Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder by Claudia Fuchs, Laura Gennaccaro, Stefania Trazzi, Stefano Bastianini, Simone Bettini, Viviana Lo Martire, Elisa Ren, Giorgio Medici, Giovanna Zoccoli, Roberto Rimondini, Elisabetta Ciani

“…CDKL5 disorder primarily affects girls and is characterized by early-onset epileptic seizures, gross motor impairment, intellectual disability, and autistic features. Although all CDKL5 female patients are heterozygous, the most valid disease-related model, the heterozygous female Cdkl5 knockout (Cdkl5 +/−) mouse, has been little characterized. …”
Get full text

Assessing the inflammation in pediatric MOGAD: Significance of CSF HMGB1 and related biomarkers by Xin Wang, Ruibin Zhao, Jiayu Fan, Chong Liu, Li Zhang, Huafang Yang, Weiyi Wang

“…We recruited 30 patients with MOGAD (20 in the acute phase and 10 in remission) and 10 control patients with noninflammatory demyelinating disease. The expanded disability status scale (EDSS) was used to assess disease severity.ResultsNLRP3, HMGB1, and IL-6 levels in the CSF were significantly higher in patients with MOGAD during the acute phase than in remission (P < 0.05, P < 0.05, P < 0.05) and the control group (P < 0.01, P < 0.0001, P < 0.01). …”
Get full text

Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeutics by Seyede Sara Pakdaman Kolour, Saeide Nematollahi, Masoud Dehbozorgi, Farnaz Fattahi, Fatemeh Movahed, Neda Esfandiari, Mohammad Saeed Kahrizi, Nima Ghavamikia, Bahareh Salmanian Hajiagha

“…The primary cause of pain and disability in the world is osteoarthritis (OA), a common joint disease characterized by the primary pathological alteration in articular cartilage deterioration. …”
Get full text

Usefulness of the Brief Scale for Psychiatric Problems in Orthopaedic Patients (BS-POP) for Predicting Poor Outcomes in Patients Undergoing Lumbar Decompression Surgery by Kazuyuki Watanabe, Koji Otani, Takuya Nikaido, Kinshi Kato, Hiroshi Kobayashi, Junichi Handa, Shoji Yabuki, Shin-Ichi Kikuchi, Shin-Ichi Konno

“…The secondary outcomes were NRS scores for low back pain, leg pain, and leg numbness and scores on the Roland–Morris Disability Questionnaire (RDQ). BS-POP was used to detect psychiatric problems before surgery. …”
Get full text

Platelet-rich fibrin and silver nano-particles loaded chitosan treatment for post- laminectomy epidural scar adhesions: in vivo rats study model by Samah Fouad, Awad Rizk, Esam Mosbah, Mostafa M. Nabeeh, Walaa Awadin, Ayman S. Elmezayyen, Ekramy Elmorsy, Adel Zaghloul

“…Abstract Objective Epidural scar fibrosis commonly leads to functional disability and pain following spinal surgery and is a prevalent manifestation of Failed Back Surgery Syndrome (FBSS). …”
Get full text

Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis by Xue Zhang, Ruli Ge, Hongliang Chen, Maxwell Ahiafor, Bin Liu, Jinbo Chen, Xueli Fan

“…Multiple sclerosis (MS) is a severe autoimmune disease that affects the central nervous system and results in disability, mediated by autoreactive T cells with evolving evidence of a remarkable contribution from humoral responses. …”
Get full text

Global burden of osteoarthritis from 1990 to 2019 attributable to high body mass index by Siming Yang, Licheng Zhou, Wanchen Gong, Bin Guo, Linfeng Wang

“…Material and methods Disability-adjusted life years (DALYs) and age-standardized DALY rates, and their corresponding estimated annual percentage changes (EAPCs), were used to compare estimated OA burdens between countries and regions. …”
Get full text

New‐Occurrence of Postoperative Modic Changes and Its Influence on the Surgical Prognosis After Percutaneous Endoscopic Lumbar Disc Discectomy by Lei Li, Chao Wang, Hao Zhang, Zhiming Liu, Zheng Lian, Han Li, Hao Tao, Xuexiao Ma

“…Pain levels and surgical outcomes were evaluated using the visual analog scale, Oswestry Disability Index, and Macnab criteria. Univariate analysis explored the relationship between postoperative MCs and pain, while subgroups investigated the associations between postoperative efficacy, recurrence, and MCs type and area. …”
Get full text

Adverse childhood experiences, sleep quality/duration and later-life lower extremity function among older adults in China: evidence from CHARLS by Jiaqiang Xiao, Xiaosheng Dong, Meng Ding, Tao Kong

“…Conclusion ACEs, particularly household mental illness and parental disability, are associated with poorer lower extremity function in older adults. …”
Get full text

Falls and Fractures in the Elderly with Sinus Node Disease: The Impact of Pacemaker Implantation by Nazmi Krasniqi, Diana Segalada, Thomas F. Lüscher, Kurt Lippuner, Laurent Haegeli, Jan Steffel, Thomas Wolber, Corinna Brunckhorst, Johannes Holzmeister, David Hürlimann, Firat Duru

