Linking evidence for targeted blood biomarkers in post-stroke cognitive impairment and dementia by Jinny Hong, Katherine Mun, Katherine Mun, Kyle C. Kern, Kyle C. Kern, Marissa Thirion, Jason D. Hinman, Jason D. Hinman

“…With improvements in acute stroke treatment and more patients surving the acute stroke period, the identification and prognostication of post-stroke disability is paramount. Post-stroke cognitive impairment and dementia (PSCID) severely impacts the morbidity and mortality of stroke survivors. …”
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Incidence, mortality, and global burden of retinoblastoma in 204 countries worldwide from 1990 to 2021: Data and systematic analysis from the Global Burden of Disease Study 2021 by Linyan Wang, Jianing Chen, Yunhan Shen, Grace Loy Ming Hooi, Shuohan Wu, Feng Xu, Hao Pei, Jianpeng Sheng, Tiansheng Zhu, Juan Ye

“…Methods: GBD 2021 data was analyzed to assess Rb incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021. …”
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mHealth Intervention for Dementia Prevention through lifestyle Optimisation (MIND-PRO) in a primary care setting: protocol for a randomised controlled trial in people with low SES... by Edo Richard, Esther Van den Berg, Ron Handels, Henrike Galenkamp, Eric P Moll van Charante, Marieke P Hoevenaar-blom, Anne Roos van der Endt, Martien J H Kas

“…Secondary outcomes include the Cardiovascular Risk Factors, Ageing and Dementia risk score and its individual risk factors, and disability, physical activity, depressive symptoms, cognitive functioning and daily distance moved.Ethics and dissemination The MIND-PRO trial is funded by the Netherlands Organisation for Health Research and Development (ZonMw, grant number 10510032120004) and approved by the Ethics Committee of Amsterdam UMC (reference: METC 2023.0770). …”
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The Effect of Whole-Body Vibration on Upper Extremity Function in Children with Cerebral Palsy: A Pilot Study by Marianna Kelaiditi, Alexandra Lepoura, Anna Christakou, Nikolaos Chrysagis, Vasiliki Sakellari

“…Cerebral palsy (CP) is the leading cause of lifelong physical disability, affecting approximately 17 million individuals worldwide. …”
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Serial Paediatrics Omics Tracking in Myalgic Encephalomyelitis (SPOT-ME): protocol paper for a multidisciplinary, observational study of clinical and biological markers of paediatr... by Adam Scheinberg, Natalie Thomas, Katherine Huang, Paul R Gooley, Elisha K Josev, Tracey Chau, Darcy Tantanis, Sarah J Knight, Christopher W Armstrong

“…Introduction Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling condition that can affect adolescents during a vulnerable period of development. …”
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Effectiveness of interventions for middle-aged and ageing population with neck pain: a systematic review and network meta-analysis protocol by Alison B Rushton, Nicola R Heneghan, Taweewat Wiangkham, Uchukarn Boonyapo, Piyameth Dilokthornsakul, Nattawan Phungwattanakul

“…Any interventions and outcome measures detailed within The International Classification of Functioning, Disability and Health domains will be included. Two independent reviewers will search key databases (AMED, CENTRAL, CINAHL, Embase, MEDLINE, PEDro and PsycINFO), grey literature, key journals and reference lists in May 2022. …”
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Mapping outcomes for recovery of consciousness in studies from 1986 to 2020: a scoping review protocol by Monica Steiner, Elizabeth Burns, Trudy Mallinson, Joshua Rosenow, Jennifer Weaver, Alison Cogan, Parie Bhandari, Erica Jacobs, Ariana Pape, Chantal Nguyen, Ann Guernon, Tom Harrod, Theresa Bender Pape, Marilyn Pacheco, Catherine Burress Kestner, Kelsey Watters, Elizabeth Yost, Henk Eilander, Berno Overbeek, Sophie Leeds, Kelly Krese, Haylee Winden, Mary Philbin, Stefani Cleaver, Vanessa Silva, Konner Nelson, André Lindsey, Angela Hartman, Kristen Maisano, Erika Cooley, Jessica Rudin Portnoff, Bailey Widener, Sarah Hollingsworth, Coty Wardwell, Julianne Angel, Ladan Hakima, Jennifer Nebel, Bint-e Zainab Awan

