Heat Shock Protein 70 Neutralizes Apoptosis-Inducing Factor by Guido Kroemer

“…Deficient apoptosis participates in cancerogenesis, whereas excessive apoptosis leads to unwarranted cell loss accounting for disparate diseases including neurodegeneration and AIDS. One critical step in the process of apoptosis consists in the permeabilization of mitochondrial membranes, leading to the release of proteins which normally are secluded behind the outer mitochondrial membrane[1]. …”
Get full text

The Relationship between Removable Dental Prostheses and Brain Activity in Elderly Individuals: Systematic Review by Arpit Sikri, Jyotsana Sikri, Rinshul Saroch, Charanjeet Singh Gill, Rimple Gupta, Chetan Pathak

“…Conclusion: Removable dental prostheses play a crucial role in enhancing neurological health and preventing cognitive decline, making them an important consideration in the management of neurodegenerative diseases.…”
Get full text

Pathogenic and therapeutic roles of extracellular vesicles in sepsis by Benshuai You, Yang Yang, Jing Wei, Chenglin Zhou, Surong Dong

“…Extracellular vesicles (EVs) released by mammalian cells and bacteria have been shown to play important roles in intercellular communication and progression of various diseases. In past decades, the functional role of EVs in sepsis and its complications has been well explored. …”
Get full text

Spontaneous Type 2 Diabetic Rodent Models by Yang-wei Wang, Guang-dong Sun, Jing Sun, Shu-jun Liu, Ji Wang, Xiao-hong Xu, Li-ning Miao

“…Diabetes mellitus, especially type 2 diabetes (T2DM), is one of the most common chronic diseases and continues to increase in numbers with large proportion of health care budget being used. …”
Get full text

MSM-TDE: multi-scale semantics mining and tiny details enhancement network for retinal vessel segmentation by Hongbin Zhang, Jin Zhang, Xuan Zhong, Ya Feng, Guangli Li, Xiong Li, Jingqin Lv, Donghong Ji

“…Abstract Retinal image segmentation is crucial for the early diagnosis of some diseases like diabetes and hypertension. Current methods face many challenges, such as inadequate multi-scale semantics and insufficient global information. …”
Get full text

Study on Fatigue Test and Life Prediction of Polyurethane Cement Composite (PUC) under High or Low Temperature Conditions by Hongshuai Gao, Quansheng Sun

“…There are many diseases in the deck pavement of long-span steel bridges under the action of vehicles, rainwater, and freezing. …”
Get full text

Transmission dynamics and control for a brucellosis model in Hinggan League of Inner Mongolia, China by Mingtao Li, Guiquan Sun, Juan Zhang, Zhen Jin, Xiangdong Sun, Youming Wang, Baoxu Huang, Yaohui Zheng

“…Brucellosis is one of the major infectious and contagious bacterial diseases in Hinggan League of Inner Mongolia, China. …”
Get full text

Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health by Jiaobo Cheng, Jielun Hu, Fang Geng, Shaoping Nie

“…In addition, the future perspectives in investigating new degradation pathways for polysaccharide, and using polysaccharides or their metabolites as therapeutic approaches for diseases mediated by the gut dysbiosis were also provided.…”
Get full text

Culture and Use of Mesenchymal Stromal Cells in Phase I and II Clinical Trials by Bourin Philippe, Sensebé Luc, Planat-Bénard Valérie, Roncalli Jérôme, Bura-Rivière Alessandra, Casteilla Louis

“…All these features lead to an increasing range of possible applications of MSCs, from treating immunological diseases to tissue and organ repair, that should be tested in phase I and II clinical trials. …”
Get full text

Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics by John Burke, Ravindra Kolhe, Monte Hunter, Carlos Isales, Mark Hamrick, Sadanand Fulzele

“…If exosomes could be extracted from stem cells in an efficient manner and packaged with particular regenerative products, then diseases such as rheumatoid arthritis, osteoarthritis, bone fractures, and other maladies could be treated with cell-free regenerative medicine via exosomes. …”
Get full text

Lipid Antigens: Revealing the Hidden Players in Adaptive Immune Responses by Tamana Eskandari, Yasamin Eivazzadeh, Fatemeh Khaleghinia, Fatemeh Kashi, Valentyn Oksenych, Dariush Haghmorad

