Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study by Juan Antonio Carrillo-Norte, Guillermo Gervasini-Rodríguez, María Ángeles Santiago-Triviño, Virginio García-López, Rafael Guerrero-Bonmatty

“…Osteoarthritis (OA) is a major source of chronic pain and disability, representing a significant global health concern that affects 10–15 % of individuals aged over 60, with a higher prevalence among females than males. …”
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A randomized controlled study of auricular point acupressure to manage chemotherapy-induced neuropathy: Study protocol. by Nada Lukkahatai, Michael V Nguyen, Jingyu Zhang, Yu-Min Cho, Chitchanok Benjasirisan, Heijingzi Monica Jia, Claudia M Campbell, Jennifer Kawi, Hulin Wu, Hongyu Wang, Rupsikha Bora, Johannes Thrul, Constance M Johnson, Thomas J Smith

“…<h4>Objective</h4>Chemotherapy-induced neuropathy (CIN) significantly impacts cancer patients, leading to functional disability, diminished quality of life, and increased healthcare costs amid the ongoing opioid crisis. …”
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Intervertebral disc regeneration – Is it possible? by Dragos Schiopu, Arnaud Devriendt, Clara Van Vyve, Tamas S. Illes

“…The dGEMRIC studies in degenerative and control discs, visual analogue scale (VAS), Oswestry disability index (ODI), lumbar lordosis, and disc thickness were reviewed before and after surgery. …”
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An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990–2021 by Zhuowen Hu, Xue Wang, Xin Zhang, Wuping Sun, Jun Mao

“…High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). This study aimed to quantify the global burdens of GBTCs attributable to high BMI from 1990 to 2021, thereby developing more rational prevention and treatment strategies for GBTC.MethodsData were extracted from the Global Burden of Disease (GBD) 2021. …”
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Physical Therapy in the Management of Pelvic Floor Muscles Hypertonia in a Woman with Hereditary Spastic Paraplegia by Aline Moreira Ribeiro, Cristine Homsi Jorge Ferreira, Elaine Cristine Lemes Mateus-Vasconcelos, Rafael Mendes Moroni, Luciane Maria Oliveira Brito, Luiz Gustavo Oliveira Brito

“…PF spasticity can lead to severe disability and interfere with daily basic functions, such as micturition and evacuation. …”
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Clinical and Imaging Prognosis in Patients with Delayed Encephalopathy after Acute Carbon Monoxide Poisoning by Jinzhi Liu, Zhihua Si, Jie Liu, Yan Lin, Jing Yuan, Shan Xu, Yan He, Tao Zhang, Aihua Wang

“…The prognosis of patients with DEACMP was poor, and they had a relatively severe disability. The early use of hyperbaric oxygen is of great significance to improve clinical efficacy and get a better prognosis.…”
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Progressive histological and behavioral deterioration of a novel mouse model of secondary hydrocephalus after subarachnoid hemorrhage by Xuehai Deng, Jianlin Ding, Chang Liu, Zhong Wang, Junchi Wang, Qiyue Duan, Weida Li, Xinlong Chen, Xiaoping Tang, Long Zhao

“…Abstract Hydrocephalus commonly occurs after subarachnoid hemorrhage (SAH) and is associated with increased morbidity and disability in patients with SAH. Choroid plexus cerebrospinal fluid (CSF) hypersecretion, obliterative arachnoiditis occluding the arachnoid villi, lymphatic obstruction, subarachnoid fibrosis, and glymphatic system injury are considered the main pathological mechanisms of hydrocephalus after SAH. …”
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In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial. by Baback Roshanravan, Sophia Z Liu, Amir S Ali, Eric G Shankland, Chessa Goss, John K Amory, H Thomas Robertson, David J Marcinek, Kevin E Conley

“…<h4>Background</h4>Loss of mitochondrial function contributes to fatigue, exercise intolerance and muscle weakness, and is a key factor in the disability that develops with age and a wide variety of chronic disorders. …”
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Epidemiological, clinical and imaging profile of Multiple Sclerosis by Làzaro Aurelio Vàzquez Gòmez, Carlos Hidalgo Mesa, Benita Mabel Beltrán González, Yunier Broche Pérez, Ana María Mederos Herrera

“…Symptoms: motor deficit, sensory deficit and cerebellar alterations were the most frequent at the beginning and at present. Disability evaluated as minimal was found in 50 patients and 31 patients had 2 to 4 lesions on nuclear magnetic resonance.…”
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Psychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review by Pietro Cappelletto, Claudia Accolla, Martina Preti, Tiziana Pisano, Carmen Barba, Renzo Guerrini

“…Abstract People with epilepsy (PWE) are at higher risk of psychiatric disorders (PD), disability, and reduced quality of life than the general population, especially in childhood and adolescence and when seizures originate from the temporal lobe. …”
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Axial spondyloarthritis in India: determining the delay in diagnosis, impact on work productivity, and attitude of patients toward treatment by Kamini Narendra Reddy, Asawari Raut, Pravin Patil

