Protocol for the impact of CBT for insomnia on pain symptoms and central sensitisation in fibromyalgia: a randomised controlled trial by Michael Robinson, Chokkalingam Siva, Christina S McCrae, Ashley F Curtis, Jason Craggs, Chelsea Deroche, Pradeep Sahota, Roland Staud

“…The following assessments will be completed: 2 weeks of daily diaries measuring sleep and pain, daily actigraphy, insomnia severity index, pain-related disability, single night of polysomnography recording, arousal (heart rate variability, cognitive affective arousal), structural and functional MRI to examine pain-related neural activity and plasticity and mood (depression, anxiety).Ethics and dissemination Ethics approval was obtained in July 2018 from the University of Missouri. …”
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Modern classification and molecular-genetic aspects of osteogenesis imperfecta by A. R. Zaripova, R. I. Khusainova

“…Osteogenesis imperfecta (imperfect osteogenesis in the Russian literature) is the most common hereditary form of bone fragility, it is a genetically and clinically heterogeneous disease with a wide range of clinical severity, often leading to disability from early childhood. It is based on genetic disorders leading to a violation of the structure of bone tissue, which leads to frequent fractures, impaired growth and posture, with the development of characteristic disabling bone deformities and associated problems, including respiratory, neurological, cardiac, renal impairment, hearing loss. …”
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Early childhood constraint therapy for sensory/motor impairment in cerebral palsy: a randomised clinical trial protocol by Garey Noritz, Olena Chorna, Jill Heathcock, Alexandra Key, Helen Carey, Ellyn Hamm, Mary Ann Nelin, Micah Murray, Amy Needham, James C Slaughter, Nathalie L Maitre

“…Introduction Cerebral palsy (CP) is the most common physical disability in childhood. It is a disorder resulting from sensory and motor impairments due to perinatal brain injury, with lifetime consequences that range from poor adaptive and social function to communication and emotional disturbances. …”
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Persistence with Early-Line Abatacept versus Tumor Necrosis Factor-Inhibitors for Rheumatoid Arthritis Complicated by Poor Prognostic Factors by Xue Han, Francis Lobo, Michael S. Broder, Eunice Chang, Sarah N. Gibbs, David J. Ridley, Irina Yermilov

“…**Background:** Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by joint swelling and destruction that leads to severe disability. There are no clear guidelines regarding the order of therapies. …”
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Genetic polymorphisms and related risk factors of ischemic stroke in a Mongolian population in China by Q. Wu, H. Wu, Yu. L. Orlov, G. Gegentana, W. Huo, A. O. Bragin, N. Wu, S. Suyalatu, F. Zhao, J. Zhao, L. E. Tabikhanova, M. Chen, H. Bai

“…Ischemic stroke is caused by an interruption in the flow of blood to the brain and a risk factor for death and disability. Recent genome-wide association studies have identified more than 40 common sequence variants associated with ischemic stroke. …”
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Enhancing individual task performance and productivity: an ethnographic observational study of supported employment among social services clients in Finland by Pirjo Juvonen-Posti, Mirkka Vuorento

“…Results The main findings were that persons with disability or decreased work ability were employed in precarious low-productivity work, with limited opportunities for more sustainable employment. …”
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Individual and joint effects of exposure to multiple organophosphate esters and the risk of depression in adults: Differences in sex, age, and physical activity by Qingmiao Wei, Jiyun Wei, Jun Liang

“…Depression, a severe mental disorder, is a prominent cause of global disability and worldwide. Organophosphate esters (OPEs) are neuron-disrupting chemicals that potentially cause depression. …”
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Long-Term Health-Related Quality of Life in Kawasaki Disease-Related Coronary Artery Aneurysm: A Large Single-Center Assessment in Nanjing, China by Yun Zhou, MD, Mei Chen, MD, Wenting Gao, MD, Yu Chen, MD, Ying Meng, MD

“…Routine outpatient HRQOL screening could be instituted to help eliminate the risk of long-term disability following initial clinical improvement.…”
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Effect of Repeated Remote Ischemic Preconditioning on Peripheral Arterial Disease in Patients Suffering from Intermittent Claudication by Mehmet Balin, Tarık Kıvrak

“…Intermittent claudication (IC) is the symptom of peripheral artery disease (PAD) and causes functional disability. Remote ischemic preconditioning (RIPC), is a phenomenon in which a short period of sub-critical ischemia, protects tissues against ischemia/reperfusion/injury. …”
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Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, C... by Nattaphol Uransilp, Pannawat Chaiyawatthanananthn, Sombat Muengtaweepongsa

“…Stroke is the leading cause of death and long-term disability. Oxidative stress is elevated during occurrence of acute ischemic stroke (AIS). …”
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Association of Prehypertension with Renin Angiotensin System: A Cross-Sectional Study on Tribal Population of Northern India by Vani Kandpal, Mohinder Pal Sachdeva, Kallur Nava Saraswathy

