Connecting Cerebral White Matter Lesions and Hypertensive Target Organ Damage by Cristina Sierra, Alfons López-Soto, Antonio Coca

“…Stroke is the second leading cause of death and the number one cause of disability worldwide and over 80% of strokes occur in the elderly. …”
Get full text

Associations between nonrestorative sleep and suicidal ideation: a Japanese general population survey by Kouju Yamada, Yoshiyuki Kaneko, Chisato Konno, Ryuji Furihata, Yuichiro Otsuka, Yoshitaka Kaneita, Makoto Uchiyama, Masahiro Suzuki

Get full text

Skipping Posterior Dynamic Transpedicular Stabilization for Distant Segment Degenerative Disease by Bilgehan Solmaz, Ahmet Levent Aydin, Cengiz Gomleksiz, Yaprak Ataker, Mehdi Sasani, Tunc Oktenoglu, Ali Fahir Ozer

“…The Oswestry Low-Back Pain Disability Questionnaire and visual analog scale (VAS) for pain were recorded preoperatively and at the third and twelfth postoperative months. …”
Get full text

Assessment of Compliance of Glucosamine and Chondroitin Sulfate in Patients with Early Osteoarthritis of the Knee by Ajit Prakash Bhaskarwar, Ashish Pande, Kailash Pati Dev Jaidev

“…Background: Osteoarthritis (OA) is one of the common causes of knee disability. Depending on the stages of the disease, various treatment modalities are available. …”
Get full text

Cognitive Rehabilitation for Executive Dysfunction in Parkinson's Disease: Application and Current Directions by Jessica Calleo, Cristina Burrows, Harvey Levin, Laura Marsh, Eugene Lai, Michele K. York

“…Cognitive dysfunction in Parkinson's disease contributes to disability, caregiver strain, and diminished quality of life. …”
Get full text

Neonatal myoclonus in Bryant-Li-Bhoj syndrome associated with a novel H3F3A variant by Moemi Hojo, Noriko Soma, Kei Yamada, Yu Kobayashi, Masaki Miura, Hitomi Fujii, Hiromi Nyuzuki, Yosuke Nishio, Taichi Oso, Tomoo Ogi, Takeshi Ikeuchi, Jun Tohyama

“…Abstract Bryant-Li-Bhoj syndrome (BLBS; OMIM # 619720, 619721), caused by germline H3F3A and H3F3B variants encoding histone H3.3, is characterized by mild to severe developmental delay, intellectual disability, failure to thrive, muscle tone abnormalities, and dysmorphic facial features. …”
Get full text

The Effect of Intradermal Injection with Two Different Injection Techniques on Pain and Functional Status in Patients with Chronic Nonspecific Neck Pain by Sadiye MURAT

“…Pain was assessed using the visual analog scale (VAS), functional status was assessed using the neck disability index (NDI), and quality of life was assessed using the Nottingham health profile before (T0), after (T1), and 3 months after (T2). …”
Get full text

Benefits of Kangaroo Mother Care for the “Larger” Low Birth Weight Infant (> 2000g) by Maria UP (SR. Lias) Urakkattil, Suman Rao P N, Pragya Dubey, Swarnarekha Bhat

“… Introduction Prematurity and low birth weight LBW are major factors in neonatal mortality and neurodevelopmental disability. Kangaroo Mother Care KMC combining skin-to-skin contact and exclusive breastfeeding is effective in LBW infants. …”
Get full text

Mortality in admitted diabetic patients in the Hospital of Puyo, Pastaza province, Ecuador by Mayra Alejandra Bayas Aranda, Johnnatan Gustavo Rivera Almeida, Edison Ramiro Samaniego Layedra, Patricia del Rocío Asadobay Escobar

“…It is described as one of the main causes of morbidity and mortality worldwide, as well as responsable for different degrees of disability and a great impact on health-related quality of life.…”
Get full text

Funding the New Biologics – CCOHTA Report on the Cost Effectiveness of Infliximab for Crohn’s Disease: Pearls and Pitfalls by John K Marshall

“…This is especially important for patients with severe Crohn’s disease, who have significant disability and for whom few therapeutic options exist.…”
Get full text

Lactic Acid Regulation: A Potential Therapeutic Option in Rheumatoid Arthritis by Qianlei Wang, James Asenso, Ning Xiao, Jinzhang Gao, Feng Xiao, Jiajie Kuai, Wei Wei, Chun Wang

