Synergic Renoprotective Effects of Combined ASC Therapy with RAAS Blockade in Experimental Advanced CKD by Marina P. C. Maires, Krislley R. Pereira, Everidiene K. V. B. Silva, Victor H. R. Souza, Flavio Teles, Paulyana F. Barbosa, Margoth R. Garnica, Felipe M. Ornellas, Irene L. Noronha, Camilla Fanelli

“…The treatments currently employed to control CKD progression are limited and mainly based on the pharmacological inhibition of RAAS, associated with diuretics and immunosuppressive drugs. However, this conservative management promotes only partial deceleration of CKD evolution and does not completely avoid the progression of the disease and the loss of renal function, which motivates the medical and scientific community to investigate new therapeutic approaches to detain renal inflammation/fibrosis and CKD progression. …”
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A rare case of acute myocardial infarction with heart failure following hump-nosed viper bite in a Sri Lankan female by W. M. D. A. S. Wanninayake, Tilan Aponso, Manohari Seneviratne, Dhanapala Dissanayake

“…Supportive therapy with loop diuretics and oxygen managed her condition, and a follow-up 2D echocardiogram revealed complete recovery of her cardiac function. …”
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Prevalence and Mortality Rates of Acute Kidney Injury among Critically Ill Patients: A Retrospective Study by Randa I. Farah, Othman A. Alfuqaha, Ali R. Younes, Hasan A. Mahmoud, Alhareth M. Al-Jboor, Mohammad M. Karajeh, Mohammad Z. Al-Masadeh, Omar I. Murad, Nathir Obeidat

“…Furthermore, we found that older age (adjusted OR (AOR): 1.04; 95% confidence interval (CI): 1.04–1.06; p=0.003), preadmission use of diuretics (AOR: 2.12; 95% CI: 1.06–4.25; p=0.03), use of ventilators (2.19; 95% CI: 1.12–2.29; p=0.02), and vasopressor use during MICU stay (AOR: 4.25; 95% CI: 2.1308.47; p=0.001) were observed to have higher mortality rates. …”
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Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions by Girvan Burnside, Munir Pirmohamed, Rostam Osanlou, Dyfrig A Hughes, Lauren Walker

“…Drugs most commonly implicated were diuretics, steroid inhalers, anticoagulants and antiplatelets, proton pump inhibitors, chemotherapeutic agents and antihypertensives. 40.4% of ADRs were classified avoidable or possibly avoidable. …”
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Unusual presentation of a patient with partial anomalous pulmonary venous connections without a septal defect: a case report and literature review by Pouya Ebrahimi, Mohammad Hossein Mandegar, Mehrdad Jafari Fesharaki, Negar Ghasemloo, Pedram Ramezani, Tooba Akbari, Fatemeh Naderi

“…Post-surgical cardiac overload caused pleural effusion and dyspnea, which were managed with diuretics. Four- and six-month follow-ups showed no abnormal findings on examination and imaging, and the patient reported no new complaints. …”
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Dissecting Causal Relationships Between Antihypertensive Drug, Gut Microbiota, and Type 2 Diabetes Mellitus and Its Complications: A Mendelian Randomization Study by He Zheng, Shiping Wu, Wenbin Wang, Weida Qiu, Yingqing Feng

“…Similarly, a 1‐SD decrease of SLC12A2 (genetically a proxy for diuretics, for example, Torasemide) gene expression was correlated with a reduced risk of T2DM (OR, 0.88; 95% CI, 0.83–0.92). …”
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Occult Renal Calcifications in Patients with Normocalcemic Primary Hyperparathyroidism and Their Association with the Parathyroid Hormone-Vitamin D Axis by Fernanda Victor, Alyne Layane Pereira Lemos, Anna Mirella de Holanda Ribas, Leonardo Bandeira, José Henrique Pimentel, Luiz Otávio de Andrade Damázio, Francisco Bandeira

“…The diagnosis of NPHPT was as follows: elevated serum PTH (reference range: 15–65 pg/mL), normal albumin-corrected serum calcium, normal urinary calcium excretion, serum 25(OH)D >30 ng/mL, eGFR (CKD-EPI) > 60 mL/min/1.73 m2, without intestinal disease, and not on medications such as thiazide diuretics, lithium, bisphosphonates, or denosumab. …”
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The Association between Antihypertensive Medication Use and Blood Pressure Is Influenced by Obesity by Jash S. Parikh, Arshdeep K. Randhawa, Sean Wharton, Heather Edgell, Jennifer L. Kuk

“…Furthermore, glucose levels and waist circumference in women were higher in those using ACE inhibitors compared to diuretics (P<0.05). Conclusion. ACE inhibitors and ARBs may be associated with more beneficial BP profiles in women with obesity, with no obesity-related BP differences for antihypertensive medication in men. …”
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Prevalence of pulmonary hypertension and associated factors among rheumatic heart disease patients in Ethiopia by Asmamaw Gedefaw, Yihealem Yabebal Ayele, Gebeyaw Wudie, Abiyot Tefera, Agerye Kassa Yirdaw, Tadele Demilew

