Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease by Angel D'Oliviera, Xuhang Dai, Saba Mottaghinia, Sophie Olson, Evan P Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S Mugridge

“…Finally, enzymology and molecular dynamics simulations indicate that kinetic discrimination occurs during a later step of Mpro-mediated proteolysis following substrate binding. …”
Get full text

High CXCR3 on Leukemic Cells Distinguishes IgHVmut from IgHVunmut in Chronic Lymphocytic Leukemia: Evidence from CD5high and CD5low Clones by Gayane Manukyan, Tomas Papajik, Zuzana Mikulkova, Renata Urbanova, Veronika Smotkova Kraiczova, Jakub Savara, Milos Kudelka, Peter Turcsanyi, Eva Kriegova

“…Comparing IgHVmut and IgHVunmut patients, high levels of CXCR3 on CD5high and CD5low subpopulations were detected in the IgHVmut patients, with better discrimination in CD5low subpopulation. Levels of CXCR3 on CD5low subpopulation were associated with time to the next treatment, thus further confirming its prognostic value. …”
Get full text

A Nomogram Based on Laboratory Data, Inflammatory Bowel Disease Questionnaire and CT Enterography for Activity Evaluation in Crohn’s Disease by Zhang H, Shen Y, Cao B, Zheng X, Zhao D, Hu J, Wu X

“…The nomogram underwent evaluation and testing in the training set (n = 84) and validation set (n = 23), respectively.Results: The discrimination performance of the combined (AUC 0.877) was marginally superior to that of IBDQ + clinical (AUC 0.854). …”
Get full text

Doctor, what is my risk of bleeding after cardiac surgery while on combined anticoagulant with antiplatelet therapy? A validated nomogram for risk assessment by Haolong Han, Haolong Han, Hang Xu, Hang Xu, Jifan Zhang, Weihui Zhang, Yi Yang, Xia Wang, Li Wang, Dongjin Wang, Weihong Ge

“…Various models were developed, validated and evaluated by using methods including ROC curves, calibration curves, the Hosmer-Lemeshow test, net reclassification improvement (NRI), integrated discrimination improvement (IDI) index, decision curve analysis (DCA) and clinical impact curves (CIC).ResultsMod2 showed the best performance (AUC of validation set = 0.863) which consists of 8 independent predictive factors (gender, age > 65 years, diabetes, anemia, atrial fibrillation, cardiopulmonary bypass time, intraoperative bleeding and postoperative drainage), with a significantly higher AUC compared to Mod1 (only preoperative factors) and Mod3 (the HAS-BLED scoring model). …”
Get full text

Predictors of the Short‐Term Outcomes of Guillain–Barré Syndrome: Exploring Electrodiagnostic and Clinical Features by Yi‐Hsiang Chen, Chia‐Lun Wu, Wei‐Chieh Weng, Yi‐Chia Wei

“…Notably, the motor conduction features, including distal and proximal CMAP and MNCV of the median and tibial nerves (all p < 0.05), were particularly important electrodiagnostic features of outcome discrimination in the AIDP subgroup. Discussion Combining clinical data with nerve conduction study and electromyography data can assist in predicting outcomes of both GBS patients and the AIDP subgroup. …”
Get full text

Stigma towards mental illness in Asian nations and low-and-middle-income countries, and comparison with high-income countries: A literature review and practice implications by Mrugesh Vaishnav, Afzal Javed, Snehil Gupta, Vinay Kumar, Parth Vaishnav, Akash Kumar, Hakimullah Salih, Petros levounis, Bernardo NG, Samia Alkhoori, Cora Luguercho, Armen Soghoyan, Elizabeth Moore, Vinay Lakra, Martin Aigner, Johannes Wancata, Jamila Ismayilova, Md. Azizul Islam, Antonio Geraldo Da Silva, Gary Chaimowitz, Wang Xiaoping, Tarek Okasha, Andreas Meyer-Lindenberg, Thomas Schulze, Roger NG, SN Chiu, Chan Kit Wa (Sherry), Andi J Tanra, Yong Chon Park, Liliya Panteleeva, Marisol Taveras, Ramune Mazaliauskiene, Ahmad Hatim Bin Sulaiman, Thelma Sanchez, Chandra Prasad Sedain, Taiwo Lateef Sheikh, Lars Lien, Ghulam Rasool, Robert Buenaventura, Harish Chandra Gambheera, Kapila Ranasinghe, Norman Sartorius, Chawanun Charnsil, Amine Larnaout, Juliet Nakku, Zarif Ashurov