“…We will chart the data by applying the WHO International Classification of Functioning, Disability and Health Framework to identify the content areas of clinical outcome assessments. …”
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可穿戴设备在卒中风险预测及卒中后管理中的应用进展 Research Progress on the Application of Wearable Devices in Stroke Risk Prediction and Post-Stroke Management... by 吴雅婷1，魏宸铭1，桑振华1，陈乐1，梁怡凡1，武剑1，2，3 (WU Yating1, WEI Chenming1, SANG Zhenhua1, CHEN Le1, LIANG Yifan1, WU Jian1,2,3)

“…Abstract: Stroke is one of the leading causes of death and disability worldwide. Traditional monitoring and management approaches can no longer meet the growing health management needs of high-risk groups and patients with stroke. …”
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Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner by Quan Vo, Zachary D. Simon, Gwoncheol Park, Dina C Nacionales, Carmelina Gorski, Evan L Barrios, Gemma Casadesus, Philip A Efron, Lyle L Moldawer, Ravinder Nagpal, Paramita Chakrabarty, Marcelo Febo

“…Sepsis is a state of systemic immune dysregulation and organ failure that is frequently associated with severe brain disability. Epidemiological studies have indicated that younger females have better prognosis and clinical outcomes relative to males, though the sex-dependent response of the brain to sepsis during post-sepsis recovery remains largely uncharacterized. …”
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Domain‐Specific Prediction of Clinical Progression in Parkinson's Disease Using the Mosaic Approach by Marlene Tahedl, Ulrich Bogdahn, Bernadette Wimmer, Dennis M. Hedderich, Jan S. Kirschke, Claus Zimmer, Benedikt Wiestler

“…ABSTRACT Purpose: Due to the highly individualized clinical manifestation of Parkinson's disease (PD), personalized patient care may require domain‐specific assessment of neurological disability. Evidence from magnetic resonance imaging (MRI) studies has proposed that heterogenous clinical manifestation corresponds to heterogeneous cortical disease burden, suggesting customized, high‐resolution assessment of cortical pathology as a candidate biomarker for domain‐specific assessment. …”
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Mobile health van as an intervention to provide clinical support and health promotion to street children and marginalised populations in the National Capital Region of Delhi: a mix... by Shanti Raman, Rajeev Seth, Yawar Qaiyum, Tanu Girotra Girotra, Id Mohammad, Indra Taneja

“…Just under 10% of encounters were referred to specialist services, 122 children were diagnosed with disability. Health education sessions were provided mainly in group settings, to over 70 000 children. …”
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Changing dynamics of bloodstream infections due to methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium in Germany, 2017–2023: a continued burd... by Simon Brinkwirth, Marcel Feig, Ines Noll, Tim Eckmanns, Achim Dörre, Sebastian Haller, Niklas Willrich

“…Despite their clinical impact, comprehensive assessments of changes of the burden of bloodstream infections in terms of Disability-Adjusted Life Years (DALYs) and attributable deaths over time are lacking, particularly in Germany. …”
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Comparative CT with stress manoeuvres for diagnosing distal isolated tibiofibular syndesmotic injury in acute ankle sprain: a protocol for an accuracy- test prospective study by João Carlos Rodrigues, Mario Lenza, Laercio Alberto Rosemberg, Durval do Carmo Santos Barros, Mario Ferretti, Alexandre Leme Godoy Santos, Marcelo Pires Prado, José Felipe Marion Alloza, Renato Amaral Masagão, Adham do Amaral e Castro, Marco Kawamura Demange

