Evaluation of prescribing practices and treatment failure for purulent skin and soft tissue infections in patients with obesity by Mackenzie L. Miller, Destiny M. Hughson, Noah D. Blower, Andrew P. Jameson, Lisa E. Dumkow

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The relationship of the carriership of allelic variations in rs2228145 (A > C) of the<i>IL6R</i> gene with the levels of <i>VCAM1</i> and <i>ICAM1</i> gene transcripts in patients... by L. V. Topchieva, V. A. Korneva, I. V. Kurbatova

“…The levels of plasma interleukin 6 and its soluble receptors were found to be elevated in subjects with cardiovascular diseases, which points to amplification of the IL-6-mediated trans-signaling pathway in cells and the development of chronic inflammation. …”
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Phytochemical Analysis, Antioxidant Potential and Antibacterial Activities of Different Anatomical Parts of Hypericum cordifolium Choisy by Sujana Sapkota, Alishma Maharjan, Sanjeeta Tiwari, Meena Rajbhandari

“…The findings of this study support the traditional use of this plant in Nepal for the treatment of diseases associated with bacterial infections. The present study revealed that the underutilized anatomical parts of H. cordifolium could be the source of various bioactive phytochemicals like other Hypericum species.…”
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The Underlying Molecular Basis and Mechanisms of Venous Thrombosis in Patients with Osteomyelitis: A Data-Driven Analysis by Peisheng Chen, Yinhuan Liu, Xiaofeng Lin, Bin Yu, Bin Chen, Fengfei Lin

“…Osteomyelitis (OM) is one of the most risky and challenging diseases. Emerging evidence indicates OM is a risk factor for increasing incidence of venous thromboembolism (VTE) development. …”
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Enteric-Coated Aspirin Induces Small Intestinal Injury via the Nrf2/Gpx4 Pathway: A Promising Model for Chronic Enteropathy by Zhang M, Xia S, Feng L, Han X, Zhang Y, Huang Y, Liu Y, Zhao K, Guan J, Tian D, Liao J, Yu Y

“…Mingyu Zhang, Suhong Xia, Lina Feng, Xu Han, Yu Zhang, Yujie Huang, Yiran Liu, Kai Zhao, Jialun Guan, Dean Tian, Jiazhi Liao, Yan Yu Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430030, People’s Republic of ChinaCorrespondence: Jiazhi Liao, Email liaojiazhi@tjh.tjmu.edu.cn; Yan Yu, Email whtj20200720@163.comBackground: Aspirin is widely used to prevent and treat cardiovascular diseases. The most common side effect is gastrointestinal damage. …”
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Unveiling the signal valve specifically tuning the TGF-β1 suppression of osteogenesis: mediation through a SMAD1-SMAD2 complex by Ying-Wen Wang, Ching-Wei Luo

“…Functional interruption of this valve can tilt the seesaw balance of BM-MSC differentiation towards osteogenesis, highlighting the interplaying co-repressors, such as HDAC1, as promising therapeutic targets to combat diverse degenerative orthopedic diseases.…”
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Exploring pre-exposure prophylaxis (PrEP) modality preferences among black cisgender women attending family planning clinics in Chicago via a cross-sectional mixed-methods study by Sadia Haider, Amy K Johnson, Emily Ott, Eleanor E Friedman, Agustina Pandiani, Amy Moore, Isa Alvarez, Catherine Desmarais

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Association between diabetes mellitus and total hip arthroplasty outcomes: an observational study using the US National Inpatient Sample by Jasvinder A Singh, Sumanth Chandrupatla, Kranti Rumalla

“…Objectives To investigate the association of diabetes with postoperative outcomes in patients undergoing primary total hip arthroplasty (THA).Design Retrospective cohort study using data from the US National Inpatient Sample (NIS).Setting Study cohort was hospitalisations for primary THA in the USA, identified from the 2016–2020 NIS.Participants We identified 2 467 215 adults in the 2016–2020 NIS who underwent primary THA using International Classification of Diseases, 10th Revision codes. Primary THA hospitlizations were analysed as the overall group and also stratified by the underlying primary diagnosis for THA.Outcome measures Outcome measures of interest were the length of hospital stay&gt;the median, total hospital charges&gt;the median, inpatient mortality, non-routine discharge, need for blood transfusion, prosthetic fracture, prosthetic dislocation and postprocedural infection, including periprosthetic joint infection, deep surgical site infection and postprocedural sepsis.Results Among 2 467 215 patients who underwent primary THA, the mean age was 68.7 years, 58.3% were female, 85.7% were white, 61.7% had Medicare payer and 20.4% had a Deyo-Charlson index (adjusted to exclude diabetes mellitus) of 2 or higher. 416 850 (17%) patients had diabetes. …”
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Comparative assessment of antibacterial effect of two types of laser and their effect on morphology and mineral content of dentin by Soha Adel Abdou, Haythem S Moharrum, Elsayed Abdallah Eltayeb

