Multi-stage structure-based virtual screening approach combining 3D pharmacophore, docking and molecular dynamic simulation towards the identification of potential selective PARP-1... by Mahmoud A. El Hassab, Wagdy M. Eldehna, Ghaneya S. Hassan, Sahar M. Abou-Seri

“…Abstract Presently, humanity is confronted with a range of diseases that have high death rates, especially those linked to cancerous growths. …”
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Association between Novel Marker (Platelet-Lymphocyte Ratio, Neutrophil-Lymphocyte Ratio, and Delta Neutrophil Index) and Outcomes in Sudden Cardiac Arrest Patients by Sang Il Han, Kyoung-Chul Cha, Young Il Roh, Sung Oh Hwang, Woo Jin Jung, Tae Youn Kim

“…Platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and delta neutrophil index (DNI) are relatively novel biomarkers that have been used in the prognosis of various diseases. We aimed to determine the usefulness of PLR, NLR, and DNI in predicting the outcomes of SCA. …”
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Distribution and characteristics of human papilloma virus infection genotyping in women in Changchun area by Pingping Zhou, Zhenwu Du, Xuyuan Qin, Jiaxin Chen, Guizhen Zhang

“…[Objective] To analyze the infection and genotyping characteristics of human papilloma virus(HPV) in women in Changchun area, and provide a theoretical basis for the prevention and treatment of HPV infection induced diseases in this area. [Methods] A total of 6 750 women who went to Changchun Cancer Hospital from October 2020 to March 2024 for the first HPV type test were selected as the study subjects, the HPV infection and the characteristics of different genotyping infections were analyzed. …”
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Obstacles and opportunities for care collaboration through the utilisation of a preventive care process for frail older adults: a study protocol for a mixed methods study design by Åsa Larsson Ranada, Elisabet Rothenberg, Helle Wijk, Martina Karin Boström, Pia Skott, Anette Erichsen

“…Preventive measures such as addressing pressure ulcers, falls, malnutrition and poor oral health often receive low priority compared with treating diseases or injuries. This study aims to enhance our understanding of how care collaboration in the preventive care process (PcP) using the Senior alert (SA) register could improve patient safety and equality of care for frail older adults in Sweden.Methods This study, conducted over 4 years, employs an explanatory mixed methods design, divided into three phases. …”
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Evidence mapping and overview of systematic reviews of the effects of acupuncture therapies by Yuqing Zhang, Gordon Guyatt, Lin Wang, Hao Wen, Liming Lu, Gabriel Rada, Lai Wang, Shuqi Ge, Yu Dong, Camila Ávila, Xiaorong Tang, Neng-Gui Xu, Zhao Zeng, Camilo Vergara, Rouhao Chen, Xiaojing Wei, Wen Luo, Jing chun Zeng, Chun-Zhi Tang

“…We used random-effect model to calculate the overall effect.Results Our search identified 120 SRs published in the last 5 years addressing acupuncture therapies across 12 therapeutic areas and 77 diseases and conditions. The SRs included 205 outcomes and involved 138 995 participants from 1402 RCTs. …”
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IL-1β Pretreatment Improves the Efficacy of Mesenchymal Stem Cells on Acute Liver Failure by Enhancing CXCR4 Expression by He Nie, Fangmei An, Jie Mei, Cheng Yang, Qiang Zhan, Qinglin Zhang

“…Mesenchymal stem cells (MSCs), with the powerful metabolic and functional supporting abilities for inflammatory diseases, may be an effective therapeutic strategy for acute liver failure (ALF). …”
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Analysis of Fine Needle Non Aspiration Cytology for the Diagnosis of Cervical Lymph Node Tuberculosis: A Cross-sectional Study by S Rajesh Kumar Jain, Samta, RK Divya, V Abhirami

