S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study by Domenico De Berardis, Stefano Marini, Nicola Serroni, Gabriella Rapini, Felice Iasevoli, Alessandro Valchera, Maria Signorelli, Eugenio Aguglia, Giampaolo Perna, Anatolia Salone, Giuseppe Di Iorio, Giovanni Martinotti, Massimo Di Giannantonio

“…Secondary outcome measures included the Snaith-Hamilton Pleasure Scale (SHAPS) and the Sheehan Disability Scale (SDS). At 8 weeks, a significant decrease in HAM-D score was observed with response achieved by 60% of the patients and remission by 36%. …”
Get full text

Global trends in the burden of ischemic heart disease based on the global burden of disease study 2021: the role of metabolic risk factors by Yifei Wang, Qing Li, Lei Bi, Bin Wang, Tingting Lv, Ping Zhang

“…Methods Data from GBD 2021 was analyzed to evaluate the global age-standardized death rates (ASDR) and disability-adjusted life years (ASRDALYs) linked to IHD. …”
Get full text

Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials by Sathish Muthu, Sathish Muthu, Sathish Muthu, Vibhu Krishnan Viswanathan, Vibhu Krishnan Viswanathan, Prakash Gangadaran, Prakash Gangadaran, Prakash Gangadaran

“…Diverse post-intervention pain scores [visual analog score (VAS)] and functional scores [Oswestry Disability Index (ODI), SF-36], as reported in the reviewed studies, were evaluated. …”
Get full text

Patient education materials for non-specific low back pain and sciatica: a protocol for a systematic review and meta-analysis by Kris Aubrey-Bassler, Amanda Hall, Michelle Swab, Bradley Furlong, Andrea Pike, Holly Etchegary, Georgia Darmonkow

“…Introduction Low back pain accounts for more disability than any other musculoskeletal condition and is associated with severe economic burden. …”
Get full text

Сandidate SNP-markers of rheumatoid arthritis that can significantly alter the affinity of the TATA-binding protein for human gene promoters by I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, I. A. Drachkova, E. A. Oshchepkova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, V. A. Kozlov

“…This is very important, since doctors consider RA as one of the most frequent causes of disability. Using the Web service SNP_TATA_Z-tester (http://beehive.bionet.nsc.ru/cgi-bin/mgs/tatascan_fox/start.pl), 227 variants of single nucleotide polymorphism (SNP) of the human gene promoters were studied. …”
Get full text

Intracranial CT findings in traumatic brain injury: A retrospective, cross-sectional study among Igbo population in Nigeria by Angel-Mary Anakwue, Felicitas Ugochinyere Idigo, Uloma Benedicta Nwogu, Sylvester Osita Ogbu, Anthony Nnamani, Kennedy Joseph, Camillus Chukwuemeka Ugwoke

“…Introduction: Traumatic brain injury (TBI) is a major cause of death and disability and in recent years has been increasingly reported even in developing countries. …”
Get full text

Measuring social vulnerability in communities and its association with leprosy burden through spatial intelligence in central West Brazil to guide strategic actions by José Francisco Martoreli Júnior, Antônio Carlos Vieira Ramos, Josilene Dália Alves, Thaís Zamboni Berra, Yan Mathias Alves, Reginaldo Bazon Vaz Tavares, Letícia Perticarrara Ferezin, Titilade Kehinde Ayandeyi Teibo, Ricardo Alexandre Arcêncio

“…Results 8389 cases of leprosy were georeferenced, the majority being male (58%), 30% of cases were not evaluated for degree of physical disability. One of the spatial scan clusters had a relative risk (RR) of 6.93 (95% CI 6.49–7.4), and another had 1360 cases with RR 1.71 (95% CI 1.62–1.82). …”
Get full text

Design and Development of a Web‐Based Registry for Outpatient Rehabilitation: A Delphi Multi‐Disciplinary, Expert Consensus Study by Seyyedeh Fatemeh Mousavi Baigi, Masoumeh Sarbaz, Davood Sobhani‐Rad, Salman Nazary‐Moghadam, Javad Heravian Shandiz, Kosar Ghaddaripouri, Reyhane Norouzi Aval, Khalil Kimiafar

“…Coding guidelines were derived from the International Classification of Functioning, Disability, and Health. A questionnaire containing data elements of outpatient rehabilitation was developed based on the systematic reviews. …”
Get full text

Unveiling new therapeutic horizons in rheumatoid arthritis: an In-depth exploration of circular RNAs derived from plasma exosomes by Guoqing Li, Hongyi Chen, Jiacheng Shen, Yimin Ding, Jingqiong Chen, Yongbin Zhang, Mingrui Tang, Nan Xu, Yuxuan Fang

“…Abstract Rheumatoid arthritis (RA), a chronic inflammatory joint disease causing permanent disability, involves exosomes, nanosized mammalian extracellular particles. …”
Get full text

Association of vitamin D receptor gene polymorphisms with rheumatoid arthritis by Noelia Marquez Pete, Cristina Perez Ramirez, Maria del Mar Maldonado Montoro, Fernando Martinez Martinez, Fernando Fernández-Llimos, Antonio Sánchez Pozo, María del Carmen Ramirez Tortosa, Alberto Jiménez Morales

“…Introduction Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology which causes progressive deterioration of the joints, leading to severe pain and functional disability. Vitamin D and its receptor (VDR) play a significant part in the onset of autoimmune diseases such as RA. …”
Get full text

Global trends and epidemiological impact of metabolic risk factors on atrial fibrillation and atrial flutter from 1990 to 2021 by Junqing Liang, Jun Shen, Yankai Guo, Manzeremu Rejiepu, Xiuwen Ling, Xiaoyan Wang, Yi Jian, Xing Zhang, Shijie Shao, Baopeng Tang, Ling Zhang

