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  1. 2261

    The Feasibility of Using the Direct Anterior Approach for Total Hip Arthroplasty or Bipolar Hemiarthroplasty to Treat Femoral Neck Fractures among the Elderly by Shigeo Ishiguro, Kunihiro Asanuma, Tomohito Hagi, Hidehiko Ohsumi, Hiroki Wakabayashi, Akihiro Sudo

    Published 2022-01-01
    “…Femoral neck fractures (FNFs) are a significant cause of mortality and disability among the elderly. Total hip arthroplasty (THA) is the preferred treatment method in active, cognitively intact patients. …”
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  2. 2262

    Stigma related to podoconiosis in Ethiopia: a systematic review by Temesgen Lera Abiso, Amene Abebe Kerbo, Eskinder Wolka Woticha, Mengistu Meskele Koyira

    Published 2024-12-01
    “…BackgroundPodoconiosis, one of the neglected tropical diseases (NTDs), affects barefoot people in impoverished regions and contributes to poverty by having negative impacts on economic output, education, and disability. Podoconiosis has enormous social, psychological, and economic implications for the affected individuals. …”
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  3. 2263

    Sarcopenia and frailty as predictor of outcome in critically ill elderly patients with multiple comorbidities by Dina mostafa Elmaleh, Dina Morsy Ahmed Mohamed

    Published 2025-01-01
    “…Frailty, a multi-system illness linked to heightened vulnerability to stresses, and sarcopenia, a loss of muscle mass and function, both raise the likelihood of unfavorable health outcomes including disability or death. This work’s objective was to study the clinical utility of sarcopenia and frailty in critically ill elderly patients with multiple comorbidities. …”
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  4. 2264

    Enhancing Sarcopenia Prediction Through an Ensemble Learning Approach: Addressing Class Imbalance for Improved Clinical Diagnosis by Dilmurod Turimov, Wooseong Kim

    Published 2024-12-01
    “…This study developed an advanced ensemble learning model aimed to improve the accuracy of predicting sarcopenia, a condition characterized by a gradual decline in muscle mass and strength, leading to increased disability and mortality. The study focused on enhancing model performance by combining various machine learning methods and addressing critical challenges, such as class imbalance and data complexity. …”
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  5. 2265

    Poststroke Erectile Dysfunction in Cameroon: Prevalence, Associated Factors, and Quality of Life by Daniel Gams Massi, Gervais Ngoupayou Mountap, Hervé Edouard Moby, Frantz Guy Epoupa Ngalle, Sidick Mouliom, Jacques Doumbe, Njankouo Yacouba Mapoure

    Published 2021-01-01
    “…It is the first cause of acquired disability including erectile dysfunction (ED). The purpose of this study was to determine the prevalence of ED in stroke patients at the Douala General Hospital, to identify associated factors and to evaluate their quality of life. …”
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  6. 2266

    A study on the global burden of non-melanoma skin cancer from 1990 to 2019 by Zixiang Si, Jieya Ying, Yingli Zhou

    Published 2024-04-01
    “…We analyzed incident cases, incidence rate, disability-adjusted life years (DALYs), DALY rate, as well as age-standardized indicators and their annualized percent change (EAPC). …”
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  7. 2267

    Sex differences in the murine HPA axis after acute and repeated restraint stress by Isabella Flor Nalepa, Vibeke Nielsen, Tanja Esther Wolf, Chadi Touma, Morten Grupe, Ayodeji A. Asuni, Cecilia Ratner

    Published 2025-12-01
    “…Chronic stress and stress-related mental illnesses such as major depressive disorder (MDD) constitute some of the leading causes of disability worldwide with a higher prevalence in women compared to men. …”
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  8. 2268

    Advances in chromosomal microarray analysis: Transforming neurology and neurosurgery by Wireko Andrew Awuah, Muhammad Hamza Shah, Vivek Sanker, Krishitha Meenu Mannan, Sruthi Ranganathan, Princess Afia Nkrumah-Boateng, Mabel Frimpong, Kwadwo Darko, Joecelyn Kirani Tan, Toufik Abdul-Rahman, Oday Atallah

    Published 2025-01-01
    “…In neurodevelopmental disorders, CMA aids in diagnosing autism and intellectual disabilities, facilitating early interventions that improve long-term outcomes. …”
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  9. 2269

    A safety and feasibility randomized placebo controlled trial exploring electroencephalographic effective connectivity neurofeedback treatment for fibromyalgia by Lucy Anderson, Dirk De Ridder, Paul Glue, Ramakrishnan Mani, Cindy van Sleeuwen, Mark Smith, Divya Bharatkumar Adhia

    Published 2025-01-01
    “…Abstract Fibromyalgia is a chronic pain condition contributing to significant disability worldwide. Neuroimaging studies identify abnormal effective connectivity between cortical areas responsible for descending pain modulation (pregenual anterior cingulate cortex, pgACC) and sensory components of pain experience (primary somatosensory cortex, S1). …”
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  10. 2270

    A Hybrid Transformer Architecture for Multiclass Mental Illness Prediction Using Social Media Text by Adnan Karamat, Muhammad Imran, Muhammad Usman Yaseen, Rasool Bukhsh, Sheraz Aslam, Nouman Ashraf

