Investigating the Safety of Fampridine in Patients with Different Stages of Multiple Sclerosis by Saeed Vaheb, Mahour Farzan, Alireza Afshari-Safavi, Narges Ebrahimi, Vahid Shaygannejad, Omid Mirmosayyeb

“…Background: Fampridine is the only drug approved by the US Food and Drug Administration (FDA) for people with multiple sclerosis (MS) to improve their movement and has exhibited a clinically significant improvement in gait function in a subset of MS patients with Expanded Disability Status Scale (ESDSS) from 4 to 7. Nevertheless, this drug has been reported to possess some adverse effects (AEs) like seizure because of its pharmacological features. …”
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Selective Serotonin Reuptake Inhibitors and Associated Bleeding Risks: A Narrative and Clinical Review by Amber N. Edinoff, Keerthiga Raveendran, Marc A. Colon, Bennett H. Thomas, Katie A. Trettin, Grace W. Hunt, Adam M. Kaye, Elyse M. Cornett, Alan D. Kaye

“…Major Depressive Disorder (MDD) is a major cause of disability worldwide and is associated with serious lasting impairment. …”
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Economic loss attributable to premature deaths and morbidity among adolescents in India and its states by G Anil Kumar, Anamika Pandey, Rakhi Dandona

“…Methods We utilised the data on the number of adolescent deaths and attributable years lived with disability (morbidity) in every state of India as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. …”
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Laboratory biomarkers for multiple sclerosis and their role in clinical practice by I. Navickaitë, G. Žemgulytė, R. Balnytė

“…However, this has also raised new challenges in predicting the course and activity of the disease before the development of new neurological deficits that aggravate the disability and in prescribing the most appropriate disease-modifying therapy for the individual patient in a timely manner. …”
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Factors affecting negative and positive emotions among spouses caring for patients with psychotic or bipolar disorder by Haruka Ogawa, Nao Shiraishi, Hiroko Yatsu, Tatsuo Akechi

“…The negative emotions of husbands were linked to personal strain, whereas those of wives were associated with patient disability in family communication. Sense of coherence was the only factor predicting positive emotions for both sexes. …”
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Perceptual Disturbances and Disorders in the ICD-11: An Overview and a Proposal for Systematic Classification by Berthold Langguth, Michael Landgrebe, Dirk De Ridder

“…The descriptions of the sensory disturbances should include (1) a causal aspect (primary versus secondary), (2) a temporal aspect (acute vs. chronic and persistent vs. intermittent), (3) a cognitive, emotional and autonomic interpretation aspect (=suffering) and (4) a social aspect (=disability). If the latter two aspects are present, we propose that the sensory disturbance is called a sensory disorder.…”
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Human platelet lysate: a potential therapeutic for intracerebral hemorrhage by Dachang Qiu, Lin Wang, Lanlan Wang, Yongfei Dong

“…Intracerebral hemorrhage (ICH) is a major public health challenge worldwide, and is associated with elevated rates of mortality, disability, and morbidity, especially in low- and middle-income nations. …”
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Coping strategies and correlations with depressive symptoms among female nurses working in Japanese general hospitals by Hideyuki Kubo, Yoshiyuki Kaneko, Kaori Saitoh, Ryuji Furihata, Maki Jike, Yuichiro Otsuka, Makoto Uchiyama, Makoto Uchiyama, Masahiro Suzuki

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Snoezelen or Controlled Multisensory Stimulation. Treatment Aspects from Israel by Joav Merrick, Carmit Cahana, Meir Lotan, Isack Kandel, Eli Carmeli

“…In Israel today, with a total population of over 6 million persons, the Division for Mental Retardation (DMR) provides services to 23,000 persons with intellectual disability (ID). Of the 23,000, residential services are provided to more than 6,000 in close to 60 residential centers, another 2,000 are provided residential care in hostels or group homes in the community in about 50 locations, while the rest are served with day-care kindergarten, day-treatment centers, sheltered workshops, or integrated care in the community. …”
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Trends, global comparisons, and projections of early onset colorectal cancer burden in China based on GBD study 2021 by Shun Seng Ong, Lianjie Xu, Xiaoyue Deng, Hai Lu, Tianshu Xu

“…The analysis focused on age-standardized incidence rates (ASIR), prevalence rates (ASPR), mortality rates (ASMR), and disability-adjusted life years (DALYs). Joinpoint regression was used to determine the average annual percentage change (AAPC), and the ARIMA model was employed to forecast trends from 2022 to 2050. …”
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Burden of mental disorders by gender in Pakistan: analysis of Global Burden of Disease Study data for 1990–2019 by Mohsin Hassan Alvi, Tehmina Ashraf, Farah Naz, Asif Sardar, Akbar Ullah, Anita Patel, Tayyeba Kiran, Anil Gumber, Nusrat Husain

