Healthcare performance of leprosy management in peripheral health facilities of Dhanusa and Mahottari, Nepal by Ram Kumar Mahato, Uttam Ghimire, Bijay Bajracharya, Binod K. C., Deepak Bam, Deepak Ghimire, Uttam Raj Pyakurel, David T. S. Hayman, Basu Dev Pandey, Chuman Lal Das, Krishna Prasad Paudel

“…All identified cases (n = 187) adhered to the complete treatment and release after treatment (RFT) scheme, out of which 84.5% were satisfied with the service they were provided. Leprosy disability and ear hand and feet (EHF) scores were not significantly reduced in treated patients during the study period, but counseling by LFPs significantly improved cases’ positive beliefs and practices regarding self-care. …”
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Changing patterns of cardiovascular diseases and subtypes induced by kidney dysfunction among 25–64 years in China from 1992 to 2021 by Guoqiang Zeng, Hongliang Wang, Pinghui Cao, Jinyang Zhao, Lingyun Liu, Hui Guo

“…Methods This study extracted data from the Global Burden of Disease (GBD) 2021, focusing on deaths and disability-adjusted life years (DALYs) caused by KD-induced CVD and subtypes, including ischemic heart disease (IHD), stroke, and lower extremity peripheral artery disease (LEPAD) among 25–64 years globally and in China from 1992 to 2021. …”
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Clinical features of early multiple sclerosis by I. Čelpačenko, R. Stankevičiūtė, M. Malciūtė, R. Balnytė

“…Delayed treatment increases the risk of disability, therefore, establishing a clear phenotype of early MS can help in a more efficient diagnostic process. …”
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Global, regional and national burden of neuroblastoma and other peripheral nervous system tumors, 1990 to 2021 and predictions to 2035: visualizing epidemiological characteristics... by Chaoyan Yue, Qi Zhang, Fenyong Sun, Qiuhui Pan

“…Methods: Based on the GBD 2021 database, this study analyzed the incidence, mortality, prevalence, and Disability-Adjusted Life-Years (DALYs) of neuroblastoma and other peripheral nervous system tumors from 1990 to 2021, stratified by sociodemographic development index (SDI) and geographic regions. …”
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Exploration of neurometabolic alterations in adolescent patients with bipolar depression and non-suicidal self-injury based on proton magnetic resonance spectroscopy by Chengji Wang, Yuan Qu, Xiaoqin Shen, Xiaoxiao Tang, Xiaoxiao Tang, Gaiyu Tong, Meier Wati, Manzeremu Naibi, Manzeremu Naibi, Cheng Zhang, Shaohong Zou

“…Its identification and diagnosis are challenging, and it is characterized by a high rate of misdiagnosis and disability. Studies have revealed that patients with ABD are more prone to non-suicidal self-injury (NSSI) compared to those with unipolar depression. …”
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Cost efficiency of inpatient rehabilitation following acquired brain injury: the first international adaptation of the UK approach by Ian D Cameron, Julie Ratcliffe, Ian Cameron, Belinda Gabbe, Rachel Milte, Ciara Ryan, Karen Roberts, Zhibin Chen, Russell Gruen, Laura Jolliffe, Natasha A Lannin, Peter Hunter, Maria Crotty, Lynne Turner-Stokes, Lisa Cameron, David Attwood, Anne Holland, Jacqui Morarty, Lynne Turner Stokes, Christine Latimer, Dina Watterson, John Rabling, Melanie Reed, Mithu Palit, Troy Huggins, Verna Smith, Elizabeth O’Shannessy, Rebecca Nicks, Alison Gehrig, Katelyn Moloney, Sophie O’Keefe, Megan Coulter, Margaret Inches, Erin Gee, Sue McLellan

“…Mean projected net lifetime savings were $A13.4 million (95% CI $A11.4, $A15.4) per patient.Conclusions This study provides proof of principle for use of the NPCNA cost-efficiency model outside the UK and yields further evidence that rehabilitation for patients with complex disabilities represents value for money. For every dollar spent on inpatient rehabilitation in this cohort, an estimated $A91 was saved in ongoing care costs.…”
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Percutaneous unilateral biportal endoscopic discectomy for symptomatic lumbar disc herniation in geriatric patients by Rongqing Qin, Rongqing Qin, Anhong Guan, Anhong Guan, Min Zhu, Pin Zhou, Bing Zhou, Bing Zhou, Ruihua Zhou, Ruihua Zhou, Zaiyong Guan, Zaiyong Guan

“…Clinical outcomes were evaluated based on operation time, total blood loss, hospital stay, visual analog scale (VAS) scores for leg pain, Oswestry disability index (ODI) scores, modified MacNab criteria, and postoperative magnetic resonance imaging findings.ResultsSurgery was successfully performed on all geriatric patients, with a mean operation time of 46 min (range: 32–68 min). …”
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Remote Sensing of Sun-Induced Fluorescence in a Deep Lake: Disentangling Quenching Mechanisms Improves Relationship With Chlorophyll-a Concentration Estimates by Remika S. Gupana, Daniel Odermatt, Abolfazl Irani Rahaghi, Camille Minaudo, Mortimer Werther, Claudia Giardino, Alexander Damm

