The Identification of Immune-Related Biomarkers for Osteoarthritis Immunotherapy Based on Single-Cell RNA Sequencing Analysis by Zhe Tan, Rong Chen, Hanyu Lin, Hong Wang

“…Globally, OA is one of the most common and leading causes of disability. Several genetic factors are involved in OA, including inherited genes, genetic susceptibility, and genetic predisposition. …”
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Psychiatric and Behavioral Complications of GPi DBS in an Adolescent with Myoclonus Dystonia by Graciela Kriegel, Melanie I. Stuckey

“…Myoclonus dystonia is a rare movement disorder that often causes significant disability. Deep brain stimulation of the internal pallidum (GPi DBS) is a recommended treatment for those who do not respond to pharmacotherapy or who have intolerable side effects. …”
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EFFECTIVENESS OF CLINICALLY SUPERVISED EXERCISE PROGRAM ASCOMPARED TO HOME BASED EXERCISE PROGRAM ON PAIN ANDDISABILITY IN KNEE OSTEOARTHRITIS by Wahaj Sheikh

“… ABSTRACT The Objectives of this study was to compare the effectiveness of clinically supervised exercise program with home based exercise program on pain and disability in knee osteoarthritis. Individuals with pain full knee were enrolled from the OPD of IPM & R, Dow University of Health Sciences (DUHS), Karachi. …”
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Health care utilization patterns of patients enrolled in an interdisciplinary program for back pain by Sara Davin, Psy.D., MPH, Brittany Lapin, PhD., MPH, Belinda Udeh, PhD, Sarah Rispinto, PhD, Nicolas R. Thompson, MS, Ryan Honomichl, PhD, Andre Machado, MD, Irene L. Katzan, MD

“…Background: Chronic low back pain is a costly condition and the leading cause of disability worldwide. A recent call to action identified the overuse of low-value health care as ineffective and potentially harmful in the context of back pain. …”
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Restorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifid... by Frank Schwab, Nagy Mekhail, Kiran V. Patel, Meredith Langhorst, Robert D. Heros, Jonathan Gentile, Sherif Costandi, Gregory Moore, Christopher Gilmore, Smith Manion, Krishnan Chakravarthy, S. Craig Meyer, Justin V. Bundy, Jordan L. Tate, Rebecca Sanders, Sandeep Vaid, Oszkar Szentirmai, Johnathan Goree, Vikas V. Patel, Jeff Lehmen, Mehul J. Desai, Jason E. Pope, Anthony Giuffrida, Salim Hayek, Sohrab Singh Virk, Richard Paicius, William R. Klemme, Robert Levy, Christopher Gilligan, the RESTORE investigators

“…The primary endpoint was a statistically significant demonstration of a clinically relevant mean improvement in the Oswestry Disability Index (ODI) between restorative neurostimulation and OMM arms: ODI (−19.7 ± 1.4 vs. −2.9 ± 1.4; p < 0.001). …”
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A New Smartphone-Based Cognitive Screening Battery for Multiple Sclerosis (icognition): Validation Study by Stijn Denissen, Delphine Van Laethem, Johan Baijot, Lars Costers, Annabel Descamps, Ann Van Remoortel, Annick Van Merhaegen-Wieleman, Marie D’hooghe, Miguel D'Haeseleer, Dirk Smeets, Diana M Sima, Jeroen Van Schependom, Guy Nagels

“…For each icognition test, validity was established by the correlation with its paper-and-pencil equivalent (concurrent validity), the correlation and intraclass correlation coefficient (ICC) between baseline and follow-up testing (test-retest reliability), the difference between people with MS and healthy participants, and the correlation with other clinical parameters such as the Expanded Disability Status Scale. ResultsAll icognition tests correlated well with their paper-and-pencil equivalents (Symbol Test: r=0.67; P<.001; Dot Test: r=0.31; P=.002; vBDS: r=0.69; P<.001), negatively correlated with the Expanded Disability Status Scale (Symbol Test: ρ=–0.34; P<.001; Dot Test: ρ=−0.32; P=.003; vBDS: ρ=−0.21; P=.04), and showed moderate test-retest reliability (Symbol Test: ICC=0.74; r=0.85; P<.001; Dot Test: ICC=0.71; r=0.74; P<.001; vBDS: ICC=0.72; r=0.83; P<.001). …”
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Psychosocial factors are associated with community mobility and participation in persons with dizziness by Pamela M. Dunlap, Jeffrey P. Staab, Patrick J. Sparto, Patrick J. Sparto, Joseph M. Furman, Susan L. Whitney, Susan L. Whitney

“…Increased psychosocial comorbidity among people with dizziness is associated with disability and poorer outcomes in vestibular rehabilitation. …”
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Why Are There So Many Ways to Measure Pain? Epistemological and Professional Challenges in Medical Standardization by Hanna Grol-Prokopczyk

