Integrating lifestyle behaviors in school education: A proactive approach to preventive medicine by Mohamad Motevalli, Fatima Cody Stanford, Günther Apflauer, Katharina Christina Wirnitzer

“…Despite recent advances in health science, the increasing prevalence of both non-communicable diseases and unhealthy lifestyle behaviors needs to be effectively controlled. …”
Get full text

Limbitis Secondary to Autologous Serum Eye Drops in a Patient with Atopic Keratoconjunctivitis by Jeffrey David Welder, Pejman Bakhtiari, Ali R. Djalilian

“…The potential side effects should be kept in mind when prescribing ASEDs for any patient, especially in those with underlying immunological diseases and circulating inflammatory factors.…”
Get full text

Computer-Aided Design of an Epitope-Based Vaccine against Epstein-Barr Virus by Julio Alonso-Padilla, Esther M. Lafuente, Pedro A. Reche

“…EBV infection is also linked to various cancers, including Burkitt’s lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis. Currently, there are no effective drugs or vaccines to treat or prevent EBV infection. …”
Get full text

PLncWX: A Machine-Learning Algorithm for Plant lncRNA Identification Based on WOA-XGBoost by Fei Guo, Zhixiang Yin, Kai Zhou, Jiasi Li

“…Studies have shown that lncRNAs can regulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels, which are not only closely related to the occurrence, development, and prevention of human diseases, but also can regulate plant flowering and participate in plant abiotic stress responses such as drought and salt. …”
Get full text

Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1 by XingChun Wang, Huan Liu, Jiaqi Chen, Yan Li, Shen Qu

“…The impaired secretion of glucagon-like peptide-1 has negative influence on diabetes, hyperlipidemia, and insulin resistance related diseases. Thus, glucagon-like peptide-1-based therapies (glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors) are now well accepted in the management of type 2 diabetes. …”
Get full text

Epidemiological Survey of Toxoplasma gondii and Associated Risk Factors in Ruminant Species of the Khyber Pakhtunkhwa Province of Pakistan by Abid Ali, Talha Omer, Asad Ullah, Abdul Haleem, Maryam Naseem, Mujeeb Ullah, Seemab, Fahad Shamim, Amna Tehreem, Muhammad Bilal, Muhammad Numan Khan

“…Toxoplasma infection is one of the most common human parasitic diseases. During 2018-2020, in the rural areas of three districts of Pakistan, we surveyed a total of 451 animals, belonging to different asymptomatic ruminant species, to determine the prevalence of Toxoplasma gondii antibodies. …”
Get full text

Quantification of Free Circulating DNA and Differential Methylation Profiling of Selected Genes as Novel Non-Invasive Biomarkers for Endometriosis Diagnosis by Moncef Benkhalifa, Pierre Alain Menoud, David Piquemal, Jack Y. Hazout, Sami Mahjoub, Mohammed Zarquaoui, Noureddine Louanjli, Rosalie Cabry, Andre Hazout

“…Cell-free DNA (Cf-DNA) in the peripheral blood of diseased and healthy individuals was discovered in the 1950s. …”
Get full text

Therapeutic proteins immunogenicity: a peptide point of view by Feliciana Real-Fernandez, Fosca Errante, Andrea Di Santo, Anna Maria Papini, Paolo Rovero

“…Protein therapeutics are extensively used in the treatment of autoimmune diseases, but a subset of patients appears to be refractory to these treatments, mainly due to the development of an immune response to the drug. …”
Get full text

Epigenetic regulation of bone remodeling and its role in the pathogenesis of primary osteoporosis by B. I. Yalaev, R. I. Khusainova

“…Discovery of molecular mechanisms of primary osteoporosis development is fundamental to understand the pathogenesis of musculoskeletal diseases in general and for identifying key links in the genetic and epigenetic regulation of bone remodelling genes. …”
Get full text

Risk Factors and Prevalence of Helicobacter pylori Infection in Persistent High Incidence Area of Gastric Carcinoma in Yangzhong City by Yangchun Zhu, Xiaoying Zhou, Junbei Wu, Jing Su, Guoxin Zhang

“…Compared to healthy individuals, people with dyspeptic diseases (peptic ulcer, gastroenteritis) presented a high prevalence of H. pylori infection. …”
Get full text

Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer by Hamiyet Donmez-Altuntas, Fahri Bayram, Nazmiye Bitgen, Sibel Ata, Zuhal Hamurcu, Gulden Baskol

“…Although thyroid cancer accounts for a small percentage of thyroid nodules, the majority are benign. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) levels are a marker of oxidative stress and play a key role in the initiation and development of a range of diseases and cancer types. This study evaluates cytokinesis-block micronucleus cytome (CBMN-cyt) assay parameters and plasma 8-OHdG levels and their association with thyroid nodule size and thyroid hormones in patients with multinodular goiter. …”
Get full text

