Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 201... by Zhen Junhai, Meng Yang, Tan Zongbiao, Yan Wenxuan, Li Tiange, Wu Yanrui, Liu Chuan, Dong Weiguo

“…Risk factors for the burden of deaths and disability-adjusted life years (DALYs) due to very EOCRC were also explored in this study. …”
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Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. by Andrés F. Zea-Vera, Carlos Andrés Rodríguez, Sebastián Giraldo, Mario Alejandro Chacón, Luis Fernando Guerrero, Ricardo Mosquera, Raúl Andrés Vallejo, Fabio Samir Vargas, María Andrea García, María A. Rengifo, Anilza Bonelo, Maximiliano Parra

“…Associated exacerbations and declining lung function contribute to increasing disability and mortality. There are no data about the prevalence of non-cystic fibrosis bronchiectasis etiologies in the Colombian population. …”
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Cost savings of reducing opioid prescribing for the treatment of people with low back pain in general practice: a modelling studyResearch in context by Anagha Killedar, Romi Haas, Alexandra Gorelik, Sean Docking, Rachelle Buchbinder, Chris G. Maher, Chung-Wei Christine Lin, Alison Hayes

“…Summary: Background: Low back pain (LBP) is the leading cause of disability worldwide. Contrary to clinical guidelines, opioids are frequently prescribed early in the management of LBP in primary care, leading to potential harm and downstream healthcare costs. …”
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Trabeculectomy versus stepwise treatment for breaking the attack of acute primary angle closure in patients with long attack duration: study design and protocol for a multicentre r... by Jing Jiang, Qing Zhang, Bo Qu, Chao Dai, Mingguang He, Ye Zhang, Ning-Li Wang, Shuning Li, Guangxian Tang, Su Jie Fan, Zhi Li, Chi Liu, Xinqi Chang, Yanyan Cheng

“…Introduction Acute primary angle closure (APAC) is a common ophthalmic emergency for Chinese patients causing potential visual disabilities. According to current guidelines published by developed countries, a stepwise protocol (medication laser or paracentesis surgery) is recommended for emergency management of APAC. …”
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Minimally invasive needle tenotomy vs. platelet rich plasma injection in the treatment of chronic elbow epicondylitis by Chantal T. Nguyen, MD, Michelle H. Lee, MD, Matthew W. Kaufman, MD, Yue Meng, MD, Jyotsna A. Koduri, MD, Geoffrey Abrams, MD, Emilie V. Cheung, MD, Michael T. Freehill, MD, Eugene Y. Roh, MD

“…Methods: A retrospective review of 51 adults (n = 23 for MINT; n = 28 for PRP) was conducted to investigate long-term outcomes in pain relief (via visual analog scale or VAS) and improvements in upper extremity function (via quick disability of the arm, shoulder, and hand questionnaire or qDASH). …”
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Balance and Gait Improvements of Postoperative Rehabilitation in Patients with Parkinson’s Disease Treated with Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) by Kazunori Sato, Noriaki Aita, Yoshihide Hokari, Eriko Kitahara, Mami Tani, Nana Izawa, Kozo Hatori, Ryota Nakamura, Fuyuko Sasaki, Satoko Sekimoto, Takayuki Jo, Genko Oyama, Taku Hatano, Yasushi Shimo, Hirokazu Iwamuro, Atsushi Umemura, Nobutaka Hattori, Toshiyuki Fujiwara

“…Postural instability is one of the major impairments, which induces disabilities of activities of daily living (ADLs). The effectiveness of STN-DBS for postural instability is unclear, and the effect of rehabilitation following STN-DBS has remained uncertain. …”
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Сandidate SNP-markers of rheumatoid arthritis that can significantly alter the affinity of the TATA-binding protein for human gene promoters by I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, I. A. Drachkova, E. A. Oshchepkova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, V. A. Kozlov

“…This is very important, since doctors consider RA as one of the most frequent causes of disability. Using the Web service SNP_TATA_Z-tester (http://beehive.bionet.nsc.ru/cgi-bin/mgs/tatascan_fox/start.pl), 227 variants of single nucleotide polymorphism (SNP) of the human gene promoters were studied. …”
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INTERPROFESSIONAL COLLABORATION AND HEALTHCARE ORGANIZATION: an exploratory investigation into the challenges and opportunities for rehabilitation professionals. by Simone Sottana, Andrea Vianello, Matteo Tognin, Deborah Mazzarotto, Marco Ceccato, Daria Visintin, Riccardo Martignon, Francesca Magaton Rizzi, Noemi Pasquon, Lucia Savietto

