The prevention opportunities of retinopathy in diabetic patients – position paper endorsed by the Polish Lipid Association by Maciej Banach, Stanisław Surma, Grzegorz Dzida, Jacek Jóźwiak, Bogusław Okopień, Jacek Rysz, Konrad Szosland, Andrzej Grzybowski

“…In this Position Paper by the Polish Lipid Association (PoLA) we have reviewed the current stage of knowledge on possible mechanisms by which fenofibrate may contribute to retinopathy prevention, available data on safety and efficacy, to finally recommend administering fenofibrate in prevention of this dangerous diabetic complication, which significantly affects quality of life and disability-adjusted life-years (DALY). This intervention – well-recognized and already in common use in diabetic patients – may significantly improve population health in Poland and worldwide.…”
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Relationship of Serum Uric Acid Level with Demographic Features, Risk Factors, Severity, Prognosis, Serum Levels of Vitamin D, Calcium, and Magnesium in Stroke by Payam Saadat, Alijan Ahmadi Ahangar, Mansor Babaei, Mandana Kalantar, Mohammad Ali Bayani, Hiva Barzegar, Hemmat Gholinia, Farbod Zahedi Tajrishi, Sekineh Faraji, Fatemeh Frajzadeh

“…A large financial burden is imposed on the families and health systems of countries in addition to the problems related to the disabilities caused by the disease for the patients. …”
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Fibrocyte enrichment and myofibroblastic adaptation causes nucleus pulposus fibrosis and associates with disc degeneration severity by Yi Sun, Yan Peng, Zezhuo Su, Kyle, K. H. So, Qiuji Lu, Maojiang Lyu, Jianwei Zuo, Yongcan Huang, Zhiping Guan, Kenneth M. C. Cheung, Zhaomin Zheng, Xintao Zhang, Victor Y. L. Leung

“…Abstract Fibrotic remodeling of nucleus pulposus (NP) leads to structural and mechanical anomalies of intervertebral discs that prone to degeneration, leading to low back pain incidence and disability. Emergence of fibroblastic cells in disc degeneration has been reported, yet their nature and origin remain elusive. …”
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Operationalizing goal setting as an outcome measure in trials involving patients with frailty, multimorbidity or complexity by Emma Tenison, Katherine Lloyd, Yoav Ben-Shlomo, Emily J. Henderson

“…Disease-specific outcomes have limitations in older people, those with cognitive impairment, multimorbidity, disability or short life expectancy. We aimed to select, and adapt as needed, a primary outcome to evaluate a multicomponent intervention for people with parkinsonism. …”
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Sleep profile in patients with septo-optic-pituitary dysplasia: protocol for a prospective cohort study by Romina Romaniello, Sabrina Signorini, Elena Ballante, Valentina Franco, Valentina De Giorgis, Ludovica Pasca, Guido Catalano, Federica Morelli, Carlo Alberto Quaranta, Helene Vitali, Francesca Dattrino, Francesca Crema, Paola Rota, Costanza Varesio

“…Introduction Children with septo-optic-pituitary dysplasia (SOD) may experience a range of visual impairments and hormonal dysfunctions beyond developmental delay/intellectual disability. The literature describes sleep fragmentation, circadian rhythm disruptions and reduced sleep efficiency. …”
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Impact of socio-demographic structure of the deaf people communities in prevalence of hereditary hearing loss by O. L. Posukh, M. S. Bady-Khoo, M. V. Zytsar, V. Yu. Mikhalskaia, S. A. Lashin, N. A. Barashkov, G. P. Romanov

“…Hearing loss caused by environmental or genetic factors concerns more than 10 % of the world population. It leads to disability and considerably reduces the life quality of deaf people. …”
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Clinical Characteristics and Outcomes of Deep Vein Thrombosis in Relation to Location: A Retrospective Analysis Study by Majed S. Al Yami PharmD, Abdulmajeed M. Alshehri PharmD, Ghadah M. Alotaibi PharmD, Mariam S. Alsulimani PharmD, Fay M. Alotaibi PharmD, Rawan A. Alotaibi PharmD, Nouf A. Alqahtani PharmD, Lama A. Alhumaidan PharmD, Lubna S. Bin Hadhir PharmD, Norah M. Alebrah PharmD, Sumaya N. Almohareb PharmD, Omar A. Alshaya PharmD, Omar S. Alkhezi PharmD, Osamah M. Alfayez PharmD, Omar A. Almohammed PhD, Amal M. Badawoud PhD

