The Hormonal dysregulation and its consequences in Obese Women - overview by Katarzyna Maria Pala, Wiktoria Tomaszewska, Paweł Siudziński, Mateusz Łyko, Alicja Skoczylas, Maria Golińska, Anna Nowak, Jakub Kurasz, Wiktoria Podlasiewicz, Piotr Dudziak, Wojciech Maj

“…Aim of Study   This study explores the effects of obesity on women's hormonal regulation, emphasizing associated conditions like PCOS, insulin resistance, infertility, and cardiometabolic diseases, while identifying mechanisms and potential interventions.   …”
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Metastatic Breast Cancer to the Gastrointestinal Tract: Report of Five Cases and Review of the Literature by Massimo Ambroggi, Elisa Maria Stroppa, Patrizia Mordenti, Claudia Biasini, Adriano Zangrandi, Emanuele Michieletti, Elena Belloni, Luigi Cavanna

“…Cyto-histological diagnosis is mandatory, to differentiate GI metastases from breast cancer to other diseases and to allow an adequate treatment.…”
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The Role of Ultrasound and Computed Tomography in the Evaluation of Subcutaneous Esophageal Bypass in a Dysphagic Patient by Simone Vetere, Maria Luisa Mennini, Daniele Pironi, Manuela Brighi, Stefano Pontone

“…Several conditions require subcutaneous colon bypass surgery in the esophageal diseases treatment. Esophageal reconstructions are high risk procedures because of their morbidity and mortality rate. …”
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Potential Role of Peptidylarginine Deiminase Enzymes and Protein Citrullination in Cancer Pathogenesis by Sunish Mohanan, Brian D. Cherrington, Sachi Horibata, John L. McElwee, Paul R. Thompson, Scott A. Coonrod

“…Recent reviews on PADs have focused on their role in autoimmune diseases. Here, we will discuss the potential role of PADs in tumor progression and tumor-associated inflammation. …”
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Sex-specific response of intramuscular fat to diet-induced obesity in rats by Hannah E. Smith, Nada Abughazaleh, Ruth A. Seerattan, Faizan Syed, Daniel Young, Antoine Dufour, David A. Hart, Raylene A. Reimer, Walter Herzog

“…Abstract Metabolic abnormalities associated with excess adiposity in obesity contribute to many noncommunicable diseases, including sarcopenic obesity. Sarcopenic obesity is the loss of muscle mass coupled with excess fat mass and fatty infiltrations in muscle tissue called myosteatosis. …”
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Canopy Spectral Characterization of Wheat Stripe Rust in Latent Period by Qi Liu, Yilin Gu, Shuhe Wang, Cuicui Wang, Zhanhong Ma

“…Stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), is one of the important wheat diseases worldwide. In this study, the spectral data were collected from wheat canopy during the latent period inoculated with three different concentrations of urediniospores and classification models based on discriminant partial least squares (DPLS) were built to differentiate leaves with and without infection of the stripe rust pathogen. …”
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pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity by Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Thais Graziela Donegá França, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Bianca Balbino, Camila Marques, Maura Rosane Valerio Ikoma, Ana Paula Masson, Célio Lopes Silva, Alexandrina Sartori

“…Considering the presence of an immune response directed to heat shock proteins (hsps) in autoimmune diseases and the immunoregulatory potential of these molecules, we evaluated the effect of a previous immunization with a genetic vaccine containing the mycobacterial hsp65 gene on EAE development. …”
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Enhancing Clinical Assessment of Skin Ulcers with Automated and Objective Convolutional Neural Network-Based Segmentation and 3D Analysis by Rosanna Cavazzana, Angelo Faccia, Aurora Cavallaro, Marco Giuranno, Sara Becchi, Chiara Innocente, Giorgia Marullo, Elia Ricci, Jacopo Secco, Enrico Vezzetti, Luca Ulrich

“…This condition mostly affects individuals over 65 years old and is often associated with chronic conditions such as diabetes, vascular issues, heart diseases, and obesity. Early detection, assessment, and treatment are crucial for recovery. …”
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Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery by Xin Qiao, Xiaolong Li, Mingyang Zhang, Ning Liu, Yanmei Wu, Shaoyong Lu, Ting Chen

“…Additionally, we discuss means to identify cryptic allosteric sites and design biased allosteric modulators based on cryptic allosteric sites through structure-based drug design, which is an advanced pharmacotherapeutic approach for treating GPCR-associated diseases.…”
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Perceptions of Biosimilars Among Healthcare Providers in Saudi Arabia by Mohammed Alqahtani, Ahmed Al-jedai, Albert Wertheimer

“…Biosimilars are safe and effective treatments for chronic diseases such as cancer and rheumatoid arthritis. The Saudi Food and Drug Authority (SFDA) manages the quality and registration of biosimilars in the Kingdom of Saudi Arabia. …”
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Spectrum of Cytopathological Causes of Cervical Lymphadenopathy- An Experience at Sahiwal Teaching Hospital by Raees Abbas Lail, Areeba Farooq, Qurrat-ul-Ain Tahir, Sadaf Shafique, Syeda Tooba Fatmi, Abdul Ghaffar

