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Frameshift variation in the HMG-CoA reductase gene and unresponsiveness to cholesterol-lowering drugs in type 2 diabetes mellitus patients
Published 2025-01-01“…Abstract Dyslipidemia, an imbalance in blood lipid levels, is a frequent complication of type 2 diabetes mellitus (DM2) and heightens the risk of cardiovascular diseases (CVDs). Statins, which inhibit 3-hydroxy-3-methylglutaryl-CoA reductase, are potent competitive inhibitors that reduce plasma cholesterol levels. …”
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Ensemble machine learning models for lung cancer incidence risk prediction in the elderly: a retrospective longitudinal study
Published 2025-01-01“…Proposed method could also be used in predicting the risk of other chronic diseases to help conduct intervention and reduce incidence.…”
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Paediatric norms for photopic electroretinogram testing based on a large cohort of Chinese preschool children
Published 2024-05-01“…Objective Full-field electroretinogram (ffERG) is an objective test to determine the electroretinal activities in response to light stimulation for investigating retinal physiology and diagnosing retinal diseases. This study aimed to establish a reference data set of photopic electroretinogram (ERG) of Chinese preschool children in Hong Kong to facilitate clinical and research studies.Methods and analysis Preschool children aged 3–7 years with normal vision were recruited from local kindergartens. …”
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Pregnant Women's Knowledge and Attitudes About Pregnancy Care: The Effect of Using the Ebumil Android Application
Published 2025-01-01“…Lack of knowledge and attitude, makes pregnant women less aware of the emergence of symptoms of certain dangerous diseases, either indirectly causing maternal death. …”
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Molecular Epidemiology and Antimicrobial Resistance of Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae in Retail Cattle Meat
Published 2024-01-01“…Enterobacteriaceae that produce extended-spectrum β-lactamases (ESBLs) can result in severe human infections, contributing to the development of complex diseases. Klebsiella pneumoniae is one of the ESBL-producing pathogens that helps to set antimicrobial resistance as a major public health problem worldwide. …”
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Knockdown of Fibromodulin Inhibits Proliferation and Migration of RPE Cell via the VEGFR2-AKT Pathway
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Total Phenolic, Flavonoid Contents, and Antioxidant Activities of Fruit, Seed, and Bark Extracts of Zanthoxylum armatum DC
Published 2020-01-01“…These plants contain polyphenols and flavonoids that act as free radical scavengers and reduce oxidative stress and may be an alternative remedy to cure various harmful human diseases. This study aims to quantify the total phenolic and flavonoid contents (TPC and TFC) and antioxidant properties of methanol extracts of fruits, seeds, and bark of an important medicinal and aromatic plant, Zanthoxylum armatum collected from wild and cultivated populations in Nepal. …”
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Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism
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Targeting AI-2 quorum sensing: harnessing natural products against Streptococcus suis biofilm infection
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The Predictive Value of Lactate Dehydrogenase for Viral Suppression in Newly Diagnosed People Living With HIV on Antiretroviral Therapy: A Retrospective Cohort Study
Published 2025-01-01“…Serum lactate dehydrogenase (LDH) levels serve as a readily accessible and rapid clinical biomarker, has significant predictive potential in various viral diseases. This study aims to evaluate the predictive value of LDH levels for viral suppression in the context of rapid ART initiation.Patients and Methods: LDH levels were measured in 393 newly diagnosed PLWH who received rapid initiation of ART and were subsequently followed up. …”
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Effect of rifampicin on the lipid profile of albino rats
Published 2013-07-01“…Histological examination of the heart revealed normal architectural structure of the heart after rifampicin administration for 20 and 60days, though pattern of plasma lipid alteration suggests dyslipidemia; therefore plasma lipid profile should be monitored routinely because of the positive relationship between increased dyslipidemia with cardiovascular diseases.…”
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A sustainable breakthrough in rodent pest control: laboratory validation of novel neem-andrographolide bait with dual toxic and contraceptive effects
Published 2025-02-01“…Abstract Background Rattus rattus causes damage to physical infrastructure and spreads diseases under commensal conditions. They have a very high reproductive potential and quickly rebuild their population after management through chemical and mechanical methods. …”
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ANTHROPOLOGICAL SPHERE OF HUMAN EXISTENCE: RESTRICTIONS ON HUMAN RIGHTS DURING PANDEMIC THREATS
Published 2020-12-01“…However, there are still no specific legal recommendations (both at the international and national levels) concerning measures on human rights protection during outbreaks of various infectious diseases. However, the influence of unexpected global challenges (especially COVID-19 and not just that) causes a change in the anthropological component of society and the state, so it requires immediate comprehensive research. …”
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