“…This cross-sectional observational study assesses the epidemiological burden of AF/AFL concerning metabolic risk factors using the Global Burden of Disease (GBD) 2021 database. Age-standardized disability-adjusted life years rate (ASDR), mortality, and estimated annual percentage change were calculated. …”
Get full text

Multi-omics approaches to deciphering complex pathological mechanisms of migraine: a systematic review by Jiaojiao Liu, Qiaosheng Ren, Boxuan Du, Xian Liu, Yuqiu An, Peichi Zhang, Lexi Li, Zhenhong Liu, Zhenhong Liu, Kegang Cao, Kegang Cao

“…BackgroundMigraine represents a chronic neurological disorder characterized by high prevalence, substantial disability rates, and significant economic burden. Its pathogenesis is complex, and there is currently no cure. …”
Get full text

Cost-effectiveness and budget impact of covering Burkitt lymphoma in children under Ghana’s National Health Insurance Scheme by Richmond Owusu, Dakota Pritchard, Lieke Fleur Heupink, Godwin Gulbi, Brian Asare, Ivy Amankwah, Joycelyn Azeez, Martha Gyansa-Lutterodt, Lydia Dsane-Selby, Ruby Aileen Mensah, William Omane-Adjekum, Francis Ruiz, Mohamed Gad, Justice Nonvignon, Lumbwe Chola, Ghana Health Technology Assessment Technical Working Group

“…Both costs (measured in $) and effects, measured using disability adjusted life years (DALYs), were discounted at a rate of 3%. …”
Get full text

Burden trends and future predictions for hypertensive heart disease attributable to non-optimal temperatures in the older adults amidst climate change, 1990–2021 by Can Xu, Xinyu Nie, Rui Xu, Ge Han, Dongjin Wang

“…This study aims to evaluate the regional, gender-specific trends in the burden of HHD attributed to non-optimal temperatures among the older adults from 1990 to 2021, and to project future trends in HHD burden under climate-induced temperature anomalies from 2022 to 2050.MethodsData were sourced from the Global Burden of Disease Study (GBD 2021), which provides estimates of mortality and disability-adjusted life years (DALYs) at global, regional, and national levels. …”
Get full text

Incorporating insulin into alginate-chitosan 3D-printed scaffolds: A comprehensive study on structure, mechanics, and biocompatibility for cartilage tissue engineering by Afsaneh Jahani, Mohammad Sadegh Nourbakhsh, Ali Moradi, Marzieh Mohammadi, Lobat Tayebi

“…Osteoarthritis is a leading cause of disability worldwide, challenging current treatments to limited cartilage self-healing capacity. …”
Get full text

Long-Term Safety and Effectiveness of Dimethyl Fumarate in Patients with Multiple Sclerosis Treated in Routine Medical Practice: Final Analysis of the ESTEEM Study by Krupa Shah Pandey, Kathryn Giles, Konstantin Balashov, Richard Macdonell, Jörg Windsheimer, Mikel Martinez, Ivan Božin, Stephanie Raynaud, Matthew Scaramozza, Oksana Mokliatchouk, Zhaonan Sun, Nicholas Belviso, Yayoi Sato, Xiaochen Lin, Annette Okai

“…The estimated proportion of patients free from confirmed disability progression sustained over 48 weeks was 87.0% at month 60. …”
Get full text

Effects of Bilateral M1 Anodal Transcranial Direct Current Stimulation on Pain and Mood in Patients with Non-Specific Chronic Low Back Pain by LU Xuefang, YUAN Peng, DENG Shukun, SU Qiuju, FANG Xiangming, CHEN Gangrui, YANG Han, SHEN Ying

“…Before and after 4 weeks of treatment, the numerical rating scale (NRS) was used to evaluate pain intensity, the oswestry disability index (ODI) was used to evaluate lumbar dysfunction degree, while the pain catastrophizing scale (PCS), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess related negative emotions.Results1) Pain intensity: After treatment, the NRS scores in the experimental and control groups significantly decreased compared with those at the baseline (<italic>P</italic>&lt;0.05). …”
Get full text

Clinical and microbiological characteristics and prognosis of invasive infection caused by Klebsiella pneumoniae in the community by Hongkui Sun, Hanlin Zhang, Wenqing Lai, Li Lei, Jianwei Li, Miaolian Chen, Haijun Li, Zhanyuan Zhao

“…Background The incidence of invasive infection of Klebsiella pneumoniae (Kp) in the community is increasing every year, and the high disability and mortality rates associated with them pose great challenges in clinical practice. …”
Get full text

Global and regional burden of bloodstream infections caused by carbapenem-resistant Gram-negative bacteria in 2019: A systematic analysis from the MICROBE database by Lei Zha, Shirong Li, Jun Guo, Yixin Hu, Lingling Pan, Hanli Wang, Yun Zhou, Qiancheng Xu, Zhiwei Lu, Xiang Kong, Xinzhao Tong, Yusheng Cheng

“…The number and rate of deaths, as well as disability-adjusted life-years linked to bloodstream infections, were systematically analyzed. …”
Get full text

Knowledge, attitudes, and beliefs regarding acute coronary syndrome in patients with type 2 diabetes: a cross-sectional study by Mohammad Amerzadeh, Mahdie Bahrami, Mojtaba Senmar, Zahra Hosseinkhani, Zahra Shafiei Kisomi

“…Abstract Introduction Cardiovascular diseases are one of the leading causes of mortality and disability among individuals with diabetes. Cardiac mortality in these patients is often associated with the prevalence of silent ischemia. …”
Get full text