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1701
Global burden of ischemic heart disease in older adult populations linked to non-optimal temperatures: past (1990–2021) and future (2022–2050) analysis
Published 2025-02-01“…BackgroundIschemic heart disease (IHD) is a leading cause of death and disability, particularly affecting the older adult population. …”
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1702
Volume contracted state, mortality and functional outcomes in patients with acute ischaemic stroke due to large vessel occlusion
Published 2025-02-01“…Background Acute ischaemic stroke (AIS) is a leading cause of mortality and disability globally, with volume contracted state (VCS), as indicated by an elevated blood urea nitrogen to creatinine (BUN/Cr) ratio, potentially influencing outcomes. …”
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1703
Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI
Published 2025-01-01“…Participants with confirmed disability improvement (CDI) had fewer HPS-positive lesions at baseline than those without CDI (P < 0.001). …”
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1704
High-Titer Rheumatoid Factor is Associated with Worse Clinical Outcomes and Higher Needs for Advanced Therapies in Rheumatoid Arthritis Under Real-Life Conditions
Published 2024-12-01“…In multivariate analyses, high-titer RF was independently associated with higher disease activity (Clinical Disease Activity Index, CDAI: β = 2.44 [0.89, 3.99], p = 0.002), worse functional capacity (Health Assessment Questionnaire Disability Index, HAQ-DI: β = 0.112 [0.018, 0.205], p = 0.020); extra-articular manifestations (OR 1.48 [1.09, 2.00], p = 0.011); increased corticosteroid (OR 1.53 [1.19, 1.96], p = 0.001) and biological disease-modifying antirheumatic drugs (bDMARD) use (OR 1.41 [1.08, 1.84], p = 0.011). …”
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1705
Clinical characteristics and outcomes of patients with chondroblastoma undergoing surgery with various adjuvant procedures: a retrospective study of 59 cases
Published 2025-01-01“…Patients with local recurrence had a high degree of disability and joint deformity (P < 0.05). Two patients received preoperative denosumab and neither experienced local recurrence nor functional impairments. …”
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1706
Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia.
Published 2024-12-01“…Associated exacerbations and declining lung function contribute to increasing disability and mortality. There are no data about the prevalence of non-cystic fibrosis bronchiectasis etiologies in the Colombian population. …”
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1707
Social-ecological perspective on the suicidal behaviour factors of early adolescents in China: a network analysis
Published 2024-02-01“…Network analysis was employed to examine the correlates of suicidal ideation, plans and attempts at four levels, namely individual (sex, academic performance, serious physical illness/disability, history of self-harm, depression, impulsivity, sleep problems, resilience), family (family economic status, relationship with mother, relationship with father, family violence, childhood abuse, parental mental illness), school (relationship with teachers, relationship with classmates, school-bullying victimisation and perpetration) and social (social support, satisfaction with society).Results In total, 37.9%, 19.0% and 5.5% of the students reported suicidal ideation, plans and attempts in the past 6 months, respectively. …”
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1708
Signature for Pain Recovery IN Teens (SPRINT): protocol for a multisite prospective signature study in chronic musculoskeletal pain
Published 2022-06-01“…Discovery of robust prognostic markers separating patients who recover from patients with persistent pain and disability is critical for developing patient-specific treatment strategies and conceiving novel approaches that benefit all patients. …”
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1709
CLN6‐related continuum phenotype caused by aberrant splicing
Published 2025-02-01“…Plain Language Summary We report a patient with CLN6 disease who developed symptoms at an intermediate age: 9 years for mild intellectual disability and 14 years for occipital seizures and progressive myoclonus epilepsy, without visual impairment. …”
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1710
Risk factors associated with degenerative glenohumeral osteoarthritis
Published 2025-02-01“…Univariate, least absolute shrinkage and selection operator and multivariate analyses identified risk factors, including age, body mass index (BMI), sex, work-related shoulder problems, shoulder disability, dislocation, previous trauma, surgery, smoking, hypertension, diabetes, depression, heart disease, OA, night pain and overall sleep quality.Results A total of 1827 cases and 1556 controls were identified for GH OA. …”
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1711
Physical health in young males and risk of chronic musculoskeletal, cardiovascular, and respiratory diseases by middle age: A population-based cohort study.