“…Severe mitral valve stenosis (AOR 7.8, 95% CI 2.4–25.7), duration of illness ≥ 3 years (AOR 7.7, 95% CI 2.1–28.5), and diuretics use (AOR 5.6, 95% CI 2.2–14.3) were factors associated with PH. …”
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The Role of the Estimated Plasma Volume Variation in Assessing Decongestion in Patients with Acute Decompensated Heart Failure by Andreea-Maria Grigore, Mihai Grigore, Ana-Maria Balahura, Gabriela Uscoiu, Ioana Verde, Camelia Nicolae, Elisabeta Bădilă, Adriana-Mihaela Ilieșiu

“…Materials and Methods: This prospective, observational, single-center study included 111 patients (mean age 74 years, 40% female) hospitalized with ADHF and treated with intravenous diuretics along with optimized medical therapy. Patients were clinically and echocardiographically evaluated at admission, with blood tests performed at both admission and discharge. …”
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Prevalence and predictors of sub-optimal laboratory monitoring of selected higher risk medicines in Irish general practice: a 5-year retrospective cohort study of community-dwellin... by Fiona Boland, Emma Wallace, Frank Moriarty, Tom Fahey, Caroline McCarthy, Ann Sinéad Doherty, Mark Feighery

“…Objectives To describe the prevalence of sub-optimal monitoring for selected higher-risk medicines in older community-dwelling adults and to evaluate patient characteristics and outcomes associated with sub-optimal monitoring.Study design Retrospective observational study (2011–2015) using historical general practice-based cohort data and linked dispensing data from a national pharmacy claims database.Setting Irish primary care.Participants 625 community-dwelling adults aged ≥70 years and prescribed at least one higher-risk medicine during the 5-year study period.Primary and secondary outcome measures The primary outcome was the prevalence of sub-optimal laboratory monitoring using a composite measure of published medication monitoring indicators, with a focus on commonly prescribed higher-risk medicines such as diuretics and anticoagulants. Poisson regression was used to assess the patient characteristics associated with sub-optimal monitoring and explanatory variables included the number of medicines, age, sex, deprivation and anxiety/depression symptoms. …”
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Postdiagnostic use of antihypertensive medications and survival in colorectal, lung, corpus uteri, melanoma and kidney cancer patients with hypertension by Rūta Everatt, Irena Kuzmickienė, Birutė Brasiūnienė, Ieva Vincerževskienė, Birutė Intaitė, Saulius Cicėnas, Ingrida Lisauskienė

“…The results suggest a lower mortality among colorectal cancer patients with a higher usage of diuretics. Increased cancer-specific mortality was observed among corpus uteri cancer patients using ARBs and among melanoma patients using beta blockers (BBs); however, there was no evidence of consistent statistically significant associations in subgroup analyses. …”
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World-wide survey on the treatment of peripheral vestibular disorders by Michael Strupp, Michael Strupp, Nils Lucca Kern, Nils Lucca Kern, Göran Laurell, Louisa Lehner, Eva Grill, Eva Grill, Ralf Strobl, Ralf Strobl

“…MD: 85% pharmacotherapy, namely 65% betahistine, 21% diuretics, 20% steroids, 16% antiemetics, 14% gentamicin; 37% surgery. …”
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Risk prediction modeling for cardiorenal clinical outcomes in patients with non-diabetic CKD using US nationwide real-world data by Christoph Wanner, Johannes Schuchhardt, Chris Bauer, Meike Brinker, Frank Kleinjung, Tatsiana Vaitsiakhovich

“…History of heart failure (HR = 2.42, 95% CI = 2.37–2.48), use of loop diuretics (HR = 1.65, 95% CI = 1.62–1.69), severely increased albuminuria-A3 (HR = 1.55, 95% CI = 1.33–1.80), atrial fibrillation or flutter (HR = 1.53, 95% CI = 1.50–1.56), and stage 4 CKD (HR = 1.48, 95% CI = 1.44–1.52) were the greatest risk factors for hospitalization for heart failure. …”
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Outcomes of patients after successful left ventricular assist device explantation: a EUROMACS study by Christiaan F.J. Antonides, Felix Schoenrath, Theo M.M.H. deBy, Rahatullah Muslem, Kevin Veen, Yunus C. Yalcin, Ivan Netuka, Jan Gummert, Evgenij V. Potapov, Bart Meyns, Mustafa Özbaran, David Schibilsky, Kadir Caliskan, the EUROMACS investigators

“…Beta‐blockers were prescribed to 85%, angiotensin‐converting enzyme inhibitors to 71%, and loop diuretics to 50% of the patients, respectively. Freedom from the composite endpoint was 100% after 30 days and 88% after 2 years. …”
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Epidemiological aspects of nephrolithiasis and chronic diseases of the cardiovascular system combination by R. V. Royuk, S. K. Yarovoy, N. A. Guseva, Sh. L. Voskanyan, V. V. Royuk, D. B. Rodin

“…The presence chronic cardiovascular diseases (CVD), especially complicated by congestive heart failure in patients with first time revealed nephrolithiasis, implies changes in the algorithms of metaphylactic of nephrolithiasis (regime of water loads, selection of diuretics and anticoagulants).…”
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