“…Background: Deep vein thrombosis (DVT) is a leading cause of death disability. DVT can be classified based on the location and extent of the clot into isolated distal DVT (iDDVT), isolated proximal DVT (iPDVT), or mixed DVT. …”
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Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population by Monika Chorąży, Natalia Wawrusiewicz-Kurylonek, Edyta Adamska-Patruno, Olga Zajkowska, Katarzyna Kapica-Topczewska, Renata Posmyk, Adam Jacek Krętowski, Jan Kochanowicz, Alina Kułakowska

“…The aim of our study was to evaluate the frequencies of alleles and genetic variants of the T-cell homeostasis-related genes, in subjects with MS, as well as to investigate the association with MS clinical manifestations and disability. Methods. 94 subjects with MS and 160 healthy individuals have been genotyped for seven common single-nucleotide variants in IL-2RA, CTLA4, CD40, and PADI4 genes. …”
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Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial by Luz E. Gasca-Lozano, Silvia Lucano-Landeros, Héctor Ruiz-Mercado, Adriana Salazar-Montes, Ana Sandoval-Rodríguez, Jesus Garcia-Bañuelos, Arturo Santos-Garcia, Judith R. Davila-Rodriguez, José Navarro-Partida, Hiram Bojórquez-Sepúlveda, Juan Castañeda-Gomez, José Domínguez-Rosales, Myriam A. Ruiz-Arcos, María Guadalupe Sánchez-Parada, Juan Armendariz-Borunda

“…Diabetic foot ulcers are one disabling complication of diabetes mellitus. Pirfenidone (PFD) is a potent modulator of extracellular matrix. …”
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Clinical Outcomes of Diffuse Axonal Injury According to Radiological Grade by Hak-Jae Lee, Hyun-Woo Sun, Jae-Seok Lee, Nak-Joon Choi, Yoon-Joong Jung, Suk-Kyung Hong

“…Purpose Patients with diffuse axonal injury experience various disabilities and have a high cost of treatment. Recent researches have revealed the underlying mechanism and pathogenesis of diffuse axonal injury. …”
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Natural population cohort study on long-lived adults: West China longevity and ageing procedure (WCLAP) by Li Wang, Yan Zhang, Qiukui Hao, Xiaoyan Chen, Birong Dong, Yan He, Meijuan Chen, Jirong Yue, Xiaochu Wu, Tianyao Zhang, Yan She, Yanling Gao, Yiping Deng

“…Baseline data, group-level follow-up data and microbiological examination data are integrated together to provide an evaluation tool, exploring sarcopenia, disability, dementia, caregiver burden, ageing biomarkers and other influencing factors.Trial registration numbers 2018-463; ChiCTR1900020754.…”
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Lactiplantibacillus plantarum AR113 alleviates microbiota dysbiosis of tongue coating and cerebral ischemia/reperfusion injury in rat by Zhiqiang Xiong, Gang Liu, Ling Fang, Xiuming Li, Yongjun Xia, Guangqiang Wang, Xin Song, Lianzhong Ai

“…Stroke is one of the leading causes of death and disability worldwide. However, information on stroke-related tongue coating microbiome (TCM) is limited, and whether TCM modulation could benefit for stroke prevention and rehabilitation is unknown. …”
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The Epidemiology of Migraine Headache in Arab Countries: A Systematic Review by Ashraf El-Metwally, Paivi Toivola, Khalid AlAhmary, Salwa Bahkali, Ali AlKhathaami, Shatha A. Al Ammar, Ibrahim M. Altamimi, Saleh M. Alosaimi, Munazza Jawed, Sami Almustanyir

