Chronic Pain in the Emergency Department: A Pilot Mixed-Methods Cross-Sectional Study Examining Patient Characteristics and Reasons for Presentations by Patricia A. Poulin, Jennifer Nelli, Steven Tremblay, Rebecca Small, Myka B. Caluyong, Jeffrey Freeman, Heather Romanow, Yehudis Stokes, Tia Carpino, Amanda Carson, Yaadwinder Shergill, Ian G. Stiell, Monica Taljaard, Howard Nathan, Catherine E. Smyth

“…We used a mixed-method design combining interviews and questionnaires addressing pain, psychological distress, signs of opioid misuse, and disability. Participants were adults who attended the EDs of a large academic tertiary care center for their CP problem. …”
Get full text

Cognitive Status Correlates with CXCL10/IP-10 Levels in Parkinson’s Disease by Natália Pessoa Rocha, Paula Luciana Scalzo, Izabela Guimarães Barbosa, Mariana Soares Souza, Isabela Boechat Morato, Érica Leandro Marciano Vieira, Paulo Pereira Christo, Antônio Lúcio Teixeira, Helton José Reis

“…Cognitive impairment and depressive symptoms are of great interest in Parkinson’s disease (PD), since they are very common and lead to increased disability with poor quality of life. Inflammatory mechanisms have been implicated in PD and its nonmotor symptoms. …”
Get full text

Clinical Outcomes of Extreme Lateral Interbody Fusion in the Treatment of Adult Degenerative Scoliosis by Adam M. Caputo, Keith W. Michael, Todd M. Chapman, Gene M. Massey, Cameron R. Howes, Robert E. Isaacs, Christopher R. Brown

“…The study group demonstrated improvement in multiple clinical outcome scores. Oswestry Disability Index scores improved from 24.8 to 19.0 (P < 0.001). …”
Get full text

Logical reasoning for human activity recognition based on multisource data from wearable device by Mahmood Alsaadi, Ismail Keshta, Janjhyam Venkata Naga Ramesh, Divya Nimma, Mohammad Shabaz, Nirupma pathak, Pavitar Parkash Singh, Sherzod Kiyosov, Mukesh Soni

“…Abstract Smart wearable devices detection and recording of people’s everyday activities is critical for health monitoring, helping persons with disabilities, and providing care for the elderly. Most of the research that is being conducted uses a machine learning-based methodology; however, these approaches frequently have issues with high computing resource consumption, burdensome training data gathering, and restricted scalability across many contexts. …”
Get full text

Addressing ADL ability in people with poststroke cognitive impairments: A Danish survey of clinical practice by E. Ghaziani, S. S. Christensen, C. H. Arens, E. E. Wæhrens

“…Background In Denmark, stroke represents a leading disability cause. While people with difficulties in performing activities of daily living (ADL) due to poststroke cognitive impairments are often referred to occupational therapy, limited knowledge is available on the nature of these services.Aim/Objective To explore how Danish occupational therapists describe their practice when addressing decreased ADL ability in people with poststroke cognitive impairments in hospital and municipality settings.Material and Methods National, cross-sectorial, web-based public survey.Results 244 occupational therapists accessed the survey; 172 were included in the analysis. …”
Get full text

Neural mechanisms of self-processing in autism: An ALE-based meta-analysis by Yue Yuan, Mingda Tao, Aibao Zhou, Xiangli Guan, Jiaomei Zhang

“…By clarifying these neurobiological disparities, we acquire a more profound comprehension of the processes that cause social disabilities in ASD. This insight could possibly guide the creation of focused treatments designed to enhance social performance and enhance the quality of life for those with ASD.…”
Get full text

Benefits of Repetitive Transcranial Magnetic Stimulation (rTMS) for Spastic Subjects: Clinical, Functional, and Biomechanical Parameters for Lower Limb and Walking in Five Hemipa... by Luc Terreaux, Raphael Gross, Fabien Leboeuf, Hubert Desal, Olivier Hamel, Jean Paul Nguyen, Chantal Pérot, Kévin Buffenoir

“…Introduction. Spasticity is a disabling symptom resulting from reorganization of spinal reflexes no longer inhibited by supraspinal control. …”
Get full text

Intravenous Immunoglobulin Therapy Administered Early after Narcolepsy Type 1 Onset in Three Patients Evaluated by Clinical and Polysomnographic Follow-Up by Elisabeth Ruppert, Hélène Zagala, Juliette Chambe, Henri Comtet, Ulker Kilic-Huck, François Lefebvre, Marc Bataillard, Carmen Schroder, Laurent Calvel, Patrice Bourgin

“…Narcolepsy type 1 is a rare disabling sleep disorder mainly characterized by excessive daytime sleepiness and cataplexy, an emotion-triggered sudden loss of muscle tone. …”
Get full text

Rubella and Congenital Rubella Syndrome in the Philippines: A Systematic Review by Anna Lena Lopez, Peter Francis N. Raguindin, Maria Asuncion Silvestre, Xenia Cathrine J. Fabay, Ariel B. Vinarao, Ricardo Manalastas

“…Previous studies show substantial disabilities due to CRS and a substantial proportion of susceptible women who are at risk for having babies affected with CRS. …”
Get full text

Too Aggressive Drop in Blood Pressure in a Hypertensive Male Leading to “Man-in-the-Barrel Syndrome” by Chamara Dalugama, Achila Jayasinghe, Udaya Ralapanawa, Shamali Abeygunawardena, Thilak Jayalath