Published 2025-01-01“…<h4>Background</h4>Cardiovascular, respiratory, and musculoskeletal disease are among the leading causes of disability in middle-aged and older people. Health and lifestyle factors in youth have known associations with cardiovascular or respiratory disease in adulthood, but largely unknown associations with musculoskeletal disease.…”
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1712
The effect of core stabilization exercises and shock wave therapy in patients with radiculopathy
Published 2018-06-01“…Lumbar radiculopathy is characterized by a wide variety of symptoms including the most common: lower back pain and lower limb pain, muscle weakness, disorders of proprioreceptive and postural control, which adversely affect the daily activities and quality of life of a person and result in a decrease in labour productivity in the working age population as well as disability development. Physical exercises and physiotherapy used during physical therapy have shown to reduce pain, improve and manage balance. …”
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1713
Impact of quality of life on overall work productivity impairment and activity impairment of patients with systemic lupus erythematosus: the PEONY study
Published 2025-01-01“…Patients completed patient-reported outcome (PRO) questionnaires, including LupusPRO, Work Productivity and Activity Impairment-Lupus, EQ-5D-5L and Health Assessment Questionnaire-Disability Index. Disease activity and organ damage were investigator-assessed. …”
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1714
Functional cognitive disorder: Beyond pseudodementia
Published 2025-01-01“…Special emphasis is placed on the prognosis of this condition, which, despite the associated disability and distress, rarely progresses to dementia. …”
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1715
Comprehensive health risk assessment of urban ambient air pollution (PM2.5, NO2 and O3) in Ghana
Published 2025-01-01“…Air pollution in Ghana causes approximately 28,000 premature deaths and disabilities annually, ranking as a leading cause of mortality and disability-adjusted life years. …”
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1716
Ibero-American consensus statement on migraine treatment
Published 2025-01-01“…Introduction and objectives: Migraine is the most common reason for neurology outpatient consultation; more than 80% of patients with migraine suffer some degree of associated disability. Migraine is an underdiagnosed disorder and patients frequently receive inappropriate treatment, which is why it is necessary to establish recommendations to improve patient management. …”
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1717
Effect of an Internet-Based Pilates Telerehabilitation Intervention in People With Multiple Sclerosis: Protocol for a Randomized Controlled Trial
Published 2025-02-01“…People with MS with mild disability, low risk of falling, preserved cognitive functions, and low anxiety and depression are potential eligible participants. …”
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1718
Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials
Published 2023-03-01“…[xvii] National Council on Disability, Organ Transplant Discrimination against People with Disabilities (Washington, DC, 2019), 25-35, https://ncd.gov/sites/default/files/NCD_Organ_Transplant_508.pdf.; Halpern and Goldberg, supra. …”
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1719
Against Futility Judgments for Patients with Prolonged Disorders of Consciousness
Published 2022-07-01“…However, these beliefs can be predicated on prejudiced perceptions about the quality of life of individuals with disabilities or chronic illnesses, a phenomenon commonly referred to as the disability paradox.[11] The paradox describes the discrepancy between patients with disabilities who report a quality of life much higher than non-disabled individuals would predict their ratings. …”
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1720
Comparative analysis of clinical efficacy of unilateral biportal endoscopic and open transforaminal lumbar interbody fusion in the treatment of lumbar degenerative
Published 2025-01-01“…Clinical efficacy was assessed preoperatively and at 1 month, 3 months, and 12 months postoperatively using the Visual Analogue Scale (VAS) and the Oswestry Disability Index (ODI). Patient satisfaction was evaluated using the modified Macnab criteria. …”
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