“… ABSTRACT: Objective Cervical lymph nodes are very often enlarged in many diseases. Fine Needle Aspiration Cytology (FNAC) is a simple, fast, and affordable procedure for diagnosing enlarged lymph nodes with a great degree of precision. …”
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A systematic screening assay identifies efficient small guide RNAs for CRISPR activation by Elin Arvidsson, Diana Duarte Lobo, Diana Duarte Lobo, Ermelinda Sabarese, Fabio Duarte, Rui Jorge Nobre, Rui Jorge Nobre, Rui Jorge Nobre, Luis Quintino, Cecilia Lundberg

“…The overall workflow was validated using therapeutically relevant genes for neurodegenerative diseases, including Tfeb, Adam17, and Sirt1. The most efficient sgRNAs also demonstrated activation of endogenous gene expression at mRNA level. …”
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Physical Activity Protects the Human Brain against Metabolic Stress Induced by a Postprandial and Chronic Inflammation by Leo Pruimboom, Charles L. Raison, Frits A. J. Muskiet

“…In recent years, it has become clear that chronic systemic low-grade inflammation is at the root of many, if not all, typically Western diseases associated with the metabolic syndrome. While much focus has been given to sedentary lifestyle as a cause of chronic inflammation, it is less often appreciated that chronic inflammation may also promote a sedentary lifestyle, which in turn causes chronic inflammation. …”
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Poly ADP-Ribosylation in a Plant Pathogenic Oomycete <i>Phytophthora infestans</i>: A Key Controller of Growth and Host Plant Colonisation by Viktoriya O. Samarskaya, Sofya Koblova, Tatiana Suprunova, Eugene A. Rogozhin, Nadezhda Spechenkova, Sofiya Yakunina, Andrew J. Love, Natalia O. Kalinina, Michael Taliansky

“…On a practical level, our data suggest that targeting the PARylation system may constitute a novel powerful approach for the management of <i>Phytophthora</i> diseases.…”
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The Evaluation of Plasma and Leukocytic IL-37 Expression in Early Inflammation in Patients with Acute ST-Segment Elevation Myocardial Infarction after PCI by Xin Wang, Xiangna Cai, Lan Chen, Duanmin Xu, Jilin Li

“…IL-37 was found to be involved in the atherosclerosis-related diseases and increased in acute coronary syndrome. …”
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Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers by Shiyi Yu, Chengyang Jiang, Yawen Yang, Fei Cheng, Fangchen Liu, Chang Liu, Xue Gong

“…Therefore, dysregulation of DNA/RNA binding proteins such as purine-rich element binding protein alpha (PURα) disrupts signaling transduction and often leads to human diseases including cancer. PURα was initially recognized as a tumor suppressor in acute myeloid leukemia (AML) and prostate cancer (PC). …”
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NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts by Selim Terhzaz, David Kerrigan, Floriane Almire, Agnieszka M. Szemiel, Joseph Hughes, Jean-Philippe Parvy, Massimo Palmarini, Alain Kohl, Xiaohong Shi, Emilie Pondeville

“…Some bunyaviruses are transmitted between vertebrate hosts by blood-sucking arthropods and cause major diseases in humans and animals. It is not understood why only some bunyaviruses have evolved the capacity to be transmitted by arthropod vectors. …”
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Pivotal Cytoprotective Mediators and Promising Therapeutic Strategies for Endothelial Progenitor Cell-Based Cardiovascular Regeneration by Hyunyun Kim, Sujin Kim, Sang Hong Baek, Sang-Mo Kwon

“…Cardiovascular diseases (CVDs), including atherosclerosis, stroke, and myocardial infarction, is a major cause of death worldwide. …”
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Development of a cell-penetrating peptide-based nanocomplex for long-term delivery of intact mitochondrial DNA into epithelial cells by Kyrie Wilson, Charles Holjencin, Hwaran Lee, Balasubramaniam Annamalai, Masaaki Ishii, Jeremy L. Gilbert, Andrew Jakymiw, Bärbel Rohrer

“…Gene therapy approaches for mitochondrial DNA (mtDNA)-associated damage/diseases have thus far been limited, and despite advancements in single gene therapy for mtDNA mutations and progress in mitochondrial transplantation, no method exists for restoring the entire mtDNA molecule in a clinically translatable manner. …”
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Design, synthesis and molecular modeling study of substituted indoline-2-ones and spiro[indole-heterocycles] with potential activity against Gram-positive bacteria by Radwan Awwad Abdoh, Aanazi Fares Kaed, Al-Agamy Mohammed, Mahrous Gamal Mohammad

“…Longstanding and firsthand infectious diseases are challenging community health threats. …”
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