“…We used the crude data of disability-adjusted life-years (DALYs) obtained from the Global Burden of Disease Study database (1990–2019) to represent burden. …”
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Temporal dynamics of neonatal hypoxic–ischemic encephalopathy injuries on magnetic resonance imaging by Holly Flyger, Samantha J. Holdsworth, Alistair J. Gunn, Laura Bennet, Hamid Abbasi

“…Moderate to severe perinatal hypoxic–ischemic encephalopathy occurs in ~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental disability. Detailed assessment is important to help identify high-risk infants, to help families, and to support appropriate interventions. …”
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Utilization of telemedicine in conjunction with wearable devices for patients with chronic musculoskeletal pain: a randomized controlled clinical trial by Kazuhiro Hayashi, Kenji Miki, Yukiko Shiro, Tomoko Tetsunaga, Toshifumi Takasusuki, Masako Hosoi, Masao Yukioka

“…The secondary outcome measures were the Pain Catastrophizing Scale (PCS), Hospital Anxiety and Depression Scale (HADS), Pain Disability Assessment Scale (PDAS), and EuroQol-five dimensions-three level (EQ-5D-3L). …”
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Effectiveness of Spinal Stabilization Exercises on Dynamic Balance in Adults with Chronic Low Back Pain by Yousef M. Alshehre, Khalid Alkhathami, Kelli Brizzolara, Mark Weber, Sharon Wang-Price

“…Participants' dynamic balance was measured using the Y-Balance Test (YBT) and the normalized composite scores, Numeric Pain Rating Scale and Modified Oswestry Low Back Pain Disability Questionnaire scores were collected at baseline, two weeks, four weeks, and eight weeks…”
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Eptinezumab-jjmr, a humanized monoclonal specific to Calcitonin Gene Related Peptide, for the preventive treatment of migraine in adults by Amnon A. Berger, Joseph Keefe, Cain W. Stark, Matthew Moore, Giovanni F. Ramírez, Julia R. Cucarola, Andrew H. Han, Alan D. Kaye, Latha Ganti

“…It is a prevalent disorder that causes significant, worldwide disability, morbidity, suffering, and costs. The pathophysiology of migraines is actively studied, though recent research points to an initiating event causing migraine generation, that is then propagated by other brain regions, a significant one being the trigeminocervical complex. …”
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Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease by Zhu J, Zhang Z, Chu Y, Xie Z, Zeng D, Jin L, Li L

“…Jiamin Zhu,1,* Zhen Zhang,1,2,* Yanhui Chu,1,* Zhongyin Xie,1 Dongmei Zeng,1 Lijiao Jin,1 Luxin Li1 1Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, People’s Republic of China; 2School of First Clinical Medical College, Mudanjiang Medical University, Mudanjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Luxin Li, Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, 157000, People’s Republic of China, Tel +86 13763617174, Email liluxin@mdjmu.edu.cnAbstract: Kidney diseases are a significant global cause of death and disability, resulting from the destruction of kidney structure and function due to an imbalance between the death of renal parenchymal cells and the proliferation or recruitment of maladaptive cells, caused by various pathogenic factors. …”
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A Sarsa(λ)-Based Control Model for Real-Time Traffic Light Coordination by Xiaoke Zhou, Fei Zhu, Quan Liu, Yuchen Fu, Wei Huang

“…However, as there are so many factors that can affect the traffic control model, it is difficult to find the optimal solution. The disability of traffic light controllers to learn from past experiences caused them to be unable to adaptively fit dynamic changes of traffic flow. …”
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Exploring the Mechanisms of Zhenbao Pills in the Treatment of Stroke through Network Pharmacology Combined with Mendelian Randomization by Yanhong Liu, Yunqi Hua, Xiaoe Jia

“…Background: Stroke causes substantial death and disability worldwide, challenging healthcare systems and impacting patients' lives. …”
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Prevalence of sexual dysfunction in HTLV-1 patients without spastic paraparesis and the association with psychiatric symptoms by Maedeh Kamrani, Narges Niazi Rad, Fariba Zemorshidi, Majid Khadem-Rezaiyan

“…Patients with spastic paraparesis, leukemia, and uveitis, and those with an expanded disability status scale (EDSS) score higher than 2 were excluded. …”
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Arthroscopic Rotator Cuff Restoration Using Sironix Suture Anchor: A Retrospective Observational Study by Krunal Shah, Ruchita Manwani, Ashok Kumar Moharana, Sachin Angrish, T. S. Deepak

“…Postoperatively, patients were followed up and functional outcomes were evaluated using the American Shoulder and Elbow Surgeons Standardization Shoulder Assessment (ASES), level of activity using the Simple Shoulder Test (SST) questionnaire, Quality of life using the Shoulder Pain and Disability Index (SPADI) scale, and Single Assessment Numerical Evaluation (SANE) score on a scale of 0–100. …”
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