The study of the regulatory region of the Drosophila melanogaster Notch gene by new methods of directed genome editing by O. V. Andreyenkov, E. I. Volkova, N. G. Andreyenkova, S. A. Demakov

“…In humans, mutations in the Notch gene cause several hereditary diseases and carcinogenesis. Studies of the regulatory zone of the Notch gene in D. melanogaster have been conducted for several decades. …”
Get full text

Timing of Wnt Inhibition Modulates Directed Differentiation of Medial Ganglionic Eminence Progenitors from Human Pluripotent Stem Cells by Ivanna Ihnatovych, Alexandra Lew, Evelyn Lazar, Anna Sheng, Timot Kellermayer, Kinga Szigeti

“…GABA interneurons and basal forebrain cholinergic neurons, derivates of the medial ganglionic eminence (MGE), are implicated in diverse neuropsychiatric diseases. Various protocols have been proposed to generate MGE progenitors: the embryoid body- (EB-) based rosette-derived (RD), the adherent (AdD), and the nonadherent (NAdD) approaches. …”
Get full text

Women’s contribution to climate change action: A gender analysis by Setyowati Retno, Rusdiyana Eksa, Widiyanto, Sugihardjo, Lestari Eny, Arwindianti Micelle Lovinia

“…This movement is embodied into such institutions as female farmer group, Family Welfare Program (FWP), and waste bank driven by women through activities food production from the surrounding environment, healthy (organic) farming practices, health education and environmental hygiene, basic health services (posyandu for toddlers, adolescents and elderly), prevention of infectious diseases through “Jumantik”, waste reduction education, education on circular economy utilization of waste, making biopores and utilizing organic waste (magot cultivation).…”
Get full text

Visfatin Amplifies Cardiac Inflammation and Aggravates Cardiac Injury via the NF-κB p65 Signaling Pathway in LPS-Treated Mice by Yewen Hu, Nan Wu, Weiping Du, Shuangshuang Wang, Jian Wang, Chaoxia Zhang, Xiaomin Chen, Caijie Shen

“…Visfatin is an adipocytokine that has been demonstrated to be involved in cardiovascular diseases. This study aims at determining the role of visfatin in sepsis-induced cardiac injury and identify its possible mechanisms. …”
Get full text

How to Deal with Pulpitis: An Overview of New Approaches by Jakub Fiegler-Rudol, Wojciech Niemczyk, Katarzyna Janik, Anna Zawilska, Małgorzata Kępa, Marta Tanasiewicz

“…<b>Background:</b> Traditional root canal therapy (RCT) effectively removes diseased or necrotic pulp tissue and replaces it with inorganic materials. …”
Get full text

Placental ischemia during pregnancy induces hypertension, cerebral inflammation, and oxidative stress in dams postpartum by Savanna Smith, Jonna Smith, Kylie Jones, Angie Castillo, Natalia Wiemann, Ahfiya Howard, Mark Cunningham

“…PE affects ~5–8% of USA pregnancies and increases the risk for HTN and cerebrovascular diseases (CVD) later in life. We hypothesize that blood pressure (BP), cerebral oxidative stress, and cerebral inflammation will increase in postpartum (PP) placental ischemic dams.Methods Placental ischemia was induced in pregnant Sprague Dawley dams, utilizing reduced uterine perfusion pressure (RUPP) surgery. …”
Get full text

New insights into microbial bile salt hydrolases: from physiological roles to potential applications by Zixing Dong, Shuangshuang Yang, Cunduo Tang, Dandan Li, Dandan Li, Yunchao Kan, Yunchao Kan, Lunguang Yao, Lunguang Yao

“…Gut microbiota has been increasingly linked to metabolic health and diseases over the past few decades. Bile acids (BAs), the major components of bile, are bidirectionally linked to intestinal microbiota, also known as the gut microbiome-BA metabolic axis. …”
Get full text

The Opposite Effects of High-Sucrose and High-Fat Diet on Fatty Acid Oxidation and Very Low Density Lipoprotein Secretion in Rat Model of Metabolic Syndrome by Monika Cahova, Helena Dankova, Eliska Palenickova, Zuzana Papackova, Ludmila Kazdova

“…We found that in rats prone to the development of MetS associated diseases dietary-induced steatosis is not simply a result of impaired TAG degradation but that it depends on other mechanisms (elevated FFA synthesis or attenuated VLDL secretion) that are specific according to diet composition.…”
Get full text

First molecular diagnosis of the human pathogen Rickettsia raoultii and other spotted fever group rickettsiae in Sudanese ixodid ticks from domestic ruminants by Nagwa Eisawi, Jabbar Ahmed, Mohammed A. Bakheit, Dina A. Hassan, Mohammed O. Hussien, Abdel Rahim M. El Hussein

“…Despite a number of recent reports describing rickettsial diseases in new locations and the discovery of new rickettsiae, medical science and research have largely neglected the diagnosis and antimicrobial treatment of rickettsial infections in subtropical and tropical areas; thus, much remains to be discovered. …”
Get full text