“…Materials and Methods: This institutional-based, cross-sectional study was conducted at the Department of Respiratory Medicine, Princess Krishnajammanni TB and Chest Diseases Hospital (PKTB and CDH), Mysore Medical College and Research Institute (MMC and RI) in Mysuru, from January 2019 to September 2022 on presumptive cervical LNTB patients who underwent FNNAC followed by an excision biopsy of the same Lymph Node (LN). …”
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European Working Time Directive and doctors’ health: a systematic review of the available epidemiological evidence by Consol Serra, Evangelia Demou, Ewan B Macdonald, Sergio Vargas-Prada, Maria Cruz Rodriguez-Jareño, Kaveh A Sanati, Alenka Škerjanc, Pedro G Reis, Ritva Helimäki-Aro

“…Study selection, quality appraisal and data extraction were carried out by independent pairs of researchers using pre-established criteria.Setting Physicians of any medical, surgical or community specialty, working in any possible setting (hospitals, primary healthcare, etc), as well as trainees, residents, junior house officers or postgraduate interns, were included.Participants The total number of participants was 14 338.Primary and secondary outcome measures Health effects classified under the International Classification of Diseases (ICD-10).Results Over 3000 citations and 110 full articles were reviewed. …”
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卒中防治科学传播发展现状与对策建议的研究进展 Research Progress on the Development Status and Countermeasures of Scientific Communication in Stroke Prevention and Treatment... by 张熙1，李杨1，张鹏骞2，3 (ZHANG Xi1, LI Yang1, ZHANG Pengqian2,3 )

“…Abstract: Stroke has become the first cause of death in our country, and it is one of the major diseases threatening our national health. It is necessary and urgent to carry out scientific communication in stroke prevention and treatment. …”
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PYRUS ZANGEZURA (ROSACEAE) AT SAINT PETERSBURG by K. G. Tkachenko, G. A. Firsov, L. F. Yandovka, A. V. Volchanskaya, N. E. Staroverov, Yu. A. Gryaznov

“…It is as winter-hardy as the common pear-tree, demonstrates resistance to diseases and pests, and may be of importance for breeding programs aimed at the development of resistant cultivars for the Northwest of Russia.…”
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High prevalence of overweight/obesity and central obesity among women in a rural district of Nepal in 2012–2013: a population-based study by Chandra Yogal, Chandra Yogal, Astrid Kamilla Stunes, Astrid Kamilla Stunes, Sunila Shakya, Biraj Karmarcharya, Rajendra Koju, Mats P. Mosti, Mats P. Mosti, Miriam K. Gustafsson, Miriam K. Gustafsson, Bjørn Olav Åsvold, Bjørn Olav Åsvold, Berit Schei, Unni Syversen, Unni Syversen

“…We aimed to estimate the prevalence of overweight/obesity and central obesity, and associated risk factors among women in a rural setting of Nepal.MethodsA cross-sectional study addressing reproductive health and non-communicable diseases (NCDs) was conducted 2012–2013 in a rural district of Nepal. …”
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Monoclonal Gammopathy of Undetermined Significance with Amyloid Deposition in the Lung and Non-Amyloid Eosinophilic Deposition in the Brain: A Case Report by Francois Abi-Fadel, Nisarg R. Desai, Gita Vatandoust, Rabih Said, Aaron Gottesman, Terenig Terjanian

“…As MGUS might be complicated by diseases such as amyloidosis and multiple myeloma, a scheduled follow-up of these patients is always necessary. …”
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Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis by Lu Sun, Jiayu Huang, Xuezi Wang, Peng Huang, Baolin Dong, Zehang Liang, Jiahong Wu, Jiancheng Wang

“…Conclusions In summary, this study pioneered the application of stromal cell enucleation technology to repair tissue damage in the reproductive system, explored the potential of cell burial in the treatment of reproductive system diseases and provided a new approach for the clinical treatment of male infertility.…”
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Modeling the co-infection of HTLV-2 and HIV-1 in vivo by A. M. Elaiw, E. A. Almohaimeed, A. D. Hobiny

