Instruments reliability to measure the skill development to prevent leprosy in postgraduate studies by Tania Alemán Martínez, Onesio Esteban de León Gutiérrez, Daniela María Hernández Alemán

“…<p><strong>Foundation:</strong> the specific skills of the profession are oriented to the professional mode of action through the application of the clinical and epidemiological method that allows diagnosing, treating, rehabilitating, promoting health and preventing diseases. <br /><strong>Objective:</strong> to evaluate the reliability of two instruments that measures the skill development level to prevent leprosy.…”
Get full text

15-Deoxy-Δ12,14-Prostaglandin J2 Inhibits Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury via Redox Pathway by Xin Liu, Shuangshuang Jia, Weiyang Li, Le Yang, Lin Yang, Lin Wang, Liying Li

“…It has been reported that bone marrow-derived mesenchymal stem cells (BMSCs) have capacity to migrate to the damaged liver and contribute to fibrogenesis in chronic liver diseases. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), an endogenous ligand for peroxisome proliferator-activated receptor gamma (PPARγ), is considered a new inhibitor of cell migration. …”
Get full text

Mental Health Insurance in India: An Examination of Policy Implementation Post-MHCA 2017 by Vijaya Chandra Reddy Avula, Sangha Mitra Godi, Shashidhara Munivenkatappa, Sridhar Amalakanti

“…Our classification process involved determining if a policy explicitly covered mental illness, which we discerned by examining definitions of mental illness, indemnification clauses or the presence of International Classification of Diseases-10 codes within the policy. Conclusion: We evaluated 235 policies provided by 30 insurance companies and found that 37.5% (88) of policies covered mental illnesses, 11.5% (28) covered persons with disabilities, whereas 51% (119) did not offer any coverage. …”
Get full text

Alpha 1-antitrypsin mitigates salt-sensitive hypertension in juvenile mice by reducing diacylglycerol concentrations and protein kinase C activity in kidney membranes by Yunus E. Dogan, Yunus E. Dogan, Yunus E. Dogan, Niharika Bala, Niharika Bala, Erika S. Galban, Erika S. Galban, Russell L. Lewis, Nancy D. Denslow, Sihong Song, Abdel A. Alli, Abdel A. Alli

“…IntroductionRecombinant alpha-1 antitrypsin (AAT) therapy has been shown to have beneficial effects to mitigate the progression of various diseases. Here, we hypothesized that administration of pharmaceutical-grade human AAT (hAAT) is effective in mitigating hypertension induced by salt-loading in juvenile mice by reducing the concentration of diacylglycerols (DAGs) and activity of protein kinase C (PKC) in the kidney.MethodsFour-week old 129Sv mice were salt-loaded to induce hypertension and then administered hAAT or vehicle.ResultsAdministration of hAAT was found to significantly reduce high blood pressure in both the active and inactive cycles of the 129Sv hypertensive mice. …”
Get full text

Резолюция Экспертного совета «Диагностика и лечение больных со сладжем в желчном пузыре» by V. T. Ivashkin, Alexey V. Okhlobystin, Dmitry S. Bordin, M. F. Osipenko, E. Ya. Seleznyova, Yu. O. Shulpekova, S. R. Abdulkhakov, O. P. Alexseyeva, I. G. Bakulin, L. G. Vologjhanina, V. B. Grinevich, N. V. Bakulina, T. A. Kolesova, N. V. Korochanskaya, I. V. Putintseva, A. S. Sarsenbayeva, N. S. Yazenok

“…At detection of gallbladder sludge in a patient with right hypochondrial pain it is necessary to carry out general examination to rule out the other diseases that may be dangerous (neoplastic, acute cholecystitis, pancreatitis). …”
Get full text

Polymorphism of the <i>Rca2</i> anthracnose resistance gene in strawberry cultivars (<i>Fragaria × ananassa</i>) by A. S. Lyzhin, I. V. Lukyanchuk, E. V. Zhbanova

“…Anthracnose, caused by phytopathogenic fungi of the genus Colletotrichum, is one of the most important strawberry diseases. Strawberry yield losses from anthracnose lesions can reach 80%. …”
Get full text

Standardization of Tragopogon graminifolius DC. Extract Based on Phenolic Compounds and Antioxidant Activity by Mohammad Hosein Farzaei, Mahnaz Khanavi, Ghazaleh Moghaddam, Farzaneh Dolatshahi, Roja Rahimi, Mohammad Reza Shams-Ardekani, Gholamreza Amin, Mannan Hajimahmoodi

“…(TG), Compositae family, is traditionally used for the treatment of various diseases like gastrointestinal and hepatic disorders. …”
Get full text

TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA by Elizabeth S. Fernandes, Carolina X. L. Brito, Simone A. Teixeira, Renato Barboza, Aramys S. dos Reis, Ana Paula S. Azevedo-Santos, Marcelo Muscará, Soraia K. P. Costa, Claudio R. F. Marinho, Susan D. Brain, Marcos A. G. Grisotto

“…Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investigated the effects of capsazepine, a TRPV1 antagonist, in malaria. …”
Get full text

A mechanistic overview on green assisted formulation of nanocomposites and their multifunctional role in biomedical applications by Mahnoor, Khafsa Malik, Abeer Kazmi, Tahira Sultana, Naveed Iqbal Raja, Yamin Bibi, Mazhar Abbas, Irfan Anjum Badruddin, M. Mahmood Ali, Muhammad Nasir Bashir

“…New studies have been conducted to determine the biomedical efficacy of nanocomposites against various diseases. Unfortunately, there has been inadequate investigation into green-assisted nanocomposites. …”
Get full text