    Published 2025-01-01
    “…To address this limitation, there is a requirement for domain-specific pretrained language models that comprehensively understand the context found in posts of person with a psychiatric disability patients. Posts from individuals with mental illness often contain metaphorical expressions, posing a challenge for existing models in understanding such figurative language. …”
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  11. 2271

    Sotos syndrome with marked overgrowth in three Japanese patients with heterozygous likely pathogenic NSD1 variants: case reports with review of literature by Yohei Masunaga, Hiroyuki Ono, Yasuko Fujisawa, Kiyosu Taniguchi, Hirotomo Saitsu, Tsutomu Ogata

    Published 2024-01-01
    “…In addition to the marked overgrowth (tall stature), patients 1–3 exhibited Sotos syndrome-compatible macrocephaly and characteristic features, whereas intellectual and developmental disabilities remained at a borderline level in patient 1 and were apparently absent from patients 2 and 3. …”
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  12. 2272
  13. 2273

    Prevention and management of degenerative lumbar spine disorders through artificial intelligence-based decision support systems: a systematic review by Paolo Giaccone, Federico D’Antoni, Fabrizio Russo, Luca Ambrosio, Giuseppe Francesco Papalia, Onorato d’Angelis, Gianluca Vadalà, Albert Comelli, Luca Vollero, Mario Merone, Rocco Papalia, Vincenzo Denaro

    Published 2025-02-01
    “…Abstract Background Low back pain is the leading cause of disability worldwide with a significant socioeconomic burden; artificial intelligence (AI) has proved to have a great potential in supporting clinical decisions at each stage of the healthcare process. …”
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  14. 2274

    A guide to selecting high-performing antibodies for Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) for use in Western Blot, immunoprecipi... by Carl Laflamme, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Charles Alende

    Published 2024-07-01
    “…Pathogenic mutations in the PPP2R5D gene are linked to clinical symptoms characterized by neurodevelopmental delay, intellectual disability, and autism spectrum disorders. The etiology of these genetic disorders remains unknown, which can partly be due to the lack of independently characterized antibodies. …”
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  15. 2275

    Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] by Céline Heinl, Ines Schadock, Maximilian Wurm, Paul Lucas Wildner, Daniel Butzke, Bettina Bert, Alexandra Bannach-Brown, Matthias Steinfath, Kai Diederich

    Published 2024-11-01
    “…In this review, we systematically analyze the age and sex of mice used to model the five leading causes of global disability-adjusted life-years over the age of 75. We compare the results with the age and sex of patients in clinical trials focusing on Alzheimer's disease, stroke, type 2 diabetes mellitus, ischemic heart disease, and chronic obstructive pulmonary disease. …”
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  16. 2276

    Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China by Q. Wu, H. Wu, Yu. L. Orlov, G. Gegentana, W. Huo, A. O. Bragin, N. Wu, S. Suyalatu, F. Zhao, J. Zhao, L. E. Tabikhanova, M. Chen, H. Bai

    Published 2017-11-01
    “…Ischemic stroke is caused by an interruption in the flow of blood to the brain and a risk factor for death and disability. Recent genome-wide association studies have identified more than 40 common sequence variants associated with ischemic stroke. …”
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  17. 2277

    CORRELATION BETWEEN KNEE OSTEOARTHRITIS (OA) GRADE AND BODY MASS INDEX (BMI) IN OUTPATIENTS OF ORTHOPAEDIC AND TRAUMATOLOGY DEPARTMENT RSUD DR. SOETOMO by Lukas Widhiyanto, Andre Triadi Desnantyo, Lilik Djuari, Maynura Kharismansha

    Published 2019-12-01
    “…Osteoarthritis (OA) is the number eight disease causes Years of Disability in developing countries. OA worsen life quality, from movement limitation until inability to perform normal daily routines. …”
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  18. 2278

    Does Scoliosis-Specific Exercise Treatment in Adolescence Alter Adult Quality of Life? by Maciej Płaszewski, Igor Cieśliński, Paweł Kowalski, Aleksandra Truszczyńska, Roman Nowobilski

    Published 2014-01-01
    “…The WHOQOL-BREF questionnaire, Oswestry Disability Questionnaire, and pain scale (VAS) were applied. …”
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  19. 2279

    Polysaccharide-based biomaterials for regenerative therapy in intervertebral disc degeneration by Xin Wang, Yixue Huang, Yilin Yang, Xin Tian, Yesheng Jin, Weimin Jiang, Hanliang He, Yong Xu, Yijie Liu

    Published 2025-02-01
    “…Intervertebral disc (IVD) degeneration represents a significant cause of chronic back pain and disability, with a substantial impact on the quality of life. …”
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  20. 2280

    Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3 by Yiting Zhang, Chao Li, Siyi Li, Yiping Lu, Sitong Du, Xinning Zeng, Xi Chen, Jie Chen

    Published 2019-01-01
    “…Occupational exposure to crystalline silica (CS) results in a persistent pulmonary inflammatory response that eventually leads to abnormal tissue repair, disability, and death. The inflammatory-immune responses occur in the early stages of CS exposure, and both innate and adaptive immunity are involved. …”
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