Update on the Role of Cannabinoid Receptors after Ischemic Stroke by Luciano S. A. Capettini, Silvia Q. Savergnini, Rafaela F. da Silva, Nikos Stergiopulos, Robson A. S. Santos, François Mach, Fabrizio Montecucco

“…Cannabinoids are considered as key mediators in the pathophysiology of inflammatory diseases, including atherosclerosis. In particular, they have been shown to reduce the ischemic injury after acute cardiovascular events, such as acute myocardial infarction and ischemic stroke. …”
Get full text

HaCaT Cells as a Reliable In Vitro Differentiation Model to Dissect the Inflammatory/Repair Response of Human Keratinocytes by Irma Colombo, Enrico Sangiovanni, Roberta Maggio, Carlo Mattozzi, Stefania Zava, Yolanda Corbett, Marco Fumagalli, Claudia Carlino, Paola Antonia Corsetto, Diletta Scaccabarozzi, Stefano Calvieri, Angela Gismondi, Donatella Taramelli, Mario Dell’Agli

“…Moreover, HaCaT cells maintained in low Ca2+ medium and 80% confluent are similar to normal keratinocytes in terms of cytokine production suggesting that HaCaT cells may be a useful model to investigate anti-inflammatory interventions/therapies on skin diseases.…”
Get full text

A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of Prunus africana (Hook. F.) Kalkman from Africa by James K. Ndung’u, Joseph M. Nguta, Isaac M. Mapenay, Gervason A. Moriasi

“…Moreover, toxicity assessments provide crucial insights into the safety profile of P. africana extracts, ensuring the development of safe pharmaceuticals to treat various diseases.…”
Get full text

Efficient Strategy to Identify Gene-Gene Interactions and Its Application to Type 2 Diabetes by Donghe Li, Sungho Won

“…The goal of the GWAS is to identify genetic susceptibility to complex diseases by assaying and analyzing hundreds of thousands of single-nucleotide polymorphisms. …”
Get full text

High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition: A Two-Dimensional Electrophoresis Study in Spontaneously Hypert... by Ibrahim González-Marrero, Leandro Castañeyra-Ruiz, Juan M. González-Toledo, Agustín Castañeyra-Ruiz, Hector de Paz-Carmona, Rafael Castro, Juan R. Hernandez-Fernaud, Agustín Castañeyra-Perdomo, Emilia M. Carmona-Calero

“…Cerebrospinal fluid (CSF) is a system linked to the brain and its composition can be altered not only by encephalic disorder, but also by systemic diseases such as arterial hypertension, which produces alterations in the choroid plexus and cerebrospinal fluid protein composition. 2D gel electrophoresis in cerebrospinal fluid extracted from the cistern magna before sacrifice of hypertensive and control rats was performed. …”
Get full text

WILD SOUR CHERRY SPECIES OF THE CAUCASUS, CENTRAL ASIA AND THE FAR EAST AND THEIR USE IN BREEDING by A. A. Yushev, Yu. S. Orlova

“…Wild sour cherries from the Caucasus, Central Asia and the Far East introduced in the 1970–80s had a range of such important traits as immunity to fungal diseases, winter hardiness, drought resistance, restrained growth, vegetative reproduction ability, and were later used by Russian breeders for the development of new varieties and clonal rootstocks for growing cherries in various ecological and geographical areas of the country. …”
Get full text

Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn by Emmanuel B. A. Adusei, Reimmel K. Adosraku, James Oppong-Kyekyeku, Cedric D. K. Amengor, Yakubu Jibira

“…Antimicrobial resistance (AMR) is a threat to the prevention and treatment of the increasing range of infectious diseases. There is therefore the need for renewed efforts into antimicrobial discovery and development to combat the menace. …”
Get full text

Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition by Yu Fu, Xin Hao, Jingru Nie, Peng Shang, Xinxing Dong, Bo Zhang, Dawei Yan, Hao Zhang

“…Our research underscores the pivotal role of porcine TRPC1 as a positive regulator in adipogenesis and lipid accumulation processes, providing a potential target for improving animal meat quality and treating obesity-related diseases in humans.…”
Get full text

Transplanted Endothelial Progenitor Cells Improve Ischemia Muscle Regeneration in Mice by Diffusion Tensor MR Imaging by Xin-Gui Peng, Yingying Bai, Judy R. James, Darya P. Shlapak, Shenghong Ju

“…DTI could be a useful tool for noninvasive evaluation of muscle tissue damage and repair in animal models and patient with ischemic diseases.…”
Get full text

Mechanistic study of the effect of a high-salt diet on the intestinal barrier by Li Chen, Junrui Tang, Yanglin Xia, Jie Wang, Li-na Xia

“…This finding suggests that HSD may contribute to the pathogenesis of various diseases.…”
Get full text

