Burden of mental disorders by gender in Pakistan: analysis of Global Burden of Disease Study data for 1990–2019 by Mohsin Hassan Alvi, Tehmina Ashraf, Farah Naz, Asif Sardar, Akbar Ullah, Anita Patel, Tayyeba Kiran, Anil Gumber, Nusrat Husain

“…We used the crude data of disability-adjusted life-years (DALYs) obtained from the Global Burden of Disease Study database (1990–2019) to represent burden. …”
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Improving stroke risk prediction by integrating XGBoost, optimized principal component analysis, and explainable artificial intelligence by Lesia Mochurad, Viktoriia Babii, Yuliia Boliubash, Yulianna Mochurad

“…Abstract The relevance of the study is due to the growing number of diseases of the cerebrovascular system, in particular stroke, which is one of the leading causes of disability and mortality in the world. To improve stroke risk prediction models in terms of efficiency and interpretability, we propose to integrate modern machine learning algorithms and data dimensionality reduction methods, in particular XGBoost and optimized principal component analysis (PCA), which provide data structuring and increase processing speed, especially for large datasets. …”
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The WAVE complex in developmental and adulthood brain disorders by Hyung-Goo Kim, Clara Berdasco, Angus C. Nairn, Yong Kim

“…De novo mutations in WAVE genes and other components of the WAVE complex have been identified in patients with developmental disorders such as intellectual disability, epileptic seizures, schizophrenia, and/or autism spectrum disorder. …”
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Usability Pitfalls of Diabetes mHealth Apps for the Elderly by Maša Isaković, Urban Sedlar, Mojca Volk, Janez Bešter

“…Diabetes mellitus has high prevalence in the ageing population and is often accompanied by other comorbidities, such as Alzheimer’s disease, and general disabilities, such as poor eyesight. These comorbidities have redefined ways in which patients use mHealth apps, including diabetes apps. …”
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Time to be seen and heard: Including children’s and adolescents’ voices in the South African TB response by C Goslett, K du Preez, G Hendricks, A Best

“…Children are particularly vulnerable to TB infection and to dangerous forms of disseminated TB such as TB meningitis, which can cause death or major lifelong disability. They have distinct challenges with diagnosis, and TB treatment for adults is not necessarily child- friendly. …”
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Idiopathic Central Precocious Puberty Associated with 11 Mb De Novo Distal Deletion of the Chromosome 9 Short Arm by Mariangela Cisternino, Erika Della Mina, Laura Losa, Alexandra Madè, Giulia Rossetti, Lorenzo Andrea Bassi, Giovanni Pieri, Baran Bayindir, Jole Messa, Orsetta Zuffardi, Roberto Ciccone

“…We report a girl with a de novo distal deletion of 9p affected by idiopathic central precocious puberty and intellectual disability. Genome-wide array-CGH revealed a terminal deletion of about 11 Mb, allowing to define her karyotype as 46; XX, del(9)(p23-pter). …”
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The Application of Parallel Robotics to Investigate the Effect of Lumbar Bracing on Trunk Muscle Activity by Gregory N. Kawchuk, Narasimha G. Prasad, Jonathan Glass, Carolyn Knight, Serena Third, Daniel Timmermans

“…Lumbar bracing is prescribed frequently for disability caused by low back pain; however, investigations into this practice demonstrate a range of patient outcomes. …”
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Factors Associated with Poststroke Fatigue: A Systematic Review by Amélie Ponchel, Stéphanie Bombois, Régis Bordet, Hilde Hénon

“…Poststroke fatigue (PSF) is a frequent, disabling symptom that lacks a consensual definition and a standardized evaluation method. …”
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Targeted correction of megabase-scale CNTN6 duplication in induced pluripotent stem cells and impacts on gene expression by Maria Gridina, Polina Orlova, Oleg Serov

“…Copy number variations of the human CNTN6 gene, resulting from megabase-scale microdeletions or microduplications in the 3p26.3 region, are frequently implicated in neurodevelopmental disorders such as intellectual disability and developmental delay. However, duplication of the full-length human CNTN6 gene presents with variable penetrance, resulting in phenotypes that range from neurodevelopmental disorders to no visible pathologies, even within the same family. …”
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Spinal Endoscopy for Delayed-Onset Lumbar Radiculopathy Resulting from Foraminal Stenosis after Osteoporotic Vertebral Fracture: A Case Report of a New Surgical Strategy by Yuyu Ishimoto, Hiroshi Yamada, Elizabeth Curtis, Cyrus Cooper, Hiroshi Hashizume, Akihito Minamide, Yukihiro Nakagawa, Munehito Yoshida