“…Rheumatoid arthritis (RA) is a chronic, persistent autoimmune disease that causes severe joint tissue damage and irreversible disability. Cumulative evidence suggests that patients suffering from RA for long durations are at risk of functional damage to cardiovascular, kidney, lung, and other tissues. …”
Get full text

Investigation of the trends and associated factors of ovarian cancer in Indonesia: A systematic analysis of the Global Burden of Disease study 1990-2021. by Brahmana Askandar Tjokroprawiro, Khoirunnisa Novitasari, Renata Alya Ulhaq, Hanif Ardiansyah Sulistya, Santi Martini

“…<h4>Methods</h4>We examined ovarian cancer incidence, mortality, and disability-adjusted life years (DALYs) using age-standardized rates from the Global Burden of Disease, Injuries, and Risk Factors Study 2021. high body mass index and occupational asbestos exposure were linked with death and DALYs. …”
Get full text

Role of circRMRP and circRPL27 in chronic obstructive pulmonary disease by Li JianFang, Zhang PengFei, Zeng XianJing, Liu Rong

“…Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability worldwide, and circRNA dysregulation is functionally associated with COPD. …”
Get full text

Integrated gene expression and alternative splicing analysis in human and mouse models of Rett syndrome by Silvia Gioiosa, Silvia Gasparini, Carlo Presutti, Arianna Rinaldi, Tiziana Castrignanò, Cecilia Mannironi

“…Abstract Mutations of the MECP2 gene lead to Rett syndrome (RTT), a rare developmental disease causing severe intellectual and physical disability. How the loss or defective function of MeCP2 mediates RTT is still poorly understood. …”
Get full text

Current evidence on the use of sugammadex for neuromuscular blockade antagonism during electroconvulsive therapy: a narrative review by Vivek Arora, Laurence Henson, Sandeep Kataria

“…Depression is a common mental health problem that is associated with significant disability and mortality. Electroconvulsive therapy (ECT) has been demonstrated to be effective at resolving expression of suicidal intent in patients with depression. …”
Get full text

Genomic Copy Number Variation Affecting Genes Involved in the Cell Cycle Pathway: Implications for Somatic Mosaicism by Ivan Y. Iourov, Svetlana G. Vorsanova, Maria A. Zelenova, Sergei A. Korostelev, Yuri B. Yurov

“…Here, we have evaluated genomic copy number variation (CNV) in genes implicated in the cell cycle pathway (according to Kyoto Encyclopedia of Genes and Genomes/KEGG) within a cohort of patients with intellectual disability, autism, and/or epilepsy, in which the phenotype was not associated with genomic rearrangements altering this pathway. …”
Get full text

The Association between Systemic Immune-Inflammation Index and All-Cause Mortality in Acute Ischemic Stroke Patients: Analysis from the MIMIC-IV Database by Shaosheng Wu, Xiaoting Shi, Quan Zhou, Xiangjie Duan, Xiongfei Zhang, Huajing Guo

“…Acute ischemic stroke (AIS) is a devastating disease and remains the leading cause of death and disability. This retrospective study aims to investigate associations between systemic immune-inflammation index (SII) and all-cause mortality in patients with AIS. …”
Get full text

Etiopathogenesis and surgical treatment of epithelial pilonidal sinus by A. Yu. Titov, I. V. Kostarev, A. K. Batischev

“…Attempts to find the radical EPS treatment method providing the lowest pain level, small wound surface and allowing the lowest possible disability period and motor activity limitation, stimulate development of new surgical treatment methods and improvement of already established operations.Conclusion. …”
Get full text

Study of Clinical and Epidemiological Factors in Patients Diagnosed with Rheumatoid Arthritis by Rolando Rodríguez Puga, Yasnier Dueñas Rodríguez

“…<strong>Foundation</strong>: rheumatoid arthritis is a chronic autoimmune disease that produces chronic and irreversible joint damage that leads to deterioration in quality of life and permanent disability with a worldwide prevalence of between 1.0 and 1.5 %. …”
Get full text

Evaluation of Urinary Tract Infection following Corticosteroid Therapy in Patients with Multiple Sclerosis Exacerbation by Aliyeh Bazi, Seyed Mohammad Baghbanian, Monireh Ghazaeian, Sahar Fallah, Narjes Hendoiee

“…Demographic data, duration of multiple sclerosis, urinary tract symptoms, the Expanded Disability Status Scale (EDSS) score, and urine data were analyzed. …”
Get full text