“…These advancements have paved the way for lipid-based vaccines and immunotherapies through the application of nanoparticles and synthetic lipid antigens designed to boost immune responses against cancers and infectious diseases. Lipid trafficking, CD1 molecule interactions, and the immune system’s response to lipid antigens are yet to be completely understood, particularly in the context of autoimmunity and microbial infections. …”
Get full text

Effect of intraocular pressure on the hemodynamics of the central retinal artery: A mathematical model by Giovanna Guidoboni, Alon Harris, Lucia Carichino, Yoel Arieli, Brent A. Siesky

“…Retinal hemodynamics plays a crucial role in the pathophysiology of several ocular diseases.There are clear evidences that the hemodynamics of the central retinal artery (CRA) is strongly affected by the level of intraocular pressure (IOP), which is the pressure inside the eye globe. …”
Get full text

Recent Progress in Bioactive Substance Encapsulation System Based on Electrospinning and Its Application in Antimicrobial Food Packaging by REN Jie, TAN Zhongmei, TIAN Zihao, WU Gaoyun, LIU Yongchen, WANG Hao, JIANG Zhanmei, MA Jiage, HOU Juncai

“…The contamination of foods by foodborne pathogenic and spoilage microorganisms is one of the major causes of foodborne diseases. Therefore, ensuring food quality and extending its shelf life are urgent concerns for researchers. …”
Get full text

Neonatal necrotizing enterocolitis complicated by glutaric acidemia type II: a case report by Yuli Zhang, Yuli Zhang, Longfei Chen, Miao Duan

“…Diagnosis of GAII was confirmed through tandem mass spectrometry analysis of a blood sample. Genetic metabolic diseases may complicate or mimic common infections, leading to potential misdiagnosis. …”
Get full text

Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives by Pablo Olivero, Carlo Lozano, Ramón Sotomayor-Zárate, Nicolás Meza-Concha, Marcelo Arancibia, Claudio Córdova, Wilfredo González-Arriagada, Ricardo Ramírez-Barrantes, Ivanny Marchant

“…We aimed to critically analyze the available findings regarding the neurobiological implications of proteostasis on the development of neurodegenerative and psychiatric diseases, considering the mitochondrial role. Proteostasis alterations in the prefrontal cortex implicate proteome instability and accumulation of misfolded proteins. …”
Get full text

In situ-formed cryomicroneedles for intradermal cell delivery by Mengjia Zheng, Tianli Hu, Yating Yang, Xuan Qie, Huaxin Yang, Yuyue Zhang, Qizheng Zhang, Ken-Tye Yong, Wei Liu, Chenjie Xu

“…Abstract Cryomicroneedles (cryoMNs) offer a convenient and minimally invasive way to precisely deliver therapeutic cells intradermally for treating local and systemic diseases. cryoMNs are manufactured by shaping and freezing the cell-containing cryogenic media in a microneedle template, which allows cells to be packaged in advance for direct usage in the clinic. …”
Get full text

Was there really a siege of Kaffa by the Mongols in 1346 the first biological war? And what was the aftermath? by Christensen Carsten Sander

“…Even though such a theory is consistent with the technology of those times and in a way with contemporary notions about the dangers and necessary caution in the treatment of such diseases, the report has a number of weaknesses in terms of practical implementation. …”
Get full text

Analytical Methods to Characterize and Purify Polymeric Nanoparticles by Cristina Fornaguera, Conxita Solans

“…Advances in polymeric nanoparticles as novel nanomedicines have opened a new class of diagnostic and therapeutic tools for many diseases. However, although the benchtop research studies in the nanoworld are numerous, their translation to currently marketed products is still limited. …”
Get full text

Advances and challenges in platelet counting: evolving from traditional microscopy to modern flow cytometry by Chen Yong, Hu Yonggang, Hu Hai

“…Platelet counting is a fundamental clinical test for diagnosing haemorrhagic diseases, coagulation abnormalities, and certain autoimmune disorders, and it also serves as a critical basis for decisions regarding platelet transfusion. …”
Get full text

The Bidirectional Signal Communication of Microbiota-Gut-Brain Axis in Hypertension by Xiaoqi Wang, Zhenzhen Chen, Bin Geng, Jun Cai

“…Hypertension is a critical risk factor of cardiovascular diseases. A new concept of microbiota-gut-brain axis has been established recently, mediating the bidirectional communication between the gut and its microbiome and the brain. …”
Get full text