Evaluation of two electronic-rehabilitation programmes for persistent knee pain: protocol for a randomised feasibility trial by Philip G Conaghan, Kim L Bennell, Mark Conner, Rana S Hinman, Sarah R Kingsbury, Elizabeth M A Hensor, Gretl A McHugh, Christine Comer, Dawn Groves-Williams, Rachel K Nelligan

“…Introduction Persistent, knee pain is a common cause of disability. Education and exercise treatment are advocated in all clinical guidelines; however, the increasing prevalence of persistent knee pain presents challenges for health services regarding appropriate and scalable delivery of these treatments. …”
Get full text

Predictors of Neurological and Functional Recovery in Patients with Moderate to Severe Ischemic Stroke: The EPICA Study by Manuel Murie-Fernández, Mercedes Molleda Marzo

“…A large proportion of patients recovered from severe dependency on activities of daily living (ADL) at D0 to a mild or moderate disability requiring some help at M3: mean NIHSS=10.8 to 5.7; median modified Rankin Scale mRS=4 to 3; Barthel index BI=40 to 70; all p values<0.001. …”
Get full text

Impact of titanium mesh cage slotting width on anterior cervical corpectomy and fusion for compression cervical spondylosis with MRI T2WI hyperintensity: a one-year follow-up study by Rongguo Yu, Xiurong Yuan, Kangkang Huang, Tingkui Wu, Hong Wang, Chen Ding, Beiyu Wang, Hao Liu

“…The patients were divided into narrower (< 2 mm) and wider (> 2 mm) groups based on the slotting width of the TMC. The Neck Disability Index (NDI) and Japanese Orthopedic Association (JOA) scores were used to assess clinical outcomes. …”
Get full text

The correlations between demographic factors, self-efficacy, and quality of life among Indonesian patients with ischemic stroke: A cross-sectional study by Nabila Azzahra, Fitria Handayani, Wahyu Hidayati

“…Background: Ischemic stroke is the primary cause of neurological disability and can lead to psychological issues that affect self-efficacy. …”
Get full text

Discrepancies in safety reporting for chronic back pain clinical trials: an observational study from ClinicalTrials.gov and publications by Nick Boyne, Alison Duke, Jack Rea, Adam Khan, Alec Young, Jared Van Vleet, Matt Vassar

“…Abstract Introduction Chronic back pain (CBP) is a leading cause of disability worldwide and is commonly managed with pharmacological, non-pharmacological, and procedural interventions. …”
Get full text

Natural population cohort study on long-lived adults: West China longevity and ageing procedure (WCLAP) by Li Wang, Yan Zhang, Qiukui Hao, Xiaoyan Chen, Birong Dong, Yan He, Meijuan Chen, Jirong Yue, Xiaochu Wu, Tianyao Zhang, Yan She, Yanling Gao, Yiping Deng

“…Baseline data, group-level follow-up data and microbiological examination data are integrated together to provide an evaluation tool, exploring sarcopenia, disability, dementia, caregiver burden, ageing biomarkers and other influencing factors.Trial registration numbers 2018-463; ChiCTR1900020754.…”
Get full text

Comparative effectiveness of manual therapy, pharmacological treatment, exercise therapy, and education for neck pain (COMPETE study): protocol of a systematic review with network... by Ana Izabela Sobral de Oliveira-Souza, Jordana Barbosa-Silva, Douglas P. Gross, Bruno R. da Costa, Nikolaus Ballenberger, Tiago V. Pereira, Liz Dennett, Susan Armijo-Olivo

“…., ET, MT, education, and/or medication) to relieve pain and disability-related outcomes in patients with neck pain? …”
Get full text

Designing smartphone-based cognitive assessments for schizophrenia: Perspectives from a multisite study by Aishwarya Raje, Abhijit R. Rozatkar, Urvakhsh Meherwan Mehta, Ritu Shrivastava, Ameya Bondre, Manaal Amir Ahmad, Anshika Malviya, Yogendra Sen, Deepak Tugnawat, Anant Bhan, Tamonud Modak, Nabagata Das, Srilakshmi Nagendra, Erlend Lane, Juan Castillo, John A. Naslund, John Torous, Soumya Choudhary