Associations of Triglyceride-Glucose Index and Its Derivatives with Hyperuricemia Risk: A Cohort Study in Chinese General Population by Qing Gu, Xue Hu, Jian Meng, Jun Ge, Sui Jun Wang, Xing Zhen Liu

“…Identification and intervention of insulin resistance may be beneficial to the prevention of hyperuricemia (HUA) and its related diseases. Thus, we conducted this longitudinal study to examine the relation of triglyceride-glucose index (TyG), a simple noninsulin-based IR assessment tool, and its derivatives with the risk of HUA. …”
Get full text

Current state of dermatovenereological medical organizations’ equipment for dermascopy by Alexey A. Kubanov, Margarita R. Rakhmatulina, Arfenya E. Karamova, Elena Yu. Novoselova, Olga G. Artamonova

“…The use of the dermascopy for diagnosing skin diseases is determined by the clinical guidelines. …”
Get full text

Enhancing the efficacy of low doses of N-acetyl-L-cysteine in mitigating CCl4-induced hepatotoxicity in animal model using physical cold plasma by Masume Farhadi, Farshad Sohbatzadeh, Akbar Hajizadeh Moghaddam, Yasaman Firouzjaei, Cheng Cheng

“…Liver diseases have become widespread especially due to various factors of modern life. …”
Get full text

Allogeneic Adipose-Derived Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Self-Reactive T Cell Responses and Dendritic Cell Function by Per Anderson, Elena Gonzalez-Rey, Francisco O’Valle, Francisco Martin, F. Javier Oliver, Mario Delgado

“…Multipotent mesenchymal stromal cells (MSCs) have emerged as a promising therapy for autoimmune diseases, including multiple sclerosis (MS). Administration of MSCs to MS patients has proven safe with signs of immunomodulation but their therapeutic efficacy remains low. …”
Get full text

Metabolic and inflammatory status in prepuberty and early adulthood for individuals with a history of extrauterine growth restriction: a cohort study by Laura Palomino-Fernández, Inmaculada Velasco, Belén Pastor-Villaescusa, Katherine Flores-Rojas, María de la Cruz Rico, Juan Roa, Ángel Gil, Mercedes Gil-Campos

“…Conclusion Individuals with a history of EUGR have increased metabolic risk in adulthood, which emphasizes the importance of clinical follow-up from childhood to prevent the development of further future associated diseases.…”
Get full text

Omega-3 Polyunsaturated Fatty Acids Enhance Neuronal Differentiation in Cultured Rat Neural Stem Cells by Masanori Katakura, Michio Hashimoto, Toshiyuki Okui, Hossain Md Shahdat, Kentaro Matsuzaki, Osamu Shido

“…Polyunsaturated fatty acids (PUFAs) can induce neurogenesis and recovery from brain diseases. However, the exact mechanisms of the beneficial effects of PUFAs have not been conclusively described. …”
Get full text

EPIMR: Prediction of Enhancer-Promoter Interactions by Multi-Scale ResNet on Image Representation by Qiaozhen Meng, Yinuo Lyu, Xiaoqing Peng, Junhai Xu, Jijun Tang, Fei Guo

“…Prediction of enhancer-promoter interactions (EPIs) is key to regulating gene expression and diagnosing genetic diseases. Due to limited resolution, biological experiments perform not as well as expected while precisely identifying specific interactions, giving rise to computational biology approaches. …”
Get full text

Anti-Inflammatory Effects of Artemisia Leaf Extract in Mice with Contact Dermatitis In Vitro and In Vivo by Chanyong Yun, Youngchul Jung, Wonjoo Chun, Beodeul Yang, Junghyun Ryu, Chiyeon Lim, Jung-Hoon Kim, Hyungwoo Kim, Su-In Cho

“…These results indicate that Artemisia leaf can be used as a therapeutic agent for inflammatory skin diseases and that its anti-inflammatory effects are closely related to the inhibition of inflammatory mediator release from macrophages and inflammatory cytokine production in inflamed tissues.…”
Get full text

Socio-economic and ecological factors linked to the adoption of foreign livestock breeds by Zimbabwean smallholders farmers in the Great Limpopo Transfrontier Conservation Area by Chiedza R. Mudavanhu, Prisca H. Mugabe, Venancio H. Imbayarwo-Chikosi, Billy Mukamuri, Alexandre Caron

“…Most farmers keep indigenous breeds because they are well adapted to local climatic conditions and resistant to livestock diseases. Conclusions: To improve the effectiveness of programmes targeting livestock production, governmental services and development, stakeholders should adopt more participatory processes and adaptive management strategies, which better reflect smallholders’ demands. …”
Get full text

The Effect of Culture Techniques of Hypoxic Stem Cell Secretome on The Number of Growth Factor TGF-β, BMP-2, VEGF by Mouli Edward, Ferdiansyah Mahyudin, Dionysius Bramta Putra Manyakori

“…Background: Mesenchymal stem/stromal cell (MSC) therapy is now an effective therapeutic modality for treating various diseases. In its application, stem cells require signaling molecules, including growth factors, cytokines, and chemokines. …”
Get full text

Simultaneous Determination of Five Components of Chaihu-Shugan-San in Beagle Plasma by HPLC-MS/MS and Its Application to a Pharmacokinetic Study after a Single Dose of Chaihu-Shuga... by Yong-liang Zhu, Hui-jun Wang, Hao Xue, Yi Zhang, Qian-shi Cheng, Ling-yun Chen, Xiang-jun Qiu

“…Chaihu-shugan-san (CHSGS) has been widely used in China to treat depression and gastrointestinal diseases for thousands of years, but little is known about its pharmacokinetic properties. …”
Get full text