“…The secondary objective is to investigate the participants’ disability outcomes by applying the Foot and Ankle Ability Measure questionnaire.Methods and analyses This study of a diagnostic accuracy test will consecutively select individuals older than 18 years with a clinical diagnosis of a suspected acute syndesmotic injury. …”
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Differential Expression of IFN-γ, IL-10, TLR1, and TLR2 and Their Potential Effects on Downgrading Leprosy Reaction and Erythema Nodosum Leprosum by Douglas Eulálio Antunes, Isabela Maria Bernardes Goulart, Mayara Ingrid Sousa Lima, Patrícia Terra Alves, Paula Cristina Brígido Tavares, Luiz Ricardo Goulart

“…Leprosy reactions are acute immunological events that occur during the evolution of chronic infectious disease causing neural damage and disabilities. A study using blood samples of 17 leprosy reaction patients and 17 reaction-free was carried out by means of associations between antigens, receptors, and expression of cytokines, using path analysis providing new insights into the immunological mechanisms involved in triggering leprosy reactions. …”
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The Global Burden and Trends of Legionella spp. Infection-Associated Diseases from 1990 to 2021: An Observational Study by Yonghong Zhong, Linfeng Shen, Yan Zhou, Yibo Sun, Xiaofang Fu, Huaqiong Huang

“…Methods Age-standardized disability-adjusted life years (ASR-DALYs) and age-standardized death rates (ASDRs) of LSIADs from 1990 to 2021 were accessed from the Global Burden of Disease (GBD) 2021, which utilized the Bayesian hierarchical meta-regression tool and the Cause of Death Ensemble model to estimate these metrics. …”
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DENND5B Gene Expression as a Trigger for the Development of Diabetes Mellitus–Peripheral Artery Disease: Insights from a Univariate and Multivariate Mendelian Randomization Study by Qiaoqiao Li, Fuli Cao, Xueping Gao, Yuan Xu, Bo Li, Tianyang Hu

“…Background: Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis that can result in limb pain, disability, or mortality. Notably, diabetes mellitus (DM) stands out as one of the most significant risk factors for the development of PAD. …”
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Endovascular Treatment for Basilar Artery Occlusion: Revisiting Evidence From Randomized Clinical Trials by Sherief Ghozy, Amr Ehab El‐Qushayri, Mohamed Elfil, Alis J. Dicpinigaitis, Krishna Amuluru, Mohammad El‐Ghanem, Chirag D. Gandhi, Fawaz Al‐Mufti

“…Background Acute ischemic stroke attributed to basilar artery occlusion is known to be associated with high rates of mortality and disability. However, the previous clinical trials did not provide evidence to support the efficacy of endovascular treatment (EVT) in patients with basilar artery occlusion. …”
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Exploring Cortical Thickness Alteration in Parkinson Disease Patients with Freezing of Gaits by E. Li, Xiuhang Ruan, Yuting Li, Guoqin Zhang, Mengyan Li, Xinhua Wei

“…Background: Freezing of gait (FoG) is a disabling gait disorder that commonly occurs in advanced stages of Parkinson’s disease (PD). …”
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Deciphering the role of miRNA-mRNA interactions in cerebral vasospasm post intracranial hemorrhage by Xiang Chu, Xiang Chu, Xiyan Zhu, Honghao Xu, Wenbing Zhao, Debin Guo, Xing Chen, Jinze Wu, Lei Li, Hao Wang, Jun Fei

“…Cerebral vasospasm (CVS), a serious complication following subarachnoid hemorrhage, is associated with high rates of mortality and disability. Emerging evidence suggests that abnormal miRNA and mRNA are involved in the development of CVS. …”
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Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…Abstract Spinal cord injury (SCI), characterized by the disruption of neural pathways and an increase in inflammatory cell infiltration, leads to profound and lasting neurological deficits, with a high risk of resulting in permanent disability. Currently, the therapeutic landscape for SCI is notably sparse, with limited effective treatment options available. …”
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