“…Here, we describe the use of spinal endoscopy for the treatment of this disabling condition, in an 80-year-old woman presenting with severe radicular pain following an osteoporotic lumbar compression fracture. …”
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Psychological Factors Associated with Phantom Limb Pain: A Review of Recent Findings by Xaver Fuchs, Herta Flor, Robin Bekrater-Bodmann

“…Additional factors such as the amount of disability and adjustment to the amputation appear to also play a role. …”
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Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling by Yong-Eun Kim, Minseong Kim, Sunwhi Kim, Raham Lee, Yusuke Ujihara, Esther Magdalena Marquez-Wilkins, Yong-Hui Jiang, Esther Yang, Hyun Kim, Changhoon Lee, Changwon Park, Il Hwan Kim

“…Abstract Autism spectrum disorder (ASD) is a neurodevelopmental disability condition arising from a combination of genetic and environmental factors. …”
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Pulmonary Rehabilitation in COPD: A Reappraisal (2008–2012) by Pierachille Santus, Linda Bassi, Dejan Radovanovic, Andrea Airoldi, Rita Raccanelli, Francesco Triscari, Francesca Giovannelli, Antonio Spanevello

“…Chronic Obstructive Pulmonary Disease (COPD) is a complex pathological condition associated with an important reduction in physical activity and psychological problems that contribute to the patient's disability and poor health-related quality of life. …”
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Early Postural Changes in Individuals with Idiopathic Parkinson’s Disease by Mohamed Elsayed Khallaf, Eman Elsayed Fayed

“…Postural changes are frequent and disabling complications of Parkinson’s disease (PD). …”
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Web-Based Specialist Support for Spinal Cord Injury Person’s Care: Lessons Learned by Vincenzo Della Mea, Dario Marin, Claudio Rosin, Agostino Zampa

“…Persons with disability from spinal cord injury (SCI) are subject to high risk of pathological events and need a regular followup even after discharge from the rehabilitation hospital. …”
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Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research by Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson

“…Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and disability worldwide with impairments ranging from mild to severe. …”
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Occupational health professionals’ and HR specialists’ perceptions of telemental health services in occupational health care settings: A qualitative study by Elina Kervinen, Lauri Vähätalo, Anna Siukola, Tiia Reho, Klas Winell, Riitta Sauni

“…Objective The rise in mental health-related work disability pensions highlights the need for more research on how occupational health care (OHC) can support mental health, including the use of telehealth (TH) services in mental health care. …”
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Internal Tremor in Long COVID May Be a Symptom of Dysautonomia and Small Fiber Neuropathy by Svetlana Blitshteyn, Ilene S. Ruhoy, Lauren R. Natbony, David S. Saperstein

“…<b>Background/Objectives:</b> Internal tremor (IT) is often reported by patients with post-acute sequelae of SARS-CoV-2, also known as Long COVID, as a distressing and disabling symptom. Similarly, physicians are typically perplexed by the nature and etiology of IT and find it extremely challenging to manage. …”
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Validation of the German Version of the New Freezing of Gait Questionnaire for People with Parkinson‘s Disease by Jana Seuthe, Kristina Kuball, Ann-Kristin Hoffmann, Burkhard Weisser, Günther Deuschl, Christian Schlenstedt

“…Freezing of gait (FOG) in Parkinson’s disease (PD) is a highly disabling symptom which impacts quality of life. The New FOG Questionnaire (NFOG-Q) is the most commonly used tool worldwide to characterize FOG severity in PD. …”
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A Qualitative Systematic Review of Older Persons’ Perceptions of Health, Ill Health, and Their Community Health Care Needs by Anne Lise Holm, Elisabeth Severinsson

“…Two main themes were interpreted on a higher level: reconciliation with how life has become: and desire to regain their identity and sense of self-worth despite disability. Two themes emerged: creating meaning led to the experience of being valued in health care and society and a mental struggle to regain independence with the help of caregivers. …”
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