“…However, co-infected patients with HTLV-2 and HIV-1 may experience a greater occurrence of HTLV-2-related T-cell malignant diseases.…”
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A novel method for detecting intracranial pressure changes by monitoring cerebral perfusion via electrical impedance tomography by Ming-xu Zhu, Jun-yao Li, Zhan-xiu Cai, Yu Wang, Wei-ce Wang, Yi-tong Guo, Guo-bin Gao, Qing-dong Guo, Xue-tao Shi, Wei-chen Li

“…Abstract Background Acute and critical neurological diseases are often accompanied with elevated intracranial pressure (ICP), leading to insufficient cerebral perfusion, which may cause severe secondary lesion. …”
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Diagnostic delay of myositis: protocol for an integrated systematic review by Christine Phillips, Matthew Cook, Anne Parkinson, Jane Desborough, Tergel Namsrai, Anita Chalmers, Christine Lowe

“…Introduction Idiopathic inflammatory myopathies (IIM). described as ‘inflammatory myositis’, are a heterogeneous group of rare muscular autoimmune diseases characterised by skeletal muscle inflammation. …”
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Quantitative proteomic studies of the intestinal mucosa provide new insights into the molecular mechanism of ulcerative colitis by Yandong Guo, Dahal Pabitra, Lei Pan, Lanbo Gong, Aimin Li, Side Liu, Jing Xiong

“…Abstract Background Differentiation between ulcerative colitis (UC) and other intestinal inflammatory diseases is difficult, and the precise etiology of UC is poorly understood. …”
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Evaluation of Intervertebral Disc Space Width Between 10th and 11th Thoracic Vertebrae in Cats Using Radiography and Magnetic Resonance Imaging by Jiwon Kim, Danbee Kwon, Bumseok Kim, Kichang Lee, Hakyoung Yoon

“…Methods In Groups 1 (101 clinically normal cats) and 2 (32 cats without spinal diseases from T8 to T13), dorsal width (DW), central width (CW) and ventral width (VW) of the T8–T13 disc spaces were measured by radiography or MRI. …”
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Medical thoracoscopy combined with intrapleural injection of urokinase for treatment of pleural infection-a multicenter, prospective, randomized controlled study: study protocol by Kaige Wang, Linhui Yang, Panwen Tian, Fen Tan, Dan Liu, Weimin Li

“…Abstract Background Pleural diseases is a common respiratory disorder, mainly characterized as pleural effusion and patients with pleural effusion caused by pneumonia and empyema constituted 29% of the cohort, which suggests pleural infection as the predominant etiology of pleural effusion in China. …”
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A new phase of China-ASEAN health cooperation: the China-ASEAN Beijing Declaration on Cooperation in Innovation of Health Products and Technologies by Jie Qiao, Siyan Zhan, Minghui Ren, Haijun Wang, Yangmu Huang, Zhenyu Zhang, Yanan Luo, Hui Yin, Zhongwei Jia, Wei Huang, Hong Zhou, Jue Liu, Xiaoyun Liu, Qiudan Sun, Xiaojia Li, Jing Bai, Fangjing Liu, Yihong Liu, Yinzi Jin, Ming Xu, on behalf of China-ASEAN Science and Technology Cooperation Center for Public Health

“…The Center held the Second Annual Forum on China-ASEAN Cooperation in Public Health on June 26–28, 2024, and the participants reached consensus on launching the China-ASEAN Beijing Declaration on Cooperation in Innovation of Health Products and Technologies, which calls on China and ASEAN countries to carry out the following actions: (1) Establish a more effective, open, and inclusive cooperation mechanism for health product innovation towards a China-ASEAN innovation ecosystem; (2) Enhance R&D capabilities by targeting new technologies, methods and appropriate and affordable health products for key populations and addressing diseases prevalent in China and ASEAN; (3) Establish a China-ASEAN Collaboration Center for Health Product Innovation, coordinate regional development plans, and enhance equitable access to pharmaceutical products at the regional level; (4) Accelerate regulatory harmonization in the region by optimizing and improving regulatory modalities of China and ASEAN Countries; and (5) Strengthen cross-sectoral cooperation to build resilient health system and achieve sustainable development of innovation cooperation. …”
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