“…However, when applying the same approach to Sentinel-3 Ocean and Land Color Instrument data, we found that the errors in remote sensing reflectance products disable such an adaptation. We conclude that enhanced atmospheric correction in the red-to-near-infrared region for oligo-mesotrophic lakes is needed to demonstrate the upscaling of our in-situ-based results. …”
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Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation by Linamara Rizzo Battistella, Felipe Fregni, Marta Imamura, Vinicius Delgado Ramos, Lucas Ramos De Pretto, Simon K H A A Van Cauwenbergh, Sabrina Saemy Tome Uchiyama, Denise Matheus, Flavia Kuhn, Ana Alice Amaral de Oliveira, Gabriella Souza Naves, Aline Rossetti Mirisola, Fernando de Quadros Ribeiro, Andre Tadeu Sugawara, Mauricio Cantarino, Rafael Andrade Santos Antunes Cavalca, Vanessa Pagano, Melina Valentim Marques, Elizabeth Mendes da Silva, Alessandra Pereira Gomes

“…It analyses participants' sociodemographic background, COVID-19 clinical manifestations, and clinical and functional evaluations.Setting Tertiary-level university hospital in São Paulo, Brazil.Participants Study participants are COVID-19 survivors admitted to hospital care for at least 24 hours to treat acute SARS-CoV-2 infection.Outcome measures Epworth Sleepiness Scale, EuroQoL-5 Dimensions-5 Levels, Functional Assessment of Chronic Illness Therapy–Fatigue, Functional Independence Measure, Functional Oral Intake Scale, Handgrip Strength, Insomnia Severity Index, Medical Research Council (MRC) Dyspnea Scale, MRC sum score, Modified Borg Dyspnea Scale, pain Visual Analogue Scale, Post-COVID-19 Functional Status, Timed Up and Go, WHO Disability Assessment Schedule 2.0, 1-Minute Sit to Stand Test.Results Many participants required invasive mechanical ventilation (41.57%, 333 of 801). …”
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Using multiomic integration to improve blood biomarkers of major depressive disorder: a case-control studyResearch in context by Amazigh Mokhtari, El Chérif Ibrahim, Arnaud Gloaguen, Claire-Cécile Barrot, David Cohen, Margot Derouin, Hortense Vachon, Guillaume Charbonnier, Béatrice Loriod, Charles Decraene, Ipek Yalcin, Cynthia Marie-Claire, Bruno Etain, Raoul Belzeaux, Andrée Delahaye-Duriez, Pierre-Eric Lutz

“…Summary: Background: Major depressive disorder (MDD) is a leading cause of disability, with a twofold increase in prevalence in women compared to men. …”
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High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions by Victor Davi R. S. Oliveira, Ana Paula M. G. Reis, Claiton V. Brenol, Ivânio A. Pereira, Karina R. Bonfiglioli, Letícia R. Pereira, Manoel B. Bértolo, Maria de Fátima L. C. Sauma, Maria Fernanda B. R. Guimarães, Paulo Louzada-Júnior, Rina D. N. Giorgi, Sebastião C. Radominski, Licia Maria H. Mota, Cleandro P. Albuquerque, Geraldo R. Castelar-Pinheiro

“…In multivariate analyses, high-titer RF was independently associated with higher disease activity (Clinical Disease Activity Index, CDAI: β = 2.44 [0.89, 3.99], p = 0.002), worse functional capacity (Health Assessment Questionnaire Disability Index, HAQ-DI: β = 0.112 [0.018, 0.205], p = 0.020); extra-articular manifestations (OR 1.48 [1.09, 2.00], p = 0.011); increased corticosteroid (OR 1.53 [1.19, 1.96], p = 0.001) and biological disease-modifying antirheumatic drugs (bDMARD) use (OR 1.41 [1.08, 1.84], p = 0.011). …”
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Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study by Yanwen Xu, Hanyu Zhu, Yuqi Su, Zhizhi Chen, Chuanliu Wang, Ming Yang, Feifei Jiang, Yunping Li, Yongming Xu

“…ObjectiveIntracerebral hemorrhage (ICH) is a common cerebrovascular disease characterized by high mortality and disability rates. Neuritin, significantly expressed in injured brain tissues, is implicated in the molecular mechanisms underlying acute brain injury. …”
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Clinical characteristics and outcomes of patients with chondroblastoma undergoing surgery with various adjuvant procedures: a retrospective study of 59 cases by Toru Hirozane, Tetsuya Sekita, Eisuke Kobayashi, Tomoaki Mori, Naofumi Asano, Toru Udaka, Takashi Tajima, Rumi Nakagawa, Kazutaka Kikuta, Akira Yoshiyama, Hideo Morioka, Itsuo Watanabe, Ukei Anazawa, Michiro Susa, Keisuke Horiuchi, Yoshihisa Suzuki, Takeshi Morii, Robert Nakayama