Basidiobolomycosis Simulating a Mycobacterium ulcerans Infection in a Togolese Rural Child by Bayaki Saka, Waguena Gnassingbe, Garba Mahamadou, Sefako Akakpo, Julienne Teclessou, Aurel Abilogun-Chokki, Abas Mouhari-Toure, Koussake Kombate, Palokinam Pitché

“…Histopathology is very important for differential diagnosis between these two diseases.…”
Get full text

γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies by Eric X. Wei, Vasiliki Leventaki, John K. Choi, Susana C. Raimondi, Elizabeth M. Azzato, Sheila A. Shurtleff, Menchu G. Ong, Diana M. Veillon, James D. Cotelingam, Rodney E. Shackelford

“…She responded to the chemotherapy protocol poorly and had persistent diseases. Following an allogeneic bone marrow transplant, she went into remission. …”
Get full text

Impact of Kefir Derived Lactobacillus kefiri on the Mucosal Immune Response and Gut Microbiota by P. Carasi, S. M. Racedo, C. Jacquot, D. E. Romanin, M. A. Serradell, M. C. Urdaci

“…The evaluation of the impact of probiotics on host health could help to understand how they can be used in the prevention of diseases. On the basis of our previous studies and in vitro assays on PBMC and Caco-2 ccl20:luc reporter system presented in this work, the strain Lactobacillus kefiri CIDCA 8348 was selected and administrated to healthy Swiss mice daily for 21 days. …”
Get full text

A Comparative Study between the Effects of Intra-Articular Injections of Platelet Rich Plasma versus Corticosteroid with Local Anaesthetic in Refractory Cases of Temporo-Mandibular... by Madhumita Batabyal, Indranil Sen, Rabi Hembrom, Pradip Kumar Ray, Arijit Nag, Kapil Bala, Jayanta Barman, Anamika Anamika

“… Abstract: Introduction: Temporomandibular disorders (TMD) are a group of disorders that affect the temporomandibular joint, associated musculoskeletal tissues or both, such as myofascial pain, internal dearrangements, and certain degenerative and rheumatological diseases. In recent practice corticosteroid and Platelet Rich Plasma (PRP) has been proposed as an intervensional mode of treatment in TMD patients. …”
Get full text

Secondary Glioblastoma Multiforme in a Child with Disseminated Juvenile Pilocytic Astrocytoma by C. S. Amene, L. A. Yeh-Nayre, J. R. Crawford

“…Secondary glioblastoma multiforme (sGBM) can occur after a long latency period following radiation treatment of various diseases including brain tumors, leukemia, and more benign disorders like tinea capitis. …”
Get full text

Information Experiences and Needs in Patients with Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension by Bodil Ivarsson, Björn Ekmehag, Trygve Sjöberg

“…Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are fatal, noncurable, but treatable diseases that strongly affect the patients. Objective. …”
Get full text

Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy by Veronica Tisato, Paolo Perri, Erika Rimondi, Elisabetta Melloni, Giuseppe Lamberti, Daniela Milani, Paola Secchiero, Giorgio Zauli

“…This methodological approach has highlighted the role of MCP-1 in the healing process following PRK and has shown a potential for the identification of expression/modulation of soluble factors for biomarker profiling in ocular surface diseases.…”
Get full text

Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial‐mesenchymal transition and modulating SIRT1/β‐catenin signaling pathway in breast cancer by Xiaoxia Jin, Yingze Wei, Yushan Liu, Xiaoyun Lu, Fei Ding, Jiatai Wang, Shuyun Yang

“…Abstract Breast cancer is one of the leading fatal diseases for women worldwide who cannot have surgery typically have to rely on systemic chemotherapy to extend their survival. …”
Get full text

A Mechanical–Electrochemical Dual-Model E-Skin for the Monitoring of Cardiovascular Healthcare by Jianxiao Fang, Yunting Jia, Zelong Liao, Bairui Qi, Tao Huang

“…The early monitoring of cardiovascular biomarkers is essential for the prevention and management of some cardiovascular diseases. Here, we present a novel, compact, and highly integrated skin electrode as a mechanical–electrochemical dual-model E-skin, designed for the real-time monitoring of heart rate and sweat ion concentration, two critical parameters for assessing cardiovascular health. …”
Get full text

Impact of Likelihood Ratios of Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibody in Clinical Diagnosis of Rheumatoid Arthritis by Two Available Platforms by Juan Irure-Ventura, María Díaz-Toledo, Noelia Palazuelos-Cayón, Marcos López-Hoyos

“…<b>Background/Objectives</b>: Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases, characterized by an articular and extra-articular involvement, where autoantibodies, such as rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibodies (ACPAs), are important biomarkers for the diagnosis. …”
Get full text