“…Ischemic damage caused by rapid lowering of blood pressure may rarely result in “man-in-the-barrel syndrome” leading to severe functional disability.…”
Get full text

Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis by Victória dos Santos Chemelo, Marco Aurelio M. Freire, Leonardo Oliveira Bittencourt, Deborah Ribeiro Frazão, Deiweson Souza-Monteiro, Sabrina C. Cartagenes, Walace Gomes-Leal, Cristiane do Socorro Ferraz Maia, Gabriel S. Rocha, Daniel Falcao, Rafael Rodrigues Lima

“…Currently, stroke stands as the second leading cause of death worldwide and the third leading cause when considering both mortality and disability together. Periodontitis is characterized by persistent inflammation in hard and soft tissues which support the teeth, primarily caused by bacterial biofilms, and is one of the most common causes of tooth loss in adults and can contribute to a systemic inflammatory burden. …”
Get full text

Human platelet lysate: a potential therapeutic for intracerebral hemorrhage by Dachang Qiu, Lin Wang, Lanlan Wang, Yongfei Dong

“…Intracerebral hemorrhage (ICH) is a major public health challenge worldwide, and is associated with elevated rates of mortality, disability, and morbidity, especially in low- and middle-income nations. …”
Get full text

Up-Regulation of Endothelin Receptors Induced by Cigarette Smoke — Involvement of MAPK in Vascular and Airway Hyper-Reactivity by Yaping Zhang, Lars Edvinsson, Cang-Bao Xu

“…Cigarette smoke exposure is well known to cause cardiovascular and airway diseases, both of which are leading causes of death and disability in the world. However, the molecular mechanisms that link cigarette smoke to cardiovascular and airway diseases are not fully understood. …”
Get full text

Severe Psychomotor Delay in a Severe Presentation of Cat-Eye Syndrome by Guillaume Jedraszak, Aline Receveur, Joris Andrieux, Michèle Mathieu-Dramard, Henri Copin, Gilles Morin

“…Many reported cases also presented with variable congenital anomalies and intellectual disability. Most patients diagnosed with CES carry a small supernumerary bisatellited marker chromosome, resulting in partial tetrasomy of 22p-22q11.21. …”
Get full text

Snoezelen or Controlled Multisensory Stimulation. Treatment Aspects from Israel by Joav Merrick, Carmit Cahana, Meir Lotan, Isack Kandel, Eli Carmeli

“…In Israel today, with a total population of over 6 million persons, the Division for Mental Retardation (DMR) provides services to 23,000 persons with intellectual disability (ID). Of the 23,000, residential services are provided to more than 6,000 in close to 60 residential centers, another 2,000 are provided residential care in hostels or group homes in the community in about 50 locations, while the rest are served with day-care kindergarten, day-treatment centers, sheltered workshops, or integrated care in the community. …”
Get full text

Early Infantile Epileptic Encephalopathy in an STXBP1 Patient with Lactic Acidemia and Normal Mitochondrial Respiratory Chain Function by Dong Li, Elizabeth Bhoj, Elizabeth McCormick, Fengxiang Wang, James Snyder, Tiancheng Wang, Yan Zhao, Cecilia Kim, Rosetta Chiavacci, Lifeng Tian, Marni J. Falk, Hakon Hakonarson

“…A wide range of clinical findings have been associated with mutations in Syntaxin Binding Protein 1 (STXBP1), including multiple forms of epilepsy, nonsyndromic intellectual disability, and movement disorders. STXBP1 mutations have recently been associated with mitochondrial pathology, although it remains unclear if this phenotype is a part of the core feature for this gene disorder. …”
Get full text

Utilization of telemedicine in conjunction with wearable devices for patients with chronic musculoskeletal pain: a randomized controlled clinical trial by Kazuhiro Hayashi, Kenji Miki, Yukiko Shiro, Tomoko Tetsunaga, Toshifumi Takasusuki, Masako Hosoi, Masao Yukioka

“…The secondary outcome measures were the Pain Catastrophizing Scale (PCS), Hospital Anxiety and Depression Scale (HADS), Pain Disability Assessment Scale (PDAS), and EuroQol-five dimensions-three level (EQ-5D-3L). …”
Get full text

Engineered tRNAs efficiently suppress CDKL5 premature termination codons by Stefano Pezzini, Aurora Mustaccia, Pierre Aboa, Giorgia Faustini, Alessio Branchini, Mirko Pinotti, Angelisa Frasca, Joseph J. Porter, John D. Lueck, Nicoletta Landsberger

“…Abstract The CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental disorder characterized by early-onset epilepsy, intellectual disability, motor and visual dysfunctions. The causative gene is CDKL5, which codes for a kinase required for brain development. …”
Get full text

Factors for Predicting Favorable Outcome of Percutaneous Epidural Adhesiolysis for Lumbar Disc Herniation by Sang Ho Moon, Jae Il Lee, Hyun Seok Cho, Jin Woo Shin, Won Uk Koh

“…Lower back pain is a common reason for disability and the most common cause is lumbar disc herniation. …”
Get full text

Reliability and Validity of the Persian Version of the Fatigue Severity Scale in Idiopathic Parkinson’s Disease Patients by Seyed-Mohammad Fereshtehnejad, Hasti Hadizadeh, Farzaneh Farhadi, Gholam Ali Shahidi, Ahmad Delbari, Johan Lökk

“…The total score of the FSS-Per significantly discriminated IPD patients with more severe disability (HY stage > 2) versus those with less severe disease (HY stage ) (AUC = 0.81 (95% CI: 0.72–0.90)). …”
Get full text