“…Introduction: Hypertension (HTN), the third risk factor driving death and disability as per Global Burden of Disease 2019, is a major public health concern. …”
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The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with age-related hearing impairment in a Taiwanese population: a case control study by Ning-Chia Chang, Hua-Ling Yang, Chia-Yen Dai, Wen-Yi Lin, Hsun-Mo Wang, Chen-Yu Chien, Kuen-Yao Ho

“…Abstract Background Age-related hearing impairment (ARHI) is a major disability among the elder population. Chronic inflammation is an important factor in the development of ARHI. …”
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A comparison of kinesiophobia, pain-activity patterns and fear-avoidance beliefs in patients with chronic low back pain by Egemen Kızılay, Fatma Kızılay, Betül Ergün

“…According to fear - avoidance models, kinesiophobia is related to pain severity and disability. Kinesiophobia is a psychological factor that attracts attention in people with persistent pain, is related to the severity and persistence of pain. …”
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Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury by Duraisamy Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Ramasamy Thangavel, Sudhanshu P. Raikwar, Smita A. Zaheer, Shankar S. Iyer, Casey Burton, Donald James, Asgar Zaheer

“…Traumatic brain injury (TBI) is one of the major health problems worldwide that causes death or permanent disability through primary and secondary damages in the brain. …”
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Multicenter Randomized Clinical Trial of Brief Psychotherapy versus Usual Treatment for Common Mental Disorders in Adults by Marco A. Luengo-Castro, Javier Fernández-Méndez, José M. García-Montes, Pedro J. Caunedo-Riesco, Juan M. García-Haro, Begoña Braña-Menéndez, Dolores González-Díaz, Andrés Cabero-Álvarez, Marcelino Cuesta-Izquierdo

“…Pre-treatment and up to 3-year assessments were conducted on clinical-administrative, symptomatic, disability, satisfaction, and psychopharmacological consumption. …”
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Estilo de vida e nível de atividade física de indivíduos com dor no ombro atendidos em um serviço público by Jessica Pagioto, Jaqueline Martins, Cesário Souza, Anamaria Oliveira

“…Esse estudo teve como objetivo caracterizar o Perfil de Estilo de Vida Individual (PEVI) de indivíduos com dor no ombro em relação à atividade física (AF), nutrição, controle do estresse, relacionamento social e comportamento preventivo e verificar a correlação entre o componente AF do PEVI e o domínio de incapacidade avaliado pelo Shoulder Pain and Disability Index (SPADI). Trata-se de um estudo transversal, com 100 indivíduos adultos e idosos com dor no ombro (55,3 ± 12 anos, 83% mulheres) atendidos em um serviço público de fisioterapia em 2015/2016. …”
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Neuroprotection in intrauterine herpesvirus infection by M.V. Khaitovych, R.I. Zhdanovych

“…Perinatal disorders of the central nervous system led to the disability of 2 (6.7%) children of the comparison group. …”
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Invasive Klebsiella pneumoniae liver abscess syndrome complicated by carbapenem-resistant Acinetobacter baumannii infection: a case report by Qiupeng Feng, Qiupeng Feng, Hua Yuan, Hua Yuan, Jin Ma, Jin Ma, Zhiqiang Guo, Zhiqiang Guo, Xiaohua Xia, Xiaohua Xia, Guang Zhao, Guang Zhao

“…This condition, known as Klebsiella pneumoniae liver abscess invasion syndrome, progresses rapidly and is associated with severe illness, high disability rates, and significant mortality. However, bloodstream infections with co-infection involving carbapenem-resistant Acinetobacter baumannii are exceedingly rare.Case presentationThe Emergency Medicine Department of the First People’s Hospital of Kunshan successfully treated a male patient diagnosed with liver, lung, and prostate abscesses. …”
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Idiopathic Central Precocious Puberty Associated with 11 Mb De Novo Distal Deletion of the Chromosome 9 Short Arm by Mariangela Cisternino, Erika Della Mina, Laura Losa, Alexandra Madè, Giulia Rossetti, Lorenzo Andrea Bassi, Giovanni Pieri, Baran Bayindir, Jole Messa, Orsetta Zuffardi, Roberto Ciccone

“…We report a girl with a de novo distal deletion of 9p affected by idiopathic central precocious puberty and intellectual disability. Genome-wide array-CGH revealed a terminal deletion of about 11 Mb, allowing to define her karyotype as 46; XX, del(9)(p23-pter). …”
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The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders by Sean D. Fraser, Sean D. Fraser, Robert J. Harvey, Robert J. Harvey

“…Consistent with these findings, we and others have identified missense variants and microdeletions in the human GlyR α2 subunit gene (GLRA2) in individuals with autism spectrum disorder (ASD), developmental delay (DD) and/or intellectual disability (ID), often accompanied by microcephaly, language delay and epilepsy. …”
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