Unravelling the transcriptomic symphony of muscle ageing: key pathways and hub genes altered by ageing and caloric restriction in rat muscle revealed by RNA sequencing by Gulam Altab, Brian J. Merry, Charles W. Beckett, Priyanka Raina, Inês Lopes, Katarzyna Goljanek-Whysall, João Pedro de Magalhães

“…Abstract Age-related muscle wasting, sarcopenia is an extensive loss of muscle mass and strength with age and a major cause of disability and accidents in the elderly. Mechanisms purported to be involved in muscle ageing and sarcopenia are numerous but poorly understood, necessitating deeper study. …”
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Multimorbidity patterns and function among adults in low- and middle-income countries: a scoping review by Karina Berner, Quinette A Louw, Eugene Nizeyimana, Diribsa Tsegaye Bedada

“…The International Classification of Functioning, Disability and Health framework was used to classify functional problems.Results Nine studies (total sample size: 62 003) were included, mainly from upper-middle-income Asian countries. …”
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Association of dysautonomia and different risk factors in patients with Guillain-Barré syndrome in a tertiary hospital in the Philippines by Gerald T. Pagaling, Lowrence Precious C. Dichoso, Nikolai Gil D. Reyes, Mario B. Prado

“…The patient demographics, comorbidities, GBS disability status scale (GBS-DS), GBS variants, parameters of dysautonomia, treatment, and outcome were recorded and analyzed. …”
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Work-Related Musculoskeletal Disorders and Associated Factors Among Bankers in Ethiopia, 2018 by Alemu Kasaw Kibret, Berihu Fisseha Gebremeskel, Kebede Embaye Gezae, Gebrerufael Solomon Tsegay

“…WMSDs are the major causes of disability and cause individual suffering and financial burdens to the individual, families, industry or employer, healthcare system, and society at large. …”
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Swiss chiropractic practice-based research network and musculoskeletal pain cohort pilot study: protocol of a nationwide resource to advance musculoskeletal health services researc... by Milo A Puhan, Viktor von Wyl, Alice Kongsted, Cesar A Hincapié, Léonie Hofstetter, Rahim Lalji

“…Introduction Musculoskeletal (MSK) pain conditions, a leading cause of global disability, are usually first managed in primary care settings such as medical, physiotherapy, and chiropractic community-based practices. …”
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Pulmonary Rehabilitation in COPD: A Reappraisal (2008–2012) by Pierachille Santus, Linda Bassi, Dejan Radovanovic, Andrea Airoldi, Rita Raccanelli, Francesco Triscari, Francesca Giovannelli, Antonio Spanevello

“…Chronic Obstructive Pulmonary Disease (COPD) is a complex pathological condition associated with an important reduction in physical activity and psychological problems that contribute to the patient's disability and poor health-related quality of life. …”
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Benefits of the Global Integration Method (Método de Integração Global - MIG) in functional priorities of parents of Brazilian children and adolescents with autism spectrum disorde... by Amanda Aparecida Alves Cunha Nascimento, Deisiane Oliveira Souto, Thalita Karla Flores Cruz, Arthur Felipe Barroso de Lima, Gabriela Silva Oliveira, Vitor Geraldi Haase

“…This study aims to identify the functional priorities of parents of Brazilian children and adolescents with ASD, analyze variations in priorities according to the levels of support and age groups of the participants, and categorize the goals according to the categories of the International Classification of Functioning, Disability, and Health (ICF). Additionally, this study aimed to evaluate changes in parents’ performance and satisfaction with functional priorities after intervention with the Global Integration Method (Métodode Integração Global - MIG). …”
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Single-cell RNA sequencing revealed PPARG promoted osteosarcoma progression: based on osteoclast proliferation by Lei Sun, Jinhao Zhang, Zhikai Xiahou, Zhenzhen Zhao, Yanchen Liang

“…It is notorious for its high invasiveness, high disability rate, high mortality rate, and poor prognosis. …”
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Genotypic Spectrum in a Cohort of Sri Lankan Patients With Homocystinuria by Hewa Warawitage Dilanthi, Kandana Liyanage Subhashinie Jayasena, Nambage Dona Priyani Dhammika, Neluwa Liyanage Ruwan Indika, Matara Mahavidanage Nishani De Silva, Imalke Kankananarachchi, Pushpa Malkanthi Gardiye Punchihewa, Dharma Irugalbandara, Sabine Schroeder, Kosala Karunaratne, Eresha Jasinge

“…Among the 14 patients, the common clinical features were ectopia lentis (100%), intellectual disability (92%) and marfanoid features (78%) at presentation while three of them had developed osteoporosis (21%). …”
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Practice on Metered Dose Inhaler Techniques and Its Associated Factors among Asthmatic Patients at Debre Markos Comprehensive Specialized Hospital, East Gojjam, Ethiopia: A Prospec... by Tadele Asmare, Anteneh Belayneh, Bekalu Dessie

“…Asthma stands 16th among the leading causes of years lived with disability and 28th among the leading causes of disease in the world. …”
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The role of polymorphic variants of arginase genes (<i>ARG1, ARG2</i>) involved in beta-2-agonist metabolism in the development and course of asthma by O. N. Savelieva, A. S. Karunas, Yu. Yu. Fedorova, R. R. Murzina, A. N. Savelieva, R. F. Gatiyatullin, E. I. Etkina, E. K. Khusnutdinova