“…Many respond to the considerable challenge of treating pain intensity by redefining their work—sometimes in the face of resistance from patients—around other, putatively more treatable domains, such as disability. The diverse, arguably unstandardized approaches to measuring pain appear attributable less to pain’s epistemological fragility than to its therapeutic intractability, and to the medical community’s diffuse social structures and professional goals.…”
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Research progress of rehabilitation nursing for stroke patients (脑卒中康复护理研究进展) by WANG Li (王丽)

“…Therefore, it is imperative to reduce the disability rate following stroke by early rehabilitation intervention. …”
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Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies by Lisa M. Billesberger, Kyle M. Fisher, Yawar J. Qadri, Richard L. Boortz-Marx

“…In addition to pain and disability, osteoarthritis is associated with depression, comorbid conditions such as diabetes, and increased caregiver burden. …”
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Comparative role of affective–Cognitive behavior therapy and jacobson's progressive muscular relaxation in managing pain among patients with fibromyalgia by M T Lakshmi Saranya, R Sreehari, C B Mithun, P I Sangeetha

“…Background: Fibromyalgia (FM) is a rheumatologic disease that advances with chronic pain and disability and represents one of the most common causes of chronic and diffuse pain in the population. …”
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Branch Retinal Artery Occlusion after Percutaneous Coronary Intervention by Tommaso La Macchia, Remo Albiero, Tommaso Invernizzi, Giorgia Ceravolo, Ida Ceravolo

“…Patients and health care providers should be aware of any visual signs. Permanent visual disability can be prevented by immediate diagnosis and prompt intervention.…”
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GaitRec-Net: A Deep Neural Network for Gait Disorder Detection Using Ground Reaction Force by Chandrasen Pandey, Diptendu Sinha Roy, Ramesh Chandra Poonia, Ayman Altameem, Soumya Ranjan Nayak, Amit Verma, Abdul Khader Jilani Saudagar

“…Walking (gait) irregularities and abnormalities are predictors and symptoms of disorder and disability. In the past, elaborate video (camera-based) systems, pressure mats, or a mix of the two has been used in clinical settings to monitor and evaluate gait. …”
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Factors Affecting Patient Satisfaction with Complete Dentures by Yara Oweis, Nadia Ereifej, Ayah Al-Asmar, Abdaljaber Nedal

“…Gender also influenced patient satisfaction with complete dentures especially the part related to psychological and social disability. Conclusions. Results of this study will help in further understanding factors influencing patient satisfaction with their complete dentures.…”
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Exploring the perspectives of child health strategy stakeholders on resilience and well-being in children and youths in Singapore: A qualitative study by Yee Keow Chiong, Kee Seng Chia

“…The factors associated with resilience are homogeneous across studies, which are individual attributes such as self-regulation and problem-solving skills, relational attributes such as secure attachment relationships, and connections to school and community.4 This is relevant to the Singaporean context, as the Singapore Mental Health Study conducted from 2016 to 2018 revealed that 1 in 5 youths, aged between 18 and 34 years old have a mental disorder.5 Mental disorders were also reported to be the largest contributor to disease burden for Singaporeans aged 10 to 34 years old, peaking for 15 to 19 year-olds, for whom it represented 25.8% of total disability-adjusted life years (DALYs).5 In 2020, suicide is the leading cause of death for those aged 10 to 29 years old. …”
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Influence of physiotherapy on forward head posture and related problems – a critical review of literature by Zbigniew Wroński, Mario Klasic, Burim Gjinovci

“…Existing evidence suggests that manual therapy has the potential to influence pain and disability in patients, prompting the research focus on postural changes. …”
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Improving stroke risk prediction by integrating XGBoost, optimized principal component analysis, and explainable artificial intelligence by Lesia Mochurad, Viktoriia Babii, Yuliia Boliubash, Yulianna Mochurad

“…Abstract The relevance of the study is due to the growing number of diseases of the cerebrovascular system, in particular stroke, which is one of the leading causes of disability and mortality in the world. To improve stroke risk prediction models in terms of efficiency and interpretability, we propose to integrate modern machine learning algorithms and data dimensionality reduction methods, in particular XGBoost and optimized principal component analysis (PCA), which provide data structuring and increase processing speed, especially for large datasets. …”
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Schools as Sites of Homelessness Prevention by Jayne Malenfant, Naomi Nichols

“…Building from experiences young people shared, this article highlights aspects of the public education system that pose problems for youth who are precariously housed or homeless, namely, the application of one-size-fits-all approaches, barriers for students with mental health or learning disability diagnoses, and the lack of clear or actionable institutional mechanisms for students to access preventative support. …”
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Pengalaman Ibu dalam Merawat Bayi dengan Prematur dan Berat Badan Lahir Rendah by Deswita

“…Many problems arise, if the infants is not treated as it should lead to disability and even death. However, there are some mothers who successfully care for premature and low birth weight infants in the house. …”
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The WAVE complex in developmental and adulthood brain disorders by Hyung-Goo Kim, Clara Berdasco, Angus C. Nairn, Yong Kim

“…De novo mutations in WAVE genes and other components of the WAVE complex have been identified in patients with developmental disorders such as intellectual disability, epileptic seizures, schizophrenia, and/or autism spectrum disorder. …”
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