“…Introduction: Cognitive deficits represent a core symptom of schizophrenia and a principal contributor to illness disability, yet evaluating cognition in routine clinical settings is often not feasible as cognitive assessments take longer than a standard doctor's visit. …”
Get full text

Global, regional, and national burden of young COPD, 1990–2021, with forecasts to 2050: a systematic analysis for the global burden of disease study 2021 by Yi Zhu, Tao Shen, Ruixin Guo, Ke Liu, Xiyu Cao, Xiuli Yang, Chuantao Zhang

“…The age-standardised prevalence rate (ASPR), age-standardised incidence rate (ASIR), age-standardised death rate (ASDR), and age-standardised disability-adjusted life years (DALYs) rate were used to describe the disease burden. …”
Get full text

Acceptability and Attitude towards a Mobile-Based Home Exercise Program among Stroke Survivors and Caregivers: A Cross-Sectional Study by Amreen Mahmood, Vevita Blaizy, Aparajita Verma, Joel Stephen Sequeira, Dola Saha, Selvam Ramachandran, N. Manikandan, Bhaskaran Unnikrishnan, John M. Solomon

“…Stroke is a leading cause of disability and requires continued care after hospital discharge. …”
Get full text

Acceptance commitment therapy (ACT) for psychological distress associated with inflammatory bowel disease (IBD): protocol for a feasibility trial of the ACTforIBD programme by Richard Gearry, Matthew Fuller-Tyszkiewicz, Andrew McCombie, Peter Gibson, Simon Knowles, Lisa Olive, Antonina Mikocka-Walus, Subhadra Evans, Leanne Raven, Daniel Romano, Eric O, Madeleine Dober, Leesa van Niekerk, Susan Chesterman

“…Using a randomised controlled trial, 25 participants will be randomised to ACTforIBD, and 25 patients to an active control condition.Ethics and dissemination This protocol has been approved by Deakin University Research Ethics Committee in September 2021 (Ref. 2021-263) and the New Zealand Central Health and Disability Ethics Committee in December 2021 (Ref. 2021 EXP 11384). …”
Get full text

Lactiplantibacillus plantarum AR113 alleviates microbiota dysbiosis of tongue coating and cerebral ischemia/reperfusion injury in rat by Zhiqiang Xiong, Gang Liu, Ling Fang, Xiuming Li, Yongjun Xia, Guangqiang Wang, Xin Song, Lianzhong Ai

“…Stroke is one of the leading causes of death and disability worldwide. However, information on stroke-related tongue coating microbiome (TCM) is limited, and whether TCM modulation could benefit for stroke prevention and rehabilitation is unknown. …”
Get full text

Global, regional, and national burden of very early-onset colorectal cancer and its risk factors from 1990 to 2019: A systematic analysis for the global burden of disease study 201... by Zhen Junhai, Meng Yang, Tan Zongbiao, Yan Wenxuan, Li Tiange, Wu Yanrui, Liu Chuan, Dong Weiguo

“…Risk factors for the burden of deaths and disability-adjusted life years (DALYs) due to very EOCRC were also explored in this study. …”
Get full text

The Epidemiology of Migraine Headache in Arab Countries: A Systematic Review by Ashraf El-Metwally, Paivi Toivola, Khalid AlAhmary, Salwa Bahkali, Ali AlKhathaami, Shatha A. Al Ammar, Ibrahim M. Altamimi, Saleh M. Alosaimi, Munazza Jawed, Sami Almustanyir

“…Recurring migraine disorders are a common medical problem, standing among the top causes of disability and sufferings. This study aimed to evaluate epidemiological evidence to report updated estimates on prevalence, risk factors, and associated comorbidities of migraine headache in the Arab countries. …”
Get full text