“…Patients with local recurrence had a high degree of disability and joint deformity (P < 0.05). Two patients received preoperative denosumab and neither experienced local recurrence nor functional impairments. …”
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Social-ecological perspective on the suicidal behaviour factors of early adolescents in China: a network analysis by Xueying Zhang, Yuan Li, Juan Chen, Peiying Li, Mengyuan Yuan, Yonghan Li, Gengfu Wang, Puyu Su

“…Network analysis was employed to examine the correlates of suicidal ideation, plans and attempts at four levels, namely individual (sex, academic performance, serious physical illness/disability, history of self-harm, depression, impulsivity, sleep problems, resilience), family (family economic status, relationship with mother, relationship with father, family violence, childhood abuse, parental mental illness), school (relationship with teachers, relationship with classmates, school-bullying victimisation and perpetration) and social (social support, satisfaction with society).Results In total, 37.9%, 19.0% and 5.5% of the students reported suicidal ideation, plans and attempts in the past 6 months, respectively. …”
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The Knee-SCHOOL: a brief patient-centered multidisciplinary educational program for knee osteoarthritis by Denise Vianna Machado Ayres, Sabrina Saemy Tome Uchiyama, Andréa Oliveira Prates, Rosana Aparecida Freitas Lopes, Antenor Bispo Santos Silva, Denise Rodrigues Tsukimoto, Rosimeire Alves Amorim, Taynah Souza Ribeiro, Artur Cesar Aquino Santos, André Tadeu Sugawara, André Tadeu Sugawara, Marcos Montagnini, Linamara Rizzo Battistella, Linamara Rizzo Battistella, Marta Imamura, Marta Imamura

“…BackgroundKnee osteoarthritis (KOA) is the most common form of arthritis in adults and a leading cause of years lived with disability, representing a significant burden on healthcare worldwide.ObjectiveDescribe the structure and educational elements of the Knee-SCHOOL, a brief patient-centered multidisciplinary educational program for patients with KOA.DesignObservational prospective study.SettingAcademically affiliated rehabilitation outpatient center in Brazil.MethodsThe program consisted of three in-person educational sessions (4.5 hr each) for 55 community dwelling adults, aged ≥50 years, with primary KOA-related pain. …”
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Global and China trends and forecasts of disease burden for female lung Cancer from 1990 to 2021: a study based on the global burden of disease 2021 database by Bilu Li, Yuyan Wu, Yanhong Zhang, Chengyun Hu, Xue Li, Shanshan Luo, Chenyu Sun, Iyad Yousef, Yefei Wang, Chaoliang Tang

“…Methods Based on the Global Burden of Disease (GBD) 2021 database, we analyzed the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of lung cancer in China and globally from 1990 to 2021. …”
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Prevalence of abnormal bone mineral density and its influencing factors among adult residents in Jiangsu province: a cross-sectional survey by Weihao WANG, Huijing HE, Yaoda HU, Xingming CHEN, Tan XU, Ji TU, Ang LI, Binbin LIN, Qihang LIU, Zhiming LU, Tianshu XI, Haibo HUANG, Da XU, Zhili CHEN, Zichao WANG, Guangliang SHAN

“…MethodsUsing stratified multistage cluster random sampling, we recruited 6 000 adult permanent residents (≥ 20 years old and living locally for at least 5 years) without disability or serious illness and, for women, not pregnant or breastfeeding, in urban and rural areas of Jiangsu province. …”
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Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma by Yan Liao, Junkai Chen, Hao Yao, Ting Zheng, Jian Tu, Weidong Chen, ZeHao Guo, Yutong Zou, Lili Wen, Xianbiao Xie

“…Abstract Background Osteosarcoma is the most common malignant bone tumor in children and adolescents, characterized by high disability and mortality rates. Over the past three decades, therapeutic outcomes have plateaued, underscoring the critical need for innovative therapeutic targets. …”
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Is the freezing index a valid outcome to assess freezing of gait during turning in Parkinson’s disease? by Maaike Goris, Pieter Ginis, Clint Hansen, Christian Schlenstedt, Christian Schlenstedt, Jeffrey M. Hausdorff, Jeffrey M. Hausdorff, Jeffrey M. Hausdorff, Nicholas D’Cruz, Wim Vandenberghe, Wim Vandenberghe, Walter Maetzler, Alice Nieuwboer, Moran Gilat

“…IntroductionFreezing of gait (FOG) is a disabling symptom for people with Parkinson’s disease (PwPD). …”
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Altered Topological Properties of Grey Matter Structural Covariance Networks in Complete Thoracic Spinal Cord Injury Patients: A Graph Theoretical Network Analysis by Wen-Li Wang, Yu-Lin Li, Mou-Xiong Zheng, Xu-Yun Hua, Jia-Jia Wu, Fei-Fei Yang, Nan Yang, Xia He, Li-Juan Ao, Jian-Guang Xu

“…Partial correlation analysis was performed to explore the relationship between the GMV of structurally changed brain regions and SCI patients’ clinical variables, including injury duration, injury level, Visual Analog Scale (VAS), American Spinal Injury Association Impairment Scale (AIS), International Classification of Functioning, Disability and Health (ICF) scale, Self-rating Depression Scale (SDS), and Self-rating Anxiety Scale (SAS), after removing the effects of age and gender. …”
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