“…Falls and fractures in the elderly are among the leading causes of disability. We investigated whether pacemaker implantation prevents falls in patients with SND in a large cohort of patients. …”
Get full text

Syngap1 promotes cognitive function through regulation of cortical sensorimotor dynamics by Thomas Vaissiere, Sheldon D. Michaelson, Thomas Creson, Jessie Goins, Daniel Fürth, Diana Balazsfi, Camilo Rojas, Randall Golovin, Konstantinos Meletis, Courtney A. Miller, Daniel O’Connor, Lorenzo Fontolan, Gavin Rumbaugh

“…Here, we demonstrate in mice that expression of the autism/intellectual disability gene, Syngap1, in cortical excitatory neurons is required for the formation of somatomotor networks that promote SMI-mediated perception. …”
Get full text

Evaluation of the role of hydroxychloroquine as a lipid profile improving and glucose adjusting drug in Egyptian females with inactive rheumatoid arthritis by Aliaa O. El-Hady, Mai M. Kamel, Yasmin T. Mosaad, Maha A. Ali, Soad S. El Molla

“…Background/aim Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that leads to joint destruction and disability with increased risk of cardiovascular disease (CVD), a leading cause of morbidity and mortality in RA. …”
Get full text

Traumatic Fracture: Dislocation of Cervicothoracic Junction—Grand Round Presentation of C7-T1 Instabilities and Different Instrumentation Techniques by Mohammad A. Alsofyani, Soufiane Ghailane, Sultan Alsalmi, Sreenath Jakinapally, Louis Boissière, Ibrahim Obeid, Jean-Marc Vital

“…At one-year postoperative follow-up, radiographs revealed bony fusion at the level of C7-T1, and the patient had no major functional disability. Conclusion. We opted for the ventral-dorsal approach in our case for maximum stabilization and to prevent mechanical complications.…”
Get full text

Advances in Serological Diagnosis of Neurocysticercosis in Korea by Chun-Seob Ahn, Jeong-Geun Kim, Sun Huh, Insug Kang, Yoon Kong

“…Cysticercosis, a parasitic disease caused by Taenia solium metacestode (TsM), has a major global public health impact in terms of disability-adjusted life years. The parasite preferentially infects subcutaneous tissue, but may invade the central nervous system, resulting in neurocysticercosis (NC). …”
Get full text

Stem Cell–Based Therapies via Different Administration Route for Stroke: A Meta-analysis of Comparative Studies by Gabriella Jeanne Mulia, Novelia Anna, John Chung-Che Wu, Hon-Ping Ma, Yung-Hsiao Chiang, Ju-Chi Ou, Kai-Yun Chen

“…Stroke, a neurological condition from compromised cerebral blood perfusion, remains a major global cause of mortality and disability. Conventional therapies like tissue plasminogen activator are limited by narrow therapeutic windows and potential adverse effects, highlighting the urgency for novel treatments. …”
Get full text

Dynamic Stabilisation in the Treatment of Degenerative Disc Disease with Modic Changes by Olcay Eser, Cengiz Gomleksiz, Mehdi Sasani, Tunc Oktenoglu, Ahmet Levent Aydin, Yaprak Ataker, Tuncer Suzer, Ali Fahir Ozer

“…The quality of life and pain scores were evaluated by visual analog scale (VAS) score and Oswestry Disability Index (ODI) preoperatively and at 3, 12, and 24 months after surgery. …”
Get full text

Social isolation in the young and middle-aged patients with stroke: role of social support, family resilience and hope by Xiao Jia Wu, Ke Ke, Hui Liu, Shao Ping Zhan, Lei Wang, Juan Feng He

“…BackgroundStroke is the leading cause of death and disability among adults in China. Social isolation in stroke survivors is a major public health concern across the globe. …”
Get full text

Multiple Sclerosis Nursing to Improve Care and Education (MSNICE): an observational study by Liesbeth Van Hijfte, Melissa Cambron, Roel Crols, Gino De La Meilleure, Nelly Govers, Ludo Vanopdenbosch, Guy Laureys, Barbara Willekens, for the MSNICE Study Group

“…The median expanded disability status scale and patient determined disease steps were respectively 2.0 (IQR 2.5) and 2.5 (IQR 3). …”
Get full text

Active Theater as a Complementary Therapy for Parkinson's Disease Rehabilitation: A Pilot Study by Nicola Modugno, Sara Iaconelli, Mariagrazia Fiorlli, Francesco Lena, Imogen Kusch, Giovanni Mirabella

“…We hypothesized that theater could reduce clinical disability and improve the quality of life of PD patients (primary end points) more efficiently than other complementary therapies because (1) in order to impersonate a character, patients are forced to regain the control of their bodies; and (2) while being part of a group, patients have a high degree of social interaction. …”
Get full text

The association between visceral fat metabolic score and stroke: mediation by declining kidney function by Yue Cao, Weixing Wen, Hao Zhang, Weiwen Li, Guolin Huang, Yuli Huang

“…Abstract Background Stroke is a leading cause of mortality and disability worldwide. Metabolic Score for Visceral Fat (METS-VF), a metric of visceral obesity, has emerged as a novel predictor of metabolic diseases. …”
Get full text