“… Introduction: In the past five years, interprofessional collaboration within the rehabilitation sector has gained significant prominence in the Italian context, emphasizing the efficacy of collaborative methodologies in the treatment of patients with complex disabilities. The recognition of eight rehabilitation professions classified under the first cycle degree class L/SNT2 (Health Professions) has established a foundation for a patient-centered and multiprofessional model of care. …”
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The prevalence and burden of musculoskeletal disorders amongst Indigenous people in Pimicikamak, northern Manitoba, Canada: A community health survey by André Bussières, Melissa Atkinson-Graham, Jennifer Ward, Muriel Scott, Jean Moss, Patricia Tavares, Deborah Kopansky-Giles, Jacqueline Ladwig, Cheryl Glazebrook, David A. Monias, Helga Hamilton, Donald Z. Mckay, Randall Smolinski, Scott Haldeman, Sheilah Hogg-Johnson, Steven Passmore

“…Objectives: To investigate the prevalence of spine symptoms and spine disability, self-care and care seeking behaviors in a random sample of Indigenous adults residing in Cross Lake, northern Manitoba, Canada. …”
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Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis protocol by Antje Timmer, Gerta Rücker, Natalia Tiles-Sar, Johanna Neuser, Dominik de Sordi, Anne Baltes, Jan Preiss, Gabriele Moser

“…Introduction Patients with inflammatory bowel diseases (IBD) often report psychological problems, unemployment, disability, sick leave and compromised quality of life. …”
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Education strategies are the most commonly used in pediatric rehabilitation implementation research: a scoping review by Sahar Ghahramani, Sophia C. Larson, Allison J. L’Hotta, Kelly M. Harris, Kim Lipsey, Elvin H. Geng, Lisa A. Juckett, Catherine R. Hoyt

“…Abstract Background Approximately one in six children has a disability, and effective, evidence-based rehabilitation can ameliorate the impact of these conditions over the lifespan. …”
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Impact of quality of life on overall work productivity impairment and activity impairment of patients with systemic lupus erythematosus: the PEONY study by Yoshiya Tanaka, Shintaro Hirata, Shingo Nakayamada, Yusuke Miyazaki, Kazuyoshi Saito, Kunihiro Yamaoka, Shigeru Iwata, Yoshiyuki Yamaguchi, Keisuke Nakatsuka, Shunpei Kosaka, Katsuhide Kusaka, Toshiki Yabe-Wada, Masakazu Fujiwara, Yoshifumi Arita, Mitsuru Hoshino, Naoko Ozaki

“…Patients completed patient-reported outcome (PRO) questionnaires, including LupusPRO, Work Productivity and Activity Impairment-Lupus, EQ-5D-5L and Health Assessment Questionnaire-Disability Index. Disease activity and organ damage were investigator-assessed. …”
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Clinical Efficacy and Safety of Trans-Sacral Epiduroscopic Laser Decompression Compared to Percutaneous Epidural Neuroplasty by Bong Ju Moon, Seong Yi, Yoon Ha, Keung Nyun Kim, Do Heum Yoon, Dong Ah Shin

“…The Visual Analog Scale (VAS) for leg pain; Oswestry Disability Index (ODI); 12-Item Short-Form Health Survey (SF-12); preoperative and postoperative 4-, 12-, and 24-week Macnab criteria; and preoperative and 24-week postoperative lumbar spinal MRIs after SELD were obtained. …”
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Global, regional, and national burden of early-onset colorectal cancer from 1990 to 2021: a systematic analysis based on the global burden of disease study 2021 by Yang Meng, Zongbiao Tan, Junhai Zhen, Di Xiao, Liwei Cai, Weiguo Dong, Changzheng Chen