“…Materials and Methods: PubMed and Google Scholar databases were screened using the following search terms: stigma, prejudice, discrimination, stereotype, perceived stigma, associate stigma (for Stigma), mental health, mental illness, mental disorder psychiatric* (for mental health), and low-and-middle-income countries, LMICs, High-income countries, and Asia, South Asian Association for Regional Cooperation/SAARC (for countries of interest). …”
Get full text

Predictive value of the perivascular fat attenuation index for MACE in young people suspected of CAD by Yani Yu, Dongkai Shan, Xi Wang, Zinuan Liu, Guanhua Dou, Junjie Yang, Yuqi Liu, Yundai Chen

“…Moreover, the new model revealed significant improvements in integrated discrimination (IDI = 0.033, 95% CI: 0.009–0.103, P = 0.014) and the net reclassification index (NRI = 0.597, 95% CI: 0.000-0.699, P = 0.024). …”
Get full text

Bilateral alterations in sensorimotor function and altered sensory strategy in individuals with unilateral chronic ankle instability by Xiaomei Hu, Xihe Hou, Lin Wang

“…Proprioception assessment included joint position sense and force sense (FS), and plantar sensation evaluation consisted of light-touch, vibration and two-point discrimination (TPD) thresholds at the heel, head of the first metatarsal (1 MF), base of the fifth metatarsal (5 MF), centre of foot and forefoot. …”
Get full text

Nomogram model and risk score predicting overall survival and guiding clinical decision in patients with Hodgkin’s lymphoma: an observational study using SEER population-based data... by Yue Yang, Shang Li, Xiao Zhu, Yi Kong, Mingtao Zhang, Xiangping Liang, Zherui Zhang, Shuzhen Tan, Yingqi Li, Yueyuan Zhong, Yingqi Shao, Jiayi Xu, Zesong Li

“…Additionally, the calibration curve and receiver operating characteristic curve were implemented to evaluate the accuracy and discrimination. Finally, we obtained 1-year, 3-year and 5-year survival rates of HL patients.Results 10 912 patients were eligible for the study. …”
Get full text

The Diagnosis Value of a Novel Model with 5 Circulating miRNAs for Liver Fibrosis in Patients with Chronic Hepatitis B by Qingqing Zhang, Qidi Zhang, Binghang Li, Ying Qu, Zhenghong Li, Lungen Lu, Rongzhou Li, Xiaobo Cai

“…The receiver operating characteristic (ROC) curve and discriminant analyses validated the ability of these predicted variables to discriminate the nonsignificant liver fibrosis group from the significant liver fibrosis group. …”
Get full text

miR-223 and Chromogranin A Affect Inflammatory Immune Cell Activation in Liver Metastasis of Neuroendocrine Neoplasms by Lukas Geisler, Katharina Detjen, Teresa Hellberg, Marlene Kohlhepp, Carsten Grötzinger, Jana Knorr, Ines Eichhorn, Raphael Mohr, Theresa Holtmann, Bertram Wiedenmann, Frank Tacke, Christoph Roderburg, Alexander Wree

“…Neutrophilic CD62L/CD63 showed good discrimination compared to healthy controls. Immune cell-derived miR-155, miR-193 and miR-223 colocalize with neutrophil in the extra-tumoral tissue alongside Nlrp3-associated caspase-1 activation. miR-223 knockdown in BON decreased the CgA intracellularly, increased in cellular granularity and caspase-1 activation. …”
Get full text

Establishment and Validation of a Machine‐Learning Prediction Nomogram Based on Lymphocyte Subtyping for Intra‐Abdominal Candidiasis in Septic Patients by Jiahui Zhang, Wei Cheng, Dongkai Li, Guoyu Zhao, Xianli Lei, Na Cui

“…A nomogram model was constructed, and the discrimination, calibration, and clinical effectiveness of the model were verified. …”
Get full text

Emerging Implications of Serum Resolvin D2 as a Biochemical Marker for Severity Assessment and Prognosis Prediction Following Moderate-Severe Traumatic Brain Injury: A Prospective... by Zong H, Zong Y, Li J, Zhao S, Wu W, Chen R, Zhao G, Li Z