Randomised cross-over trial of vildagliptin and pioglitazone as add-on therapy in patients with type 2 diabetes: predicting Which One is Right Here (WORTH) study protocol by Yannan Jiang, Tony R Merriman, Rui Qian Yeu, Rebecca Brandon, Dale Griffiths, Kate Smallman, Allan Moffitt, Glenn Doherty, Ryan Paul, Jennie Harré Hindmarsh, Kerry Macaskill-Smith, Brandon Orr-Walker, Rinki Murphy

“…Secondary outcomes include weight change, frequency of side effects and patient preference.Ethics and dissemination Ethical approval of the trial has been obtained from the New Zealand Health and Disability Ethics Committee (18/STH/242). The trial commenced in February 2019 and recruitment is expected to be completed by March 2020. …”
Get full text

Systemic Vascular Function Is Associated with Muscular Power in Older Adults by Kevin S. Heffernan, Angela Chalé, Cynthia Hau, Gregory J. Cloutier, Edward M. Phillips, Patrick Warner, Heather Nickerson, Kieran F. Reid, Jeffrey T. Kuvin, Roger A. Fielding

“…Age-associated loss of muscular strength and muscular power is a critical determinant of loss of physical function and progression to disability in older adults. In this study, we examined the association of systemic vascular function and measures of muscle strength and power in older adults. …”
Get full text

Clinical and molecular analyses of isolated central congenital hypothyroidism based on a survey conducted in Japan by Nao Shibata, Chikahiko Numakura, Takashi Hamajima, Kenichi Miyako, Ikuma Fujiwara, Jun Mori, Akihiko Saitoh, Keisuke Nagasaki

“…One and two patients with IGSF1 variant had obesity and intellectual disability, respectively. Left amblyopia was identified in the patient with a TBL1X variant. …”
Get full text

Effect of Treatment Delay, Stroke Type, and Thrombolysis on the Effect of Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome after Acute Stroke: A Systematic Review and Meta-Ana... by Philip M. Bath, Lisa Woodhouse, Kailash Krishnan, Craig Anderson, Eivind Berge, Gary A. Ford, Thompson G. Robinson, Jeffrey L. Saver, Nikola Sprigg, Joanna M. Wardlaw, Blood pressure in Acute Stroke Collaboration (BASC)

“…Secondary outcomes included measures of disability, mood, and quality of life. Results. Five trials (4,197 participants) were identified, all involving glyceryl trinitrate (GTN). …”
Get full text

The burden of depression, anxiety and schizophrenia among the older population in ageing and aged countries: an analysis of the Global Burden of Disease Study 2019 by Wu Hong, Ying Cheng, Yu Fang, Jinxin Zheng, Shiyang Guan, Meiti Wang

“…However, the burden of these disorders in ageing and aged countries has not been analysed.Aims To investigate the burden of depression, anxiety and schizophrenia among older adults in ageing and aged countries.Methods Using data from the Global Burden of Disease Study 2019, we calculated the estimated annual percentage change (EAPC) in the age-standardised incidence rates (ASIR) and age-standardised disability-adjusted life years (DALYs) rates (ASDR) for depression, anxiety and schizophrenia of older people in ageing countries (China, India, Indonesia) and aged countries (Japan, Italy, Portugal) between 1990 and 2019. …”
Get full text

Association of calf circumference with osteoporosis and hip fracture in middle-aged and older adults: a secondary analysis by Mumin Cao, Yuanwei Zhang, Mengze Tong, Xiangxu Chen, Ziang Xu, Renwang Sheng, Liu Shi, Cheng Zhang, Wenbin Fan, Tian Xie, Yingjuan Li, Jinyu Wang, Wei Gao, Yunfeng Rui

“…Abstract Background Osteosarcopenia is a geriatric syndrome associated with an increased risk of frailty, falls, fractures, disability, and death. Calf circumference (CC) has been used as a simple and practical skeletal muscle marker to diagnose sarcopenia. …”
Get full text