“…Uncontrolled asthma symptoms are a cause of disease progression and development, they lead to an increase in the patient’s disability. The sensitivity to asthma therapy largely depends on the interaction of genetic and epigenetic factors, which account for about 50–60 % of variability of therapeutic response. …”
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The Link Between Gut Microbiota and Depression: Exploring the Correlation by Adam Juśkiewicz, Olga Grelewicz, Natalia Kucy, Elwira Servaas, Mateusz Haber, Paula Kula, Adrianna Czachor, Alicja Kotula

“… Introduction: Depression represents a significant global health challenge, affecting approximately 4.4% of the global population and ranking as the leading cause of disability worldwide. Despite advancements in pharmacotherapy and psychotherapeutic interventions, a substantial proportion of individuals with depression experience treatment resistance, recurrence of symptoms, or inadequate response to standard treatments. …”
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A case of 49,XXXYY followed-up from infancy to adulthood with review of literature by Junko Kanno, Akinobu Miura, Sayaka Kawashima, Hirohito Shima, Dai Suzuki, Miki Kamimura, Ikuma Fujiwara, Masayuki Kamimura, Mitsugu Uematsu, Masataka Kudo, Atsuo Kikuchi

“…Subsequent examinations were conducted due to various symptoms, including delayed motor development, intellectual disability, facial dysmorphisms, forearm deformities, hip dysplasia, cryptorchidism, micropenis, primary hypogonadism, and essential tremor. …”
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The Effect of Blood Flow Restriction Therapy on Shoulder Function Following Shoulder Stabilization Surgery: A Case Series by John H. McGinniss, John S. Mason, Jamie B. Morris, Will Pitt, Erin M. Miller, Michael S. Crowell

“…Statistically significant and clinically meaningful improvements were reported on the Single Assessment Numeric Evaluation (*p* \< 0.001; mean difference, 17.7; CI: 9.4, 25.9) and Shoulder Pain and Disability Index (*p* \< 0.001; mean difference, -31.1; CI: -44.2, -18.0) from six to 12 weeks postoperatively. …”
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Global, regional and national burden of asthma attributable to NO2 from 1990 to 2021: an analysis from the Global Burden of Disease Study 2021 by Chunyi Zhang, Jian Sun, Jingli Li, E Qin, Lingjing Liu, Guimei Pu

“…Objectives This study aims to systematically assess the global, regional, and national burden of asthma attributable to nitrogen dioxide (NO₂) pollution.Design and setting Analysis of population-level data from 1990 to 2021 obtained from the Global Burden of Disease Study 2021, covering 204 countries and territories.Participants Participants included patients with asthma attributable to NO₂ pollution.Main outcomes and measures Asthma-related disability-adjusted life-years (DALYs) and age-standardised DALY rates (ASDR) attributable to NO₂ pollution across 204 countries and territories. …”
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Gastric cancer incidence, mortality and burden in adolescents and young adults: a time-trend analysis and comparison among China, South Korea, Japan and the USA by Jian Li, Yao Zhang, Si Lin Wu, Yi Fu, Ji Sheng Wang

“…The trend magnitude and directions over time for incidence and mortality of GCAYA were analysed and compared among four countries.Main outcomes and measures Outcomes included new cases, deaths, mortality-to-incidence ratios (MIRs), disability-adjusted life years, and their age-standardised rates and estimated annual percentage changes (AAPCs).Results There were 49 008 new cases and 27 895 deaths from GCAYA in 2019, nearly half of which occurred in China. …”
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Burdens of Tracheal, Bronchus, and Lung Cancer From 1990 to 2021 in China Compared to the Global Projection of 2036: Findings From the 2021 Global Burden of Disease Study by Yuxing Chen, Qingpeng Zeng, Muyu Li, Jiahui Jin, Jun Zhao

“…Methods We conducted an analysis of incidence, prevalence, mortality, and disability‐adjusted life years (DALYs) from 1990 to 2021. …”
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High-Intensity Interval Training Improves Physical Function, Prevents Muscle Loss, and Modulates Macrophage-Mediated Inflammation in Skeletal Muscle of Cerebral Ischemic Mice by Lu Luo, Meixi Liu, Hongyu Xie, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Junfa Wu, Congyu Jiang, Yi Wu

“…Although skeletal muscle is the main effector organ largely accounting for disability after stroke, considerably less attention is paid to the secondary abnormalities of stroke-related skeletal muscle loss. …”
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Acupuncture as prophylaxis for chronic migraine: a protocol for a single-blinded, double-dummy randomised controlled trial by Claire Shuiqing Zhang, Bin Li, Lin Zeng, Lu Liu, Luo-peng Zhao, Kelun Wang, Jingxia Zhao, Linpeng Wang, Xianghong Jing

“…The primary outcome is the reduction of monthly headache days, and the secondary outcomes include the reduction of the number of days with acute headache medications, and changes of Migraine Disability Assessment, Migraine-Specific Quality of Life Questionnaire, Headache Impact Test, State-Trait Anxiety Inventory-trait, and Beck Depression Inventory-II scores from baseline to endpoints.Ethics and dissemination Ethical approval of this study was granted by the Research Ethical Committee of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University (2017BL-045-01). …”
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Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures by Caitlin C. Clements, Anne-Michelle Engelstad, Carol L. Wilkinson, Carly Hyde, Megan Hartney, Alexandra Simmons, Helen Tager-Flusberg, Shafali Jeste, Charles A. Nelson

“…These results highlight the challenge of using resting state EEG features as biomarkers in trials with neurodevelopmental disabilities when epilepsy and anti-epileptic medication are common.…”
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