“…Recurring migraine disorders are a common medical problem, standing among the top causes of disability and sufferings. This study aimed to evaluate epidemiological evidence to report updated estimates on prevalence, risk factors, and associated comorbidities of migraine headache in the Arab countries. …”
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Genotypic Spectrum in a Cohort of Sri Lankan Patients With Homocystinuria by Hewa Warawitage Dilanthi, Kandana Liyanage Subhashinie Jayasena, Nambage Dona Priyani Dhammika, Neluwa Liyanage Ruwan Indika, Matara Mahavidanage Nishani De Silva, Imalke Kankananarachchi, Pushpa Malkanthi Gardiye Punchihewa, Dharma Irugalbandara, Sabine Schroeder, Kosala Karunaratne, Eresha Jasinge

“…Among the 14 patients, the common clinical features were ectopia lentis (100%), intellectual disability (92%) and marfanoid features (78%) at presentation while three of them had developed osteoporosis (21%). …”
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Clinical and molecular analyses of isolated central congenital hypothyroidism based on a survey conducted in Japan by Nao Shibata, Chikahiko Numakura, Takashi Hamajima, Kenichi Miyako, Ikuma Fujiwara, Jun Mori, Akihiko Saitoh, Keisuke Nagasaki

“…One and two patients with IGSF1 variant had obesity and intellectual disability, respectively. Left amblyopia was identified in the patient with a TBL1X variant. …”
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Advancing sustainable healthcare through multidisciplinary stroke team rehabilitation by Hanna C. Persson, Hanna C. Persson, Malin Reinholdsson, Malin Reinholdsson, Elvira Lange, Elvira Lange, Elvira Lange, Stefi Barna, Annie Palstam, Annie Palstam, Annie Palstam, Annie Palstam

“…The vulnerability of individuals with disabilities to climate change has been highlighted, calling for global collaboration to address climate justice and health equity. …”
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Predictors of irritability in pediatric autistic populations: a scoping review by Sara Alatrash, Sara Alatrash, Tithi Paul, Julia Carbone, Melanie Penner, Melanie Penner, Atena Roshan Fekr, Atena Roshan Fekr, Azadeh Kushki, Azadeh Kushki

“…IntroductionAutism is characterized by social communication differences and repetitive behaviors, affecting 1%–2% of children. Irritability is a disabling condition affecting 19%–80% of autistic children. …”
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Burdens of Tracheal, Bronchus, and Lung Cancer From 1990 to 2021 in China Compared to the Global Projection of 2036: Findings From the 2021 Global Burden of Disease Study by Yuxing Chen, Qingpeng Zeng, Muyu Li, Jiahui Jin, Jun Zhao

“…Methods We conducted an analysis of incidence, prevalence, mortality, and disability‐adjusted life years (DALYs) from 1990 to 2021. …”
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Epidemiology of snake bites and envenomations in the Bofidji Group – West, Equateur Province, Democratic Republic of the Congo by Blaise Engomba Mokekola, Jean-Paul Koto-Te-Nyiwa Ngbolua, Guy Bayeli Ilumbe, Idrissa Zabo Assumani, Aristarque Mulonda, Monizi Mawunu, Gires Mboyo Engomba, Colette Ashande Masengo, Godefroid Libono Ekamba

“… Introduction Snakebites are a major public health concern in the Democratic Republic of the Congo (DRC) and tropical Africa, causing thousands of deaths and disabilities annually. Limited access to antivenom and modern healthcare forces rural communities to rely on traditional remedies. …”
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Epidemiology of urinary tract infections in the Middle East and North Africa, 1990–2021 by Fatemeh Amiri, Saeid Safiri, Reza Aletaha, Mark J. M. Sullman, Kamaleddin Hassanzadeh, Ali-Asghar Kolahi, Shahnam Arshi

“…Abstract Objective This research reports the incidence, mortality, and disability-adjusted life years (DALYs) associated with urinary tract infections (UTIs) in the Middle East and North Africa (MENA) region, stratified by sex, age, and Socio-demographic Index (SDI) from 1990 to 2021. …”
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