“…AxSpA not only reduces work productivity but also leads to work disability. There is a need to address the patient's concerns regarding modern medicine so that their health-seeking behavior is improved.…”
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Effectiveness of Traditional Healers in Program to Control Leprosy in Nagan Raya District in Aceh by Teuku Alamsyah, Said Usman, Mutia Yusuf, Said Devi Elvin

“…Nagan Raya was the District in Aceh with the highest number of cases; new cases in 2015 comprised 26 with Paucibacillary (PB) and 21 with Multibacillary (MB) with a total of 4.26% with Grade II disability. The phenomena of handling and treatment by the people in Nagan Raya involve treatment by traditional healers, “Tabib”, to treat the leprosy, with treatments known as Peundang locally. …”
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Severe Psychomotor Delay in a Severe Presentation of Cat-Eye Syndrome by Guillaume Jedraszak, Aline Receveur, Joris Andrieux, Michèle Mathieu-Dramard, Henri Copin, Gilles Morin

“…Many reported cases also presented with variable congenital anomalies and intellectual disability. Most patients diagnosed with CES carry a small supernumerary bisatellited marker chromosome, resulting in partial tetrasomy of 22p-22q11.21. …”
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The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective by Sheng Chen, Min Wang, Shuai Zhang, Xin Huang, Xinke Sui, Dou Li, Changqing Zhong, Wei Wu

“…The main cause of GARD-related clinical symptoms and signs of GARD is the structural damage and functional disability, which were caused by repeated contact between the mucous epithelium of the reflux tract and the acidic and non-acidic components of the reflux. …”
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Acupuncture as a Therapeutic Intervention for Alleviating Pain Associated with Knee Osteoarthritis in the Elderly by Ida Ayu Suptika Strisanti, Ida Ayu Anom Rastiti, Kadek Buja Harditya, I Dewa Ayu Agra Darmawati, Komang Rosa Tri Anggaraeni

“…KOA is a major cause of disability and immobility, significantly impacting the quality of life of the elderly. …”
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Research on stroke patients' perception of recurrence risk: A scoping review protocol. by Shanshan Zhu, Xueting Sun, Xin Guo, Meiqi Xu, Dingding Li, Shuaiyou Wang, Yage Shi, Chenjun Liu, Hongru Wang, Huimin Zhang

“…<h4>Introduction</h4>Stroke, a major global cause of death and disability, has a high recurrence rate that significantly affects patients' physical, psychological, and economic well-being. …”
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Study on the Application of O2O Peer Tutor Collaborative Health Management Program in Rural Diabetes Patients with Non-standard Treatment by JIA Honghong, DU Qiuhui, ZHANG Zichen, ZHOU Yuqiu

“…Diabetes health management is focused on preventing and controlling diabetic complications in rural areas of China, as well as lowering disability and death rates. Objective To explore the effects of O2O peer mentor collaborative health management on the risk perception and diabetes management self-efficacy in rural patients with non-standard diabetes treatment. …”
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Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review by Ren Y, Chen G, Hong Y, Wang Q, Lan B, Huang Z

“…Yisong Ren, Gang Chen, Ying Hong, Qianying Wang, Bo Lan, Zhaozhao Huang Department of Critical Care Medicine, Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611731, People’s Republic of ChinaCorrespondence: Zhaozhao Huang, Department of Critical Care Medicine, Chengdu Pidu District Hospital of Traditional Chinese Medicine, No. 169, Zhongxin Avenue, Pidu District, Chengdu, Sichuan Province, 611731, People’s Republic of China, Email tcmhzz@126.comAbstract: Cerebral ischemia-reperfusion injury (CIRI) is clinically characterized by high rates of morbidity, disability, mortality, and recurrence as well as high economic burden. …”
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Burden and mortality of breast cancer attributed to diabetes and smoking in women: a secondary analysis based on Global Burden of Disease 2019 in North Africa and the Middle East by Fatemeh Khosravi Shadmani, Ali Jafari-Khounigh, Leili Abedi Gheshlaghi, Leila Rezakhani, Mozafar Khazaei

“…In this study, we used data for disability-adjusted life years (DALYs) and mortality of BC in MENA countries. …”
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Engineered tRNAs efficiently suppress CDKL5 premature termination codons by Stefano Pezzini, Aurora Mustaccia, Pierre Aboa, Giorgia Faustini, Alessio Branchini, Mirko Pinotti, Angelisa Frasca, Joseph J. Porter, John D. Lueck, Nicoletta Landsberger

“…Abstract The CDKL5 deficiency disorder (CDD) is a severe neurodevelopmental disorder characterized by early-onset epilepsy, intellectual disability, motor and visual dysfunctions. The causative gene is CDKL5, which codes for a kinase required for brain development. …”
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