Global, regional, and national burden of pancreatic cancer from 1990 to 2021, its attributable risk factors, and projections to 2050: a systematic analysis of the global burden of... by Tianyu Li, Chen Lin, Weibin Wang

“…This study examines global and regional trends in pancreatic cancer incidence, Disability Adjusted Life Years (DALYs), and mortality from 1990 to 2021, utilizing data from the most recent Global Burden of Disease (GBD) 2021 database. …”
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Effect of Nebivolol and Olmesartan on 24-Hour Brachial and Aortic Blood Pressure in the Acute Stage of Ischemic Stroke by Eleni Georgianou, Panagiotis I. Georgianos, Konstantinos Petidis, Konstantinos Markakis, Ioanna Zografou, Asterios Karagiannis

“…Elevated blood pressure (BP) in the acute phase of ischemic stroke is associated with heightened risk of early disability and death. However, whether BP-lowering in this setting is beneficial and the exact levels at which BP should be targeted remain unclear. …”
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Development of a Motion-Based Video Game for Postural Training: A Feasibility Study on Older Adults With Adult Degenerative Scoliosis by Frances K. W. Wan, Alex T. H. Mak, Claire W. Y. Chung, Joanne Y. W. Yip

“…Interventions that help seniors to improve sagittal balance are needed to inhibit the progression of pain and disability. A motion-sensing video game (active game) is developed in this study to monitor sitting and standing postures in real-time and facilitate the postural learning process by using optical sensors to measure body movement and a video game to provide visual feedback. …”
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Pelnac® artificial dermis assisted by vacuum sealing drainage for treatment of severe avulsion injuries of the fingers by Zhenmu Lv, Yujie Wang, Jingliang Chen, Qingfu Zhang, Haitao Zhao

“…The average score on the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire was 13.2 (SD 8.5, range 0 to 47). …”
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Prevention and treatment of recurrent fractures after percutaneous vertebroplasty with denosumab in patients with osteoporotic vertebral compression fractures by Shouyu Xiang, Cheng Tang, Long Ling, Wei Liu, Bingwen Bai, Yanming Cao

“…[Methods] A total of 72 patients diagnosed with osteoporotic vertebral compression fracture and treated by percutaneous vertebroplasty in the orthopedic department of the Second Affiliated Hospital of Guangzhou Medical University from January 2022 to December 2022 were selected as the study subjects.Patients were randomly divided into two groups, each had 36 cases.The control group received conventional anti-osteoporosis treatment, and the observation group added denosumab on the basis of control group treatment.Both groups were followed for 1 year, while the fracture rate and the levels of bone mineral density(BMD), visual analogue scale(VAS) score, oswestry disability index(ODI), beck value, sagittal cobb angle and procollagen type ⅠN-terminal propeptid(PINP) and β-carboxy-terminal cross-linked telopeptide of type Ⅰ collagen(β-CTX) were compared between the two groups. …”
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Factors Associated with Serious Injuries among Adolescents in Ghana: Findings from 2012 Global School Health Survey by Martin Ackah, Mohammed Gazali Salifu, Hosea Boakye

“…Injuries are of public health concern and the leading cause of residual disability and death among teenagers, especially in low- and middle-income countries (LMICs). …”
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Efficacy of acupuncture for primary osteoporosis: a systematic review and meta-analysis of randomized controlled trials by Tianyi Ma, Tiantian Zhang, Le Zhang, Haoming Zhao, Ke Liu, Jianjun Kuang, Liang Ou

“…The outcomes included bone mineral density (BMD), visual analogue scale (VAS) scores, clinical effectiveness rate, estradiol (E2), Oswestry Disability Index (ODI), and levels of serum alkaline phosphatase (ALP). …”
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Short-Term Postoperative Pain and Function of Unilateral Biportal Endoscopic Discectomy versus Percutaneous Endoscopic Lumbar Discectomy for Single-Segment Lumbar Disc Herniation:... by Weihao Zhu, Yu Yao, Jie Hao, Wenbin Li, Feng Zhang

“…Computer searches of PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang databases were performed to search for studies on UBE versus PELD for single-segment lumbar disc herniation (ssLDH) from the time of database construction to Mar. 2022, and two investigators independently performed literature screening and data extraction, and evaluation of the quality of the included studies was observed as operation time, complications, and visual analogue scale (VAS) at each preoperative and postoperative stage as well as Oswestry Disability Index (ODI), and meta-analysis was performed by applying the Review Manager 5.4 software. …”
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Global, regional, and national esophageal cancer deaths and DALYs attributable to diet low in vegetables and fruits, 1990–2019: analysis for the global burden of disease study by Bing Cui, Aqin Chen, Chengcheng Xu

“…Decomposition analysis quantified the contributions of aging, population dynamics, and epidemiological changes to deaths and disability-adjusted life years (DALYs). Frontier analysis was used to evaluate the relationship between dietary risk-related disease burden and sociodemographic progress.ResultsIn 2019, inadequate vegetable and fruit intake contributed to 65,919 global EC deaths, accounting for 0.12% of all deaths, with an age-standardized death rate of 0.81 per 100,000 population. …”
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The BET inhibitor JQ1 targets fat metabolism and counteracts obesity by Claudia Fornelli, Alessia Sofia Cento, Lorenzo Nevi, Raffaella Mastrocola, Gustavo Ferreira Alves, Giuseppina Caretti, Massimo Collino, Fabio Penna