“…Background/aim Scientists have proven that the main cause of endodontic diseases and failures is the existence of micro-organisms in the root canals and inside the dentinal tubules. …”
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Atypical Mucin Expression Predicts Worse Overall Survival in Resectable Pancreatic Ductal Adenocarcinoma by Yunzhen Qian, Yitao Gong, Yu Liu, Yusheng Chen, Ruijie Wang, Zhengjie Dai, Xuan Zou, Yesiboli Tasiheng, Guopei Luo, Xuan Lin, Xu Wang, He Cheng, Xianjun Yu, Chen Liu

“…More and more evidences show that mucins are involved in the development of pancreatic diseases. However, the relationship between mucin expression and prognosis of PDAC patients has been controversial in the past decades; therefore, we aim to figure out the association of mucin expression with survival in PDAC patients who underwent radical resection. …”
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Evaluation of the effect of soil and irrigation water characteristics on the chemical composition and antimicrobial activity of Mentha spicata L. essential oil: A plant used in tra... by Vajiheh Gandomi Hosnaroodi, Mansureh Ghavam

“…Mentha spicata L. is one of the most important essential oil species of the lamiaceae family, which the people of Kashan use as a sedative, to treat flatulence, Intestinal and stomach diseases heartache are traditionally used. The present study was designed and carried out in order to evaluate and compare the composition, yield, and antimicrobial properties of the essential oil of this plant from 5 plain areas of Kashan (Lathor, Meshkat, Taher Abad, Issa Abad, and Fin) with different water and soil characteristics. …”
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Occurrence of Enteric Viruses in Surface Water and the Relationship with Changes in Season and Physical Water Quality Dynamics by Wasonga Michael Opere, Maingi John, Omwoyo Ombori

“…Enteric viruses can affect both human and animal’s health by causing diseases such as gastrointestinal and respiratory infections. …”
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Delivery, maternal and neonatal outcomes in nulliparous women with gestational diabetes undergoing epidural labour analgesia: a propensity score-matched analysis by Yu Chen, Xin Ye, Han Wu, Yanqing Chen, Huanghui Wu, Xueling Yuan, Xiaofang Yu, Xiaodan Wu

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Cost-effectiveness of targeted next-generation sequencing (tNGS) for detection of tuberculosis drug resistance in India, South Africa and Georgia: a modeling analysisResearch in co... by Suvesh Shrestha, Angelina Addae, Cecily Miller, Nazir Ismail, Alice Zwerling

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Skeletal Muscle-Derived Stem/Progenitor Cells: A Potential Strategy for the Treatment of Acute Kidney Injury by Egle Pavyde, Romaldas Maciulaitis, Mykolas Mauricas, Gintaras Sudzius, Ernesta Ivanauskaite Didziokiene, Arvydas Laurinavicius, Neringa Sutkeviciene, Edgaras Stankevicius, Justinas Maciulaitis, Arvydas Usas

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Shared Genes and Pathways in Ulcerative Colitis and Ankylosing Spondylitis: Functional Validation and Implications for Diagnosis by Li L, An G, Li F, Zhang D, Zhu X, Liang C, Zhao Y, Xie K, Zhou P, Zhu H, Jin X, Du L

“…Gene set enrichment analysis (GSEA) was used to obtain information on key gene pathways and interactions with UC or AS-related diseases, followed by immune infiltration analysis. …”
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Acid-Base Balance in Healthy Adults: Beneficial Effects of Bicarbonate and Sodium-Rich Mineral Water in a Randomized Controlled Trial: The BicarboWater Study by Katharina Mansouri, Theresa Greupner, Edda van de Flierdt, Inga Schneider, Andreas Hahn

“…Background. Noncommunicable diseases (NCDs) are a global health challenge. The complex etiology of NCDs involves genetic, environmental, and lifestyle factors, including dietary habits. …”
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Global cervical cancer elimination: quantifying the status, progress, and gaps by Liangru Zhou, Yi Li, Hongyun Wang, Ruixi Qin, Zhen Han, Ruifeng Li

“…Methods Data were obtained from the International Agency for Research on Cancer, WHO, United Nations International Children's Emergency Fund, and country responses to the WHO National Capacity Survey on Non-Communicable Diseases. This retrospective analysis examined data from 194 countries and regions, stratified by national income (high-income countries (HICs) vs low- and middle-income countries (LMICs)) and geographic location (continents such as Europe, Asia, and North America). …”
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Development and validation of a deep learning-enhanced prediction model for the likelihood of pulmonary embolism by Yu Tian, Yu Tian, Jingjie Liu, Shan Wu, Yucong Zheng, Rongye Han, Qianhui Bao, Lei Li, Lei Li, Tao Yang

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Medial Open-Wedge High Tibial Osteotomy with Partial Meniscectomy and Without Cyst Excision for Popliteal Cysts: A Case Series by Kang-Il Kim, Jun-Ho Kim

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