Gremese, Alberto Cauli, Arduino Aleksander Mangoni, Pier Sergio Saba, Ciriaco Carru, Gianfranco Ferraccioli, Alessandro Mathieu, Giuseppe Passiu

“…Peripheral microvascular ED was documented in one-third of RA patients (33.5%); in multiple logistic regression analysis, ACPA negativity and higher triglycerides concentrations were independently associated with the presence of peripheral ED [OR (95% CI) = 1.708 (1.218–2.396), p<0.01 and OR (95% CI) = 1.005 (1.002–1.009), p<0.01, respectively]. …”
Get full text

Association between lipid accumulation products and mortality outcomes in patients with osteoporosis and osteopenia by Yazhou Liu, Ying Yang, Yuhao Li, Wenbo Ding, Xiaodong Yang

“…Results: This study included 4959 patients diagnosed with OP or osteopenia, followed over a comprehensive duration of 12 years, during which 800 instances of all-cause mortality and 194 deaths attributed to cardiovascular diseases were documented. A linear negative correlation was identified between LAP and both all-cause and cardiovascular mortality among patients with OP or osteopenia. …”
Get full text

Monacolin K as a Natural Alternative for Synthetic Statins by Julia Kozakiewicz, Aleksandra Okońska, Michał Ziemba, Kamil Kościelecki, Agnieszka Kalisz, Magdalena Krakowiak, Aleksandra Kaczmarek

“…It should be emphasized that the long-term safety of regular use of these preparations has not been fully documented. Some people taking these supplements experience side effects similar to those seen with statins. …”
Get full text