“…Serum RvD2 levels exhibited strong discrimination efficiency for the probability of poor prognosis (P< 0.001), with similar ability as Rotterdam scores (P=0.337) and GCS scores (P=0.300). …”
Get full text

Involvement of the posterior limb of the internal capsule independently predicts the prognosis of patients with basal ganglia and thalamic hemorrhage by Sohan Gupta, Mengxuan Xiao, Na Liu, Na Liu, Yunxiao Zhao, Xiaolin Zhao, Yunqiang Huang, Yongming Wu, Zhenzhou Lin, Zhong Ji, Haihao Xu, Minzhen Zhu, Suyue Pan, Kaibin Huang

“…Multivariate logistic regression analysis was used to identify independent risk factors associated with unfavorable prognosis. The discrimination was verified using receiver operating characteristic curve (ROC) analysis, while the calibration was verified by the Hosmer-Lemeshow test.ResultsOf the 305 patients included, 188 from Nanfang Hospital were assigned to the development cohort, and 117 from Heyuan People's Hospital and Huadu District People's Hospital were assigned to the validation cohort. …”
Get full text

Genomic characterization and radiation tolerance of Naganishia kalamii sp. nov. and Cystobasidium onofrii sp. nov. from Mars 2020 mission assembly facilities by Patrick Leo, Marcus de Melo Texeira, Atul M. Chander, Nitin K. Singh, Anna C. Simpson, Andrey Yurkov, Fathi Karouia, Jason E. Stajich, Christopher E. Mason, Kasthuri Venkateswaran

“…The phylogenetic analyses revealed that single gene phylogenies (ITS or LSU) were not conclusive, and MLSA and WGS-based phylogenies were more advantageous for species discrimination in the two genera. The genomic analysis predicted proteins associated with dehydration and desiccation stress-response and the presence of genes that are directly related to osmotolerance and psychrotolerance in both novel yeasts described. …”
Get full text

Forty years of HIV infection and AIDS in Taiwan: Reflection on the past and looking toward the future by Sung-Hsi Huang, Hsun-Yin Huang, Stephane Wen-Wei Ku, Po-Hsien Kuo, Kuan-Yin Lin, Guan-Jhou Chen, Chia-Chi Lee, Yen-Fang Huang, Chien-Ching Hung

“…Challenges remain to achieve HIV elimination and long-term successful management of HIV infection, which include stigma and discrimination, late presentation of HIV infection, and accelerated ageing with increasing rates of co-morbidities among people with HIV.…”
Get full text

The Role of P‐Wave Variables in Enhancing Prediction of New‐Onset Atrial Fibrillation in Patients With Acute Myocardial Infarction by Na Yang, Xiaoyan Li, Bo Wu, Longhao Dai, Shaobin Yang, Qinning Zhang, Shaobin Jia

“…Conclusions The addition of P‐wave variables to AF risk factors from literature and guidelines significantly improved NOAF risk discrimination. P‐wave variables were strongly associated with NOAF after AMI. …”
Get full text

Typologie et caractéristiques des pâturages de la commune urbaine de Téra dans l'ouest du Niger by Hamza Seydou Korombé, Idrissa Soumana, Abdoul Aziz Maman Lawal, Ibrahim Djibo, Sanoussi Atta

“…Dans chaque placette, la biomasse a été prélevée dans 5 placeaux de 1 m2. La discrimination des différents pâturages a été réalisée sur la base d’Analyses Factorielles des Correspondances Détendancées (AFCD) couplées à des Classifications Hiérarchiques Ascendantes (CHA). …”
Get full text

Être touareg dans le Sud libyen en transition: une citoyenneté encore inachevée by Pauline Poupart

“…This article draws a portrait of a civil movement named La Lil Tamyiz (“No to discrimination”), formed at the beginning of 2020 by a group of young Tuaregs originating from the regions of Ghat, Ubari and Sebha. …”
Get full text

Clinico-Epidemiological Profile of Children Orphaned due to AIDS Residing in Care Giving Institutions in Coastal South India by Rekha Thapar, Meher Singha, Nithin Kumar, Prasanna Mithra, Bhaskaran Unnikrishnan, Ramesh Holla, Vaman Kulkarni, B. B. Darshan, Avinash Kumar

“…Five of the participants felt discriminated in their schools. Only two of the participants felt discriminated by their friends because of their HIV status. …”
Get full text