“…Introduction: Obesity, one of the most frequent health problems in the adult population, is a condition characterized by excessive white adipose tissue accumulation and accompanied by the increased risk to develop other disorders such as type II diabetes, cardiovascular disorders, physical disability, frailty and sarcopenia. Total fat mass frequently increases during aging, often coexisting with sarcopenia, thus resulting in an emerging condition defined sarcopenic obesity (SO). …”
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Autopercepción de la condición física, funcionalidad y calidad de vida en estudiantes universitarios by Tuillang Alexander Yuing, Claudio Soto-Espíndola, Nathalie Andrea Valdés-Valdés, Guillermo Méndez-Rebolledo, Eduardo Guzmán-Muñoz

“…El nivel de actividad física se midió a través del Cuestionario Internacional de Actividad Física versión corta, la condición física mediante la International Fitness Scale, la funcionalidad de miembros superiores a través del Cuestionario Disabilities of Arm, Shoulder and Hand, para la funcionalidad de miembros inferiores la Lower Extremity Functional Scale y la percepción de la calidad de vida con el cuestionario de salud SF-36. …”
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Application of Dragonnet and Conformal Inference for Estimating Individualized Treatment Effects for Personalized Stroke Prevention: Retrospective Cohort Study by Sermkiat Lolak, John Attia, Gareth J McKay, Ammarin Thakkinstian

“… Abstract BackgroundStroke is a major cause of death and disability worldwide. Identifying individuals who would benefit most from preventative interventions, such as antiplatelet therapy, is critical for personalized stroke prevention. …”
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Immunonutrition for traumatic brain injury in children and adolescents: protocol for a systematic review and meta-analysis by Linan Zeng, Lingli Zhang, Hailong Li, Rong Peng, Lijun Yang, Xinwei Chen, Zhenyan Bo

“…Introduction Traumatic brain injury (TBI) is the leading cause of paediatric trauma death and disability worldwide. The ‘Guidelines for the Management of Severe Traumatic Brain Injury (Fourth Edition)’ recommend that nutritional goals should be achieved within 5–7 days of injury. …”
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Examining the Outcomes of Hybrid Coronary Revascularization in Acute STEMI Patients from 2015 to 2022 by Mozhgan Bahramian, Seyed Ali Moezi bady, Maryam Bahramian, Ahmad Amouzeshi

“…The global rise of chronic diseases, especially cardiovascular disease (CVD), poses a significant public health challenge, being a leading cause of death and disability worldwide. In Iran, the surge in CVD incidence and its risk factors, along with a decrease in the age of onset, has notably increased the reliance on coronary artery bypass grafting (CABG) as a life-saving intervention. …”
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Global burden of musculoskeletal disorders and attributable factors in 204 countries and territories: a secondary analysis of the Global Burden of Disease 2019 study by Binyan Wang, Ding Ye, Shiwen Liu, Shuzhen Fan, Yaxuan Wang, Yuxuan Zhan

“…Objective To evaluate the global burden of musculoskeletal (MSK) disorders, as well as the five common conditions, and their relevant risk factors from 1990 to 2019.Design Data from the Global Burden of Disease Study 2019 were used in this study.Setting and participants Individuals of all ages and genders from 204 countries and territories in 21 regions.Main outcome measures The outcomes were the numbers and age-standardised rates (ASRs) of incident cases, deaths and disability-adjusted life-years (DALYs) of MSK disorders. …”
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Health and economic impact of oral PrEP provision across subgroups in western Kenya: a modelling analysis by Linxuan Wu, Sarah Cox, Monisha Sharma, Brian Pfau, Rachel Wittenauer

“…PrEP provision to SDCs was associated with the lowest incremental cost-effectiveness ratio (ICER), $245 per disability-adjusted life year (DALY) averted (CI $179 to $435), followed by women and men with multiple partners ($1898 (CI $1002 to $6771) and $2351 (CI $1 831 to $3494) per DALY averted, respectively). …”
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Immunoglobulin replacement therapy in patients with primary and secondary immunodeficiencies: impact of infusion method on immunoglobulin-specific perceptions of quality of life an... by Rajiv Mallick, Noemi Hahn, Christopher Scalchunes

“…Patient reported infusion time efficiency, physical and mental health (PROMIS GPH-2 and PROMIS GMH-2 respectively), patient acceptability of their symptom state (PASS), upper extremity disability (Quick DASH) and general health perception (via the GHP) are also investigated. …”
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Diabetic Peripheral Neuropathy Affects Pinch Strength and Hand Dexterity in Elderly Patients by Qi Zhang, Yifang Lin, Xinhua Liu, Li Zhang, Yan Zhang, Dong Zhao, Qi Lu, Jie Jia

“…Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes, leading to disability and decreased quality of life. In past research and clinical studies, the lower limb function of DPN patients was often the principal subject of research, with little attention given to the upper limb and hand. …”
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Development of cohort definitions and algorithms to identify patients with Lennox-Gastaut syndrome or Dravet syndrome from real-world administrative healthcare databases by Drishti Shah, Victoria Divino, Justin Chen, Arturo Benitez, Jeannine Roth, J. Scott Andrews

“…Multiple seizure types, developmental delay, and intellectual disabilities were considered by the physicians to be key diagnostic features. …”
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PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration by Weixing Xu, Rana Dhar, Danyang Zheng, Qi Peng, Yue Li, Sheng Mei, Huifang Tang

“…Abstract Intervertebral Disc degeneration (IDD) is one of the leading causes of disability, and current therapies are ineffective. Phosphodiesterase 4B (PDE4B) plays an essential role in regulating the activation of nuclear factor E2-related factor 2 (Nrf2), while Nrf2 regulates ferroptosis. …”
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