“…Over the same period, the death rate decreased from 2.98/100000 to 2.30/100000 (AAPC = − 0.84), whereas the disability-adjusted life-year (DALY) decreased from 148.46/100000 to 115.42/100000 (AAPC = − 0.82). …”
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Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review by Jiaojiao Liu, Qiaosheng Ren, Boxuan Du, Xian Liu, Yuqiu An, Peichi Zhang, Lexi Li, Zhenhong Liu, Zhenhong Liu, Kegang Cao, Kegang Cao

“…BackgroundMigraine represents a chronic neurological disorder characterized by high prevalence, substantial disability rates, and significant economic burden. Its pathogenesis is complex, and there is currently no cure. …”
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Systemic Diseases in Patients with Congenital Aniridia: A Report from the Homburg Registry for Congenital Aniridia by Jessica Obst, Fabian N. Fries, Maryam Amini, Annamária Náray, Cristian Munteanu, Tanja Stachon, Shweta Suiwal, Neil Lagali, Berthold Seitz, Barbara Käsmann-Kellner, Nóra Szentmáry

“…Systemic diseases were detected in 155 of 337 (46%) patients, with the most common being obesity (29 [8.6%]), thyroid disease (28 [8.3%]), hypertension (26 [7.7%]), intellectual disability (22 [6.5%]), diabetes mellitus (19 [5.6%]), auditory perception disorder/speech development delay (16 [4.7%]), and epilepsy (12 [3.6%]). …”
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Application of an integrated behaviour-change model on grandparental adherence towards childhood domestic injury prevention in Hong Kong: a longitudinal study by Martin S Hagger, Patrick Ip, Derwin King Chung Chan, Roni Man Ying Chiu, Catherine M Capio, Patrick S H Yung, Agnes Y K Lai

“…Background/purpose Every year, unintentional injury claims thousands of children’s lives and causes disabilities in many more. For very young children, these injuries often occur at home. …”
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Intersectional discrimination, exclusion and the socio-political economy of global mental health: A systematic scoping review of the literature by Rochelle A. Burgess, Sorcha Ní Chobhthaigh, Bijayalaxmi Biswal, Diana Ceccolini, Babatunde Fadipe, Denaneer Khan, Neena Aggarwal, Ishrat Pabla, Camila Solis, Ramya Pillutla, Piyali Sarkar, Eric Frasco, Valentina lemmi, Soumitra Pathare, Crick Lund

“…In this scoping review, we explore the extent to which the current mental health evidence base acknowledges the impact of intersectional structural determinants of mental health outcomes, via the mechanism of discrimination - linked to a range of commonly underexplored socio-political factors (Protocol registration DOI:10.17605/OSF.IO/CGJQH).We included nine social phenomena widely acknowledged in social theory as contributing to the patterning of social determinants: (1) Political Dynamics, (2) Racism, Caste & Xenophobia, (3) Gender & Sexuality, (4) Neighbourhood Dynamics, (5) Class & Working conditions, (6) Colonialism, (7) Indigeneity, (8) Religious & Spiritual Identities (9) Age & Disability. We explored these factors intersectionally, including studies with two or more factors in their analyses. …”
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Incorporating insulin into alginate-chitosan 3D-printed scaffolds: A comprehensive study on structure, mechanics, and biocompatibility for cartilage tissue engineering by Afsaneh Jahani, Mohammad Sadegh Nourbakhsh, Ali Moradi, Marzieh Mohammadi, Lobat Tayebi

“…Osteoarthritis is a leading cause of disability worldwide, challenging current treatments to limited cartilage self-healing capacity. …”
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Content and face validity in virtual reality with children: a validation in five steps+1 of a wheelchair basketball game by Imanol Ceberio, Mohammad Al-Rashaida, Maitane García, Juan Francisco Lopez Paz, Monika Salgueiro, Nicole Passi, Humberto Pavel, Imanol Amayra

“…This simulation is designed to promote empathy and understanding towards children with motor disabilities through adapted sport scenes. This study proposed a validation approach with six phases to assess technical and aesthetic aspects.MethodSample: a) Content validity study, 20 children (11–18 years old) were recruited as lay and content experts, who assessed the properties of grade of realism and physical fidelity of wheelchair basketball scenarios. b) Face validity study, 395 children were recruited as lay experts and divided into two groups (7–9 years old and 10–12 years old), or into ten subgroups according to Age × Gender interaction. …”
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